Details for: NDUFV1

Gene ID: 4723

Symbol: NDUFV1

Ensembl ID: ENSG00000167792

Description: NADH:ubiquinone oxidoreductase core subunit V1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 306.1489
    Cell Significance Index: -47.6200
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 178.9126
    Cell Significance Index: -45.3800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 129.5362
    Cell Significance Index: -52.6300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 124.9252
    Cell Significance Index: -58.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 115.6137
    Cell Significance Index: -59.4700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 88.0150
    Cell Significance Index: -59.0600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 55.6485
    Cell Significance Index: -53.1300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 45.9465
    Cell Significance Index: -56.6500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3857
    Cell Significance Index: -43.9000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 15.1949
    Cell Significance Index: -59.9600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 13.9413
    Cell Significance Index: -42.8200
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 9.3531
    Cell Significance Index: -20.4700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.7672
    Cell Significance Index: 92.7900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.7362
    Cell Significance Index: 78.7000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.4812
    Cell Significance Index: 191.3600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.3654
    Cell Significance Index: 63.6600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.3320
    Cell Significance Index: 157.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.2197
    Cell Significance Index: 33.2000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.1986
    Cell Significance Index: 164.6000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1.1363
    Cell Significance Index: 29.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.0811
    Cell Significance Index: 590.3900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.0775
    Cell Significance Index: 194.2400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.0657
    Cell Significance Index: 55.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0127
    Cell Significance Index: 203.1500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.0094
    Cell Significance Index: 65.1200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.0058
    Cell Significance Index: 29.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.9942
    Cell Significance Index: 21.5400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.9933
    Cell Significance Index: 122.1300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.9841
    Cell Significance Index: 69.6000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.9743
    Cell Significance Index: 74.7700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.9650
    Cell Significance Index: 20.2000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.9647
    Cell Significance Index: 71.9000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.9585
    Cell Significance Index: 27.6200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9574
    Cell Significance Index: 423.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9364
    Cell Significance Index: 44.0100
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.8435
    Cell Significance Index: 9.1700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.8108
    Cell Significance Index: 22.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7351
    Cell Significance Index: 94.2400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6883
    Cell Significance Index: 8.8200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.5648
    Cell Significance Index: 15.0800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.5311
    Cell Significance Index: 12.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.5140
    Cell Significance Index: 102.0100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5075
    Cell Significance Index: 182.0200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.3762
    Cell Significance Index: 12.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3675
    Cell Significance Index: 36.3500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3380
    Cell Significance Index: 21.3000
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.3190
    Cell Significance Index: 4.7100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2827
    Cell Significance Index: 9.8300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2719
    Cell Significance Index: 44.2200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2701
    Cell Significance Index: 243.8500
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.2419
    Cell Significance Index: 3.6300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2184
    Cell Significance Index: 41.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1924
    Cell Significance Index: 10.0200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.1390
    Cell Significance Index: 1.1100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1243
    Cell Significance Index: 91.1500
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0908
    Cell Significance Index: 15.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0505
    Cell Significance Index: 95.0200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.0504
    Cell Significance Index: 2.8300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0353
    Cell Significance Index: 1.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0334
    Cell Significance Index: 61.6900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0260
    Cell Significance Index: 17.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0160
    Cell Significance Index: 24.5900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0140
    Cell Significance Index: 10.5600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0134
    Cell Significance Index: 0.2300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0049
    Cell Significance Index: 3.1000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0108
    Cell Significance Index: -0.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0156
    Cell Significance Index: -0.9600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0175
    Cell Significance Index: -23.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0262
    Cell Significance Index: -2.6800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0448
    Cell Significance Index: -20.3300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0681
    Cell Significance Index: -50.4200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0908
    Cell Significance Index: -51.2200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0924
    Cell Significance Index: -2.3600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1069
    Cell Significance Index: -66.7400
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.1227
    Cell Significance Index: -1.1300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1696
    Cell Significance Index: -48.8100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1961
    Cell Significance Index: -15.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2117
    Cell Significance Index: -30.7800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.2136
    Cell Significance Index: -14.7700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2495
    Cell Significance Index: -28.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2899
    Cell Significance Index: -33.7900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3020
    Cell Significance Index: -63.6200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3551
    Cell Significance Index: -9.5200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3795
    Cell Significance Index: -25.5200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.4768
    Cell Significance Index: -8.4300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4823
    Cell Significance Index: -6.5800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.5057
    Cell Significance Index: -22.3700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5348
    Cell Significance Index: -55.6900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5449
    Cell Significance Index: -32.7100
  • Cell Name: germ cell (CL0000586)
    Fold Change: -0.5543
    Cell Significance Index: -4.1900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5840
    Cell Significance Index: -22.1200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6241
    Cell Significance Index: -15.6000
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.6392
    Cell Significance Index: -7.6200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.6539
    Cell Significance Index: -18.7500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.7341
    Cell Significance Index: -45.0100
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.7825
    Cell Significance Index: -9.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8260
    Cell Significance Index: -24.3300
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.8984
    Cell Significance Index: -9.3000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.9062
    Cell Significance Index: -22.1100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.9498
    Cell Significance Index: -10.7900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Mitochondrial localization:** NDUV1 is a mitochondrial protein, suggesting its involvement in the electron transport chain, which is essential for energy production in cells. 2. **Electron transport chain complex I:** NDUV1 is a core subunit of complex I, the first enzyme in the electron transport chain, which generates the proton motive force necessary for ATP synthesis. 3. **Iron-sulfur cluster binding:** NDUV1 contains four iron-sulfur clusters, which are essential for the enzyme's activity and stability. 4. **Aerobic respiration:** NDUV1 is involved in aerobic respiration, the process by which cells generate energy in the presence of oxygen. **Pathways and Functions:** 1. **Mitochondrial electron transport:** NDUV1 plays a crucial role in the electron transport chain, generating the proton motive force necessary for ATP synthesis. 2. **Aerobic respiration:** NDUV1 is involved in aerobic respiration, the process by which cells generate energy in the presence of oxygen. 3. **Proton motive force-driven ATP synthesis:** NDUV1 contributes to the generation of the proton motive force, which drives ATP synthesis by the enzyme ATP synthase. 4. **Heat production by uncoupling proteins:** NDUV1 may also be involved in the regulation of heat production by uncoupling proteins, which can affect cellular energy metabolism. **Clinical Significance:** 1. **Neurodegenerative disorders:** Dysregulation of NDUV1 has been implicated in neurodegenerative disorders, such as Parkinson's disease and Alzheimer's disease, which are characterized by energy metabolism dysregulation. 2. **Metabolic disorders:** NDUV1 dysfunction has been linked to metabolic disorders, such as diabetes and obesity, which are characterized by impaired energy metabolism. 3. **Cancer:** NDUV1 has been identified as a potential oncogene, with its dysregulation contributing to cancer development and progression. 4. **Mitochondrial disorders:** NDUV1 mutations have been associated with mitochondrial disorders, which are characterized by impaired energy metabolism and organ dysfunction. In conclusion, NDUV1 plays a critical role in mitochondrial function and energy metabolism, and its dysregulation has been implicated in various diseases. Further research is needed to elucidate the mechanisms underlying NDUV1 dysfunction and to explore its therapeutic potential in diseases associated with mitochondrial dysfunction.

Genular Protein ID: 1564357165

Symbol: NDUV1_HUMAN

Name: NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

UniProtKB Accession Codes:

P49821 O60924 O60940 Q16104 Q6IBR3 Q96BF8 Q96HS7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioCyc 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CORUM 1 CTD 1 CarbonylDB 1 ChEBI 13 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 1 EMBL 14 Ensembl 3 ExpressionAtlas 1 GO 14 Gene3D 3 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 REPRODUCTION-2DPAGE 2 RNAct 1 Reactome 3 RefSeq 2 Rhea 4 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9892733

Title: The structure of the human NDUFV1 gene encoding the 51-kDa subunit of mitochondrial complex I.

PubMed ID: 9892733

DOI: 10.1007/s003359900941

PubMed ID: 9571201

Title: Cloning of the human mitochondrial 51 kDa subunit (NDUFV1) reveals a 100% antisense homology of its 3'UTR with the 5'UTR of the gamma-interferon inducible protein (IP-30) precursor: is this a link between mitochondrial myopathy and inflammation?

PubMed ID: 9571201

DOI: 10.1006/bbrc.1998.8486

PubMed ID: 10931946

Title: Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.

PubMed ID: 10931946

DOI: 10.1073/pnas.160270997

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1478657

Title: The human mitochondrial NADH: ubiquinone oxidoreductase 51-kDa subunit maps adjacent to the glutathione S-transferase P1-1 gene on chromosome 11q13.

PubMed ID: 1478657

DOI: 10.1016/s0888-7543(05)80144-2

PubMed ID: 8288251

Title: Chromosomal localization of the human gene encoding the 51-kDa subunit of mitochondrial complex I (NDUFV1) to 11q13.

PubMed ID: 8288251

DOI: 10.1006/geno.1993.1493

PubMed ID: 12611891

Title: The subunit composition of the human NADH dehydrogenase obtained by rapid one-step immunopurification.

PubMed ID: 12611891

DOI: 10.1074/jbc.c300064200

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28844695

Title: Architecture of human mitochondrial respiratory megacomplex I2III2IV2.

PubMed ID: 28844695

DOI: 10.1016/j.cell.2017.07.050

PubMed ID: 31536960

Title: Rewiring of the Human Mitochondrial Interactome during Neuronal Reprogramming Reveals Regulators of the Respirasome and Neurogenesis.

PubMed ID: 31536960

DOI: 10.1016/j.isci.2019.08.057

PubMed ID: 10080174

Title: Mutant NDUFV1 subunit of mitochondrial complex I causes leukodystrophy and myoclonic epilepsy.

PubMed ID: 10080174

DOI: 10.1038/6772

PubMed ID: 11349233

Title: Large-scale deletion and point mutations of the nuclear NDUFV1 and NDUFS1 genes in mitochondrial complex I deficiency.

PubMed ID: 11349233

DOI: 10.1086/320603

Sequence Information:

  • Length: 464
  • Mass: 50817
  • Checksum: 8C261EA3B0267256
  • Sequence:
    • MLATRRLLGW SLPARVSVRF SGDTTAPKKT SFGSLKDEDR IFTNLYGRHD WRLKGSLSRG 
DWYKTKEILL KGPDWILGEI KTSGLRGRGG AGFPTGLKWS FMNKPSDGRP KYLVVNADEG 
EPGTCKDREI LRHDPHKLLE GCLVGGRAMG ARAAYIYIRG EFYNEASNLQ VAIREAYEAG 
LIGKNACGSG YDFDVFVVRG AGAYICGEET ALIESIEGKQ GKPRLKPPFP ADVGVFGCPT 
TVANVETVAV SPTICRRGGT WFAGFGRERN SGTKLFNISG HVNHPCTVEE EMSVPLKELI 
EKHAGGVTGG WDNLLAVIPG GSSTPLIPKS VCETVLMDFD ALVQAQTGLG TAAVIVMDRS 
TDIVKAIARL IEFYKHESCG QCTPCREGVD WMNKVMARFV RGDARPAEID SLWEISKQIE 
GHTICALGDG AAWPVQGLIR HFRPELEERM QRFAQQHQAR QAAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.