SP100 | ENSG00000067066 | NCBI 6672

Details for: SP100

Gene ID: 6672

Symbol: SP100

Ensembl ID: ENSG00000067066

Description: SP100 nuclear antigen

Associated with

Cytokine signaling in immune system
(R-HSA-1280215)
Immune system
(R-HSA-168256)
Interferon gamma signaling
(R-HSA-877300)
Interferon signaling
(R-HSA-913531)
Metabolism of proteins
(R-HSA-392499)
Post-translational protein modification
(R-HSA-597592)
Sumo e3 ligases sumoylate target proteins
(R-HSA-3108232)
Sumoylation
(R-HSA-2990846)
Sumoylation of dna damage response and repair proteins
(R-HSA-3108214)
Chromo shadow domain binding
(GO:0070087)
Chromosome, telomeric region
(GO:0000781)
Cytoplasm
(GO:0005737)
Dna-binding transcription factor activity, rna polymerase ii-specific
(GO:0000981)
Dna binding
(GO:0003677)
Dna damage response, signal transduction by p53 class mediator
(GO:0030330)
Identical protein binding
(GO:0042802)
Kinase binding
(GO:0019900)
Maintenance of protein location
(GO:0045185)
Mre11 complex
(GO:0030870)
Negative regulation of dna-binding transcription factor activity
(GO:0043433)
Negative regulation of dna-templated transcription
(GO:0045892)
Negative regulation of dna binding
(GO:0043392)
Negative regulation of endothelial cell migration
(GO:0010596)
Negative regulation of protein export from nucleus
(GO:0046826)
Negative regulation of transcription by rna polymerase ii
(GO:0000122)
Negative regulation of viral transcription
(GO:0032897)
Nuclear body
(GO:0016604)
Nuclear periphery
(GO:0034399)
Nucleolus
(GO:0005730)
Nucleoplasm
(GO:0005654)
Nucleus
(GO:0005634)
Pml body
(GO:0016605)
Positive regulation of dna-binding transcription factor activity
(GO:0051091)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)
Protein dimerization activity
(GO:0046983)
Protein domain specific binding
(GO:0019904)
Protein homodimerization activity
(GO:0042803)
Regulation of angiogenesis
(GO:0045765)
Regulation of extrinsic apoptotic signaling pathway via death domain receptors
(GO:1902041)
Regulation of fas signaling pathway
(GO:1902044)
Regulation of transcription by rna polymerase ii
(GO:0006357)
Response to cytokine
(GO:0034097)
Response to retinoic acid
(GO:0032526)
Response to type ii interferon
(GO:0034341)
Response to type i interferon
(GO:0034340)
Retinoic acid receptor signaling pathway
(GO:0048384)
Rna polymerase ii-specific dna-binding transcription factor binding
(GO:0061629)
Telomere maintenance
(GO:0000723)
Type ii interferon-mediated signaling pathway
(GO:0060333)
Type i interferon-mediated signaling pathway
(GO:0060337)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 274.8397
Cell Significance Index: -42.7500
Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 171.7569
Cell Significance Index: -43.5700
Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 121.5240
Cell Significance Index: -49.3700
Cell Name: smooth muscle fiber of ileum (CL1000278)
Fold Change: 110.1832
Cell Significance Index: -52.0200
Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 105.7573
Cell Significance Index: -54.4000
Cell Name: ileal goblet cell (CL1000326)
Fold Change: 77.8663
Cell Significance Index: -52.2500
Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 52.7158
Cell Significance Index: -50.3300
Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 41.5952
Cell Significance Index: -51.2900
Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 18.8432
Cell Significance Index: -41.2400
Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 16.2187
Cell Significance Index: -49.8200
Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 13.8468
Cell Significance Index: -54.6400
Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 12.9943
Cell Significance Index: -34.8100
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 3.5682
Cell Significance Index: 51.3200
Cell Name: preadipocyte (CL0002334)
Fold Change: 2.2765
Cell Significance Index: 44.4300
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.9099
Cell Significance Index: 35.3000
Cell Name: vascular lymphangioblast (CL0005022)
Fold Change: 1.8646
Cell Significance Index: 32.9500
Cell Name: lung endothelial cell (CL1001567)
Fold Change: 1.7273
Cell Significance Index: 89.9700
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 1.4113
Cell Significance Index: 173.5300
Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 1.3698
Cell Significance Index: 40.2300
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 1.3574
Cell Significance Index: 81.4900
Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 1.3044
Cell Significance Index: 153.8300
Cell Name: early pro-B cell (CL0002046)
Fold Change: 1.1742
Cell Significance Index: 75.7600
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 1.1699
Cell Significance Index: 210.9000
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.1440
Cell Significance Index: 87.7900
Cell Name: centrilobular region hepatocyte (CL0019029)
Fold Change: 1.0101
Cell Significance Index: 17.0200
Cell Name: odontoblast (CL0000060)
Fold Change: 0.9482
Cell Significance Index: 121.5500
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.9414
Cell Significance Index: 153.1100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.9399
Cell Significance Index: 129.0700
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.8290
Cell Significance Index: 164.5200
Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.7865
Cell Significance Index: 21.0800
Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: 0.7668
Cell Significance Index: 38.7500
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.7175
Cell Significance Index: 647.8200
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.6882
Cell Significance Index: 14.7100
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.6313
Cell Significance Index: 15.7800
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: 0.6128
Cell Significance Index: 28.8000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.5506
Cell Significance Index: 25.6700
Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.4683
Cell Significance Index: 46.3300
Cell Name: peg cell (CL4033014)
Fold Change: 0.3523
Cell Significance Index: 8.1400
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: 0.3471
Cell Significance Index: 9.9500
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.3309
Cell Significance Index: 146.3000
Cell Name: cell in vitro (CL0001034)
Fold Change: 0.2815
Cell Significance Index: 153.7400
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: 0.2645
Cell Significance Index: 165.1700
Cell Name: endothelial cell of placenta (CL0009092)
Fold Change: 0.2334
Cell Significance Index: 1.4100
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: 0.2261
Cell Significance Index: 6.3200
Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1752
Cell Significance Index: 4.7700
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1577
Cell Significance Index: 7.1500
Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.1394
Cell Significance Index: 7.2400
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.1345
Cell Significance Index: 22.9800
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: 0.0419
Cell Significance Index: 78.8200
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: 0.0401
Cell Significance Index: 4.5900
Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: 0.0347
Cell Significance Index: 2.5800
Cell Name: lens epithelial cell (CL0002224)
Fold Change: 0.0333
Cell Significance Index: 51.2400
Cell Name: lactocyte (CL0002325)
Fold Change: 0.0240
Cell Significance Index: 3.1000
Cell Name: anterior lens cell (CL0002223)
Fold Change: 0.0199
Cell Significance Index: 36.6200
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: 0.0183
Cell Significance Index: 11.6100
Cell Name: abnormal cell (CL0001061)
Fold Change: -0.0116
Cell Significance Index: -1.1900
Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0285
Cell Significance Index: -20.9200
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0309
Cell Significance Index: -23.4200
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0323
Cell Significance Index: -18.2200
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0356
Cell Significance Index: -26.3400
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0357
Cell Significance Index: -48.5400
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: -0.0631
Cell Significance Index: -12.0100
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: -0.0751
Cell Significance Index: -51.9200
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: -0.0901
Cell Significance Index: -2.4100
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0910
Cell Significance Index: -41.3200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: -0.1238
Cell Significance Index: -44.4100
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.1462
Cell Significance Index: -30.8000
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: -0.1490
Cell Significance Index: -2.1400
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.1562
Cell Significance Index: -22.7100
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1790
Cell Significance Index: -51.5000
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -0.2092
Cell Significance Index: -5.5900
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: -0.2210
Cell Significance Index: -44.3400
Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: -0.2356
Cell Significance Index: -2.1700
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.2418
Cell Significance Index: -28.1800
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: -0.2983
Cell Significance Index: -9.5600
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -0.3055
Cell Significance Index: -10.7400
Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.3608
Cell Significance Index: -25.5200
Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: -0.4108
Cell Significance Index: -46.8900
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: -0.4685
Cell Significance Index: -50.9600
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.4985
Cell Significance Index: -51.9100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: -0.5977
Cell Significance Index: -12.9500
Cell Name: periportal region hepatocyte (CL0019026)
Fold Change: -0.6030
Cell Significance Index: -8.9000
Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.6067
Cell Significance Index: -48.0500
Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.6574
Cell Significance Index: -8.9700
Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.6680
Cell Significance Index: -10.0100
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.6696
Cell Significance Index: -41.0500
Cell Name: pro-T cell (CL0000827)
Fold Change: -0.6758
Cell Significance Index: -17.2700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.8110
Cell Significance Index: -54.5300
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.8743
Cell Significance Index: -53.7400
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: -0.9003
Cell Significance Index: -9.3300
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.9129
Cell Significance Index: -57.5400
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: -0.9734
Cell Significance Index: -20.7300
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -0.9763
Cell Significance Index: -25.1000
Cell Name: granulosa cell (CL0000501)
Fold Change: -1.0243
Cell Significance Index: -26.9400
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -1.0333
Cell Significance Index: -57.9900
Cell Name: mesenchymal cell (CL0008019)
Fold Change: -1.0833
Cell Significance Index: -18.1300
Cell Name: fallopian tube secretory epithelial cell (CL4030006)
Fold Change: -1.0943
Cell Significance Index: -16.9300
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -1.1449
Cell Significance Index: -60.1100
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -1.1935
Cell Significance Index: -35.1600
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -1.2321
Cell Significance Index: -54.5000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics** SP100 exhibits several distinct characteristics that enable it to perform its diverse functions. These include: 1. **Chromo-shadow domain**: This domain allows SP100 to bind to specific DNA sequences, transcription factors, and other proteins, facilitating its regulatory roles. 2. **DNA-binding capabilities**: SP100 can bind to DNA, influencing gene expression and DNA damage response. 3. **Transcriptional regulation**: SP100 modulates transcriptional activity by interacting with RNA polymerase II and other transcription factors. 4. **Immune system involvement**: SP100 is expressed in immune cells and participates in cytokine signaling pathways, influencing immune responses. 5. **Sumoylation**: SP100 is a target of sumoylation, a post-translational modification that regulates protein-protein interactions and stability. **Pathways and Functions** SP100 is involved in several key signaling pathways and cellular processes, including: 1. **DNA damage response**: SP100 participates in the repair of DNA damage by interacting with proteins involved in the nucleotide excision repair pathway. 2. **Cytokine signaling**: SP100 modulates cytokine signaling in the immune system, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 3. **Transcriptional regulation**: SP100 regulates transcriptional activity by interacting with RNA polymerase II and other transcription factors. 4. **Angiogenesis**: SP100 negatively regulates angiogenesis, the formation of new blood vessels, by inhibiting the expression of pro-angiogenic genes. 5. **Apoptosis**: SP100 regulates apoptosis (programmed cell death) by interacting with proteins involved in the extrinsic and intrinsic apoptotic pathways. **Clinical Significance** Dysregulation of SP100 has been implicated in various diseases, including: 1. **Autoimmune disorders**: SP100 is recognized as an autoantigen in autoimmune diseases, such as systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). 2. **Cancer**: Aberrant expression of SP100 has been observed in certain types of cancer, including leukemia and lymphoma. 3. **Neurological disorders**: SP100 has been implicated in the pathogenesis of neurodegenerative diseases, such as Alzheimer's disease and Parkinson's disease. 4. **Infectious diseases**: SP100 plays a role in the regulation of immune responses to viral and bacterial infections. In summary, SP100 is a multifunctional protein that plays a critical role in the regulation of various cellular processes, including DNA damage response, transcriptional regulation, and immune system function. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its mechanisms of action.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Nuclear autoantigen Sp-100
Q6ZMK3_HUMAN

Genular Protein ID: 2840058629

Symbol: SP100_HUMAN

Name: Nuclear autoantigen Sp-100

UniProtKB Accession Codes:

P23497 B4DDX5 B8ZZD8 E7EUA7 E9PH61 F8WFE2 O75450 Q13343 Q8TE34 Q96F70 Q96T24 Q96T95 Q9NP33 Q9UE32

Database IDs:

Citations:

PubMed ID: 2258622

Title: Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis.

PubMed ID: 2258622

PubMed ID: 8695863

Title: LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies.

PubMed ID: 8695863

PubMed ID: 9636146

Title: Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment.

PubMed ID: 9636146

DOI: 10.1073/pnas.95.13.7316

PubMed ID: 11313457

Title: Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification.

PubMed ID: 11313457

DOI: 10.1128/mcb.21.10.3314-3324.2001

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8810287

Title: The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility.

PubMed ID: 8810287

DOI: 10.1074/jbc.271.41.25253

PubMed ID: 10233977

Title: Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption.

PubMed ID: 10233977

DOI: 10.1128/jvi.73.6.5137-5143.1999

PubMed ID: 9973607

Title: Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif.

PubMed ID: 9973607

DOI: 10.1242/jcs.112.5.733

PubMed ID: 10766566

Title: Back to the roots of a new exon-the molecular archaeology of a SP100 splice variant.

PubMed ID: 10766566

DOI: 10.1006/geno.1999.6008

PubMed ID: 11574059

Title: Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and Alu insertion events.

PubMed ID: 11574059

DOI: 10.1186/gb-2001-2-9-research0040

PubMed ID: 9412458

Title: Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1.

PubMed ID: 9412458

DOI: 10.1083/jcb.139.7.1621

PubMed ID: 10212234

Title: The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers.

PubMed ID: 10212234

DOI: 10.1074/jbc.274.18.12555

PubMed ID: 12470659

Title: Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein.

PubMed ID: 12470659

DOI: 10.1016/s0006-291x(02)02755-9

PubMed ID: 11909962

Title: Sp100 interacts with ETS-1 and stimulates its transcriptional activity.

PubMed ID: 11909962

DOI: 10.1128/mcb.22.8.2687-2702.2002

PubMed ID: 14647468

Title: Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression.

PubMed ID: 14647468

DOI: 10.1038/sj.onc.1207079

PubMed ID: 15247905

Title: SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion.

PubMed ID: 15247905

DOI: 10.1038/sj.onc.1207891

PubMed ID: 15882967

Title: The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain.

PubMed ID: 15882967

DOI: 10.1016/j.bbrc.2005.04.016

PubMed ID: 16177824

Title: Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100.

PubMed ID: 16177824

DOI: 10.1038/sj.emboj.7600820

PubMed ID: 15767676

Title: Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex.

PubMed ID: 15767676

DOI: 10.1128/mcb.25.7.2708-2721.2005

PubMed ID: 15592518

Title: SP100 inhibits ETS1 activity in primary endothelial cells.

PubMed ID: 15592518

DOI: 10.1038/sj.onc.1208245

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17245429

Title: FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies.

PubMed ID: 17245429

DOI: 10.1038/sj.emboj.7601504

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21118961

Title: Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program.

PubMed ID: 21118961

DOI: 10.1158/0008-5472.can-10-1483

PubMed ID: 23907639

Title:

PubMed ID: 23907639

DOI: 10.1158/0008-5472.can-13-1715

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 22086178

Title: Cdc20 mediates D-box-dependent degradation of Sp100.

PubMed ID: 22086178

DOI: 10.1016/j.bbrc.2011.10.146

PubMed ID: 21274506

Title: SP100 reduces malignancy of human glioma cells.

PubMed ID: 21274506

DOI: 10.3892/ijo.2011.927

PubMed ID: 21880768

Title: Human cytomegalovirus infection causes degradation of Sp100 proteins that suppress viral gene expression.

PubMed ID: 21880768

DOI: 10.1128/jvi.00758-11

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 27211601

Title: SUMO5, a novel poly-sumo isoform, regulates pml nuclear bodies.

PubMed ID: 27211601

DOI: 10.1038/srep26509

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

Length: 879
Mass: 100417
Checksum: CA55547DE21B2A10
Sequence:

MAGGGGDLST RRLNECISPV ANEMNHLPAH SHDLQRMFTE DQGVDDRLLY DIVFKHFKRN 
KVEISNAIKK TFPFLEGLRD RDLITNKMFE DSQDSCRNLV PVQRVVYNVL SELEKTFNLP 
VLEALFSDVN MQEYPDLIHI YKGFENVIHD KLPLQESEEE EREERSGLQL SLEQGTGENS 
FRSLTWPPSG SPSHAGTTPP ENGLSEHPCE TEQINAKRKD TTSDKDDSLG SQQTNEQCAQ 
KAEPTESCEQ IAVQVNNGDA GREMPCPLPC DEESPEAELH NHGIQINSCS VRLVDIKKEK 
PFSNSKVECQ AQARTHHNQA SDIIVISSED SEGSTDVDEP LEVFISAPRS EPVINNDNPL 
ESNDEKEGQE ATCSRPQIVP EPMDFRKLST FRESFKKRVI GQDHDFSESS EEEAPAEASS 
GALRSKHGEK APMTSRSTST WRIPSRKRRF SSSDFSDLSN GEELQETCSS SLRRGSGSQP 
QEPENKKCSC VMCFPKGVPR SQEARTESSQ ASDMMDTMDV ENNSTLEKHS GKRRKKRRHR 
SKVNGLQRGR KKDRPRKHLT LNNKVQKKRW QQRGRKANTR PLKRRRKRGP RIPKDENINF 
KQSELPVTCG EVKGTLYKER FKQGTSKKCI QSEDKKWFTP REFEIEGDRG ASKNWKLSIR 
CGGYTLKVLM ENKFLPEPPS TRKKRILESH NNTLVDPCEE HKKKNPDASV KFSEFLKKCS 
ETWKTIFAKE KGKFEDMAKA DKAHYEREMK TYIPPKGEKK KKFKDPNAPK RPPLAFFLFC 
SEYRPKIKGE HPGLSIDDVV KKLAGMWNNT AAADKQFYEK KAAKLKEKYK KDIAAYRAKG 
KPNSAKKRVV KAEKSKKKKE EEEDEEDEQE EENEEDDDK

Genular Protein ID: 2563039109

Symbol: Q6ZMK3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6ZMK3

Database IDs:

Sequence Information:

Length: 187
Mass: 22267
Checksum: 4EB9CC195D51AEBB
Sequence:

PENSNICEVC NKWGRLFCCD TCPRSFHEHC HIPSVEANKN PWSCIFCRIK TIQERCPESQ 
SGHQESEVLM RQMLPEEQLK CEFLLLKVYC DSKSCFFASE PYYNREGSQG PQKPMWLNKV 
KTSLNEQTYT RVEGFVQDMR LIFHNHKEFY REDKFTRLGI QVQDIFEKNF RNIFAIQETS 
KNIIMFI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: SP100

Associated with

Cells (max top 100)

Other Information

Isolation and characterization of cDNA encoding a human nuclear antigen predominantly recognized by autoantibodies from patients with primary biliary cirrhosis. PubMed ID: 2258622

LYSP100-associated nuclear domains (LANDs): description of a new class of subnuclear structures and their relationship to PML nuclear bodies. PubMed ID: 8695863

Interaction of SP100 with HP1 proteins: a link between the promyelocytic leukemia-associated nuclear bodies and the chromatin compartment. PubMed ID: 9636146

Common properties of nuclear protein SP100 and TIF1alpha chromatin factor: role of SUMO modification. PubMed ID: 11313457

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. PubMed ID: 15815621

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

The interferon (IFN)-stimulated gene Sp100 promoter contains an IFN-gamma activation site and an imperfect IFN-stimulated response element which mediate type I IFN inducibility. PubMed ID: 8810287

Viral immediate-early proteins abrogate the modification by SUMO-1 of PML and Sp100 proteins, correlating with nuclear body disruption. PubMed ID: 10233977

Splice variants of the nuclear dot-associated Sp100 protein contain homologies to HMG-1 and a human nuclear phosphoprotein-box motif. PubMed ID: 9973607

Back to the roots of a new exon-the molecular archaeology of a SP100 splice variant. PubMed ID: 10766566

Molecular archeology of an SP100 splice variant revisited: dating the retrotranscription and Alu insertion events. PubMed ID: 11574059

Evidence for covalent modification of the nuclear dot-associated proteins PML and Sp100 by PIC1/SUMO-1. PubMed ID: 9412458

The nuclear dot protein sp100, characterization of domains necessary for dimerization, subcellular localization, and modification by small ubiquitin-like modifiers. PubMed ID: 10212234

Recruitment of NBS1 into PML oncogenic domains via interaction with SP100 protein. PubMed ID: 12470659

Sp100 interacts with ETS-1 and stimulates its transcriptional activity. PubMed ID: 11909962

Sp100 is important for the stimulatory effect of homeodomain-interacting protein kinase-2 on p53-dependent gene expression. PubMed ID: 14647468

SP100 expression modulates ETS1 transcriptional activity and inhibits cell invasion. PubMed ID: 15247905

The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. PubMed ID: 15882967

Mediation of Epstein-Barr virus EBNA-LP transcriptional coactivation by Sp100. PubMed ID: 16177824

Suppression of alternative lengthening of telomeres by Sp100-mediated sequestration of the MRE11/RAD50/NBS1 complex. PubMed ID: 15767676

SP100 inhibits ETS1 activity in primary endothelial cells. PubMed ID: 15592518

Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. PubMed ID: 17081983

FLASH links the CD95 signaling pathway to the cell nucleus and nuclear bodies. PubMed ID: 17245429

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions. PubMed ID: 19690332

Sp100 as a potent tumor suppressor: accelerated senescence and rapid malignant transformation of human fibroblasts through modulation of an embryonic stem cell program. PubMed ID: 21118961