Details for: SLC14A2

Gene ID: 8170

Symbol: SLC14A2

Ensembl ID: ENSG00000132874

Description: solute carrier family 14 member 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 36.5167
    Cell Significance Index: -5.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.4528
    Cell Significance Index: -5.7000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 11.0141
    Cell Significance Index: -5.2000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.6311
    Cell Significance Index: -5.7100
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 3.5327
    Cell Significance Index: 41.0700
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 3.1122
    Cell Significance Index: 39.1900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 1.9598
    Cell Significance Index: -5.2500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3811
    Cell Significance Index: 14.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3763
    Cell Significance Index: 71.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.3703
    Cell Significance Index: 16.3800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.3421
    Cell Significance Index: 8.5300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2760
    Cell Significance Index: 55.3700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.2683
    Cell Significance Index: 167.5300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 0.2443
    Cell Significance Index: 4.1200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2437
    Cell Significance Index: 14.6300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2117
    Cell Significance Index: 7.4400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1711
    Cell Significance Index: 3.3400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1564
    Cell Significance Index: 17.0200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.1418
    Cell Significance Index: 3.0200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1377
    Cell Significance Index: 9.2600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1180
    Cell Significance Index: 1.6100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.1157
    Cell Significance Index: 7.1100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1110
    Cell Significance Index: 100.2400
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1076
    Cell Significance Index: 10.6400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.1051
    Cell Significance Index: 2.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1035
    Cell Significance Index: 1.5600
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0984
    Cell Significance Index: 2.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0857
    Cell Significance Index: 2.4700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0829
    Cell Significance Index: 13.4800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0799
    Cell Significance Index: 28.6500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0757
    Cell Significance Index: 11.0100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 0.0642
    Cell Significance Index: 0.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0617
    Cell Significance Index: 4.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0499
    Cell Significance Index: 2.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0415
    Cell Significance Index: 8.2400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0385
    Cell Significance Index: 72.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0282
    Cell Significance Index: 38.2800
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0244
    Cell Significance Index: 0.3600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0244
    Cell Significance Index: 0.3500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0169
    Cell Significance Index: 26.0200
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0146
    Cell Significance Index: 0.2100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0102
    Cell Significance Index: 6.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0089
    Cell Significance Index: 16.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0085
    Cell Significance Index: 0.4400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0074
    Cell Significance Index: 1.3300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0069
    Cell Significance Index: 0.1500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0002
    Cell Significance Index: -0.0900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0002
    Cell Significance Index: -0.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0019
    Cell Significance Index: -1.4100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0032
    Cell Significance Index: -0.9100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0032
    Cell Significance Index: -1.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0033
    Cell Significance Index: -1.4800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0066
    Cell Significance Index: -4.8300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0072
    Cell Significance Index: -5.4300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0075
    Cell Significance Index: -4.1200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0090
    Cell Significance Index: -1.5400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0092
    Cell Significance Index: -1.9300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0133
    Cell Significance Index: -1.6400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0137
    Cell Significance Index: -0.3000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0159
    Cell Significance Index: -1.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0161
    Cell Significance Index: -1.6400
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.0169
    Cell Significance Index: -0.2100
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0194
    Cell Significance Index: -0.4000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0196
    Cell Significance Index: -1.1000
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0205
    Cell Significance Index: -2.3900
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.0207
    Cell Significance Index: -0.4400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0244
    Cell Significance Index: -2.8000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0250
    Cell Significance Index: -1.5300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0252
    Cell Significance Index: -0.4000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0283
    Cell Significance Index: -1.3200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0284
    Cell Significance Index: -0.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0287
    Cell Significance Index: -0.9200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0341
    Cell Significance Index: -4.6900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0364
    Cell Significance Index: -4.7000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0366
    Cell Significance Index: -2.8100
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0389
    Cell Significance Index: -1.0600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0392
    Cell Significance Index: -2.7700
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0411
    Cell Significance Index: -1.1000
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0429
    Cell Significance Index: -4.4700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0455
    Cell Significance Index: -5.3600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0461
    Cell Significance Index: -1.5100
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0486
    Cell Significance Index: -0.9600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0486
    Cell Significance Index: -3.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0524
    Cell Significance Index: -1.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0530
    Cell Significance Index: -3.9500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0604
    Cell Significance Index: -0.8600
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0643
    Cell Significance Index: -1.2900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0644
    Cell Significance Index: -1.8000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0682
    Cell Significance Index: -4.4000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0739
    Cell Significance Index: -1.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0749
    Cell Significance Index: -3.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.0802
    Cell Significance Index: -2.0000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0826
    Cell Significance Index: -3.8800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0851
    Cell Significance Index: -2.9800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0886
    Cell Significance Index: -0.6000
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.0990
    Cell Significance Index: -2.1400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.1013
    Cell Significance Index: -0.9600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1022
    Cell Significance Index: -1.4900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Transmembrane Transport:** SLC14A2 is a transmembrane protein, consisting of 12 transmembrane segments, which facilitate the transport of solutes across the plasma membrane. 2. **Solute Specificity:** The protein exhibits high specificity for urea, metal ions, and small molecules, while also transporting bile salts and organic acids. 3. **Cellular Expression:** SLC14A2 is expressed in various cell types, including innate lymphoid cells, taste receptor cells, kidney epithelial cells, and cardiac muscle myoblasts. 4. **Evolutionary Conservation:** The protein exhibits high sequence similarity across species, suggesting its conserved role in maintaining cellular homeostasis. **Pathways and Functions:** SLC14A2 is involved in several cellular pathways, including: 1. **Urea Transport:** The protein plays a critical role in urea transport, regulating the concentration of urea in the blood and maintaining proper pH balance. 2. **Metal Ion Transport:** SLC14A2 facilitates the transport of metal ions, such as calcium and magnesium, which are essential for various cellular processes. 3. **Amine Compound Transport:** The protein transports small molecules, including amine compounds, which are involved in cellular signaling and homeostasis. 4. **Bile Salt Transport:** SLC14A2 contributes to the transport of bile salts, which are essential for fat digestion and absorption. 5. **Cell Signaling:** The protein may also modulate cell signaling pathways, influencing cellular growth, differentiation, and survival. **Clinical Significance:** Dysregulation of SLC14A2 has been implicated in various diseases, including: 1. **Nephropathy:** Abnormal expression of SLC14A2 has been linked to kidney disease, including chronic kidney disease and acute kidney injury. 2. **Lymphoma:** Mutations in SLC14A2 have been identified in certain types of lymphoma, highlighting its potential role in cancer development. 3. **Cardiac Disease:** Alterations in SLC14A2 expression have been observed in cardiac muscle myoblasts, suggesting its involvement in cardiovascular disease. 4. **Neurological Disorders:** The protein's role in transporting small molecules may also be relevant to neurological disorders, such as Parkinson's disease and Alzheimer's disease. In conclusion, SLC14A2 is a multifunctional protein that plays a critical role in maintaining cellular homeostasis and regulating various physiological processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into its functions and clinical significance.

Genular Protein ID: 1001205523

Symbol: UT2_HUMAN

Name: Urea transporter 2

UniProtKB Accession Codes:

Q15849 A8K8Q7 Q2TBD6 Q96PH5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 2 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 5 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 3 Rhea 2 SMR 1 STRING 1 SignaLink 1 TCDB 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8647271

Title: Molecular characterization of a new urea transporter in the human kidney.

PubMed ID: 8647271

DOI: 10.1016/0014-5793(96)00425-5

PubMed ID: 11502588

Title: Cloning and characterization of the human urea transporter UT-A1 and mapping of the human Slc14a2 gene.

PubMed ID: 11502588

DOI: 10.1152/ajprenal.2001.281.3.f400

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8997401

Title: Functional differentiation of the human red blood cell and kidney urea transporters.

PubMed ID: 8997401

DOI: 10.1152/ajprenal.1996.271.6.f1264

PubMed ID: 17702749

Title: The UT-A1 urea transporter interacts with snapin, a SNARE-associated protein.

PubMed ID: 17702749

DOI: 10.1074/jbc.m705866200

Sequence Information:

  • Length: 920
  • Mass: 101209
  • Checksum: 23BF379DC0767619
  • Sequence:
    • MSDPHSSPLL PEPLSSRYKL YEAEFTSPSW PSTSPDTHPA LPLLEMPEEK DLRSSNEDSH 
IVKIEKLNER SKRKDDGVAH RDSAGQRCIC LSKAVGYLTG DMKEYRIWLK DKHLALQFID 
WVLRGTAQVM FINNPLSGLI IFIGLLIQNP WWTITGGLGT VVSTLTALAL GQDRSAIASG 
LHGYNGMLVG LLMAVFSEKL DYYWWLLFPV TFTAMSCPVL SSALNSIFSK WDLPVFTLPF 
NIAVTLYLAA TGHYNLFFPT TLVEPVSSVP NITWTEMEMP LLLQAIPVGV GQVYGCDNPW 
TGGVFLVALF ISSPLICLHA AIGSIVGLLA ALSVATPFET IYTGLWSYNC VLSCIAIGGM 
FYALTWQTHL LALICALFCA YMEAAISNIM SVVGVPPGTW AFCLATIIFL LLTTNNPAIF 
RLPLSKVTYP EANRIYYLTV KSGEEEKAPS GGGGEHPPTA GPKVEEGSEA VLSKHRSVFH 
IEWSSIRRRS KVFGKGEHQE RQNKDPFPYR YRKPTVELLD LDTMEESSEI KVETNISKTS 
WIRSSMAASG KRVSKALSYI TGEMKECGEG LKDKSPVFQF FDWVLRGTSQ VMFVNNPLSG 
ILIILGLFIQ NPWWAISGCL GTIMSTLTAL ILSQDKSAIA AGFHGYNGVL VGLLMAVFSD 
KGDYYWWLLL PVIIMSMSCP ILSSALGTIF SKWDLPVFTL PFNITVTLYL AATGHYNLFF 
PTTLLQPASA MPNITWSEVQ VPLLLRAIPV GIGQVYGCDN PWTGGIFLIA LFISSPLICL 
HAAIGSTMGM LAALTIATPF DSIYFGLCGF NSTLACIAIG GMFYVITWQT HLLAIACALF 
AAYLGAALAN MLSVFGLPPC TWPFCLSALT FLLLTTNNPA IYKLPLSKVT YPEANRIYYL 
SQERNRRASI ITKYQAYDVS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.