LINC02615 | ENSG00000251432 | NCBI 100507487

Details for: LINC02615

Gene ID: 100507487

Gene Type: ncRNA (Non-coding RNA) - A functional RNA molecule that is transcribed from DNA but not translated into a protein. Includes classes like miRNA and lncRNA.

Symbol: LINC02615

Ensembl ID: ENSG00000251432

Description: long intergenic non-protein coding RNA 2615

Cell Significance Landscape

Display Count:

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

pulmonary alveolar type 2 cell CL0002063

CSI 8.65

rCSI 13.41%

PRS 97.86
erythroblast CL0000765

CSI 6.24

rCSI 16.55%

PRS 97.52
choroid plexus epithelial cell CL0000706

CSI 5.77

rCSI 9.46%

PRS 95.54
kidney interstitial alternatively activated macrophage CL1000695

CSI 5.62

rCSI 14.66%

PRS 98.77
mesothelial cell CL0000077

CSI 5.59

rCSI 21.86%

PRS 91.63
lung ciliated cell CL1000271

CSI 5.33

rCSI 6.16%

PRS 95.62
melanocyte CL0000148

CSI 4.8

rCSI 3.56%

PRS 96.59
retinal rod cell CL0000604

CSI 4.39

rCSI 7.74%

PRS 95.76
adipocyte CL0000136

CSI 4.11

rCSI 5.27%

PRS 94.63
Mueller cell CL0000636

CSI 4.05

rCSI 9.25%

PRS 95.37
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 3.79

rCSI 5.37%

PRS 97.43
lung secretory cell CL1000272

CSI 3.58

rCSI 8.85%

PRS 98.68
regulatory T cell CL0000815

CSI 3.3

rCSI 3.83%

PRS 93.14
hepatic stellate cell CL0000632

CSI 3.18

rCSI 11.91%

PRS 96.75
endocardial cell CL0002350

CSI 3.04

rCSI 14.54%

PRS 96.47
kidney connecting tubule epithelial cell CL1000768

CSI 2.67

rCSI 6.78%

PRS 96.18
chondrocyte CL0000138

CSI 2.65

rCSI 4.22%

PRS 96.07
VIP GABAergic cortical interneuron CL4023016

CSI 2.64

rCSI 3.15%

PRS 93.65
retinal cone cell CL0000573

CSI 2.56

rCSI 4.12%

PRS 94.42
pvalb GABAergic cortical interneuron CL4023018

CSI 2.51

rCSI 3.12%

PRS 92.46
cytotoxic T cell CL0000910

CSI 2.37

rCSI 13.59%

PRS 95.22
Bergmann glial cell CL0000644

CSI 2.36

rCSI 3.23%

PRS 94.58
epithelial cell of proximal tubule CL0002306

CSI 2.33

rCSI 5.68%

PRS 94.8
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 2.25

rCSI 5.81%

PRS 97.24
regular ventricular cardiac myocyte CL0002131

CSI 2.09

rCSI 13.03%

PRS 94.89
epicardial adipocyte CL1000309

CSI 2.05

rCSI 6.68%

PRS 96.54
parietal epithelial cell CL1000452

CSI 1.96

rCSI 5.24%

PRS 96.46
cardiac muscle cell CL0000746

CSI 1.94

rCSI 2.78%

PRS 94.21
retinal ganglion cell CL0000740

CSI 1.93

rCSI 4.26%

PRS 93.55
basal cell of epidermis CL0002187

CSI 1.88

rCSI 3.34%

PRS 80.38
cardiac neuron CL0010022

CSI 1.85

rCSI 5.91%

PRS 97.32
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 1.72

rCSI 2.09%

PRS 85.75
pulmonary alveolar type 1 cell CL0002062

CSI 1.39

rCSI 8.01%

PRS 96.66
direct pathway medium spiny neuron CL4023026

CSI 1.19

rCSI 28.43%

PRS 91.65
helper T cell CL0000912

CSI 1.18

rCSI 1.67%

PRS 93.89
glial cell CL0000125

CSI 1.17

rCSI 4.46%

PRS 94.94
indirect pathway medium spiny neuron CL4023029

CSI 1.1

rCSI 26.61%

PRS 91.34
kidney distal convoluted tubule epithelial cell CL1000849

CSI 0.33

rCSI 3.48%

PRS 96.01

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Context Genes (max 20):

Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

Legend:

Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
STRING PPI Edge
Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description

## Summary [LINC02615](/details-gene/100507487) is a long intergenic non-protein coding RNA (lncRNA) located on chromosome 4q28.2. As a non-coding RNA, it is presumed to function as a regulatory molecule, influencing gene expression at the transcriptional or post-transcriptional level. Expression data reveals that [LINC02615](/details-gene/100507487) has a highly specific and significant expression profile in a diverse array of specialized cell types. It is most prominently expressed in [pulmonary alveolar type 2 cells](/details-cell/CL0002063), suggesting a key role in lung biology. Additionally, it shows significant expression in hematopoietic precursors like [erythroblasts](/details-cell/CL0000765), secretory epithelial cells of the brain such as [choroid plexus epithelial cells](/details-cell/CL0000706), and various cells within the kidney, retina, and skin. This pattern suggests that [LINC02615](/details-gene/100507487) is not a broad lineage marker but may be involved in executing or maintaining the unique physiological functions of these distinct cell types. ## Cellular Roles and Expression Landscape The expression profile of [LINC02615](/details-gene/100507487) is characterized by high significance in specific cell populations across multiple organ systems, indicating a role in specialized cellular functions rather than broad developmental processes. **Overall**, the gene's expression is most significant in several functional contexts: * **Respiratory System:** The highest significance score for [LINC02615](/details-gene/100507487) is observed in [pulmonary alveolar type 2 cells](/details-cell/CL0002063) (CSI: 8.65), which are critical for producing pulmonary surfactant and repairing alveolar epithelium. Its notable presence in other lung cells, including [lung ciliated cells](/details-cell/CL1000271) and [lung secretory cells](/details-cell/CL1000272), further cements its potential importance in maintaining respiratory tissue homeostasis. * **Hematopoiesis and Immunity:** A high CSI in [erythroblasts](/details-cell/CL0000765) suggests a potential regulatory role during erythropoiesis, the process of red blood cell formation. It is also significant in [kidney interstitial alternatively activated macrophages](/details-cell/CL1000695) and [regulatory T cells](/details-cell/CL0000815), pointing towards a possible role in modulating immune responses, particularly in tissue repair and immune suppression contexts. * **Epithelial and Secretory Tissues:** The gene is a significant marker in [choroid plexus epithelial cells](/details-cell/CL0000706), which are responsible for producing cerebrospinal fluid in the brain. Its expression in [mesothelial cells](/details-cell/CL0000077), which line the body's serous cavities, and [kidney loop of Henle thin descending limb epithelial cells](/details-cell/CL1001111) is consistent with a role in tissues involved in transport and barrier functions. * **Sensory and Other Specialized Cells:** [LINC02615](/details-gene/100507487) is also significantly expressed in specialized cells such as [melanocytes](/details-cell/CL0000148) (pigment production), [retinal rod cells](/details-cell/CL0000604) (photoreception), and [Mueller cells](/details-cell/CL0000636) (retinal glia), suggesting its involvement in the unique biology of these cell types. ## Pathways and Molecular Function As a long non-coding RNA, [LINC02615](/details-gene/100507487) does not encode a protein. Instead, it is likely to exert its function by regulating the expression of other genes. It may act as a scaffold for protein complexes, a decoy for microRNAs, or a guide for chromatin-modifying enzymes to specific genomic loci. While detailed functional annotations are not available, its cell-specific expression pattern allows for inference of its potential molecular roles: * The strong expression in highly secretory cells like [pulmonary alveolar type 2 cells](/details-cell/CL0002063) and [choroid plexus epithelial cells](/details-cell/CL0000706) suggests [LINC02615](/details-gene/100507487) may be involved in regulatory networks that control the synthesis and secretion of lipids, proteins, and fluids. * Its significance in [erythroblasts](/details-cell/CL0000765) points to a potential role in the transcriptional control of genes essential for hemoglobin production or the dramatic cellular remodeling that occurs during terminal erythroid differentiation. * In immune cells like [kidney interstitial alternatively activated macrophages](/details-cell/CL1000695), it may modulate signaling pathways related to M2 polarization, phagocytosis, or tissue repair. ## Research Directions The highly specific expression pattern of [LINC02615](/details-gene/100507487) in functionally critical cell types makes it a compelling subject for further investigation, particularly in the context of diseases affecting the lung, blood, and central nervous system. **Proposed Testable Hypotheses:** 1. [LINC02615](/details-gene/100507487) is essential for the maturation and function of [pulmonary alveolar type 2 cells](/details-cell/CL0002063), where it regulates the expression of key surfactant protein genes (e.g., *SFTPB*, *SFTPC*). Its dysregulation could be a contributing factor in the pathology of respiratory distress syndrome or idiopathic pulmonary fibrosis. 2. In [erythroblasts](/details-cell/CL0000765), [LINC02615](/details-gene/100507487) acts as a key regulator in the globin-switching mechanism or the process of enucleation during terminal red blood cell differentiation. 3. [LINC02615](/details-gene/100507487) modulates the expression of ion transporters and channels in [choroid plexus epithelial cells](/details-cell/CL0000706), thereby controlling the rate and composition of cerebrospinal fluid production. **Suggested Experimental Approach:** To test the hypothesis regarding its role in [pulmonary alveolar type 2 cell](/details-cell/CL0002063) function, a loss-of-function study could be performed. This would involve using CRISPR-Cas9 to knock out [LINC02615](/details-gene/100507487) in a human alveolar epithelial cell line or in primary human alveolar type 2 cells differentiated from iPSCs. Transcriptomic analysis (RNA-seq) of knockout versus control cells would reveal its downstream gene targets, with a specific focus on surfactant-associated genes. Functional validation could include assays to measure phospholipid secretion and analysis of lamellar body formation using electron microscopy. **Therapeutic Potential:** As a lncRNA with a highly cell-type-specific expression profile, [LINC02615](/details-gene/100507487) represents an attractive therapeutic target. Its specificity may allow for targeted interventions with minimal off-target effects. Therapeutic strategies would likely involve nucleic acid-based drugs, such as antisense oligonucleotides (ASOs) or siRNAs, to inhibit its function. For lung diseases, these agents could potentially be delivered directly to the target cells via inhalation. If [LINC02615](/details-gene/100507487) is found to be pathogenic when overexpressed (e.g., in fibrosis), its inhibition could be therapeutic. Conversely, if its loss of function contributes to disease (e.g., respiratory distress), developing methods to stabilize or upregulate its expression could be beneficial.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.