Details for: FOXP1

Gene ID: 27086

Symbol: FOXP1

Ensembl ID: ENSG00000114861

Description: forkhead box P1

Associated with

  • Developmental biology
    (R-HSA-1266738)
  • Transcriptional regulation of pluripotent stem cells
    (R-HSA-452723)
  • Cellular response to tumor necrosis factor
    (GO:0071356)
  • Chromatin
    (GO:0000785)
  • Core promoter sequence-specific dna binding
    (GO:0001046)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna-binding transcription repressor activity, rna polymerase ii-specific
    (GO:0001227)
  • Dna damage response
    (GO:0006974)
  • Endothelial cell activation
    (GO:0042118)
  • Identical protein binding
    (GO:0042802)
  • Macrophage activation
    (GO:0042116)
  • Metal ion binding
    (GO:0046872)
  • Monocyte activation
    (GO:0042117)
  • Negative regulation of androgen receptor signaling pathway
    (GO:0060766)
  • Negative regulation of b cell apoptotic process
    (GO:0002903)
  • Negative regulation of cell growth involved in cardiac muscle cell development
    (GO:0061052)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of gene expression
    (GO:0010629)
  • Negative regulation of transcription by rna polymerase ii
    (GO:0000122)
  • Nuclear androgen receptor binding
    (GO:0050681)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Osteoclast development
    (GO:0036035)
  • Osteoclast differentiation
    (GO:0030316)
  • Positive regulation of b cell receptor signaling pathway
    (GO:0050861)
  • Positive regulation of endothelial cell migration
    (GO:0010595)
  • Positive regulation of hydrogen peroxide-mediated programmed cell death
    (GO:1901300)
  • Positive regulation of interleukin-21 production
    (GO:0032745)
  • Positive regulation of smooth muscle cell proliferation
    (GO:0048661)
  • Protein binding
    (GO:0005515)
  • Regulation of chemokine (c-x-c motif) ligand 2 production
    (GO:2000341)
  • Regulation of defense response to bacterium
    (GO:1900424)
  • Regulation of endothelial tube morphogenesis
    (GO:1901509)
  • Regulation of gene expression
    (GO:0010468)
  • Regulation of inflammatory response
    (GO:0050727)
  • Regulation of interleukin-1 beta production
    (GO:0032651)
  • Regulation of interleukin-12 production
    (GO:0032655)
  • Regulation of macrophage colony-stimulating factor production
    (GO:1901256)
  • Regulation of monocyte differentiation
    (GO:0045655)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Regulation of tumor necrosis factor production
    (GO:0032680)
  • Response to lipopolysaccharide
    (GO:0032496)
  • Response to testosterone
    (GO:0033574)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Striatum development
    (GO:0021756)
  • T follicular helper cell differentiation
    (GO:0061470)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 753.6393
    Cell Significance Index: -117.2300
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 418.8361
    Cell Significance Index: -106.2400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 246.2972
    Cell Significance Index: -100.0600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 244.3221
    Cell Significance Index: -115.3500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 220.8267
    Cell Significance Index: -113.5900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 171.9913
    Cell Significance Index: -115.4100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 104.9183
    Cell Significance Index: -100.1700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 98.2071
    Cell Significance Index: -121.0900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 35.4143
    Cell Significance Index: -94.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 34.0686
    Cell Significance Index: -104.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 32.0344
    Cell Significance Index: -70.1100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.3035
    Cell Significance Index: -123.5300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 15.9598
    Cell Significance Index: 141.6700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 11.7199
    Cell Significance Index: 250.5200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 9.7903
    Cell Significance Index: 273.6100
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 9.7072
    Cell Significance Index: 59.8900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 7.8083
    Cell Significance Index: 2246.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 7.1522
    Cell Significance Index: 401.3400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 5.7031
    Cell Significance Index: 252.2600
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 5.3431
    Cell Significance Index: 202.3300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 4.3690
    Cell Significance Index: 85.2700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 4.2556
    Cell Significance Index: 326.5700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 4.2547
    Cell Significance Index: 844.3600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.8209
    Cell Significance Index: 264.2400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 3.1127
    Cell Significance Index: 624.4000
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.5333
    Cell Significance Index: 36.4400
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.2055
    Cell Significance Index: 791.0700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1979
    Cell Significance Index: 141.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 1.9447
    Cell Significance Index: 90.6700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.8671
    Cell Significance Index: 229.5800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7946
    Cell Significance Index: 30.2300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6565
    Cell Significance Index: 298.6200
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 1.5647
    Cell Significance Index: 23.1000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.3705
    Cell Significance Index: 15.5700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.0641
    Cell Significance Index: 470.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.0059
    Cell Significance Index: 908.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.8951
    Cell Significance Index: 40.5700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.6733
    Cell Significance Index: 73.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.6069
    Cell Significance Index: 31.6100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.5494
    Cell Significance Index: 15.8300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5192
    Cell Significance Index: 24.4000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.5035
    Cell Significance Index: 274.9900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.4751
    Cell Significance Index: 56.0300
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3524
    Cell Significance Index: 5.0600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2788
    Cell Significance Index: 27.5800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2312
    Cell Significance Index: 39.4800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2134
    Cell Significance Index: 40.6200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1676
    Cell Significance Index: 23.0100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0435
    Cell Significance Index: 81.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0267
    Cell Significance Index: 41.1800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0217
    Cell Significance Index: 1.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0157
    Cell Significance Index: 0.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0050
    Cell Significance Index: -9.1900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0371
    Cell Significance Index: -50.4700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0620
    Cell Significance Index: -45.9300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0683
    Cell Significance Index: -1.1700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0720
    Cell Significance Index: -54.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0841
    Cell Significance Index: -52.5000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0887
    Cell Significance Index: -65.0200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1357
    Cell Significance Index: -86.1900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1552
    Cell Significance Index: -4.9700
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1636
    Cell Significance Index: -92.2800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1919
    Cell Significance Index: -87.1100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2116
    Cell Significance Index: -27.1200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2494
    Cell Significance Index: -17.6400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2786
    Cell Significance Index: -36.0000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2809
    Cell Significance Index: -9.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3003
    Cell Significance Index: -63.2500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3263
    Cell Significance Index: -33.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3485
    Cell Significance Index: -18.1100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3885
    Cell Significance Index: -10.5800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5988
    Cell Significance Index: -68.6100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.6391
    Cell Significance Index: -16.8100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6674
    Cell Significance Index: -97.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6729
    Cell Significance Index: -16.8200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6766
    Cell Significance Index: -78.8500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6789
    Cell Significance Index: -77.5000
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.7221
    Cell Significance Index: -6.6500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.7320
    Cell Significance Index: -44.9900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7845
    Cell Significance Index: -27.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.8055
    Cell Significance Index: -10.9900
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8134
    Cell Significance Index: -12.0100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8435
    Cell Significance Index: -17.9700
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8673
    Cell Significance Index: -18.9900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9831
    Cell Significance Index: -28.1800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0609
    Cell Significance Index: -17.7600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -1.1123
    Cell Significance Index: -19.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1142
    Cell Significance Index: -116.0200
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.1236
    Cell Significance Index: -6.9100
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -1.1740
    Cell Significance Index: -12.7900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.3087
    Cell Significance Index: -103.6500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.3576
    Cell Significance Index: -85.5700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.3884
    Cell Significance Index: -30.0800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.5395
    Cell Significance Index: -80.8300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.5531
    Cell Significance Index: -104.4300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.5699
    Cell Significance Index: -96.2500
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.6296
    Cell Significance Index: -39.7600
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -1.6833
    Cell Significance Index: -17.4200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -1.7637
    Cell Significance Index: -11.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -2.0692
    Cell Significance Index: -65.9000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **DNA-binding domain:** FOXP1 possesses a conserved forkhead box (FOX) domain, which enables it to bind to specific DNA sequences and regulate gene expression. 2. **Transcriptional regulation:** FOXP1 acts as a transcriptional repressor or activator, depending on the context, and regulates the expression of various genes involved in immune responses, cell growth, and differentiation. 3. **Cellular expression:** FOXP1 is widely expressed in epithelial cells, hepatoblasts, and cardiac myocytes, highlighting its involvement in tissue homeostasis and immune responses. 4. **Signaling pathways:** FOXP1 has been implicated in several signaling pathways, including those involved in inflammation, immune response, and cell growth. **Pathways and Functions:** 1. **Immune response:** FOXP1 regulates the expression of genes involved in immune responses, including those involved in the regulation of T cell receptor signaling and the production of cytokines. 2. **Inflammation:** FOXP1 has been shown to regulate the expression of genes involved in inflammation, including those involved in the production of cytokines and chemokines. 3. **Cell growth and differentiation:** FOXP1 regulates the expression of genes involved in cell growth and differentiation, including those involved in the regulation of androgen receptor signaling and cardiac muscle cell development. 4. **Transcriptional regulation:** FOXP1 acts as a transcriptional regulator, binding to specific DNA sequences and influencing the expression of genes involved in various cellular processes. **Clinical Significance:** 1. **Immunological disorders:** FOXP1 has been implicated in several immunological disorders, including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** FOXP1 has been shown to be overexpressed in various types of cancer, including breast, lung, and prostate cancer. 3. **Cardiovascular disease:** FOXP1 has been implicated in the regulation of cardiac muscle cell growth and differentiation, and has been shown to be involved in the development of cardiovascular disease. 4. **Neurological disorders:** FOXP1 has been implicated in several neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the Forkhead Box P1 gene (FOXP1) is a crucial transcription factor that plays a pivotal role in various cellular processes, including immune response, development, and tissue homeostasis. Its dysregulation has been implicated in several immunological disorders, cancer, cardiovascular disease, and neurological disorders, highlighting the importance of further research into the functional implications of FOXP1 in these diseases.

Genular Protein ID: 2256491707

Symbol: FOXP1_HUMAN

Name: Forkhead box protein P1

UniProtKB Accession Codes:

Q9H334 A3QVP8 B3KV70 G5E9V8 Q8NAN6 Q9BSG9 Q9H332 Q9H333 Q9P0R1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CDD 1 CTD 1 ChiTaRS 1 ComplexPortal 3 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 23 Ensembl 12 EvolutionaryTrace 1 ExpressionAtlas 1 GO 43 Gene3D 2 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 3 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 16 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 11751404

Title: The FOXP1 winged helix transcription factor is a novel candidate tumor suppressor gene on chromosome 3p.

PubMed ID: 11751404

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 17344859

Title: Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia.

PubMed ID: 17344859

DOI: 10.1038/nature05690

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 15286807

Title: Integrin engagement regulates monocyte differentiation through the forkhead transcription factor Foxp1.

PubMed ID: 15286807

DOI: 10.1172/jci21100

PubMed ID: 18640093

Title: FOXP1 is an androgen-responsive transcription factor that negatively regulates androgen receptor signaling in prostate cancer cells.

PubMed ID: 18640093

DOI: 10.1016/j.bbrc.2008.07.056

PubMed ID: 18799727

Title: Down-regulation of the forkhead transcription factor Foxp1 is required for monocyte differentiation and macrophage function.

PubMed ID: 18799727

DOI: 10.1182/blood-2008-01-137018

PubMed ID: 18347093

Title: Cooperative regulation in development by SMRT and FOXP1.

PubMed ID: 18347093

DOI: 10.1101/gad.1637108

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 20950788

Title: De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment.

PubMed ID: 20950788

DOI: 10.1016/j.ajhg.2010.09.017

PubMed ID: 21924763

Title: An alternative splicing switch regulates embryonic stem cell pluripotency and reprogramming.

PubMed ID: 21924763

DOI: 10.1016/j.cell.2011.08.023

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24023716

Title: FoxP1 stimulates angiogenesis by repressing the inhibitory guidance protein semaphorin 5B in endothelial cells.

PubMed ID: 24023716

DOI: 10.1371/journal.pone.0070873

PubMed ID: 25267198

Title: FOXP1 directly represses transcription of pro-apoptotic genes and cooperates with NF-kappaB to promote survival of human B-cells.

PubMed ID: 25267198

DOI: 10.1182/blood-2014-01-553412

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25027557

Title: Transcriptional Regulation by FOXP1, FOXP2, and FOXP4 Dimerization.

PubMed ID: 25027557

DOI: 10.1007/s12031-014-0359-7

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28218735

Title: Aurora kinase A regulates Survivin stability through targeting FBXL7 in gastric cancer drug resistance and prognosis.

PubMed ID: 28218735

DOI: 10.1038/oncsis.2016.80

PubMed ID: 30250039

Title: Functional characterization of TBR1 variants in neurodevelopmental disorder.

PubMed ID: 30250039

DOI: 10.1038/s41598-018-32053-6

PubMed ID: 32891193

Title: Mutations of the transcriptional corepressor ZMYM2 cause syndromic urinary tract malformations.

PubMed ID: 32891193

DOI: 10.1016/j.ajhg.2020.08.013

PubMed ID: 21416545

Title: Solution structure and backbone dynamics of the DNA-binding domain of FOXP1: insight into its domain swapping and DNA binding.

PubMed ID: 21416545

DOI: 10.1002/pro.626

PubMed ID: 19352412

Title: Assessing the impact of FOXP1 mutations on developmental verbal dyspraxia.

PubMed ID: 19352412

DOI: 10.1038/ejhg.2009.43

PubMed ID: 20848658

Title: Identification of FOXP1 deletions in three unrelated patients with mental retardation and significant speech and language deficits.

PubMed ID: 20848658

DOI: 10.1002/humu.21362

PubMed ID: 26647308

Title: Identification and functional characterization of de novo FOXP1 variants provides novel insights into the etiology of neurodevelopmental disorder.

PubMed ID: 26647308

DOI: 10.1093/hmg/ddv495

PubMed ID: 29463886

Title: A set of regulatory genes co-expressed in embryonic human brain is implicated in disrupted speech development.

PubMed ID: 29463886

DOI: 10.1038/s41380-018-0020-x

Sequence Information:

  • Length: 677
  • Mass: 75317
  • Checksum: AEE92D47BB20964B
  • Sequence:
    • MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD LAHAQQQQQQ 
ALQVARQLLL QQQQQQQVSG LKSPKRNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV 
LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA 
FQQQLLQMQQ LQQQHLLSLQ RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT 
AEETTGNNHS SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH 
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ LELQLAKDKE 
RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP QSLPHTPTTP TAPLTPVTQG 
PSVITTTSMH TVGPIRRRYS DKYNVPISSA DIAQNQEFYK NAEVRPPFTY ASLIRQAILE 
SPEKQLTLNE IYNWFTRMFA YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE 
FQKRRPQKIS GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS 
AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS LVTTANHSPD 
FDHDRDYEDE PVNEDME

Genular Protein ID: 2991120222

Symbol: A0A3B3IT66_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A3B3IT66

Database IDs:

ARBA 6 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 4 GO 4 Gene3D 2 GeneTree 1 HGNC 1 InterPro 7 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 1 SMART 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

Sequence Information:

  • Length: 577
  • Mass: 64777
  • Checksum: 85C6806FED237075
  • Sequence:
    • MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ QEQLQLQLLQ 
QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ RQGLLTIQPG QPALPLQPLA 
QGMIPTELQQ LWKEVTSAHT AEETTGNNHS SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ 
LSVHTPKRES LSHEEHPHSH PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ 
CRVQMQVVQQ LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP 
QSLPHTPTTP TAPLTPVTQG PSVITTTSMH TVGPIRRRYS DKYNVPISSA DIAQNQEFYK 
NAEVRPPFTY ASLIRQAILE SPEKQLTLNE IYNWFTRMFA YFRRNAATWK NAVRHNLSLH 
KCFVRVENVK GAVWTVDEVE FQKRRPQKIS GNPSLIKNMQ SSHAYCTPLN AALQASMAEN 
SIPLYTTASM GNPTLGNLAS AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL 
DPEEAEGPLS LVTTANHSPD FDHDRDYEDE PVNEDME

Genular Protein ID: 355786242

Symbol: Q8TEA2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8TEA2

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 7 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1 SMART 1 SUPFAM 1

Sequence Information:

  • Length: 677
  • Mass: 75217
  • Checksum: DF8CD6A9DEAE2E1A
  • Sequence:
    • MMQESGTETK SNGSAIQNGS GGSNHLLECG GLREGRSNGE TPAVDIGAAD LAHAQQQQQQ 
ALQVARQLLL QQQQQQQVSG LKSPKGNDKQ PALQVPVSVA MMTPQVITPQ QMQQILQQQV 
LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ QEQLQLQLLQ QQHAGKQPKE QQQVATQQLA 
FQQQLLQMQQ LQQQHLLSLQ RQGLLTIQPG QPALPLQPLA QGMIPTELQQ LWKEVTSAHT 
AEETTGNNHS SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ LSVHTPKRES LSHEEHPHSH 
PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ CRVQMQVVQQ LELQLAKDKE 
RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP QSIPHTPTTP TAPLTPVTQG 
PSVITTTSMH TVGPIRRRYS DKYNVPISSA DIAQNQEFYK NAEVRPPFTY ASLIRQAILE 
SPEKQLTLNE IYNWFTRMFA YFRRNAATWK NAVRHNLSLH KCFVRVENVK GAVWTVDEVE 
FQKRRPQKIS GNPSLIKNMQ SSHAYCTPLN AALQASMAEN SIPLYTTASM GNPTLGNLAS 
AIREELNGAM EHTNSNESDS SPGRSPMQAV HPVHVKEEPL DPEEAEGPLS LVTTANHSPD 
FDHDRDYEDE PVNEDME

Genular Protein ID: 3407505963

Symbol: Q8N2P0_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8N2P0

Database IDs:

ARBA 1 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 InterPro 2 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 2 RefSeq 1 SAM 1

Sequence Information:

  • Length: 359
  • Mass: 40437
  • Checksum: 5FD207DF6F441AF1
  • Sequence:
    • MMTPQVITPQ QMQQILQQQV LSPQQLQVLL QQQQALMLQQ QQLQEFYKKQ QEQLQLQLLQ 
QQHAGKQPKE QQQVATQQLA FQQQLLQMQQ LQQQHLLSLQ RQGLLTIQPG QPALPLQPLA 
QGMIPTELQQ LWKEVTSAHT AEETTGNNHS SLDLTTTCVS SSAPSKTSLI MNPHASTNGQ 
LSVHTPKRES LSHEEHPHSH PLYGHGVCKW PGCEAVCEDF QSFLKHLNSE HALDDRSTAQ 
CRVQMQVVQQ LELQLAKDKE RLQAMMTHLH VKSTEPKAAP QPLNLVSSVT LSKSASEASP 
QSLPHTPTTP TAPPDSRHPR PLCHHNHQHA HGGTHPQAVL RQIQRAHFVS RYCAEPRIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.