BDP1 | ENSG00000145734 | NCBI 55814

Details for: BDP1

Gene ID: 55814

Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: BDP1

Ensembl ID: ENSG00000145734

Description: BDP1 general transcription factor IIIB subunit

Cell Significance Landscape

Display Count:

Associated with

Gene expression (transcription)
(R-HSA-74160)
Rna polymerase iii abortive and retractive initiation
(R-HSA-749476)
Rna polymerase iii transcription
(R-HSA-74158)
Rna polymerase iii transcription initiation
(R-HSA-76046)
Rna polymerase iii transcription initiation from type 1 promoter
(R-HSA-76061)
Rna polymerase iii transcription initiation from type 2 promoter
(R-HSA-76066)
Rna polymerase iii transcription initiation from type 3 promoter
(R-HSA-76071)
Nucleoplasm
(GO:0005654)
Protein binding
(GO:0005515)
Rna polymerase iii preinitiation complex assembly
(GO:0070898)
Tfiiic-class transcription factor complex binding
(GO:0001156)
Transcription factor tfiiib complex
(GO:0000126)

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

retinal ganglion cell CL0000740

CSI 31.19

rCSI 68.91%

PRS 9.4
L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040

CSI 25.7

rCSI 62.47%

PRS 7.47
central memory CD8-positive, alpha-beta T cell CL0000907

CSI 24.17

rCSI 16.28%

PRS 15.69
L6b glutamatergic cortical neuron CL4023038

CSI 22.61

rCSI 70.66%

PRS 8.2
renal alpha-intercalated cell CL0005011

CSI 20.53

rCSI 27.45%

PRS 17.3
L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041

CSI 19.14

rCSI 68.88%

PRS 7.11
pvalb GABAergic cortical interneuron CL4023018

CSI 18.2

rCSI 22.64%

PRS 7.12
near-projecting glutamatergic cortical neuron CL4023012

CSI 17.92

rCSI 67.71%

PRS 7.8
lamp5 GABAergic cortical interneuron CL4023011

CSI 17.67

rCSI 29.66%

PRS 7.68
L2/3 intratelencephalic projecting glutamatergic neuron CL4030059

CSI 16.61

rCSI 36.03%

PRS 7.18
chandelier pvalb GABAergic cortical interneuron CL4023036

CSI 15.76

rCSI 49.29%

PRS 8.78
sst GABAergic cortical interneuron CL4023017

CSI 15.43

rCSI 19.9%

PRS 8.05
sncg GABAergic cortical interneuron CL4023015

CSI 14.14

rCSI 22.74%

PRS 8.39
epithelial cell of proximal tubule CL0002306

CSI 12.67

rCSI 30.95%

PRS 13.04
neuron CL0000540

CSI 11.87

rCSI 31.61%

PRS 10.27
corticothalamic-projecting glutamatergic cortical neuron CL4023013

CSI 11.81

rCSI 69.54%

PRS 8.01
central nervous system neuron CL2000029

CSI 11.38

rCSI 83.62%

PRS 6.67
paneth cell CL0000510

CSI 10.69

rCSI 15.78%

PRS 20.56
CD4-positive helper T cell CL0000492

CSI 10.68

rCSI 8.08%

PRS 18.06
cardiac endothelial cell CL0010008

CSI 10.26

rCSI 41.41%

PRS 11.55
caudal ganglionic eminence derived cortical interneuron CL4023064

CSI 9.77

rCSI 17.26%

PRS 7.63
granulocyte monocyte progenitor cell CL0000557

CSI 7.85

rCSI 6.8%

PRS 14.56
common dendritic progenitor CL0001029

CSI 7.67

rCSI 9.63%

PRS 16.64
medium spiny neuron CL1001474

CSI 7.49

rCSI 64.5%

PRS 4.33
helper T cell CL0000912

CSI 7.46

rCSI 10.55%

PRS 18.25
inflammatory macrophage CL0000863

CSI 7.32

rCSI 12.51%

PRS 26.23
transit amplifying cell of colon CL0009011

CSI 6.99

rCSI 8.21%

PRS 15.35
GABAergic amacrine cell CL4030027

CSI 6.59

rCSI 22.57%

PRS 11.53
chondrocyte CL0000138

CSI 5.93

rCSI 9.43%

PRS 11.18
perivascular cell CL4033054

CSI 5.53

rCSI 7.57%

PRS 14.84
L5/6 near-projecting glutamatergic neuron CL4030067

CSI 5.37

rCSI 17.66%

PRS 6.77
retinal pigment epithelial cell CL0002586

CSI 5.26

rCSI 10.45%

PRS 13.9
double negative thymocyte CL0002489

CSI 4.67

rCSI 3.24%

PRS 15.31
kidney loop of Henle thin ascending limb epithelial cell CL1001107

CSI 4.64

rCSI 11.99%

PRS 12.18
ON parasol ganglion cell CL4033052

CSI 4.56

rCSI 64.68%

PRS 9.08
VIP GABAergic cortical interneuron CL4023016

CSI 4.48

rCSI 5.35%

PRS 7.49
brush cell of tracheobronchial tree CL0002075

CSI 4.45

rCSI 13.21%

PRS 19.14
ON midget ganglion cell CL4033046

CSI 4.29

rCSI 87.31%

PRS 10.01
kidney loop of Henle thin descending limb epithelial cell CL1001111

CSI 4.27

rCSI 6.06%

PRS 12.16
cerebral cortex GABAergic interneuron CL0010011

CSI 4.25

rCSI 12.53%

PRS 15.96
OFF midget ganglion cell CL4033047

CSI 4.22

rCSI 85.83%

PRS 10.95
kidney loop of Henle thick ascending limb epithelial cell CL1001106

CSI 4.18

rCSI 36.1%

PRS 23.04
GABAergic interneuron CL0011005

CSI 3.94

rCSI 62.16%

PRS 6.86
parietal epithelial cell CL1000452

CSI 3.8

rCSI 10.14%

PRS 11.05
direct pathway medium spiny neuron CL4023026

CSI 3.7

rCSI 88.65%

PRS 5.91
indirect pathway medium spiny neuron CL4023029

CSI 3.65

rCSI 88.18%

PRS 6.79
dendritic cell, human CL0001056

CSI 3.37

rCSI 5.17%

PRS 15.25
kidney interstitial alternatively activated macrophage CL1000695

CSI 3.37

rCSI 8.77%

PRS 11.94
myeloid lineage restricted progenitor cell CL0000839

CSI 3.08

rCSI 15.88%

PRS 25.67
mature B cell CL0000785

CSI 3.04

rCSI 2.64%

PRS 16.12
endothelial cell of pericentral hepatic sinusoid CL0019022

CSI 2.92

rCSI 9.01%

PRS 20.12
L4 intratelencephalic projecting glutamatergic neuron CL4030063

CSI 2.91

rCSI 6.97%

PRS 7.18
class switched memory B cell CL0000972

CSI 2.74

rCSI 2.04%

PRS 21.93
enterocyte of epithelium of large intestine CL0002071

CSI 2.67

rCSI 14.02%

PRS 23.06
kidney distal convoluted tubule epithelial cell CL1000849

CSI 2.67

rCSI 28.23%

PRS 18.03
CD4-positive, alpha-beta thymocyte CL0000810

CSI 2.58

rCSI 2.07%

PRS 23.67
bronchial goblet cell CL1000312

CSI 2.4

rCSI 9.6%

PRS 28.54
T follicular helper cell CL0002038

CSI 2.35

rCSI 1.76%

PRS 21.15
kidney collecting duct intercalated cell CL1001432

CSI 2.33

rCSI 16.67%

PRS 28.63
plasmacytoid dendritic cell, human CL0001058

CSI 2.28

rCSI 1.59%

PRS 13.7
renal principal cell CL0005009

CSI 2.23

rCSI 5.78%

PRS 17.25
myofibroblast cell CL0000186

CSI 2.2

rCSI 3.05%

PRS 18.75
naive B cell CL0000788

CSI 2.19

rCSI 1.88%

PRS 22.9
CD8-positive, alpha-beta thymocyte CL0000811

CSI 2.19

rCSI 3.41%

PRS 31.31
adventitial cell CL0002503

CSI 2.07

rCSI 4.94%

PRS 20.27
primitive red blood cell CL0002355

CSI 2.05

rCSI 11.06%

PRS 24.44
transit amplifying cell of small intestine CL0009012

CSI 2.03

rCSI 8.93%

PRS 24.34
lymphoid lineage restricted progenitor cell CL0000838

CSI 2.03

rCSI 7.91%

PRS 21.41
activated type II NK T cell CL0000931

CSI 1.93

rCSI 2.17%

PRS 20.92
thymocyte CL0000893

CSI 1.88

rCSI 6.69%

PRS 40.48
central memory CD4-positive, alpha-beta T cell CL0000904

CSI 1.83

rCSI 1.08%

PRS 18
myeloid leukocyte CL0000766

CSI 1.82

rCSI 1.68%

PRS 13.26
respiratory suprabasal cell CL4033048

CSI 1.82

rCSI 2.33%

PRS 15.08
pro-B cell CL0000826

CSI 1.81

rCSI 1.5%

PRS 13.07
lung secretory cell CL1000272

CSI 1.81

rCSI 4.48%

PRS 12.06
midbrain dopaminergic neuron CL2000097

CSI 1.76

rCSI 11.28%

PRS 19.62
epithelial cell CL0000066

CSI 1.74

rCSI 2.68%

PRS 18.55
hepatic stellate cell CL0000632

CSI 1.67

rCSI 6.27%

PRS 11.07
midzonal region hepatocyte CL0019028

CSI 1.6

rCSI 3.76%

PRS 19.7
alpha-beta T cell CL0000789

CSI 1.59

rCSI 1.87%

PRS 17.33
alveolar macrophage CL0000583

CSI 1.59

rCSI 2.62%

PRS 15.2
Mueller cell CL0000636

CSI 1.59

rCSI 3.62%

PRS 11.43
enteric smooth muscle cell CL0002504

CSI 1.58

rCSI 2.26%

PRS 14.72
plasmablast CL0000980

CSI 1.52

rCSI 1.2%

PRS 15.52
microcirculation associated smooth muscle cell CL0008035

CSI 1.52

rCSI 4.39%

PRS 14.82
CD16-positive, CD56-dim natural killer cell, human CL0000939

CSI 1.51

rCSI 1.01%

PRS 33.85
Kupffer cell CL0000091

CSI 1.5

rCSI 3.43%

PRS 12.6
cerebral cortex endothelial cell CL1001602

CSI 1.49

rCSI 2.58%

PRS 9.95
enteroendocrine cell of small intestine CL0009006

CSI 1.49

rCSI 3.28%

PRS 20.03
endothelial cell of placenta CL0009092

CSI 1.45

rCSI 7.12%

PRS 17.74
H1 horizontal cell CL0004217

CSI 1.43

rCSI 5.68%

PRS 18.37
glutamatergic neuron CL0000679

CSI 1.42

rCSI 2.91%

PRS 13.3
group 3 innate lymphoid cell CL0001071

CSI 1.41

rCSI 1.06%

PRS 13.55
memory B cell CL0000787

CSI 1.4

rCSI 1.38%

PRS 48.46
CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792

CSI 1.38

rCSI 1.35%

PRS 20.52
alveolar type 1 fibroblast cell CL4028004

CSI 1.37

rCSI 1.5%

PRS 14.95
immature B cell CL0000816

CSI 1.37

rCSI 1.02%

PRS 19.35
B cell CL0000236

CSI 1.34

rCSI 1.79%

PRS 51.48
stem cell CL0000034

CSI 1.33

rCSI 1.29%

PRS 9.03
early lymphoid progenitor CL0000936

CSI 1.32

rCSI 1.16%

PRS 14.67

stromal cell CL0000499

CSI -4.1

rCSI -11.6%

PRS 18.6%
placental villous trophoblast CL2000060

CSI -2.8

rCSI -4.4%

PRS 12.2%
adipocyte CL0000136

CSI -2.3

rCSI -2.9%

PRS 13.0%
intestine goblet cell CL0019031

CSI -1.9

rCSI -1.7%

PRS 13.1%
mesenchymal stem cell CL0000134

CSI -1.2

rCSI -12.6%

PRS 23.6%
myeloid dendritic cell CL0000782

CSI -0.9

rCSI -1.4%

PRS 19.2%
exhausted T cell CL0011025

CSI -0.6

rCSI -9.5%

PRS 48.9%
megakaryocyte CL0000556

CSI -0.4

rCSI -1.7%

PRS 23.4%
fibroblast of breast CL4006000

CSI -0.3

rCSI -1.4%

PRS 33.3%
pancreatic A cell CL0000171

CSI -0.2

rCSI -0.2%

PRS 14.0%
retinal blood vessel endothelial cell CL0002585

CSI -0.2

rCSI -0.2%

PRS 14.3%
brain vascular cell CL4023072

CSI -0.1

rCSI -1.4%

PRS 12.3%
lung ciliated cell CL1000271

CSI -0.1

rCSI -0.1%

PRS 9.6%
erythroblast CL0000765

CSI 0.0

rCSI -0.1%

PRS 21.5%
type B pancreatic cell CL0000169

CSI 0.0

rCSI 0.1%

PRS 12.2%
cytotoxic T cell CL0000910

CSI 0.1

rCSI 0.3%

PRS 19.1%
odontoblast CL0000060

CSI 0.1

rCSI 1.4%

PRS 55.1%
deuterosomal cell CL4033044

CSI 0.1

rCSI 0.2%

PRS 21.9%
OFF-bipolar cell CL0000750

CSI 0.1

rCSI 0.1%

PRS 21.2%
cerebellar neuron CL1001611

CSI 0.1

rCSI 0.7%

PRS 5.4%
lung microvascular endothelial cell CL2000016

CSI 0.1

rCSI 1.7%

PRS 40.4%
macroglial cell CL0000126

CSI 0.1

rCSI 0.2%

PRS 18.3%
erythroid progenitor cell CL0000038

CSI 0.1

rCSI 0.5%

PRS 20.1%
pluripotent stem cell CL0002248

CSI 0.1

rCSI 2.8%

PRS 30.0%
pancreatic epsilon cell CL0005019

CSI 0.1

rCSI 0.5%

PRS 30.9%
ciliated epithelial cell CL0000067

CSI 0.1

rCSI 0.1%

PRS 9.5%
type EC enteroendocrine cell CL0000577

CSI 0.1

rCSI 0.4%

PRS 21.4%
tracheobronchial serous cell CL0019001

CSI 0.1

rCSI 0.5%

PRS 25.0%
melanocyte CL0000148

CSI 0.1

rCSI 0.1%

PRS 11.6%
cerebral cortex pyramidal neuron CL4023111

CSI 0.1

rCSI 0.8%

PRS 35.1%
keratocyte CL0002363

CSI 0.1

rCSI 0.3%

PRS 19.6%
regular atrial cardiac myocyte CL0002129

CSI 0.1

rCSI 0.5%

PRS 13.9%
vein endothelial cell of respiratory system CL4033008

CSI 0.2

rCSI 1.0%

PRS 25.5%
contractile cell CL0000183

CSI 0.2

rCSI 0.5%

PRS 10.1%
duct epithelial cell CL0000068

CSI 0.2

rCSI 0.3%

PRS 13.8%
pancreatic stellate cell CL0002410

CSI 0.2

rCSI 1.0%

PRS 19.6%
mesenchymal cell CL0008019

CSI 0.2

rCSI 0.5%

PRS 13.3%
Hofbauer cell CL3000001

CSI 0.2

rCSI 0.4%

PRS 16.2%
cerebral cortex neuron CL0010012

CSI 0.2

rCSI 0.8%

PRS 13.5%
IgG plasma cell CL0000985

CSI 0.2

rCSI 0.2%

PRS 22.4%
serotonergic neuron CL0000850

CSI 0.2

rCSI 0.9%

PRS 5.2%
common lymphoid progenitor CL0000051

CSI 0.2

rCSI 0.3%

PRS 24.9%
metallothionein-positive alveolar macrophage CL4033042

CSI 0.2

rCSI 2.4%

PRS 49.1%
colon macrophage CL0009038

CSI 0.2

rCSI 1.0%

PRS 26.9%
lung neuroendocrine cell CL1000223

CSI 0.2

rCSI 0.3%

PRS 15.0%
eye photoreceptor cell CL0000287

CSI 0.2

rCSI 2.6%

PRS 32.5%
basal-myoepithelial cell of mammary gland CL0002324

CSI 0.2

rCSI 0.4%

PRS 28.3%
mucous neck cell CL0000651

CSI 0.2

rCSI 0.3%

PRS 21.0%
respiratory goblet cell CL0002370

CSI 0.2

rCSI 2.6%

PRS 25.1%
OFFx cell CL4033036

CSI 0.2

rCSI 1.1%

PRS 12.7%
squamous epithelial cell CL0000076

CSI 0.2

rCSI 0.6%

PRS 16.5%
diffuse bipolar 3b cell CL4033030

CSI 0.3

rCSI 1.6%

PRS 13.2%
alternatively activated macrophage CL0000890

CSI 0.3

rCSI 0.3%

PRS 20.0%
luminal epithelial cell of mammary gland CL0002326

CSI 0.3

rCSI 0.5%

PRS 20.0%
group 2 innate lymphoid cell CL0001069

CSI 0.3

rCSI 1.4%

PRS 43.5%
Cajal-Retzius cell CL0000695

CSI 0.3

rCSI 2.1%

PRS 28.2%
effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062

CSI 0.3

rCSI 1.4%

PRS 17.1%
enterocyte of epithelium of small intestine CL1000334

CSI 0.3

rCSI 4.2%

PRS 32.3%
intermediate monocyte CL0002393

CSI 0.3

rCSI 0.4%

PRS 12.9%
eosinophil CL0000771

CSI 0.3

rCSI 1.8%

PRS 33.7%
mesothelial cell CL0000077

CSI 0.3

rCSI 1.1%

PRS 2.6%
bronchus fibroblast of lung CL2000093

CSI 0.3

rCSI 0.2%

PRS 13.8%
foveolar cell of stomach CL0002179

CSI 0.3

rCSI 0.6%

PRS 21.0%
brush cell CL0002204

CSI 0.3

rCSI 0.6%

PRS 33.7%
CD14-positive, CD16-negative classical monocyte CL0002057

CSI 0.3

rCSI 1.8%

PRS 29.0%
myoepithelial cell CL0000185

CSI 0.3

rCSI 0.8%

PRS 16.2%
pancreatic ductal cell CL0002079

CSI 0.3

rCSI 0.6%

PRS 13.3%
Bergmann glial cell CL0000644

CSI 0.3

rCSI 0.4%

PRS 13.3%
pro-T cell CL0000827

CSI 0.3

rCSI 7.7%

PRS 71.8%
amacrine cell CL0000561

CSI 0.3

rCSI 1.0%

PRS 10.1%
peripheral nervous system neuron CL2000032

CSI 0.3

rCSI 0.5%

PRS 11.7%
mesodermal cell CL0000222

CSI 0.4

rCSI 0.4%

PRS 12.9%
promonocyte CL0000559

CSI 0.4

rCSI 0.6%

PRS 17.5%
CD1c-positive myeloid dendritic cell CL0002399

CSI 0.4

rCSI 0.4%

PRS 15.4%
retinal rod cell CL0000604

CSI 0.4

rCSI 0.6%

PRS 12.9%
dopaminergic neuron CL0000700

CSI 0.4

rCSI 2.1%

PRS 5.4%
tracheobronchial smooth muscle cell CL0019019

CSI 0.4

rCSI 0.7%

PRS 17.3%
progenitor cell CL0011026

CSI 0.4

rCSI 0.8%

PRS 22.5%
GABAergic neuron CL0000617

CSI 0.4

rCSI 1.4%

PRS 9.0%
glial cell CL0000125

CSI 0.4

rCSI 1.5%

PRS 13.3%
epithelial cell of nephron CL1000449

CSI 0.4

rCSI 3.9%

PRS 52.3%
intrahepatic cholangiocyte CL0002538

CSI 0.4

rCSI 1.0%

PRS 23.7%
colon epithelial cell CL0011108

CSI 0.4

rCSI 0.4%

PRS 12.2%
collagen secreting cell CL0000667

CSI 0.4

rCSI 2.4%

PRS 45.3%
basophil CL0000767

CSI 0.4

rCSI 0.9%

PRS 26.4%
effector memory CD4-positive, alpha-beta T cell CL0000905

CSI 0.4

rCSI 0.6%

PRS 31.3%
erythrocyte CL0000232

CSI 0.4

rCSI 1.0%

PRS 18.2%
CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203

CSI 0.4

rCSI 0.5%

PRS 17.3%
diffuse bipolar 6 cell CL4033032

CSI 0.4

rCSI 2.2%

PRS 15.0%
fibroblast of cardiac tissue CL0002548

CSI 0.4

rCSI 2.1%

PRS 8.7%
cerebellar granule cell CL0001031

CSI 0.4

rCSI 0.6%

PRS 11.9%
S cone cell CL0003050

CSI 0.4

rCSI 1.9%

PRS 9.7%
natural T-regulatory cell CL0000903

CSI 0.4

rCSI 0.8%

PRS 35.4%
acinar cell CL0000622

CSI 0.5

rCSI 0.7%

PRS 17.1%
paneth cell of epithelium of small intestine CL1000343

CSI 0.5

rCSI 1.3%

PRS 20.2%
H2 horizontal cell CL0004218

CSI 0.5

rCSI 2.3%

PRS 14.1%
forebrain radial glial cell CL0013000

CSI 0.5

rCSI 1.5%

PRS 19.1%
enteroglial cell CL4040002

CSI 0.5

rCSI 2.4%

PRS 23.5%
epicardial adipocyte CL1000309

CSI 0.5

rCSI 1.5%

PRS 15.7%
retinal bipolar neuron CL0000748

CSI 0.5

rCSI 0.9%

PRS 9.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Interaction Source:

Pathway Categories (for ONTOLOGY source):

Baseline Cell Type:

Baseline Cell Context(s): Comma-separated if multiple.

Target Cell Type:

Target Cell Context(s): Comma-separated if multiple.

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Query Gene
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
Node Size: Proportional to Target Cell CSI magnitude
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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

Description
Proteins

## Summary [BDP1](/details-gene/55814) is a protein-coding gene located on chromosome 5q13.2 that encodes a subunit of the general transcription factor IIIB (TFIIIB). As an essential component of the RNA polymerase III transcription machinery, [BDP1](/details-gene/55814) plays a fundamental role in gene expression, specifically in the synthesis of small non-coding RNAs such as transfer RNAs (tRNAs) and 5S ribosomal RNA. **Overall**, its expression profile indicates high significance in metabolically active and functionally complex cell types, particularly diverse neuronal populations including [retinal ganglion cell](/details-cell/CL0000740)s and various cortical glutamatergic neurons. Its prominence extends to specific immune and epithelial cell subsets, suggesting a crucial role in supporting the high translational and metabolic demands of these specialized cells. ## Cellular Roles and Expression Landscape The expression landscape of [BDP1](/details-gene/55814) highlights its role as a key transcriptional component in cells with high metabolic and biosynthetic activity. The gene shows the highest significance in the central nervous system, consistently ranking as a top marker in a wide array of neuronal subtypes. These include [retinal ganglion cell](/details-cell/CL0000740) (CSI: 31.19), multiple classes of cortical neurons such as [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 25.70), [L6b glutamatergic cortical neuron](/details-cell/CL4023038) (CSI: 22.61), and various GABAergic interneurons. This pattern suggests that robust RNA Polymerase III-mediated transcription, driven by [BDP1](/details-gene/55814), is indispensable for maintaining the complex structure and function of the mammalian brain. Beyond the nervous system, [BDP1](/details-gene/55814) is a significant factor in other specialized cell types. It is highly ranked in immune cells poised for rapid response, such as the [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907) (CSI: 24.17), likely to support the protein synthesis required for clonal expansion and effector function. Similarly, its high significance in [renal alpha-intercalated cell](/details-cell/CL0005011) (CSI: 20.53) and [epithelial cell of proximal tubule](/details-cell/CL0002306) (CSI: 12.67) is consistent with the high energetic and transport activities of these kidney cells. Conversely, the gene's significance is markedly low in cell types with different functional roles. It is an anti-marker for [stromal cell](/details-cell/CL0000499) (CSI: -4.10), [adipocyte](/details-cell/CL0000136) (CSI: -2.26), and [mesenchymal stem cell](/details-cell/CL0000134) (CSI: -1.15), suggesting a less critical role in structural and progenitor cells. Notably, its negative CSI score in [exhausted T cell](/details-cell/CL0011025) (CSI: -0.56) contrasts sharply with its high score in central memory T cells, implying that downregulation of [BDP1](/details-gene/55814)-mediated transcription may be associated with T cell hypo-responsiveness. ## Pathways and Molecular Function Functional annotations confirm that [BDP1](/details-gene/55814) is fundamentally involved in transcription by RNA polymerase III. It is a core component of the [transcription factor tfiiib complex](/https://www.ebi.ac.uk/QuickGO/term/GO:0000126) located in the [nucleoplasm](/https://www.ebi.ac.uk/QuickGO/term/GO:0005654). Its molecular function involves binding to other protein components of the transcription machinery, specifically the [Tfiiic-class transcription factor complex](/https://www.ebi.ac.uk/QuickGO/term/GO:0001156). Reactome pathway analysis places [BDP1](/details-gene/55814) at the heart of [RNA Polymerase III Transcription](/https://reactome.org/content/detail/R-HSA-74158). It is explicitly implicated in the critical step of [RNA polymerase iii preinitiation complex assembly](/https://www.ebi.ac.uk/QuickGO/term/GO:0070898), a prerequisite for transcription. The gene product is involved in transcription initiation from all major promoter types recognized by RNA Pol III, including type 1 ([R-HSA-76061](https://reactome.org/content/detail/R-HSA-76061)), type 2 ([R-HSA-76066](https://reactome.org/content/detail/R-HSA-76066)), and type 3 ([R-HSA-76071](https://reactome.org/content/detail/R-HSA-76071)). This broad role underscores its importance in producing a wide range of essential small RNAs, a function consistent with its high expression in biosynthetically active cells like neurons and memory T cells. Research indicates that different human TFIIIB complexes, containing factors like [BDP1](/details-gene/55814), can direct transcription from distinct promoter architectures, highlighting a layer of regulatory complexity ([Link](https://doi.org/10.1101/gad.836400)). Furthermore, its activity is known to be regulated by post-translational modifications, such as CK2-mediated phosphorylation, which represses RNA Pol III transcription during specific phases of the cell cycle ([Link](https://doi.org/10.1016/j.molcel.2004.09.008)). ## Research Directions The data suggest that the transcriptional activity mediated by [BDP1](/details-gene/55814) is a critical determinant of cellular functional state, particularly in the immune system. The stark contrast in its significance between highly functional [central memory CD8-positive, alpha-beta T cell](/details-cell/CL0000907)s and hypo-responsive [exhausted T cell](/details-cell/CL0011025)s provides a compelling basis for further investigation. **Proposed Hypotheses:** 1. The downregulation of [BDP1](/details-gene/55814) expression is a causal mechanism in the establishment and maintenance of T cell exhaustion. By limiting the cell's capacity for tRNA synthesis, reduced [BDP1](/details-gene/55814) activity may create a bottleneck in protein translation, preventing the sustained production of effector molecules required to clear chronic infections or tumors. 2. In the central nervous system, the exceptionally high expression of [BDP1](/details-gene/55814) in specific neuronal subtypes like [retinal ganglion cell](/details-cell/CL0000740)s reflects a unique vulnerability to disruptions in RNA Pol III transcription. Neurodegenerative conditions affecting these cells may be linked to perturbations in the [BDP1](/details-gene/55814)-driven transcriptional machinery. **Key Experimental Approach:** To test the first hypothesis regarding T cell exhaustion, a targeted genetic approach could be employed. One could generate a conditional knockout mouse where [BDP1](/details-gene/55814) is specifically deleted in T cells (e.g., using a *Lck*-Cre or *Cd4*-Cre driver). These mice and their littermate controls would then be subjected to a chronic viral infection model, such as with Lymphocytic Choriomeningitis Virus (LCMV) Clone 13. The progression of T cell exhaustion would be monitored over time by analyzing virus-specific T cells for key exhaustion markers (e.g., PD-1, LAG-3, TIM-3) via flow cytometry, assessing effector function through ex vivo cytokine stimulation, and measuring viral titers. A more rapid or severe exhaustion phenotype in the knockout T cells would provide strong evidence that [BDP1](/details-gene/55814) is essential for sustaining T cell functionality during chronic antigen stimulation. **Therapeutic Potential:** As a general transcription factor essential for basic cellular processes, [BDP1](/details-gene/55814) presents a challenging therapeutic target. Systemic inhibition would likely lead to significant toxicity in highly proliferative and metabolically active healthy tissues, such as the gut epithelium and hematopoietic system. However, given that dysregulated RNA Pol III transcription is a hallmark of some cancers, developing strategies to selectively inhibit this pathway in malignant cells remains an area of interest. Conversely, strategies aimed at augmenting [BDP1](/details-gene/55814) activity or expression could represent a novel approach to reversing T cell exhaustion in immunotherapy, though achieving cell-type specificity would be a major hurdle. Therefore, targeting upstream regulators of [BDP1](/details-gene/55814) may offer a more viable therapeutic window than direct modulation of the protein itself.

Disclaimer: This in-silico analysis is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Transcription factor TFIIIB component B'' homolog

Genular Protein ID: 1957741077

Symbol: BDP1_HUMAN

Name: Transcription factor TFIIIB component B'' homolog

UniProtKB Accession Codes:

A6H8Y1 Q68DS6 Q68DY5 Q6MZL9 Q6PIM7 Q86W98 Q96LR8 Q9C0H4 Q9H197 Q9H1A1 Q9HAW1 Q9HAW2 Q9HCY0 Q9ULH9

Database IDs:

Citations:

PubMed ID: 11040218

Title: Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters.

PubMed ID: 11040218

DOI: 10.1101/gad.836400

PubMed ID: 11161782

Title: The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1.

PubMed ID: 11161782

DOI: 10.1006/geno.2000.6396

PubMed ID: 10574462

Title: Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10574462

DOI: 10.1093/dnares/6.5.337

PubMed ID: 11214970

Title: Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 11214970

DOI: 10.1093/dnares/7.6.347

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 11121026

Title: A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements.

PubMed ID: 11121026

DOI: 10.1073/pnas.97.26.14200

PubMed ID: 14592981

Title: TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo.

PubMed ID: 14592981

DOI: 10.1093/emboj/cdg544

PubMed ID: 15096501

Title: Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity.

PubMed ID: 15096501

DOI: 10.1074/jbc.m312790200

PubMed ID: 15469824

Title: CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression.

PubMed ID: 15469824

DOI: 10.1016/j.molcel.2004.09.008

PubMed ID: 16542149

Title: The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB.

PubMed ID: 16542149

DOI: 10.1515/bc.2006.037

PubMed ID: 16769183

Title: A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes.

PubMed ID: 16769183

DOI: 10.1016/j.gene.2006.03.012

PubMed ID: 16956891

Title: Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III.

PubMed ID: 16956891

DOI: 10.1074/jbc.m600468200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 24312468

Title: Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss.

PubMed ID: 24312468

DOI: 10.1371/journal.pone.0080323

Sequence Information:

Length: 2624
Mass: 293885
Checksum: CB7B80EBBF06B557
Sequence:

MFRRARLSVK PNVRPGVGAR GSTASNPQRG RESPRPPDPA TDSASKPAEP TDVPTVDFGG 
AEPQEKAPRS STEKTGGDND VEESSRSSST VSQRRKRISS TSSLVKSSVS VPSESHPLST 
INQEAPQPTA TSTKEKQPCS DRYRIYKAQK LREMLKEELR KEKKQWKNKY AINESQRPPD 
RSKMTMRDFI YYLPDNNPMT SSLEQEKKTE KPSTPVQTRE QEGKSTPNAE DNEMEEETDD 
GPLLVPRVKV AEDGSIILDE ESLTVEVLRT KGPCVVEEND PIFERGSTTT YSSFRKNYYS 
KPWSNKETDM FFLAISMVGT DFSMIGQLFP HRARIEIKNK FKREEKTNGW RIDKAFQEKR 
PFDFDFFAHL LQKVLAEEEK RKQKSVKNHS LKEKKSTKPR KNVKVKKVAC EGVNNDPDES 
MSSRISDTER SQKDAQTVEE ESLTLSREDA EQVALEVDLN QKKRRRKKQD GANELGVNNL 
LENATVQAGP SKGEKHKNKC QAIRPELKEG ECSKEQMLSC TQNIDGIVGF ASTEKVEKRT 
DPILSLSNQQ DATSVATESS ESSTSDLPSF EVGIRALCEV NNAEGSCIEE RNVDLKNNSL 
EIDQTENVKP MLRGRFQRPK PNLSRAGKKS VLSQGKTESE SKNSHSKTSV EKNHVEKDKM 
NTLDILRMET TERENPEAET VSVLGEKNCL QEGSQLKALR PVQVRGRLQK PKPNAGKAAE 
RKEILISQEE IGANVEKNEN ESCADRDTPQ HMEDQSRKDF EEEDVILQPE KNDSFQNVQP 
DEPKVLNECL SVQENNKANK LNQVPILRTR FQKPKPNIGR GTGRREISSK EEVLEKILVS 
GEMAAALRET VRLDTSPKEM VPAEINTKEM QSDLKETGRR AISPREKILD VIDDTIEMET 
GLKAMGREIC LREKTPEVID ATEEIDKDLE EAGRREISPQ KNGPEEVKPL GEVETDLKAT 
GNESSPREKT PEVTDATEEI DKNLEETGRR KISPRENGPE EVKPVDEMET DLNATGRESS 
PREKTPEVID ATEEIDLEET EREVSPQENG LEEVKPLGEM ETDLKATGRD SFPRGKTPEV 
IDAIEEIEID LEETEREISP QENGLEEVKP LGEMQTDLKA TGREISPREK TPEVIDATEE 
IDKDLEETGR REISPEENGP EEVKPVDEME TDLKTTGREG SSREKTREVI DAAEVIETDL 
EETEREISPQ ENGPEEVKPV GKMETDLKEI REEISQREKV LAEFSAIREK EIDLKETGKR 
DIPIMEKVSG KMAVVEEMEA DLKETGKENF RERGSEEICV TEEKVAELKQ TGKTDISPRE 
NELEETSTSR QTDTHLMQSG SNDFSAVPSL DIQNISSEVL SMMHTPVEEK RNSEKEVSSH 
FSHFKISSQT HESDKTEVQG IQSPDVPEQF SDINLSKSLP QEQKPLEIKP APFVRSRFKR 
PKPNLARAAL KRETTESEKY IYEKKSETKK METIVMQENN EQTDTLPSQH DEASLMISRE 
KDTLGHRNEE AVILPCTQTE RNLSPSNSCE PKEESQSAPV QKNDSVVSVG TNNVNTFQQE 
MKESVIQTAR QVRGRLQRPR PNIRKTGQRQ IVDKGEAKGI IKEGRTILPK DETEKKVLTV 
SNSQIETEIE VPSSAVPEHR MYENQSQVVL VENLHVNKTN ETIRHENKPY VPSSAQMTRR 
KFQKAKPNLG RAHSKKEEPV LEKVTTDQSK EGKPEDHLLQ KGASNTQLLL KEKAELLTSL 
EVSARKDCVG SKESALAKID AELEEVGPSR RVGEETVGDN SPSSVVEEQY LNKLTSCPQP 
LNETSYSKIA LDGKTTISST SEYERNRGER RSHKKFKPNV TRGRGSKRVR GKTSKKEPRA 
SKAMLVTLRA SQEEDDDADD FESDYEEESY HLAPEEVNKA PVFVPVGLRS PEPVSAQIEE 
TMEELEITVN VPDVGCIAVV EHELPNTDVT TEEMKQEENL SVPFEMTTSE HIQDEPGTND 
GSTEAAITLL TMGDLVLQSE ISSEQGDVGV CIIPHVHSKD KSHIPSSLDN VNHKIVHECQ 
ELSSPVITTS PASFEENKIV LEEQSSREEI SLMEKVKENA TPTRNTISKV TSNLRIRSRL 
AKPKPNLEKT LGTNRLDDYQ EVSSLCVTKG AEMETQRETE KNASKATELE NKNLGPVTTA 
ENKDQSKLAC VHGIKGTSIS SEVNLTERNE NQEESSQEVH MLSVAPVASS ETGPCTLGLD 
RGLGENSVEE PQIKDSKGDS VLTLPVPEYT PTSIPEVQQE NIINPQDLTV NLVANVPQDG 
EDEQAFILTL VEIPANAVEE FTDATAQFMP NPLLPAPILV KSVNTEERGD MSICLPATSV 
GQDAMGLSIS GRDNSKKPPD NLDLVSRKRF QCRLDKNDHI PPAKKRSLTL RDDCQEYTTE 
VHSKELTNVF EETGESHKGQ DIFLTSGSTL TTPEPQRQQV EAAFQSRGSR SPDACMDKNV 
PQLPQDEMIV SDKEERTDAA PKSQQMDSRT SSSKASLSRP GRRPLGFLSL ICSKNSLESD 
EPMQVHSKKR LKPLIPGLRK KLKRSNPFNE SQEKNRESSD LLPSPSVITT QSENISSSAT 
QVSCDQPLLK EGYKSAQKRA PQGEATTVSE YFFNDIFIEV DETE

Details for: BDP1

Cell Significance Landscape

Associated with

Significant Cells

Network Configuration

Legend:

Other Information

Different human TFIIIB activities direct RNA polymerase III transcription from TATA-containing and TATA-less promoters. PubMed ID: 11040218

The transcription factor-like nuclear regulator (TFNR) contains a novel 55-amino-acid motif repeated nine times and maps closely to SMN1. PubMed ID: 11161782

Prediction of the coding sequences of unidentified human genes. XV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 10574462

Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. PubMed ID: 11214970

Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. PubMed ID: 12168954

The full-ORF clone resource of the German cDNA consortium. PubMed ID: 17974005

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

A stable complex of a novel transcription factor IIB- related factor, human TFIIIB50, and associated proteins mediate selective transcription by RNA polymerase III of genes with upstream promoter elements. PubMed ID: 11121026

TFIIIB is phosphorylated, disrupted and selectively released from tRNA promoters during mitosis in vivo. PubMed ID: 14592981

Transcription factor (TF)-like nuclear regulator, the 250-kDa form of Homo sapiens TFIIIB', is an essential component of human TFIIIC1 activity. PubMed ID: 15096501

CK2 phosphorylation of Bdp1 executes cell cycle-specific RNA polymerase III transcription repression. PubMed ID: 15469824

The zinc finger protein ZNF297B interacts with BDP1, a subunit of TFIIIB. PubMed ID: 16542149

A role for Yin Yang-1 (YY1) in the assembly of snRNA transcription complexes. PubMed ID: 16769183

Epstein-Barr virus induces cellular transcription factors to allow active expression of EBER genes by RNA polymerase III. PubMed ID: 16956891

A quantitative atlas of mitotic phosphorylation. PubMed ID: 18669648

Linkage study and exome sequencing identify a BDP1 mutation associated with hereditary hearing loss. PubMed ID: 24312468