Details for: PICALM

Gene ID: 8301

Symbol: PICALM

Ensembl ID: ENSG00000073921

Description: phosphatidylinositol binding clathrin assembly protein

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 564.1446
    Cell Significance Index: -87.7500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 372.1761
    Cell Significance Index: -94.4000
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 218.6929
    Cell Significance Index: -90.0900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 206.7895
    Cell Significance Index: -97.6300
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 196.7966
    Cell Significance Index: -79.9500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 175.3938
    Cell Significance Index: -90.2200
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 145.4497
    Cell Significance Index: -97.6000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 84.6615
    Cell Significance Index: -80.8300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 76.7181
    Cell Significance Index: -94.5900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 33.9006
    Cell Significance Index: -90.8200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 29.3932
    Cell Significance Index: -90.2800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 28.4339
    Cell Significance Index: -62.2300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 24.5106
    Cell Significance Index: -96.7200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 4.5799
    Cell Significance Index: 65.8700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.5231
    Cell Significance Index: 90.5600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.6359
    Cell Significance Index: 202.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.5289
    Cell Significance Index: 507.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 2.2778
    Cell Significance Index: 127.8200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.0335
    Cell Significance Index: 403.5600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.0105
    Cell Significance Index: 39.2400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9295
    Cell Significance Index: 692.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8106
    Cell Significance Index: 111.2900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.6268
    Cell Significance Index: 84.7400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 1.4642
    Cell Significance Index: 36.6000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.2906
    Cell Significance Index: 34.4600
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.0678
    Cell Significance Index: 738.5200
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0410
    Cell Significance Index: 113.2300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.0359
    Cell Significance Index: 28.9500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.8756
    Cell Significance Index: 38.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.7355
    Cell Significance Index: 17.6400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.7188
    Cell Significance Index: 48.3300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.6654
    Cell Significance Index: 81.8200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6426
    Cell Significance Index: 24.3400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6425
    Cell Significance Index: 408.0700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.5894
    Cell Significance Index: 907.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5473
    Cell Significance Index: 1030.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.5433
    Cell Significance Index: 97.9500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.4986
    Cell Significance Index: 226.3000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4750
    Cell Significance Index: 13.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.3803
    Cell Significance Index: 8.2400
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.3443
    Cell Significance Index: 2.0800
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3189
    Cell Significance Index: 5.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3168
    Cell Significance Index: 584.1800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1939
    Cell Significance Index: 105.9100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1882
    Cell Significance Index: 83.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1814
    Cell Significance Index: 246.6600
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1586
    Cell Significance Index: 143.1900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0786
    Cell Significance Index: 14.9700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0457
    Cell Significance Index: 6.2700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0494
    Cell Significance Index: -36.5900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0555
    Cell Significance Index: -2.6100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0801
    Cell Significance Index: -58.7200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0855
    Cell Significance Index: -13.9100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0916
    Cell Significance Index: -57.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1014
    Cell Significance Index: -76.7900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1065
    Cell Significance Index: -18.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1157
    Cell Significance Index: -11.8200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1358
    Cell Significance Index: -76.5600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1472
    Cell Significance Index: -2.4800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1757
    Cell Significance Index: -17.3800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2857
    Cell Significance Index: -41.5300
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2932
    Cell Significance Index: -84.3700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.3149
    Cell Significance Index: -5.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3206
    Cell Significance Index: -67.5300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.3290
    Cell Significance Index: -22.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.3449
    Cell Significance Index: -44.2200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3817
    Cell Significance Index: -49.3100
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: -0.3939
    Cell Significance Index: -4.9600
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4619
    Cell Significance Index: -11.2700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4642
    Cell Significance Index: -54.7500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4710
    Cell Significance Index: -13.4400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.4997
    Cell Significance Index: -17.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.5132
    Cell Significance Index: -53.4400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5624
    Cell Significance Index: -64.2000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5682
    Cell Significance Index: -8.1600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5762
    Cell Significance Index: -67.1500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5793
    Cell Significance Index: -27.0100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.5932
    Cell Significance Index: -26.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6078
    Cell Significance Index: -69.6300
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6652
    Cell Significance Index: -9.8200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6750
    Cell Significance Index: -35.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.6806
    Cell Significance Index: -43.9100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.7336
    Cell Significance Index: -15.6800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.7472
    Cell Significance Index: -55.6900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.8611
    Cell Significance Index: -60.9000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9486
    Cell Significance Index: -20.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.0222
    Cell Significance Index: -80.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1349
    Cell Significance Index: -69.5800
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1702
    Cell Significance Index: -24.2800
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: -1.1818
    Cell Significance Index: -12.2400
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.2189
    Cell Significance Index: -25.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.2717
    Cell Significance Index: -80.1500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.3863
    Cell Significance Index: -39.7400
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.4458
    Cell Significance Index: -21.3400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.5524
    Cell Significance Index: -21.1800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.5958
    Cell Significance Index: -83.7900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.6252
    Cell Significance Index: -53.2100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.6691
    Cell Significance Index: -53.1600
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.8377
    Cell Significance Index: -22.9200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -1.8837
    Cell Significance Index: -39.9800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structure:** PICALM is a 71-kDa protein consisting of three domains: a phosphatidylinositol-binding domain, a clathrin-binding domain, and a cytoplasmic domain. 2. **Function:** PICALM regulates clathrin-mediated endocytosis, cargo recognition, and vesicle formation, influencing cellular processes such as protein localization, signaling, and membrane trafficking. 3. **Localization:** PICALM is primarily expressed in the central nervous system, with significant expression in mature microglial cells, oligodendrocytes, and neurons. 4. **Regulation:** PICALM interacts with various proteins, including clathrin, AP-1, and AP-2, to modulate its activity and influence downstream signaling pathways. **Pathways and Functions:** 1. **Clathrin-mediated endocytosis:** PICALM plays a crucial role in the formation and internalization of clathrin-coated vesicles, facilitating the uptake of proteins and lipids. 2. ** Cargo recognition:** PICALM interacts with clathrin and other proteins to recognize and bind cargo, regulating the specificity and efficiency of clathrin-mediated endocytosis. 3. **Protein localization:** PICALM influences the localization of proteins to the cell surface, plasma membrane, and endosomes, modulating their activity and signaling. 4. **Signaling:** PICALM interacts with various signaling pathways, including those involving Rho GTPases, influencing cell migration, proliferation, and survival. 5. **Membrane trafficking:** PICALM regulates membrane trafficking, including vesicle formation, movement, and fusion, influencing cellular processes such as protein secretion and endocytosis. **Clinical Significance:** 1. **Neurodegenerative diseases:** PICALM dysregulation has been implicated in Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS), highlighting its potential as a therapeutic target. 2. **Cardiovascular diseases:** PICALM has been linked to cardiovascular diseases, including atherosclerosis and hypertension, suggesting its role in regulating blood pressure and vascular function. 3. **Cancer:** PICALM has been implicated in cancer progression, including metastasis and angiogenesis, indicating its potential as a therapeutic target in cancer therapy. 4. **Other diseases:** PICALM has been linked to other diseases, including autoimmune disorders, inflammatory diseases, and metabolic disorders, highlighting its broad involvement in cellular processes. In conclusion, PICALM is a critical regulator of membrane trafficking and cellular processes, with significant implications for our understanding of disease mechanisms and therapeutic strategies. Further research is necessary to fully elucidate the functions and dysregulations of PICALM in various diseases, ultimately leading to the development of novel therapeutic interventions.

Genular Protein ID: 1680223874

Symbol: PICAL_HUMAN

Name: Phosphatidylinositol-binding clathrin assembly protein

UniProtKB Accession Codes:

Q13492 B4DTM3 E9PN05 F8VPG7 O60700 Q4LE54 Q6GMQ6 Q86XZ9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 10 Ensembl 5 ExpressionAtlas 1 GO 63 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 MoonDB 1 MoonProt 1 NCBI Taxonomy 1 NIAGADS 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 4 RefSeq 5 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8643484

Title: The t(10;11)(p13;q14) in the U937 cell line results in the fusion of the AF10 gene and CALM, encoding a new member of the AP-3 clathrin assembly protein family.

PubMed ID: 8643484

DOI: 10.1073/pnas.93.10.4804

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16554811

Title: Human chromosome 11 DNA sequence and analysis including novel gene identification.

PubMed ID: 16554811

DOI: 10.1038/nature04632

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9737689

Title: Alternative splicing in wild-type AF10 and CALM cDNAs and in AF10-CALM and CALM-AF10 fusion cDNAs produced by the t(10;11)(p13-14;q14-q21) suggests a potential role for truncated AF10 polypeptides.

PubMed ID: 9737689

DOI: 10.1038/sj.leu.2401109

PubMed ID: 10436022

Title: Clathrin assembly lymphoid myeloid leukemia (CALM) protein: localization in endocytic-coated pits, interactions with clathrin, and the impact of overexpression on clathrin-mediated traffic.

PubMed ID: 10436022

DOI: 10.1091/mbc.10.8.2687

PubMed ID: 16262731

Title: Effect of clathrin assembly lymphoid myeloid leukemia protein depletion on clathrin coat formation.

PubMed ID: 16262731

DOI: 10.1111/j.1600-0854.2005.00355.x

PubMed ID: 16491119

Title: The novel CALM interactor CATS influences the subcellular localization of the leukemogenic fusion protein CALM/AF10.

PubMed ID: 16491119

DOI: 10.1038/sj.onc.1209438

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22118466

Title: The molecular basis for the endocytosis of small R-SNAREs by the clathrin adaptor CALM.

PubMed ID: 22118466

DOI: 10.1016/j.cell.2011.10.038

PubMed ID: 21808019

Title: SNARE motif-mediated sorting of synaptobrevin by the endocytic adaptors clathrin assembly lymphoid myeloid leukemia (CALM) and AP180 at synapses.

PubMed ID: 21808019

DOI: 10.1073/pnas.1107067108

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23741335

Title: Uncoupling the functions of CALM in VAMP sorting and clathrin-coated pit formation.

PubMed ID: 23741335

DOI: 10.1371/journal.pone.0064514

PubMed ID: 24067654

Title: Adaptor complex AP2/PICALM, through interaction with LC3, targets Alzheimer's APP-CTF for terminal degradation via autophagy.

PubMed ID: 24067654

DOI: 10.1073/pnas.1315110110

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25241929

Title: PICALM modulates autophagy activity and tau accumulation.

PubMed ID: 25241929

DOI: 10.1038/ncomms5998

PubMed ID: 25898166

Title: CALM regulates clathrin-coated vesicle size and maturation by directly sensing and driving membrane curvature.

PubMed ID: 25898166

DOI: 10.1016/j.devcel.2015.03.002

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 27574975

Title: A Novel Sequence in AP180 and CALM Promotes Efficient Clathrin Binding and Assembly.

PubMed ID: 27574975

DOI: 10.1371/journal.pone.0162050

Sequence Information:

  • Length: 652
  • Mass: 70755
  • Checksum: AC3227E9D32AFEDA
  • Sequence:
    • MSGQSLTDRI TAAQHSVTGS AVSKTVCKAT THEIMGPKKK HLDYLIQCTN EMNVNIPQLA 
DSLFERTTNS SWVVVFKSLI TTHHLMVYGN ERFIQYLASR NTLFNLSNFL DKSGLQGYDM 
STFIRRYSRY LNEKAVSYRQ VAFDFTKVKR GADGVMRTMN TEKLLKTVPI IQNQMDALLD 
FNVNSNELTN GVINAAFMLL FKDAIRLFAA YNEGIINLLE KYFDMKKNQC KEGLDIYKKF 
LTRMTRISEF LKVAEQVGID RGDIPDLSQA PSSLLDALEQ HLASLEGKKI KDSTAASRAT 
TLSNAVSSLA STGLSLTKVD EREKQAALEE EQARLKALKE QRLKELAKKP HTSLTTAASP 
VSTSAGGIMT APAIDIFSTP SSSNSTSKLP NDLLDLQQPT FHPSVHPMST ASQVASTWGD 
PFSATVDAVD DAIPSLNPFL TKSSGDVHLS ISSDVSTFTT RTPTHEMFVG FTPSPVAQPH 
PSAGLNVDFE SVFGNKSTNV IVDSGGFDEL GGLLKPTVAS QNQNLPVAKL PPSKLVSDDL 
DSSLANLVGN LGIGNGTTKN DVNWSQPGEK KLTGGSNWQP KVAPTTAWNA ATMAPPVMAY 
PATTPTGMIG YGIPPQMGSV PVMTQPTLIY SQPVMRPPNP FGPVSGAQIQ FM

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.