Details for: PPP1R12A

Gene ID: 4659

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: PPP1R12A

Ensembl ID: ENSG00000058272

Description: protein phosphatase 1 regulatory subunit 12A

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 45.12
    rCSI 75.74%
    PRS 8.46
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 39.85
    rCSI 96.84%
    PRS 8.23
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 39.06
    rCSI 70.97%
    PRS 11.65
  • enteric smooth muscle cell CL0002504
    CSI 38.58
    rCSI 55.05%
    PRS 16.12
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 34.94
    rCSI 75.8%
    PRS 8.29
  • oligodendrocyte precursor cell CL0002453
    CSI 33.68
    rCSI 74.11%
    PRS 8.57
  • myoepithelial cell CL0000185
    CSI 33.29
    rCSI 84.22%
    PRS 17.79
  • smooth muscle cell CL0000192
    CSI 31.02
    rCSI 73.98%
    PRS 41.33
  • L6b glutamatergic cortical neuron CL4023038
    CSI 29.64
    rCSI 92.63%
    PRS 9.01
  • sncg GABAergic cortical interneuron CL4023015
    CSI 28.34
    rCSI 45.58%
    PRS 9.23
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 26.96
    rCSI 97.02%
    PRS 7.86
  • microcirculation associated smooth muscle cell CL0008035
    CSI 26.82
    rCSI 77.66%
    PRS 16.23
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 26.76
    rCSI 33.29%
    PRS 7.85
  • perivascular cell CL4033054
    CSI 26.46
    rCSI 36.17%
    PRS 16.23
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 24.62
    rCSI 58.89%
    PRS 8.15
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 23.77
    rCSI 78.11%
    PRS 7.75
  • renal interstitial pericyte CL1001318
    CSI 23.68
    rCSI 65.25%
    PRS 13.34
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 23.46
    rCSI 88.68%
    PRS 8.62
  • sst GABAergic cortical interneuron CL4023017
    CSI 21.09
    rCSI 27.19%
    PRS 8.87
  • neuron CL0000540
    CSI 21.03
    rCSI 55.99%
    PRS 11.4
  • Hofbauer cell CL3000001
    CSI 20.39
    rCSI 38.5%
    PRS 17.8
  • vascular associated smooth muscle cell CL0000359
    CSI 20.32
    rCSI 65.9%
    PRS 17.48
  • retinal ganglion cell CL0000740
    CSI 17.47
    rCSI 38.6%
    PRS 10.28
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 16.51
    rCSI 14.91%
    PRS 12.71
  • VIP GABAergic cortical interneuron CL4023016
    CSI 16.34
    rCSI 19.52%
    PRS 8.25
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 15.9
    rCSI 28.09%
    PRS 8.39
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 15.86
    rCSI 93.37%
    PRS 8.86
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 15.17
    rCSI 47.46%
    PRS 9.66
  • endothelial cell of placenta CL0009092
    CSI 15.03
    rCSI 74.1%
    PRS 19.39
  • transit amplifying cell of colon CL0009011
    CSI 14.63
    rCSI 17.19%
    PRS 16.81
  • stromal cell of ovary CL0002132
    CSI 12.34
    rCSI 33.92%
    PRS 23.62
  • central nervous system neuron CL2000029
    CSI 11.43
    rCSI 83.98%
    PRS 7.6
  • large pre-B-II cell CL0000957
    CSI 11.19
    rCSI 31.95%
    PRS 24.54
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 10.74
    rCSI 8.28%
    PRS 13.02
  • GABAergic amacrine cell CL4030027
    CSI 10.38
    rCSI 35.56%
    PRS 12.51
  • enteroglial cell CL4040002
    CSI 10.27
    rCSI 53.99%
    PRS 25.42
  • mural cell CL0008034
    CSI 9.38
    rCSI 31.77%
    PRS 12.67
  • astrocyte of the cerebral cortex CL0002605
    CSI 9.25
    rCSI 20.75%
    PRS 8.81
  • forebrain radial glial cell CL0013000
    CSI 9.12
    rCSI 29.27%
    PRS 20.74
  • renal principal cell CL0005009
    CSI 8.92
    rCSI 23.19%
    PRS 18.84
  • mesangial cell CL0000650
    CSI 8.51
    rCSI 34.7%
    PRS 19.07
  • basophil CL0000767
    CSI 8.42
    rCSI 17.81%
    PRS 28.92
  • H2 horizontal cell CL0004218
    CSI 8.26
    rCSI 41.05%
    PRS 15.26
  • myofibroblast cell CL0000186
    CSI 8.17
    rCSI 11.32%
    PRS 20.52
  • vascular leptomeningeal cell CL4023051
    CSI 8.08
    rCSI 14.16%
    PRS 10.59
  • cardiac muscle cell CL0000746
    CSI 7.64
    rCSI 10.97%
    PRS 11.09
  • small intestine goblet cell CL1000495
    CSI 7.58
    rCSI 16.6%
    PRS 19.07
  • regular atrial cardiac myocyte CL0002129
    CSI 7.23
    rCSI 23.27%
    PRS 15.18
  • cerebral cortex endothelial cell CL1001602
    CSI 6.88
    rCSI 11.89%
    PRS 10.89
  • glutamatergic neuron CL0000679
    CSI 6.81
    rCSI 13.99%
    PRS 14.37
  • myeloid dendritic cell CL0000782
    CSI 6.41
    rCSI 9.28%
    PRS 21.13
  • pericyte CL0000669
    CSI 6.4
    rCSI 17.04%
    PRS 36.36
  • parietal epithelial cell CL1000452
    CSI 6.01
    rCSI 16.06%
    PRS 11.97
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 5.8
    rCSI 17.88%
    PRS 21.64
  • unswitched memory B cell CL0000970
    CSI 5.73
    rCSI 4.82%
    PRS 23
  • medium spiny neuron CL1001474
    CSI 5.31
    rCSI 45.77%
    PRS 5.24
  • bronchiolar smooth muscle cell CL4033017
    CSI 5.17
    rCSI 77.52%
    PRS 43.5
  • colon macrophage CL0009038
    CSI 5.15
    rCSI 23.81%
    PRS 29.6
  • retinal blood vessel endothelial cell CL0002585
    CSI 5.11
    rCSI 8.17%
    PRS 15.67
  • neural crest cell CL0011012
    CSI 4.98
    rCSI 3.93%
    PRS 9.85
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 4.87
    rCSI 25.16%
    PRS 27.87
  • midbrain dopaminergic neuron CL2000097
    CSI 4.6
    rCSI 29.45%
    PRS 21.33
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 4.34
    rCSI 11.23%
    PRS 13.36
  • blood vessel smooth muscle cell CL0019018
    CSI 4.25
    rCSI 34.55%
    PRS 14.74
  • keratocyte CL0002363
    CSI 4.25
    rCSI 10.21%
    PRS 21.43
  • ON parasol ganglion cell CL4033052
    CSI 4.24
    rCSI 60.11%
    PRS 10.2
  • hematopoietic stem cell CL0000037
    CSI 4.03
    rCSI 2.68%
    PRS 17.12
  • late pro-B cell CL0002048
    CSI 3.96
    rCSI 9.93%
    PRS 40.62
  • OFF midget ganglion cell CL4033047
    CSI 3.82
    rCSI 77.68%
    PRS 11.96
  • ON midget ganglion cell CL4033046
    CSI 3.81
    rCSI 77.53%
    PRS 10.97
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 3.8
    rCSI 44.06%
    PRS 52.15
  • intermediate monocyte CL0002393
    CSI 3.74
    rCSI 5.64%
    PRS 14.17
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.73
    rCSI 89.93%
    PRS 7.58
  • multi-ciliated epithelial cell CL0005012
    CSI 3.7
    rCSI 3.69%
    PRS 12.22
  • promyelocyte CL0000836
    CSI 3.61
    rCSI 5.21%
    PRS 19.91
  • epithelial cell of proximal tubule CL0002306
    CSI 3.56
    rCSI 8.69%
    PRS 14.19
  • GABAergic interneuron CL0011005
    CSI 3.47
    rCSI 54.77%
    PRS 8.52
  • smooth muscle cell of the pulmonary artery CL0002591
    CSI 3.45
    rCSI 26.47%
    PRS 47.68
  • mucosal invariant T cell CL0000940
    CSI 3.4
    rCSI 2.75%
    PRS 22.91
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI 3.4
    rCSI 6.77%
    PRS 23.83
  • renal beta-intercalated cell CL0002201
    CSI 3.34
    rCSI 7.97%
    PRS 17.01
  • common myeloid progenitor CL0000049
    CSI 3.34
    rCSI 2.7%
    PRS 14.17
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 3.33
    rCSI 12.97%
    PRS 23.39
  • mature T cell CL0002419
    CSI 3.32
    rCSI 2.58%
    PRS 20.61
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 3.31
    rCSI 4.5%
    PRS 34.03
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 3.3
    rCSI 2.64%
    PRS 25.85
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 3.25
    rCSI 2.44%
    PRS 40.4
  • paneth cell of epithelium of small intestine CL1000343
    CSI 3.21
    rCSI 9%
    PRS 22.09
  • ON-bipolar cell CL0000749
    CSI 3.21
    rCSI 4.77%
    PRS 17.39
  • eosinophil CL0000771
    CSI 3.2
    rCSI 20.97%
    PRS 36.56
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 3.14
    rCSI 5.94%
    PRS 30.93
  • naive T cell CL0000898
    CSI 2.99
    rCSI 2.08%
    PRS 20.3
  • megakaryocyte progenitor cell CL0000553
    CSI 2.93
    rCSI 53.68%
    PRS 41.02
  • endothelial cell of vascular tree CL0002139
    CSI 2.88
    rCSI 15.73%
    PRS 23.84
  • stem cell CL0000034
    CSI 2.83
    rCSI 2.73%
    PRS 10.04
  • pro-B cell CL0000826
    CSI 2.82
    rCSI 2.34%
    PRS 14.34
  • interneuron CL0000099
    CSI 2.82
    rCSI 5.66%
    PRS 10.6
  • cholangiocyte CL1000488
    CSI 2.79
    rCSI 16.71%
    PRS 22.67
  • fraction A pre-pro B cell CL0002045
    CSI 2.77
    rCSI 3.17%
    PRS 29.28
  • stromal cell CL0000499
    CSI 2.76
    rCSI 7.76%
    PRS 20.25
  • kidney epithelial cell CL0002518
    CSI -5.1
    rCSI -9.7%
    PRS 32.8%
  • colon epithelial cell CL0011108
    CSI -4.1
    rCSI -4.2%
    PRS 13.3%
  • enteroendocrine cell CL0000164
    CSI -4.0
    rCSI -5.5%
    PRS 15.9%
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI -4.0
    rCSI -9.0%
    PRS 14.8%
  • enterocyte CL0000584
    CSI -2.7
    rCSI -4.4%
    PRS 22.7%
  • peripheral nervous system neuron CL2000032
    CSI -2.5
    rCSI -3.4%
    PRS 12.8%
  • luminal cell of prostate epithelium CL0002340
    CSI -2.1
    rCSI -11.3%
    PRS 25.6%
  • platelet CL0000233
    CSI -1.4
    rCSI -5.9%
    PRS 28.7%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI -1.1
    rCSI -0.8%
    PRS 19.5%
  • retinal rod cell CL0000604
    CSI -0.8
    rCSI -1.4%
    PRS 14.1%
  • exhausted T cell CL0011025
    CSI -0.8
    rCSI -12.7%
    PRS 52.0%
  • germinal center B cell CL0000844
    CSI -0.7
    rCSI -2.1%
    PRS 34.8%
  • pulmonary alveolar type 1 cell CL0002062
    CSI -0.6
    rCSI -3.5%
    PRS 18.7%
  • dopaminergic neuron CL0000700
    CSI -0.4
    rCSI -2.3%
    PRS 6.4%
  • neuroplacodal cell CL0000032
    CSI -0.4
    rCSI -3.7%
    PRS 39.2%
  • OFF-bipolar cell CL0000750
    CSI -0.2
    rCSI -0.3%
    PRS 23.1%
  • Bergmann glial cell CL0000644
    CSI -0.1
    rCSI -0.2%
    PRS 14.4%
  • S cone cell CL0003050
    CSI 0.0
    rCSI 0.1%
    PRS 11.0%
  • hair follicular keratinocyte CL2000092
    CSI 0.0
    rCSI 0.6%
    PRS 53.5%
  • respiratory suprabasal cell CL4033048
    CSI 0.0
    rCSI 0.1%
    PRS 16.5%
  • respiratory hillock cell CL4030023
    CSI 0.0
    rCSI 0.1%
    PRS 24.2%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 0.0
    rCSI 0.2%
    PRS 18.7%
  • pre-conventional dendritic cell CL0002010
    CSI 0.1
    rCSI 1.0%
    PRS 44.8%
  • type B pancreatic cell CL0000169
    CSI 0.1
    rCSI 0.2%
    PRS 13.3%
  • lung ciliated cell CL1000271
    CSI 0.1
    rCSI 0.1%
    PRS 10.5%
  • cerebellar neuron CL1001611
    CSI 0.1
    rCSI 1.1%
    PRS 6.6%
  • foveolar cell of stomach CL0002179
    CSI 0.1
    rCSI 0.3%
    PRS 23.0%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.1
    rCSI 0.8%
    PRS 11.2%
  • kidney granular cell CL0000648
    CSI 0.1
    rCSI 1.9%
    PRS 62.6%
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 0.1
    rCSI 0.6%
    PRS 48.2%
  • follicular B cell CL0000843
    CSI 0.1
    rCSI 0.5%
    PRS 50.5%
  • B-1 B cell CL0000819
    CSI 0.1
    rCSI 3.6%
    PRS 61.0%
  • eye photoreceptor cell CL0000287
    CSI 0.2
    rCSI 1.7%
    PRS 35.4%
  • enteric neuron CL0007011
    CSI 0.2
    rCSI 2.2%
    PRS 35.2%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.2
    rCSI 2.4%
    PRS 35.1%
  • fibroblast of cardiac tissue CL0002548
    CSI 0.2
    rCSI 0.8%
    PRS 9.8%
  • H1 horizontal cell CL0004217
    CSI 0.2
    rCSI 0.7%
    PRS 19.9%
  • helper T cell CL0000912
    CSI 0.2
    rCSI 0.3%
    PRS 19.8%
  • transit amplifying cell CL0009010
    CSI 0.2
    rCSI 0.3%
    PRS 23.2%
  • serotonergic neuron CL0000850
    CSI 0.2
    rCSI 0.8%
    PRS 6.3%
  • basophil mast progenitor cell CL0002028
    CSI 0.2
    rCSI 1.0%
    PRS 50.2%
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.2
    rCSI 1.1%
    PRS 34.9%
  • neuroendocrine cell CL0000165
    CSI 0.2
    rCSI 0.8%
    PRS 29.3%
  • paneth cell CL0000510
    CSI 0.2
    rCSI 0.3%
    PRS 22.5%
  • mature alpha-beta T cell CL0000791
    CSI 0.2
    rCSI 0.8%
    PRS 24.6%
  • retinal bipolar neuron CL0000748
    CSI 0.2
    rCSI 0.4%
    PRS 10.4%
  • diffuse bipolar 4 cell CL4033031
    CSI 0.2
    rCSI 2.7%
    PRS 14.7%
  • periportal region hepatocyte CL0019026
    CSI 0.2
    rCSI 0.9%
    PRS 19.9%
  • IgG plasma cell CL0000985
    CSI 0.2
    rCSI 0.3%
    PRS 24.7%
  • respiratory goblet cell CL0002370
    CSI 0.3
    rCSI 2.7%
    PRS 27.4%
  • duct epithelial cell CL0000068
    CSI 0.3
    rCSI 0.4%
    PRS 15.1%
  • memory T cell CL0000813
    CSI 0.3
    rCSI 0.5%
    PRS 31.9%
  • pancreatic stellate cell CL0002410
    CSI 0.3
    rCSI 1.6%
    PRS 21.5%
  • cytotoxic T cell CL0000910
    CSI 0.3
    rCSI 1.5%
    PRS 20.8%
  • retina horizontal cell CL0000745
    CSI 0.3
    rCSI 0.4%
    PRS 13.3%
  • respiratory basal cell CL0002633
    CSI 0.3
    rCSI 0.3%
    PRS 16.8%
  • kidney interstitial cell CL1000500
    CSI 0.3
    rCSI 4.9%
    PRS 65.3%
  • mammary gland epithelial cell CL0002327
    CSI 0.3
    rCSI 1.1%
    PRS 25.7%
  • alveolar macrophage CL0000583
    CSI 0.3
    rCSI 0.5%
    PRS 16.7%
  • basal cell of epidermis CL0002187
    CSI 0.3
    rCSI 0.6%
    PRS 13.3%
  • ventricular cardiac muscle cell CL2000046
    CSI 0.3
    rCSI 1.1%
    PRS 52.2%
  • myelocyte CL0002193
    CSI 0.3
    rCSI 2.1%
    PRS 44.5%
  • epithelial cell of nephron CL1000449
    CSI 0.3
    rCSI 3.1%
    PRS 55.6%
  • melanocyte of skin CL1000458
    CSI 0.3
    rCSI 0.5%
    PRS 8.0%
  • OFFx cell CL4033036
    CSI 0.4
    rCSI 1.6%
    PRS 14.1%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.4
    rCSI 0.6%
    PRS 21.9%
  • intestinal epithelial cell CL0002563
    CSI 0.4
    rCSI 0.4%
    PRS 15.0%
  • myeloid dendritic cell, human CL0001057
    CSI 0.4
    rCSI 2.0%
    PRS 44.3%
  • macroglial cell CL0000126
    CSI 0.4
    rCSI 0.9%
    PRS 19.7%
  • lung endothelial cell CL1001567
    CSI 0.4
    rCSI 0.9%
    PRS 33.7%
  • type L enteroendocrine cell CL0002279
    CSI 0.4
    rCSI 0.7%
    PRS 28.0%
  • centrilobular region hepatocyte CL0019029
    CSI 0.4
    rCSI 1.0%
    PRS 22.5%
  • cerebral cortex pyramidal neuron CL4023111
    CSI 0.4
    rCSI 2.3%
    PRS 37.6%
  • colonocyte CL1000347
    CSI 0.4
    rCSI 0.6%
    PRS 19.6%
  • Cajal-Retzius cell CL0000695
    CSI 0.4
    rCSI 3.0%
    PRS 30.1%
  • retinal cone cell CL0000573
    CSI 0.4
    rCSI 0.6%
    PRS 11.0%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.4
    rCSI 3.0%
    PRS 26.1%
  • transit amplifying cell of small intestine CL0009012
    CSI 0.4
    rCSI 1.8%
    PRS 26.5%
  • pancreatic acinar cell CL0002064
    CSI 0.4
    rCSI 0.5%
    PRS 15.6%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 0.4
    rCSI 1.2%
    PRS 20.9%
  • chondrocyte CL0000138
    CSI 0.4
    rCSI 0.7%
    PRS 12.2%
  • activated CD8-positive, alpha-beta T cell, human CL0001049
    CSI 0.4
    rCSI 0.7%
    PRS 28.4%
  • T-helper 17 cell CL0000899
    CSI 0.4
    rCSI 0.3%
    PRS 25.3%
  • colon goblet cell CL0009039
    CSI 0.4
    rCSI 1.0%
    PRS 21.5%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.4
    rCSI 0.5%
    PRS 16.9%
  • smooth muscle cell of prostate CL1000487
    CSI 0.5
    rCSI 2.6%
    PRS 52.6%
  • lung secretory cell CL1000272
    CSI 0.5
    rCSI 1.1%
    PRS 13.2%
  • small pre-B-II cell CL0000954
    CSI 0.5
    rCSI 0.4%
    PRS 29.5%
  • pancreatic A cell CL0000171
    CSI 0.5
    rCSI 0.5%
    PRS 15.3%
  • amacrine cell CL0000561
    CSI 0.5
    rCSI 1.3%
    PRS 11.1%
  • mesothelial cell CL0000077
    CSI 0.5
    rCSI 1.8%
    PRS 3.2%
  • progenitor cell CL0011026
    CSI 0.5
    rCSI 1.0%
    PRS 24.0%
  • erythroid progenitor cell CL0000038
    CSI 0.5
    rCSI 2.7%
    PRS 21.9%
  • CD8-positive, alpha-beta thymocyte CL0000811
    CSI 0.5
    rCSI 0.7%
    PRS 34.1%
  • lung neuroendocrine cell CL1000223
    CSI 0.5
    rCSI 0.7%
    PRS 16.5%
  • class switched memory B cell CL0000972
    CSI 0.5
    rCSI 0.4%
    PRS 24.1%
  • effector memory CD8-positive, alpha-beta T cell CL0000913
    CSI 0.5
    rCSI 0.4%
    PRS 21.6%
  • T-helper 1 cell CL0000545
    CSI 0.5
    rCSI 0.9%
    PRS 37.1%
  • type EC enteroendocrine cell CL0000577
    CSI 0.5
    rCSI 1.8%
    PRS 23.4%
  • alveolar adventitial fibroblast CL4028006
    CSI 0.5
    rCSI 0.8%
    PRS 14.3%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

Loading network (please wait)...

Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [PPP1R12A](/details-gene/4659), or Protein Phosphatase 1 Regulatory Subunit 12A, encodes a critical regulatory protein also known as the myosin phosphatase target subunit 1 (MYPT1). It functions as a key component of the myosin light chain phosphatase complex, which plays a central role in protein dephosphorylation, particularly in the regulation of cellular contractility and cytoskeletal organization. Expression data indicates that **Overall**, [PPP1R12A](/details-gene/4659) is highly significant in various neuronal populations, including [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) and multiple types of glutamatergic neurons, as well as in contractile cells such as [enteric smooth muscle cell](/details-cell/CL0002504) and [myoepithelial cell](/details-cell/CL0000185). Its involvement in fundamental processes like the '[Cell cycle](/details-go/R-HSA-1640170)' and '[Signaling by rho gtpases](/details-go/R-HSA-194315)' underscores its importance in both cellular division and signal transduction. ## Cellular Roles and Expression Landscape The expression profile of [PPP1R12A](/details-gene/4659) highlights its specialized roles in the central nervous system and in tissues requiring precise control of mechanical force and cell shape. **Overall**, the gene shows the highest significance in a diverse set of neuronal subtypes, including inhibitory [lamp5 GABAergic cortical interneuron](/details-cell/CL4023011) (CSI: 45.12) and excitatory [L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040) (CSI: 39.85). This broad neuronal expression is consistent with its annotated function in '[Neuron projection morphogenesis](/details-go/GO:0048812)', suggesting it is integral to establishing and maintaining complex neural circuits. Beyond neurons, [PPP1R12A](/details-gene/4659) is a key gene in cells defined by their contractile or cytoskeletal functions. It is highly significant in [enteric smooth muscle cell](/details-cell/CL0002504) (CSI: 38.58), [myoepithelial cell](/details-cell/CL0000185) (CSI: 33.29), and [smooth muscle cell](/details-cell/CL0000192) (CSI: 31.02), which aligns perfectly with its role as a myosin phosphatase regulator. Additionally, its high significance in progenitor populations like [differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059) (CSI: 39.06) and [oligodendrocyte precursor cell](/details-cell/CL0002453) (CSI: 33.68) suggests a role in glial cell development and division. Conversely, [PPP1R12A](/details-gene/4659) shows low to negative significance in a range of other lineages. Its minimal role in various epithelial cells, such as [kidney epithelial cell](/details-cell/CL0002518) (CSI: -5.05) and [colon epithelial cell](/details-cell/CL0011108) (CSI: -4.05), as well as in hematopoietic cells like [platelet](/details-cell/CL0000233) (CSI: -1.43) and [CD4-positive, alpha-beta memory T cell](/details-cell/CL0000897) (CSI: -1.11), indicates that its function is highly specialized and not a general housekeeping role. ## Pathways and Molecular Function Functionally, [PPP1R12A](/details-gene/4659) acts primarily as a '[Phosphatase regulator activity](/details-go/GO:0019208)', specifically exhibiting '[Myosin phosphatase regulator activity](/details-go/GO:0017020)'. It forms a complex with the catalytic subunit of protein phosphatase 1 (PP1) to dephosphorylate target proteins, most notably the myosin light chain, which leads to the relaxation of smooth muscle and the disassembly of actin stress fibers. This is corroborated by its localization to the '[Actin cytoskeleton](/details-go/GO:0015629)', '[Stress fiber](/details-go/GO:0001725)', and '[Focal adhesion](/details-go/GO:0005925)'. The activity of the [PPP1R12A](/details-gene/4659)-PP1 complex is tightly controlled by upstream signaling pathways, particularly '[Signaling by rho gtpases](/details-go/R-HSA-194315)'. Rho-associated kinase (ROCK) can phosphorylate [PPP1R12A](/details-gene/4659), inhibiting its phosphatase activity and thereby promoting contractility [Link](https://pubmed.ncbi.nlm.nih.gov/11331307/). This places the gene as a central integrator in the '[Rho gtpase effectors](/details-go/R-HSA-195258)' pathway. Furthermore, its involvement in the '[Cell cycle, mitotic](/details-go/R-HSA-69278)' pathway, particularly the '[G2/m transition](/details-go/R-HSA-69275)', is consistent with its high expression in precursor cells and its localization to the '[Centrosome](/details-go/GO:0005813)' and '[Kinetochore](/details-go/GO:0000776)', suggesting a role in regulating the cytoskeletal rearrangements necessary for cell division. ## Research Directions The specific expression patterns and well-defined molecular functions of [PPP1R12A](/details-gene/4659) provide a basis for several testable hypotheses regarding its role in physiology and disease. 1. **Hypothesis 1:** Given its high significance in multiple cortical neuron subtypes and its role in '[Neuron projection morphogenesis](/details-go/GO:0048812)', [PPP1R12A](/details-gene/4659) is essential for regulating dendritic spine maturation and synaptic plasticity in the adult brain by controlling local actin-myosin dynamics. 2. **Hypothesis 2:** Based on its high expression in [oligodendrocyte precursor cell](/details-cell/CL0002453) and its link to the '[Mitotic cell cycle](/details-go/GO:0000278)', aberrant regulation or mutation of [PPP1R12A](/details-gene/4659) could impair the proliferation and differentiation of these precursors, contributing to demyelinating disorders. **Experimental Approach:** To test the first hypothesis, one could utilize conditional knockout mouse models to delete [PPP1R12A](/details-gene/4659) specifically in cortical excitatory neurons post-development. The impact on synaptic structure and function could be assessed using two-photon in vivo imaging to monitor dendritic spine turnover and electrophysiological recordings from brain slices to measure long-term potentiation (LTP). This would directly link its molecular function in cytoskeletal regulation to higher-order brain functions like learning and memory. **Therapeutic Potential:** As a central regulator of smooth muscle contraction, [PPP1R12A](/details-gene/4659) and its associated pathways have long been considered targets for conditions like hypertension. However, its broad expression in the central nervous system presents a challenge for systemic therapies due to potential neurological side effects. A more promising strategy could involve developing therapeutics that target specific protein-protein interactions of the [PPP1R12A](/details-gene/4659) complex, for example, by designing small molecules that selectively block its phosphorylation by ROCK [Link](https://pubmed.ncbi.nlm.nih.gov/11287000/). Such an approach would represent a strategy of **inhibition** of a negative regulatory event, effectively activating the phosphatase to promote relaxation in pathological states of hypercontraction.

Genular Protein ID: 2429070281

Symbol: MYPT1_HUMAN

Name: Protein phosphatase 1 regulatory subunit 12A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9286714

Title: Localization of the gene coding for myosin phosphatase, target subunit 1 (MYPT1) to human chromosome 12q15-q21.

PubMed ID: 9286714

DOI: 10.1006/geno.1997.4859

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11342221

Title: Molecular cloning and analysis of the 5'-flanking region of human MYPT1 gene.

PubMed ID: 11342221

DOI: 10.1016/s0167-4781(00)00285-2

PubMed ID: 19245366

Title: MYPT1, the targeting subunit of smooth-muscle myosin phosphatase, is a substrate for the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH).

PubMed ID: 19245366

DOI: 10.1042/bj20081905

PubMed ID: 10567269

Title: Regulation of myosin phosphatase by a specific interaction with cGMP-dependent protein kinase Ialpha.

PubMed ID: 10567269

DOI: 10.1126/science.286.5444.1583

PubMed ID: 11287000

Title: Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity.

PubMed ID: 11287000

DOI: 10.1016/s0014-5793(01)02283-9

PubMed ID: 11067852

Title: Identification, characterization, and functional analysis of heart-specific myosin light chain phosphatase small subunit.

PubMed ID: 11067852

DOI: 10.1074/jbc.m008566200

PubMed ID: 11331307

Title: Rho-kinase--mediated contraction of isolated stress fibers.

PubMed ID: 11331307

DOI: 10.1083/jcb.153.3.569

PubMed ID: 11283607

Title: Caspase-3-mediated cleavage of ROCK I induces MLC phosphorylation and apoptotic membrane blebbing.

PubMed ID: 11283607

DOI: 10.1038/35070019

PubMed ID: 11719507

Title: Phosphorylation of the myosin-binding subunit of myosin phosphatase by Raf-1 and inhibition of phosphatase activity.

PubMed ID: 11719507

DOI: 10.1074/jbc.m106343200

PubMed ID: 12873707

Title: Dimerization of cGMP-dependent protein kinase 1alpha and the myosin-binding subunit of myosin phosphatase: role of leucine zipper domains.

PubMed ID: 12873707

DOI: 10.1016/s0898-6568(03)00057-3

PubMed ID: 12923170

Title: PDZ domain-mediated interaction of interleukin-16 precursor proteins with myosin phosphatase targeting subunits.

PubMed ID: 12923170

DOI: 10.1074/jbc.m306669200

PubMed ID: 12773565

Title: RhoE binds to ROCK I and inhibits downstream signaling.

PubMed ID: 12773565

DOI: 10.1128/mcb.23.12.4219-4229.2003

PubMed ID: 15144186

Title: Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.

PubMed ID: 15144186

DOI: 10.1021/ac035352d

PubMed ID: 15194681

Title: Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.

PubMed ID: 15194681

DOI: 10.1074/jbc.m405957200

PubMed ID: 15723050

Title: Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion.

PubMed ID: 15723050

DOI: 10.1038/ncb1230

PubMed ID: 17126281

Title: Novel ZIP kinase isoform lacks leucine zipper.

PubMed ID: 17126281

DOI: 10.1016/j.abb.2006.09.026

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16417406

Title: Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis.

PubMed ID: 16417406

DOI: 10.1371/journal.pbio.0040038

PubMed ID: 17904578

Title: Interactions between the leucine-zipper motif of cGMP-dependent protein kinase and the C-terminal region of the targeting subunit of myosin light chain phosphatase.

PubMed ID: 17904578

DOI: 10.1016/j.jmb.2007.08.049

PubMed ID: 18477460

Title: Myosin phosphatase-targeting subunit 1 regulates mitosis by antagonizing polo-like kinase 1.

PubMed ID: 18477460

DOI: 10.1016/j.devcel.2008.02.013

PubMed ID: 18782776

Title: Probing the interaction between the coiled coil leucine zipper of cGMP-dependent protein kinase Ialpha and the C terminus of the myosin binding subunit of the myosin light chain phosphatase.

PubMed ID: 18782776

DOI: 10.1074/jbc.m804916200

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19131646

Title: ROCK isoform regulation of myosin phosphatase and contractility in vascular smooth muscle cells.

PubMed ID: 19131646

DOI: 10.1161/circresaha.108.188524

PubMed ID: 19997641

Title: Distinct roles for ROCK1 and ROCK2 in the regulation of keratinocyte differentiation.

PubMed ID: 19997641

DOI: 10.1371/journal.pone.0008190

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20354225

Title: New roles for the LKB1-NUAK pathway in controlling myosin phosphatase complexes and cell adhesion.

PubMed ID: 20354225

DOI: 10.1126/scisignal.2000616

PubMed ID: 20634291

Title: Smoothelin-like 1 protein regulates myosin phosphatase-targeting subunit 1 expression during sexual development and pregnancy.

PubMed ID: 20634291

DOI: 10.1074/jbc.m110.143966

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21457715

Title: Chelerythrine perturbs lamellar actomyosin filaments by selective inhibition of myotonic dystrophy kinase-related Cdc42-binding kinase.

PubMed ID: 21457715

DOI: 10.1016/j.febslet.2011.03.054

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 31883643

Title: Loss-of-function variants in PPP1R12A: from isolated sex reversal to holoprosencephaly spectrum and urogenital malformations.

PubMed ID: 31883643

DOI: 10.1016/j.ajhg.2019.12.004

PubMed ID: 19701943

Title: Solution structure of the inhibitory phosphorylation domain of myosin phosphatase targeting subunit 1.

PubMed ID: 19701943

DOI: 10.1002/prot.22529

Sequence Information:

  • Length: 1030
  • Mass: 115281
  • Checksum: EA43E9BFF5DA08FF
  • Sequence:
  • MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RQKTKVKFDD GAVFLAACSS GDTDEVLKLL 
    HRGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN QPDNEGWIPL HAAASCGYLD 
    IAEFLIGQGA HVGAVNSEGD TPLDIAEEEA MEELLQNEVN RQGVDIEAAR KEEERIMLRD 
    ARQWLNSGHI NDVRHAKSGG TALHVAAAKG YTEVLKLLIQ AGYDVNIKDY DGWTPLHAAA 
    HWGKEEACRI LVDNLCDMEM VNKVGQTAFD VADEDILGYL EELQKKQNLL HSEKRDKKSP 
    LIESTANMDN NQSQKTFKNK ETLIIEPEKN ASRIESLEQE KVDEEEEGKK DESSCSSEED 
    EEDDSESEAE TDKTKPLASV TNANTSSTQA APVAVTTPTV SSGQATPTSP IKKFPTTATK 
    ISPKEEERKD ESPATWRLGL RKTGSYGALA EITASKEGQK EKDTAGVTRS ASSPRLSSSL 
    DNKEKEKDSK GTRLAYVAPT IPRRLASTSD IEEKENRDSS SLRTSSSYTR RKWEDDLKKN 
    SSVNEGSTYH KSCSFGRRQD DLISSSVPST TSTPTVTSAA GLQKSLLSST STTTKITTGS 
    SSAGTQSSTS NRLWAEDSTE KEKDSVPTAV TIPVAPTVVN AAASTTTLTT TTAGTVSSTT 
    EVRERRRSYL TPVRDEESES QRKARSRQAR QSRRSTQGVT LTDLQEAEKT IGRSRSTRTR 
    EQENEEKEKE EKEKQDKEKQ EEKKESETSR EDEYKQKYSR TYDETYQRYR PVSTSSSTTP 
    SSSLSTMSSS LYASSQLNRP NSLVGITSAY SRGITKENER EGEKREEEKE GEDKSQPKSI 
    RERRRPREKR RSTGVSFWTQ DSDENEQEQQ SDTEEGSNKK ETQTDSISRY ETSSTSAGDR 
    YDSLLGRSGS YSYLEERKPY SSRLEKDDST DFKKLYEQIL AENEKLKAQL HDTNMELTDL 
    KLQLEKATQR QERFADRSLL EMEKRERRAL ERRISEMEEE LKMLPDLKAD NQRLKDENGA 
    LIRVISKLSK

Genular Protein ID: 1830357167

Symbol: B2RAH5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 1030
  • Mass: 115329
  • Checksum: 5CA630A6EFF8C004
  • Sequence:
  • MKMADAKQKR NEQLKRWIGS ETDLEPPVVK RQKTKVKFDD GAVFLAACSS GDTDEVLKLL 
    HRGADINYAN VDGLTALHQA CIDDNVDMVK FLVENGANIN QPDNEGWIPL HAAASCGYLD 
    IAEFLIGQGA HVGAVNSEGD TPLDIAEEEA MEELLQNEVN RQGVDIEAAR KEEERIMLRD 
    ARQWLNSGHI NDVRHAKSGG TALHVAAAKG YTEVLKLLIQ AGYDVNIKDY DGWTPLHAAA 
    HWGKEEACRI LVDNLCDMEM VNKVGQTAFD VADEDILGYL EELQKKQNLL HSEKRDKKSP 
    LIESTANMDN NQSQKTFKNK ETLIIEPEKN ASRIESLEQE KVDEEEEGKK DESSCSSEED 
    EEDDSESEAE TDKTKPLASV TNANTSSTQA APVAVTTPTV SSGQATPTSP IKKFPTTATK 
    ISPKEEERKD ESPATWRLGL RKTGSYGALA EITASKEGQK EKDTAGVTRS ASSPRLSSSL 
    DNKEKEKDSK GTRLAYVAPT IPRRLASTSD IEEKENRDSS SLRTSSSYTR RKWEDDLKKN 
    SSVNEGSTYH KSCSFGRRQD DLISSSVPST TSTPTVTSAA GLQKSLLSST STTTKITTGS 
    SSAGTQSSTS NRLWAEDSTE KEKDSVPTAV TIPVAPTVVN AAASTTTLTT TTAGTVSSTT 
    EVRERRRSYL TPVRDEESES QRKARSRQAR QSRRSTQGVT LTDLQEAEKT IGRSRSTRTR 
    EQENEEKEKE EKEKQDKEKQ EEKKESETSR EDEYKQKYSR TYDETYQRYR PVSTSSSTTP 
    SSSLSTMSSS LYASSQLNRP NSLVGITSAY SRGITKENER EGEKREEEKE GEYKSQPKSI 
    RERRRPREKR RSTGVSFWTQ DSDENEQEQQ SDTEEGSNKK ETQTDSISRY ETSSTSAGDR 
    YDSLLGRSGS YSYLEERKPY SSRLEKDDST DFKKLYEQIL AENEKLKAQL HDTNMELTDL 
    KLQLEKATQR QERFADRSLL EMEKRERRAL ERRISEMEEE LKMLPDLKAD NQRLKDENGA 
    LIRVISKLSK