Details for: CELF1
Gene ID: 10658
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: CELF1
Ensembl ID: ENSG00000149187
Description: CUGBP Elav-like family member 1
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
-
CSI 46.81rCSI 78.57%PRS 8.47
-
CSI 44.23rCSI 57.01%PRS 8.88
-
CSI 43.95rCSI 54.67%PRS 7.86
-
CSI 40.45rCSI 65.05%PRS 9.25
-
CSI 36.98rCSI 89.88%PRS 8.24
-
CSI 34.21rCSI 40.86%PRS 8.26
-
CSI 32.43rCSI 57.27%PRS 8.4
-
CSI 32.17rCSI 69.79%PRS 8.33
-
CSI 27.53rCSI 86.05%PRS 9.02
-
CSI 24.63rCSI 88.64%PRS 7.87
-
CSI 24.59rCSI 76.9%PRS 9.67
-
CSI 21.84rCSI 82.55%PRS 8.63
-
CSI 21.1rCSI 69.34%PRS 7.77
-
CSI 20.35rCSI 48.67%PRS 8.17
-
CSI 18.64rCSI 41.17%PRS 10.29
-
CSI 17.26rCSI 45.97%PRS 11.44
-
CSI 15.95rCSI 20.48%PRS 14.18
-
CSI 14.48rCSI 49.6%PRS 12.54
-
CSI 14.06rCSI 82.79%PRS 8.87
-
CSI 13.82rCSI 34.97%PRS 17.81
-
CSI 13.42rCSI 17.94%PRS 18.97
-
CSI 12.33rCSI 46.21%PRS 12.18
-
CSI 12.27rCSI 73.52%PRS 22.75
-
CSI 12.22rCSI 60.78%PRS 15.3
-
CSI 10.49rCSI 20.39%PRS 14.65
-
CSI 9.98rCSI 14.15%PRS 13.37
-
CSI 9.86rCSI 72.44%PRS 7.62
-
CSI 9.54rCSI 11.03%PRS 10.47
-
CSI 9.51rCSI 38.36%PRS 12.77
-
CSI 9.45rCSI 17.85%PRS 17.82
-
CSI 9.45rCSI 25.47%PRS 18.42
-
CSI 9.29rCSI 80.01%PRS 5.27
-
CSI 9.18rCSI 45.23%PRS 19.41
-
CSI 8.88rCSI 13.64%PRS 16.78
-
CSI 7.83rCSI 17.24%PRS 21.88
-
CSI 7.78rCSI 11.88%PRS 14.34
-
CSI 7.51rCSI 61.1%PRS 14.76
-
CSI 7.42rCSI 14.74%PRS 15.26
-
CSI 6.97rCSI 22.68%PRS 17.32
-
CSI 6.66rCSI 8.54%PRS 16.54
-
CSI 6.6rCSI 15.75%PRS 17.03
-
CSI 6.43rCSI 11.52%PRS 13.3
-
CSI 6.4rCSI 15.02%PRS 21.34
-
CSI 6.33rCSI 16.53%PRS 22.5
-
CSI 6.31rCSI 13.82%PRS 19.09
-
CSI 6.23rCSI 15.81%PRS 10.91
-
CSI 6.19rCSI 16.55%PRS 11.99
-
CSI 6.18rCSI 5.95%PRS 14.82
-
CSI 5.22rCSI 7.87%PRS 14.18
-
CSI 5.16rCSI 4.34%PRS 23.03
-
CSI 5.03rCSI 6.12%PRS 18.02
-
CSI 4.7rCSI 66.76%PRS 10.22
-
CSI 4.67rCSI 7.13%PRS 18.16
-
CSI 4.55rCSI 29.13%PRS 21.39
-
CSI 4.49rCSI 10.96%PRS 14.21
-
CSI 4.31rCSI 7.05%PRS 11.08
-
CSI 4.18rCSI 14.13%PRS 23.59
-
CSI 4.11rCSI 83.71%PRS 10.99
-
CSI 4.09rCSI 3.03%PRS 12.67
-
CSI 3.99rCSI 81.24%PRS 11.99
-
CSI 3.95rCSI 9.4%PRS 21.51
-
CSI 3.93rCSI 8.08%PRS 14.39
-
CSI 3.74rCSI 5.52%PRS 22.49
-
CSI 3.72rCSI 89.12%PRS 6.65
-
CSI 3.72rCSI 20.31%PRS 23.89
-
CSI 3.68rCSI 88.83%PRS 7.59
-
CSI 3.62rCSI 3.34%PRS 14.55
-
CSI 3.6rCSI 9.56%PRS 23.35
-
CSI 3.52rCSI 9.11%PRS 13.38
-
CSI 3.42rCSI 14.1%PRS 43.23
-
CSI 3.41rCSI 10.51%PRS 21.67
-
CSI 3.36rCSI 10.9%PRS 17.5
-
CSI 3.35rCSI 13.03%PRS 19.89
-
CSI 3.3rCSI 52.05%PRS 8.59
-
CSI 3.28rCSI 2.88%PRS 10.38
-
CSI 3.17rCSI 9.07%PRS 25.31
-
CSI 3.07rCSI 3.14%PRS 26.61
-
CSI 2.94rCSI 2.78%PRS 14.95
-
CSI 2.93rCSI 2.37%PRS 22.96
-
CSI 2.89rCSI 2.2%PRS 18.71
-
CSI 2.85rCSI 2.16%PRS 19.71
-
CSI 2.82rCSI 5.66%PRS 10.61
-
CSI 2.78rCSI 7.26%PRS 13.15
-
CSI 2.76rCSI 3.79%PRS 29.32
-
CSI 2.72rCSI 3.2%PRS 16.83
-
CSI 2.66rCSI 3.08%PRS 12.57
-
CSI 2.58rCSI 7.64%PRS 20.65
-
CSI 2.54rCSI 1.78%PRS 36.08
-
CSI 2.54rCSI 3.25%PRS 13.94
-
CSI 2.53rCSI 2.6%PRS 23.36
-
CSI 2.53rCSI 3.89%PRS 20.22
-
CSI 2.53rCSI 9.15%PRS 24.58
-
CSI 2.5rCSI 3.42%PRS 15.87
-
CSI 2.46rCSI 2.11%PRS 24.68
-
CSI 2.42rCSI 3.02%PRS 20.21
-
CSI 2.4rCSI 6.22%PRS 36.82
-
CSI 2.38rCSI 3.31%PRS 14.76
-
CSI 2.33rCSI 5.31%PRS 12.54
-
CSI 2.32rCSI 3.42%PRS 13.16
-
CSI 2.16rCSI 3.1%PRS 11.1
-
CSI -2.5rCSI -3.8%PRS 25.0%
-
CSI -1.9rCSI -19.5%PRS 14.3%
-
CSI -1.5rCSI -2.4%PRS 34.1%
-
CSI -1.2rCSI -3.0%PRS 17.1%
-
CSI -1.1rCSI -1.5%PRS 16.3%
-
CSI -0.9rCSI -1.1%PRS 19.0%
-
CSI -0.6rCSI -1.2%PRS 10.4%
-
CSI -0.6rCSI -1.3%PRS 29.5%
-
CSI -0.5rCSI -2.5%PRS 48.8%
-
CSI -0.5rCSI -3.5%PRS 30.2%
-
CSI -0.3rCSI -0.7%PRS 14.5%
-
CSI -0.2rCSI -0.7%PRS 52.3%
-
CSI 0.0rCSI 0.1%PRS 25.8%
-
CSI 0.0rCSI 0.0%PRS 13.4%
-
CSI 0.0rCSI 0.2%PRS 27.9%
-
CSI 0.0rCSI 0.4%PRS 27.4%
-
CSI 0.0rCSI 0.2%PRS 27.1%
-
CSI 0.1rCSI 0.5%PRS 52.2%
-
CSI 0.1rCSI 0.3%PRS 20.8%
-
CSI 0.1rCSI 0.5%PRS 11.3%
-
CSI 0.1rCSI 1.4%PRS 35.3%
-
CSI 0.1rCSI 0.2%PRS 21.9%
-
CSI 0.1rCSI 0.5%PRS 6.4%
-
CSI 0.1rCSI 1.3%PRS 39.5%
-
CSI 0.1rCSI 3.1%PRS 46.5%
-
CSI 0.1rCSI 0.2%PRS 29.3%
-
CSI 0.1rCSI 0.7%PRS 27.9%
-
CSI 0.1rCSI 0.7%PRS 34.9%
-
CSI 0.2rCSI 0.5%PRS 15.2%
-
CSI 0.2rCSI 1.0%PRS 22.0%
-
CSI 0.2rCSI 1.3%PRS 12.9%
-
CSI 0.2rCSI 0.3%PRS 18.5%
-
CSI 0.2rCSI 0.7%PRS 23.4%
-
CSI 0.2rCSI 0.4%PRS 25.8%
-
CSI 0.2rCSI 0.3%PRS 14.3%
-
CSI 0.2rCSI 0.5%PRS 23.7%
-
CSI 0.2rCSI 1.2%PRS 45.2%
-
CSI 0.2rCSI 0.4%PRS 31.9%
-
CSI 0.2rCSI 1.3%PRS 21.6%
-
CSI 0.2rCSI 0.2%PRS 24.1%
-
CSI 0.2rCSI 0.6%PRS 21.5%
-
CSI 0.3rCSI 0.3%PRS 14.2%
-
CSI 0.3rCSI 1.1%PRS 19.1%
-
CSI 0.3rCSI 0.5%PRS 31.0%
-
CSI 0.3rCSI 0.3%PRS 13.2%
-
CSI 0.3rCSI 2.1%PRS 13.9%
-
CSI 0.3rCSI 0.3%PRS 16.8%
-
CSI 0.3rCSI 1.6%PRS 26.5%
-
CSI 0.3rCSI 0.6%PRS 36.3%
-
CSI 0.3rCSI 0.5%PRS 18.8%
-
CSI 0.3rCSI 0.5%PRS 15.1%
-
CSI 0.3rCSI 0.8%PRS 19.7%
-
CSI 0.3rCSI 1.1%PRS 23.4%
-
CSI 0.3rCSI 1.5%PRS 29.2%
-
CSI 0.3rCSI 3.0%PRS 55.7%
-
CSI 0.3rCSI 1.6%PRS 37.4%
-
CSI 0.4rCSI 1.9%PRS 16.3%
-
CSI 0.4rCSI 0.6%PRS 16.7%
-
CSI 0.4rCSI 3.2%PRS 6.7%
-
CSI 0.4rCSI 3.3%PRS 39.3%
-
CSI 0.4rCSI 0.2%PRS 17.2%
-
CSI 0.4rCSI 1.0%PRS 20.9%
-
CSI 0.4rCSI 0.5%PRS 27.3%
-
CSI 0.4rCSI 0.7%PRS 28.0%
-
CSI 0.4rCSI 0.8%PRS 21.6%
-
CSI 0.4rCSI 0.6%PRS 13.3%
-
CSI 0.4rCSI 6.2%PRS 35.2%
-
CSI 0.4rCSI 0.7%PRS 14.1%
-
CSI 0.4rCSI 2.7%PRS 32.9%
-
CSI 0.4rCSI 2.0%PRS 33.4%
-
CSI 0.4rCSI 2.9%PRS 14.2%
-
CSI 0.4rCSI 0.8%PRS 37.1%
-
CSI 0.4rCSI 2.7%PRS 37.6%
-
CSI 0.4rCSI 0.6%PRS 21.9%
-
CSI 0.4rCSI 2.5%PRS 47.9%
-
CSI 0.4rCSI 2.5%PRS 6.4%
-
CSI 0.4rCSI 1.7%PRS 29.3%
-
CSI 0.4rCSI 0.7%PRS 16.5%
-
CSI 0.5rCSI 0.5%PRS 16.9%
-
CSI 0.5rCSI 1.0%PRS 29.0%
-
CSI 0.5rCSI 2.0%PRS 38.9%
-
CSI 0.5rCSI 1.8%PRS 30.9%
-
CSI 0.5rCSI 3.3%PRS 15.9%
-
CSI 0.5rCSI 0.8%PRS 19.0%
-
CSI 0.5rCSI 0.7%PRS 21.2%
-
CSI 0.5rCSI 0.3%PRS 19.8%
-
CSI 0.5rCSI 1.4%PRS 24.6%
-
CSI 0.5rCSI 2.3%PRS 14.2%
-
CSI 0.5rCSI 0.9%PRS 38.6%
-
CSI 0.5rCSI 3.6%PRS 38.4%
-
CSI 0.5rCSI 0.6%PRS 16.7%
-
CSI 0.5rCSI 0.7%PRS 20.1%
-
CSI 0.5rCSI 1.0%PRS 23.9%
-
CSI 0.5rCSI 1.2%PRS 29.4%
-
CSI 0.5rCSI 1.0%PRS 11.7%
-
CSI 0.5rCSI 0.4%PRS 14.2%
-
CSI 0.6rCSI 3.1%PRS 18.7%
-
CSI 0.6rCSI 0.6%PRS 13.3%
-
CSI 0.6rCSI 0.6%PRS 23.0%
-
CSI 0.6rCSI 0.7%PRS 24.9%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 3290153310
Symbol: CELF1_HUMAN
Name: CUGBP Elav-like family member 1
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8948631
Title: Identification of a (CUG)n triplet repeat RNA-binding protein and its expression in myotonic dystrophy.
PubMed ID: 8948631
PubMed ID: 10893231
Title: A family of human RNA-binding proteins related to the Drosophila Bruno translational regulator.
PubMed ID: 10893231
PubMed ID: 11686919
Title: Coexpression of the CUG-binding protein reduces DM protein kinase expression in COS cells.
PubMed ID: 11686919
PubMed ID: 11707455
Title: c-Jun ARE targets mRNA deadenylation by an EDEN-BP (embryo deadenylation element-binding protein)-dependent pathway.
PubMed ID: 11707455
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 10536163
Title: CUG repeat binding protein (CUGBP1) interacts with the 5' region of C/EBPbeta mRNA and regulates translation of C/EBPbeta isoforms.
PubMed ID: 10536163
PubMed ID: 11124939
Title: RNA CUG repeats sequester CUGBP1 and alter protein levels and activity of CUGBP1.
PubMed ID: 11124939
PubMed ID: 11158314
Title: The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing.
PubMed ID: 11158314
PubMed ID: 12799066
Title: A functional deadenylation assay identifies human CUG-BP as a deadenylation factor.
PubMed ID: 12799066
PubMed ID: 12649496
Title: Antagonistic regulation of alpha-actinin alternative splicing by CELF proteins and polypyrimidine tract binding protein.
PubMed ID: 12649496
DOI: 10.1261/rna.2191903
PubMed ID: 14726956
Title: Competition of CUGBP1 and calreticulin for the regulation of p21 translation determines cell fate.
PubMed ID: 14726956
PubMed ID: 14759258
PubMed ID: 16946708
Title: Interaction of muscleblind, CUG-BP1 and hnRNP H proteins in DM1-associated aberrant IR splicing.
PubMed ID: 16946708
PubMed ID: 16862542
Title: ETR-3 represses Tau exons 2/3 inclusion, a splicing event abnormally enhanced in myotonic dystrophy type I.
PubMed ID: 16862542
DOI: 10.1002/jnr.20980
PubMed ID: 16601207
Title: CUG-BP binds to RNA substrates and recruits PARN deadenylase.
PubMed ID: 16601207
DOI: 10.1261/rna.59606
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28431233
Title: A Compendium of RNA-Binding Proteins that Regulate MicroRNA Biogenesis.
PubMed ID: 28431233
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
DOI: 10.1038/nsmb.3366
PubMed ID: 20947024
Title: Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1.
PubMed ID: 20947024
Sequence Information:
- Length: 486
- Mass: 52063
- Checksum: C4C13D772273A01D
- Sequence:
MNGTLDHPDQ PDLDAIKMFV GQVPRTWSEK DLRELFEQYG AVYEINVLRD RSQNPPQSKG CCFVTFYTRK AALEAQNALH NMKVLPGMHH PIQMKPADSE KNNAVEDRKL FIGMISKKCT ENDIRVMFSS FGQIEECRIL RGPDGLSRGC AFVTFTTRAM AQTAIKAMHQ AQTMEGCSSP MVVKFADTQK DKEQKRMAQQ LQQQMQQISA ASVWGNLAGL NTLGPQYLAL YLQLLQQTAS SGNLNTLSSL HPMGGLNAMQ LQNLAALAAA ASAAQNTPSG TNALTTSSSP LSVLTSSGSS PSSSSSNSVN PIASLGALQT LAGATAGLNV GSLAGMAALN GGLGSSGLSN GTGSTMEALT QAYSGIQQYA AAALPTLYNQ NLLTQQSIGA AGSQKEGPEG ANLFIYHLPQ EFGDQDLLQM FMPFGNVVSA KVFIDKQTNL SKCFGFVSYD NPVSAQAAIQ SMNGFQIGMK RLKVQLKRSK NDSKPY
Genular Protein ID: 1520219164
Symbol: G5EA30_HUMAN
Name: N/A
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 11237011
Title: Initial sequencing and analysis of the human genome.
PubMed ID: 11237011
DOI: 10.1038/35057062
PubMed ID: 11181995
PubMed ID: 15496913
Title: Finishing the euchromatic sequence of the human genome.
PubMed ID: 15496913
DOI: 10.1038/nature03001
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 28112733
Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.
PubMed ID: 28112733
Sequence Information:
- Length: 514
- Mass: 55143
- Checksum: 31E7DF974827F9B3
- Sequence:
MAAFKLDFLP EMMVDHCSLN SSPVSKKMNG TLDHPDQPDL DAIKMFVGQV PRTWSEKDLR ELFEQYGAVY EINVLRDRSQ NPPQSKGCCF VTFYTRKAAL EAQNALHNMK VLPGMHHPIQ MKPADSEKNN AVEDRKLFIG MISKKCTEND IRVMFSSFGQ IEECRILRGP DGLSRGCAFV TFTTRAMAQT AIKAMHQAQT MEGCSSPMVV KFADTQKDKE QKRMAQQLQQ QMQQISAASV WGNLAGLNTL GPQYLALYLQ LLQQTASSGN LNTLSSLHPM GGLNAMQLQN LAALAAAASA AQNTPSGTNA LTTSSSPLSV LTSSAGSSPS SSSSNSVNPI ASLGALQTLA GATAGLNVGS LAGMAALNGG LGSSGLSNGT GSTMEALTQA YSGIQQYAAA ALPTLYNQNL LTQQSIGAAG SQKEGPEGAN LFIYHLPQEF GDQDLLQMFM PFGNVVSAKV FIDKQTNLSK CFGFVSYDNP VSAQAAIQSM NGFQIGMKRL KVQLKRSKND SKPY