Details for: PICALM
Gene ID: 8301
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: PICALM
Ensembl ID: ENSG00000073921
Description: phosphatidylinositol binding clathrin assembly protein
Selected Context(s): Overall
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 53.81rCSI 93.07%PRS 11.32
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CSI 40.99rCSI 52.63%PRS 14.72
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CSI 37.31rCSI 52.89%PRS 13.87
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CSI 32.77rCSI 55%PRS 8.76
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CSI 32.4rCSI 49.49%PRS 14.91
-
CSI 31.25rCSI 75.94%PRS 8.55
-
CSI 28.31rCSI 35.22%PRS 8.15
-
CSI 27.92rCSI 92.55%PRS 14.6
-
CSI 26.42rCSI 82.56%PRS 9.37
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CSI 26.3rCSI 58.1%PRS 10.71
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CSI 25.07rCSI 65.35%PRS 13.64
-
CSI 23.89rCSI 70.59%PRS 11.36
-
CSI 23.62rCSI 37.99%PRS 9.58
-
CSI 21.47rCSI 77.26%PRS 8.19
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CSI 20.8rCSI 26.81%PRS 9.21
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CSI 20.48rCSI 25.47%PRS 15.71
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CSI 19.31rCSI 23.07%PRS 8.57
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CSI 18.79rCSI 71.01%PRS 8.99
-
CSI 18.49rCSI 45.76%PRS 13.75
-
CSI 17.88rCSI 31.57%PRS 8.74
-
CSI 17.62rCSI 47.1%PRS 12.42
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CSI 17.6rCSI 33.23%PRS 18.59
-
CSI 17.23rCSI 26%PRS 14.8
-
CSI 17.18rCSI 68.07%PRS 20.62
-
CSI 16.67rCSI 42.29%PRS 11.31
-
CSI 16.63rCSI 23.87%PRS 11.53
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CSI 16.44rCSI 66.15%PRS 34.61
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CSI 15.22rCSI 47.59%PRS 10.06
-
CSI 14.92rCSI 73.52%PRS 20.21
-
CSI 14.51rCSI 49.7%PRS 12.95
-
CSI 14.42rCSI 37.45%PRS 19.53
-
CSI 13.99rCSI 45.39%PRS 18.15
-
CSI 13.3rCSI 78.29%PRS 9.21
-
CSI 13.25rCSI 23.22%PRS 11.04
-
CSI 12.98rCSI 34.57%PRS 11.93
-
CSI 12.58rCSI 27.55%PRS 19.86
-
CSI 12.5rCSI 62.16%PRS 15.88
-
CSI 12.36rCSI 17.9%PRS 22.08
-
CSI 11.89rCSI 33.31%PRS 23.01
-
CSI 11.72rCSI 47.79%PRS 20.01
-
CSI 11.41rCSI 37.13%PRS 18.01
-
CSI 11.39rCSI 38.59%PRS 13.47
-
CSI 11.17rCSI 30.79%PRS 13.84
-
CSI 9.99rCSI 24.4%PRS 14.75
-
CSI 9.42rCSI 24.57%PRS 23.26
-
CSI 9.21rCSI 67.68%PRS 7.97
-
CSI 9.08rCSI 40.36%PRS 14.6
-
CSI 8.65rCSI 47.28%PRS 24.79
-
CSI 8.55rCSI 40%PRS 30.28
-
CSI 8.38rCSI 19.02%PRS 20.63
-
CSI 8.2rCSI 18.04%PRS 9.54
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CSI 7.97rCSI 18.2%PRS 12.98
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CSI 7.87rCSI 32.71%PRS 20.61
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CSI 7.57rCSI 9.37%PRS 13.06
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CSI 7.55rCSI 41.89%PRS 41.53
-
CSI 7.48rCSI 13.44%PRS 12.43
-
CSI 7.37rCSI 11.23%PRS 13.88
-
CSI 7.33rCSI 12.01%PRS 11.49
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CSI 7.31rCSI 11.67%PRS 16.33
-
CSI 7.22rCSI 13.76%PRS 23.72
-
CSI 7.21rCSI 15.64%PRS 8.85
-
CSI 7.21rCSI 14.47%PRS 11.03
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CSI 7.2rCSI 12.89%PRS 13.79
-
CSI 7.17rCSI 5.56%PRS 14.19
-
CSI 7.11rCSI 13.04%PRS 53.31
-
CSI 7.1rCSI 21.06%PRS 21.44
-
CSI 7.05rCSI 41.62%PRS 15.39
-
CSI 7.01rCSI 41.98%PRS 23.81
-
CSI 6.94rCSI 6.08%PRS 19.69
-
CSI 6.92rCSI 7.99%PRS 13.06
-
CSI 6.78rCSI 10.36%PRS 18.9
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CSI 6.74rCSI 37.7%PRS 29.08
-
CSI 6.73rCSI 16.1%PRS 8.55
-
CSI 6.72rCSI 9.33%PRS 15.33
-
CSI 6.57rCSI 15.18%PRS 12
-
CSI 6.52rCSI 9.03%PRS 21.21
-
CSI 6.41rCSI 5.31%PRS 14.94
-
CSI 6.36rCSI 9.11%PRS 20.41
-
CSI 6.26rCSI 8.56%PRS 16.88
-
CSI 6.24rCSI 4.93%PRS 10.24
-
CSI 6.2rCSI 11.27%PRS 54.35
-
CSI 5.86rCSI 11.9%PRS 6.74
-
CSI 5.82rCSI 6.24%PRS 13.69
-
CSI 5.74rCSI 46.67%PRS 15.24
-
CSI 5.62rCSI 12.61%PRS 9.16
-
CSI 5.52rCSI 4.46%PRS 23.74
-
CSI 5.51rCSI 10.94%PRS 15.85
-
CSI 5.41rCSI 5.6%PRS 17.49
-
CSI 5.27rCSI 4.01%PRS 19.55
-
CSI 5.25rCSI 6.68%PRS 17.3
-
CSI 5.15rCSI 5.64%PRS 16.99
-
CSI 5.12rCSI 19.91%PRS 20.67
-
CSI 5.1rCSI 15.07%PRS 12.54
-
CSI 5.07rCSI 18.98%PRS 12.64
-
CSI 5.06rCSI 11.19%PRS 13.85
-
CSI 5rCSI 4.82%PRS 15.41
-
CSI 4.96rCSI 12.83%PRS 13.88
-
CSI 4.92rCSI 18.58%PRS 21.52
-
CSI 4.9rCSI 26.05%PRS 30.27
-
CSI 4.81rCSI 5.02%PRS 15.25
-
CSI -9.7rCSI -7.3%PRS 15.6%
-
CSI -3.5rCSI -9.0%PRS 15.1%
-
CSI -3.1rCSI -16.8%PRS 26.6%
-
CSI -0.9rCSI -7.7%PRS 7.7%
-
CSI -0.7rCSI -3.5%PRS 27.3%
-
CSI -0.5rCSI -1.9%PRS 26.1%
-
CSI 0.0rCSI 0.2%PRS 22.3%
-
CSI 0.1rCSI 0.5%PRS 21.7%
-
CSI 0.1rCSI 1.3%PRS 26.8%
-
CSI 0.1rCSI 0.2%PRS 23.4%
-
CSI 0.3rCSI 0.2%PRS 18.4%
-
CSI 0.3rCSI 0.5%PRS 29.1%
-
CSI 0.3rCSI 1.6%PRS 22.9%
-
CSI 0.3rCSI 0.6%PRS 24.8%
-
CSI 0.3rCSI 0.5%PRS 32.2%
-
CSI 0.3rCSI 0.3%PRS 16.2%
-
CSI 0.3rCSI 3.0%PRS 40.5%
-
CSI 0.3rCSI 5.8%PRS 53.1%
-
CSI 0.4rCSI 1.2%PRS 28.5%
-
CSI 0.4rCSI 2.3%PRS 26.1%
-
CSI 0.4rCSI 10.5%PRS 47.8%
-
CSI 0.4rCSI 2.5%PRS 49.3%
-
CSI 0.5rCSI 1.1%PRS 15.4%
-
CSI 0.5rCSI 7.3%PRS 36.4%
-
CSI 0.5rCSI 3.6%PRS 27.0%
-
CSI 0.5rCSI 1.2%PRS 26.7%
-
CSI 0.5rCSI 2.5%PRS 19.5%
-
CSI 0.5rCSI 7.6%PRS 63.2%
-
CSI 0.5rCSI 2.4%PRS 50.2%
-
CSI 0.5rCSI 2.3%PRS 27.6%
-
CSI 0.5rCSI 10.4%PRS 44.4%
-
CSI 0.6rCSI 4.7%PRS 55.3%
-
CSI 0.6rCSI 2.7%PRS 40.3%
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CSI 0.6rCSI 1.7%PRS 24.5%
-
CSI 0.7rCSI 2.0%PRS 22.4%
-
CSI 0.7rCSI 2.8%PRS 14.3%
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CSI 0.7rCSI 5.2%PRS 48.4%
-
CSI 0.7rCSI 0.5%PRS 17.9%
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CSI 0.8rCSI 1.1%PRS 20.6%
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CSI 0.8rCSI 1.1%PRS 19.6%
-
CSI 0.8rCSI 1.0%PRS 17.2%
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CSI 0.8rCSI 1.1%PRS 13.3%
-
CSI 0.8rCSI 2.0%PRS 22.3%
-
CSI 0.9rCSI 4.9%PRS 7.0%
-
CSI 0.9rCSI 4.8%PRS 17.2%
-
CSI 0.9rCSI 6.7%PRS 39.6%
-
CSI 1.0rCSI 0.8%PRS 14.8%
-
CSI 1.0rCSI 2.5%PRS 20.3%
-
CSI 1.0rCSI 1.3%PRS 16.3%
-
CSI 1.1rCSI 1.9%PRS 14.7%
-
CSI 1.1rCSI 12.1%PRS 15.8%
-
CSI 1.1rCSI 1.7%PRS 17.5%
-
CSI 1.1rCSI 1.2%PRS 10.9%
-
CSI 1.1rCSI 3.1%PRS 21.8%
-
CSI 1.1rCSI 2.3%PRS 33.7%
-
CSI 1.1rCSI 2.0%PRS 22.7%
-
CSI 1.2rCSI 1.5%PRS 21.0%
-
CSI 1.2rCSI 7.6%PRS 22.3%
-
CSI 1.2rCSI 5.6%PRS 15.0%
-
CSI 1.2rCSI 2.3%PRS 15.2%
-
CSI 1.2rCSI 1.9%PRS 13.9%
-
CSI 1.3rCSI 3.7%PRS 45.3%
-
CSI 1.3rCSI 4.9%PRS 30.3%
-
CSI 1.3rCSI 1.1%PRS 13.3%
-
CSI 1.3rCSI 3.3%PRS 38.7%
-
CSI 1.3rCSI 1.7%PRS 19.7%
-
CSI 1.3rCSI 2.1%PRS 17.4%
-
CSI 1.3rCSI 1.1%PRS 16.7%
-
CSI 1.3rCSI 2.0%PRS 26.1%
-
CSI 1.3rCSI 3.5%PRS 19.2%
-
CSI 1.3rCSI 1.2%PRS 22.5%
-
CSI 1.3rCSI 4.7%PRS 24.3%
-
CSI 1.3rCSI 3.5%PRS 14.6%
-
CSI 1.3rCSI 2.4%PRS 13.7%
-
CSI 1.4rCSI 3.4%PRS 18.5%
-
CSI 1.4rCSI 5.2%PRS 14.9%
-
CSI 1.4rCSI 1.3%PRS 15.2%
-
CSI 1.4rCSI 2.1%PRS 17.1%
-
CSI 1.4rCSI 2.0%PRS 13.7%
-
CSI 1.4rCSI 3.1%PRS 22.7%
-
CSI 1.4rCSI 2.5%PRS 19.7%
-
CSI 1.5rCSI 1.8%PRS 25.9%
-
CSI 1.5rCSI 4.2%PRS 20.9%
-
CSI 1.5rCSI 8.2%PRS 40.7%
-
CSI 1.5rCSI 2.2%PRS 15.7%
-
CSI 1.6rCSI 9.6%PRS 38.4%
-
CSI 1.6rCSI 1.9%PRS 14.7%
-
CSI 1.6rCSI 16.2%PRS 15.2%
-
CSI 1.6rCSI 10.0%PRS 11.7%
-
CSI 1.6rCSI 7.1%PRS 11.7%
-
CSI 1.7rCSI 3.6%PRS 23.9%
-
CSI 1.7rCSI 26.4%PRS 9.4%
-
CSI 1.7rCSI 39.8%PRS 27.2%
-
CSI 1.7rCSI 2.8%PRS 19.2%
-
CSI 1.7rCSI 3.8%PRS 16.6%
-
CSI 1.7rCSI 2.4%PRS 16.5%
-
CSI 1.7rCSI 13.1%PRS 13.7%
-
CSI 1.7rCSI 2.7%PRS 17.0%
-
CSI 1.8rCSI 4.2%PRS 23.0%
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CSI 1.8rCSI 3.7%PRS 22.5%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1680223874
Symbol: PICAL_HUMAN
Name: Phosphatidylinositol-binding clathrin assembly protein
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 8643484
Title: The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.
PubMed ID: 8643484
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 16554811
Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.
PubMed ID: 16554811
DOI: 10.1038/nature04632
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 9737689
Title: Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.
PubMed ID: 9737689
PubMed ID: 10436022
Title: Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.
PubMed ID: 10436022
PubMed ID: 16262731
Title: Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.
PubMed ID: 16262731
PubMed ID: 16491119
Title: The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.
PubMed ID: 16491119
PubMed ID: 18669648
Title: A quantitative atlas of mitotic phosphorylation.
PubMed ID: 18669648
PubMed ID: 19413330
Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.
PubMed ID: 19413330
DOI: 10.1021/ac9004309
PubMed ID: 20068231
Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.
PubMed ID: 20068231
PubMed ID: 21269460
Title: Initial characterization of the human central proteome.
PubMed ID: 21269460
PubMed ID: 22118466
Title: The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.
PubMed ID: 22118466
PubMed ID: 21808019
Title: SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.
PubMed ID: 21808019
PubMed ID: 21406692
Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.
PubMed ID: 21406692
PubMed ID: 22814378
Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.
PubMed ID: 22814378
PubMed ID: 23741335
Title: Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.
PubMed ID: 23741335
PubMed ID: 24067654
Title: Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.
PubMed ID: 24067654
PubMed ID: 23186163
Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.
PubMed ID: 23186163
DOI: 10.1021/pr300630k
PubMed ID: 24275569
Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.
PubMed ID: 24275569
PubMed ID: 25218447
Title: Uncovering global SUMOylation signaling networks in a site-specific manner.
PubMed ID: 25218447
DOI: 10.1038/nsmb.2890
PubMed ID: 25241929
Title: PICALM modulates autophagy activity and tau accumulation.
PubMed ID: 25241929
DOI: 10.1038/ncomms5998
PubMed ID: 25898166
Title: CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.
PubMed ID: 25898166
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 27574975
Title: A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.
PubMed ID: 27574975
Sequence Information:
- Length: 652
- Mass: 70755
- Checksum: AC3227E9D32AFEDA
- Sequence:
MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM