Details for: PKN2

Gene ID: 5586

Symbol: PKN2

Ensembl ID: ENSG00000065243

Description: protein kinase N2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.98
    Marker Score: 1479
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.79
    Marker Score: 3470
  • Cell Name: germ cell (CL0000586)
    Fold Change: 2.78
    Marker Score: 4851
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.7
    Marker Score: 3269
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.7
    Marker Score: 3630
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.64
    Marker Score: 11034.5
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.6
    Marker Score: 46067
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.55
    Marker Score: 5596
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.42
    Marker Score: 2095
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.36
    Marker Score: 50461
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.36
    Marker Score: 851.5
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.35
    Marker Score: 1368
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.33
    Marker Score: 1795
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.32
    Marker Score: 1298
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.32
    Marker Score: 1289
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.28
    Marker Score: 34136
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.25
    Marker Score: 19765
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.21
    Marker Score: 44032
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.19
    Marker Score: 1520
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.18
    Marker Score: 636
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.18
    Marker Score: 1146
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.16
    Marker Score: 72811
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.15
    Marker Score: 8968.5
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.13
    Marker Score: 894
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.13
    Marker Score: 2455
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.12
    Marker Score: 47312
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.11
    Marker Score: 77996
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.1
    Marker Score: 2006
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.1
    Marker Score: 8721
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.1
    Marker Score: 16103
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.1
    Marker Score: 79772
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.1
    Marker Score: 4037
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.1
    Marker Score: 665
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.09
    Marker Score: 1223
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.08
    Marker Score: 2246
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.07
    Marker Score: 2292
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.04
    Marker Score: 1536.5
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.02
    Marker Score: 638
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.01
    Marker Score: 1787
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 2.01
    Marker Score: 1125
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2
    Marker Score: 576
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.99
    Marker Score: 967
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.98
    Marker Score: 7670
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.98
    Marker Score: 9148
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.97
    Marker Score: 2379
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.94
    Marker Score: 2201
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.92
    Marker Score: 117954
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 1.9
    Marker Score: 1137
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.89
    Marker Score: 17797
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.88
    Marker Score: 2771
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.83
    Marker Score: 1585
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 1.81
    Marker Score: 4327
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.79
    Marker Score: 18513
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.78
    Marker Score: 16873
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.76
    Marker Score: 7181
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.75
    Marker Score: 2253
  • Cell Name: glial cell (CL0000125)
    Fold Change: 1.74
    Marker Score: 1915
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.73
    Marker Score: 1821
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.72
    Marker Score: 27640
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.72
    Marker Score: 14737
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 1.7
    Marker Score: 4562
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 1.69
    Marker Score: 1716
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.69
    Marker Score: 613
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.67
    Marker Score: 6201
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.67
    Marker Score: 2067
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.67
    Marker Score: 624
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.66
    Marker Score: 3025
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.65
    Marker Score: 817
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 1.64
    Marker Score: 1116
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.64
    Marker Score: 2316
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.62
    Marker Score: 444
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 1.62
    Marker Score: 12091
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 1.61
    Marker Score: 8452
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 1.61
    Marker Score: 5058
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.6
    Marker Score: 929
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 1.6
    Marker Score: 1885
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 1.58
    Marker Score: 1520
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.57
    Marker Score: 579
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.54
    Marker Score: 382
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 1.54
    Marker Score: 5467
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.53
    Marker Score: 621
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.53
    Marker Score: 485
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.53
    Marker Score: 52916.5
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.52
    Marker Score: 8141
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.51
    Marker Score: 385
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.51
    Marker Score: 2330
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.51
    Marker Score: 787
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.5
    Marker Score: 1377
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.49
    Marker Score: 719
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.49
    Marker Score: 1580
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.48
    Marker Score: 4856
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.48
    Marker Score: 502
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 1.46
    Marker Score: 1202
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 1.45
    Marker Score: 531
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.45
    Marker Score: 1537
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 1.43
    Marker Score: 1770
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 1.43
    Marker Score: 3612
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.43
    Marker Score: 893
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.43
    Marker Score: 429
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 1.43
    Marker Score: 4790

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Other Information

**Key Characteristics** PKN2 is a serine/threonine kinase enzyme that belongs to the PKN family of kinases. It is a small protein with a molecular weight of approximately 40 kDa. PKN2 is highly conserved across species, with high sequence similarity to other PKN family members. The enzyme is activated by diacylglycerol (DAG) and phospholipase C (PLC), which leads to its phosphorylation and activation. PKN2 has a dual specificity for serine and threonine residues, allowing it to phosphorylate a wide range of substrates. **Pathways and Functions** PKN2 is involved in various signaling pathways that regulate cell motility, cytoskeleton organization, and gene expression. Some of the key pathways and functions of PKN2 include: 1. **Rho GTPase signaling**: PKN2 is a downstream effector of Rho GTPases, which regulate cell motility, cytoskeleton organization, and cell migration. 2. **Apoptotic process**: PKN2 is involved in the regulation of apoptosis, particularly in the context of cancer cell death. 3. **Cell adhesion**: PKN2 regulates cell adhesion by phosphorylating proteins involved in the adhesion complex, such as cadherins and catenins. 4. **Mitotic cell cycle**: PKN2 is involved in the regulation of the mitotic cell cycle, particularly in the context of cell proliferation and differentiation. 5. **Viral genome replication**: PKN2 has been shown to regulate the replication of certain viruses, such as HIV-1. **Clinical Significance** Dysregulation of PKN2 has been implicated in various diseases, including: 1. **Cancer**: Overexpression of PKN2 has been observed in various types of cancer, including breast, lung, and colon cancer. 2. **Cardiovascular disorders**: PKN2 has been implicated in the regulation of cardiovascular function, and its dysregulation has been linked to cardiovascular disease. 3. **Neurodegenerative diseases**: PKN2 has been implicated in the regulation of neuronal function, and its dysregulation has been linked to neurodegenerative diseases, such as Alzheimer's and Parkinson's disease. 4. **Infectious diseases**: PKN2 has been shown to regulate the replication of certain viruses, such as HIV-1. In conclusion, PKN2 is a serine/threonine kinase enzyme that plays a crucial role in various cellular processes, including cell adhesion, migration, proliferation, and differentiation. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disorders, and neurodegenerative diseases. Further research is needed to fully understand the role of PKN2 in human disease and to develop therapeutic strategies to target its dysregulation.

Genular Protein ID: 4261385730

Symbol: PKN2_HUMAN

Name: Serine/threonine-protein kinase N2

UniProtKB Accession Codes:

Q16513 B4DQ21 B4DTP5 B4DVG1 D3DT24 Q08AF4 Q9H1W4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 4 CPTAC 1 CTD 1 ChEBI 12 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 DrugCentral 1 EC 3 ELM 1 EMBL 10 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 39 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 12 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 4 PIR 1 PRO 1 PROSITE 6 PROSITE-ProRule 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 Reactome 5 RefSeq 5 Rhea 6 SABIO-RK 1 SAM 1 SIGNOR 1 SMART 4 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7988719

Title: Identification of multiple, novel, protein kinase C-related gene products.

PubMed ID: 7988719

DOI: 10.1016/0014-5793(94)01202-4

PubMed ID: 7851406

Title: Cloning and expression patterns of two members of a novel protein-kinase-C-related kinase family.

PubMed ID: 7851406

DOI: 10.1111/j.1432-1033.1995.tb20395.x

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15123640

Title: Hyaluronan-CD44 interaction with Rac1-dependent protein kinase N-gamma promotes phospholipase Cgamma1 activation, Ca(2+) signaling, and cortactin-cytoskeleton function leading to keratinocyte adhesion and differentiation.

PubMed ID: 15123640

DOI: 10.1074/jbc.m403608200

PubMed ID: 9368003

Title: Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. Identification by a novel, small pool expression cloning strategy.

PubMed ID: 9368003

DOI: 10.1074/jbc.272.47.29449

PubMed ID: 9121475

Title: The PRK2 kinase is a potential effector target of both Rho and Rac GTPases and regulates actin cytoskeletal organization.

PubMed ID: 9121475

DOI: 10.1128/mcb.17.4.2247

PubMed ID: 10226025

Title: PDK1 acquires PDK2 activity in the presence of a synthetic peptide derived from the carboxyl terminus of PRK2.

PubMed ID: 10226025

DOI: 10.1016/s0960-9822(99)80186-9

PubMed ID: 10026169

Title: Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.

PubMed ID: 10026169

DOI: 10.1074/jbc.274.9.5542

PubMed ID: 10818102

Title: MEK kinase 2 binds and activates protein kinase C-related kinase 2. Bifurcation of kinase regulatory pathways at the level of an MAPK kinase kinase.

PubMed ID: 10818102

DOI: 10.1074/jbc.m003148200

PubMed ID: 10926925

Title: Inhibition of Akt and its anti-apoptotic activities by tumor necrosis factor-induced protein kinase C-related kinase 2 (PRK2) cleavage.

PubMed ID: 10926925

DOI: 10.1074/jbc.m001753200

PubMed ID: 10792047

Title: Phosphorylation of protein kinase N by phosphoinositide-dependent protein kinase-1 mediates insulin signals to the actin cytoskeleton.

PubMed ID: 10792047

DOI: 10.1073/pnas.090491897

PubMed ID: 11356191

Title: The protein kinase C-related kinase PRK2 interacts with the protein tyrosine phosphatase PTP-BL via a novel PDZ domain binding motif.

PubMed ID: 11356191

DOI: 10.1016/s0014-5793(01)02401-2

PubMed ID: 11781095

Title: Regulation of both PDK1 and the phosphorylation of PKC-zeta and -delta by a C-terminal PRK2 fragment.

PubMed ID: 11781095

DOI: 10.1021/bi010719z

PubMed ID: 11777936

Title: Fyn tyrosine kinase is a downstream mediator of Rho/PRK2 function in keratinocyte cell-cell adhesion.

PubMed ID: 11777936

DOI: 10.1083/jcb.200105140

PubMed ID: 15364941

Title: Protein kinase C-related kinase 2 regulates hepatitis C virus RNA polymerase function by phosphorylation.

PubMed ID: 15364941

DOI: 10.1074/jbc.m408617200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17332740

Title: Rho GTPases regulate PRK2/PKN2 to control entry into mitosis and exit from cytokinesis.

PubMed ID: 17332740

DOI: 10.1038/sj.emboj.7601637

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18835241

Title: The C-terminus of PRK2/PKNgamma is required for optimal activation by RhoA in a GTP-dependent manner.

PubMed ID: 18835241

DOI: 10.1016/j.abb.2008.09.008

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20188095

Title: Protein kinase C-related kinase targets nuclear localization signals in a subset of class IIa histone deacetylases.

PubMed ID: 20188095

DOI: 10.1016/j.febslet.2010.02.057

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20974804

Title: The Rho target PRK2 regulates apical junction formation in human bronchial epithelial cells.

PubMed ID: 20974804

DOI: 10.1128/mcb.01001-10

PubMed ID: 21754995

Title: Regulatory domain selectivity in the cell-type specific PKN-dependence of cell migration.

PubMed ID: 21754995

DOI: 10.1371/journal.pone.0021732

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 27104747

Title: STAR syndrome-associated CDK10/Cyclin M regulates actin network architecture and ciliogenesis.

PubMed ID: 27104747

DOI: 10.1080/15384101.2016.1147632

Sequence Information:

  • Length: 984
  • Mass: 112035
  • Checksum: 687EC417A0F51C1D
  • Sequence:
    • MASNPERGEI LLTELQGDSR SLPFSENVSA VQKLDFSDTM VQQKLDDIKD RIKREIRKEL 
KIKEGAENLR KVTTDKKSLA YVDNILKKSN KKLEELHHKL QELNAHIVVS DPEDITDCPR 
TPDTPNNDPR CSTSNNRLKA LQKQLDIELK VKQGAENMIQ MYSNGSSKDR KLHGTAQQLL 
QDSKTKIEVI RMQILQAVQT NELAFDNAKP VISPLELRME ELRHHFRIEF AVAEGAKNVM 
KLLGSGKVTD RKALSEAQAR FNESSQKLDL LKYSLEQRLN EVPKNHPKSR IIIEELSLVA 
ASPTLSPRQS MISTQNQYST LSKPAALTGT LEVRLMGCQD ILENVPGRSK ATSVALPGWS 
PSETRSSFMS RTSKSKSGSS RNLLKTDDLS NDVCAVLKLD NTVVGQTSWK PISNQSWDQK 
FTLELDRSRE LEISVYWRDW RSLCAVKFLR LEDFLDNQRH GMCLYLEPQG TLFAEVTFFN 
PVIERRPKLQ RQKKIFSKQQ GKTFLRAPQM NINIATWGRL VRRAIPTVNH SGTFSPQAPV 
PTTVPVVDVR IPQLAPPASD STVTKLDFDL EPEPPPAPPR ASSLGEIDES SELRVLDIPG 
QDSETVFDIQ NDRNSILPKS QSEYKPDTPQ SGLEYSGIQE LEDRRSQQRF QFNLQDFRCC 
AVLGRGHFGK VLLAEYKNTN EMFAIKALKK GDIVARDEVD SLMCEKRIFE TVNSVRHPFL 
VNLFACFQTK EHVCFVMEYA AGGDLMMHIH TDVFSEPRAV FYAACVVLGL QYLHEHKIVY 
RDLKLDNLLL DTEGFVKIAD FGLCKEGMGY GDRTSTFCGT PEFLAPEVLT ETSYTRAVDW 
WGLGVLIYEM LVGESPFPGD DEEEVFDSIV NDEVRYPRFL STEAISIMRR LLRRNPERRL 
GASEKDAEDV KKHPFFRLID WSALMDKKVK PPFIPTIRGR EDVSNFDDEF TSEAPILTPP 
REPRILSEEE QEMFRDFDYI ADWC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.