Details for: SND1

Gene ID: 27044

Symbol: SND1

Ensembl ID: ENSG00000197157

Description: staphylococcal nuclease and tudor domain containing 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 408.4986
    Cell Significance Index: -63.5400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 237.5382
    Cell Significance Index: -60.2500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 151.2743
    Cell Significance Index: -71.4200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 149.1174
    Cell Significance Index: -60.5800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 133.3048
    Cell Significance Index: -68.5700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 106.5241
    Cell Significance Index: -71.4800
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 64.0906
    Cell Significance Index: -61.1900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 53.9679
    Cell Significance Index: -66.5400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.4843
    Cell Significance Index: -65.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.5277
    Cell Significance Index: -63.0500
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 18.9483
    Cell Significance Index: -41.4700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 17.2134
    Cell Significance Index: -67.9300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 11.6967
    Cell Significance Index: 312.3200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.3502
    Cell Significance Index: 231.6900
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.2422
    Cell Significance Index: 643.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4952
    Cell Significance Index: 500.5400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.8539
    Cell Significance Index: 3490.7500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.8108
    Cell Significance Index: 1635.0500
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.7198
    Cell Significance Index: 28.9700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.6557
    Cell Significance Index: 593.8800
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 1.6245
    Cell Significance Index: 264.2100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5666
    Cell Significance Index: 43.7800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.4437
    Cell Significance Index: 246.5200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.4294
    Cell Significance Index: 80.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.3588
    Cell Significance Index: 104.2700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.1400
    Cell Significance Index: 788.4500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0250
    Cell Significance Index: 140.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 1.0099
    Cell Significance Index: 27.0600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9317
    Cell Significance Index: 41.2100
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.9228
    Cell Significance Index: 19.7300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8695
    Cell Significance Index: 474.8500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.8688
    Cell Significance Index: 32.9000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.8294
    Cell Significance Index: 55.7700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.8243
    Cell Significance Index: 22.0500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.6914
    Cell Significance Index: 124.6500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.6820
    Cell Significance Index: 32.0600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.6449
    Cell Significance Index: 30.0700
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.5289
    Cell Significance Index: 62.3700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.5036
    Cell Significance Index: 61.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.4905
    Cell Significance Index: 63.3800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.4871
    Cell Significance Index: 309.3900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4585
    Cell Significance Index: 13.2100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.3826
    Cell Significance Index: 23.5200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 0.3688
    Cell Significance Index: 9.4800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.3482
    Cell Significance Index: 158.0500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3452
    Cell Significance Index: 65.7000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.2845
    Cell Significance Index: 4.8800
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.2550
    Cell Significance Index: 3.0400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2495
    Cell Significance Index: 339.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2379
    Cell Significance Index: 366.2400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1825
    Cell Significance Index: 336.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1584
    Cell Significance Index: 70.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1306
    Cell Significance Index: 5.9200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1042
    Cell Significance Index: 6.7200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0849
    Cell Significance Index: 1.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0093
    Cell Significance Index: -7.0300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0291
    Cell Significance Index: -4.2400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0399
    Cell Significance Index: -29.5600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0463
    Cell Significance Index: -28.9100
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0559
    Cell Significance Index: -40.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0777
    Cell Significance Index: -43.8400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0963
    Cell Significance Index: -7.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1053
    Cell Significance Index: -10.7600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1131
    Cell Significance Index: -14.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1457
    Cell Significance Index: -0.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1813
    Cell Significance Index: -38.1900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1841
    Cell Significance Index: -9.5900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1852
    Cell Significance Index: -18.3200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1918
    Cell Significance Index: -3.2100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1942
    Cell Significance Index: -3.7900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2099
    Cell Significance Index: -5.9900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2101
    Cell Significance Index: -60.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.2630
    Cell Significance Index: -9.2400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.3460
    Cell Significance Index: -39.4900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3484
    Cell Significance Index: -36.2800
  • Cell Name: serous secreting cell of bronchus submucosal gland (CL4033005)
    Fold Change: -0.3677
    Cell Significance Index: -3.6800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3906
    Cell Significance Index: -20.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4116
    Cell Significance Index: -47.9700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.4241
    Cell Significance Index: -6.1000
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4252
    Cell Significance Index: -48.7100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.4329
    Cell Significance Index: -6.3900
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4438
    Cell Significance Index: -6.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4757
    Cell Significance Index: -10.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.5203
    Cell Significance Index: -13.6800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.5964
    Cell Significance Index: -8.5700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.6098
    Cell Significance Index: -17.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.6201
    Cell Significance Index: -15.5000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.6293
    Cell Significance Index: -44.5100
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.6368
    Cell Significance Index: -13.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.6701
    Cell Significance Index: -16.0700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.6845
    Cell Significance Index: -43.1400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.6941
    Cell Significance Index: -9.9400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.7335
    Cell Significance Index: -15.3500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7676
    Cell Significance Index: -60.8000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7884
    Cell Significance Index: -41.4000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.8095
    Cell Significance Index: -28.1300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.8394
    Cell Significance Index: -7.7300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.8539
    Cell Significance Index: -12.9900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.8659
    Cell Significance Index: -53.0900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.9040
    Cell Significance Index: -23.1000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SND1 is a protein-coding gene that contains a nuclease domain, a Tudor domain, and a coiled-coil region. The nuclease domain is responsible for its endonuclease activity, which cleaves RNA molecules. The Tudor domain is involved in protein-protein interactions and RNA binding. The coiled-coil region mediates protein-protein interactions and dimerization. SND1 is highly expressed in various cell types, including syncytiotrophoblast cells, cortical cells of the adrenal gland, and epithelial cells of the lower respiratory tract. **Pathways and Functions:** SND1 is involved in multiple signaling pathways, including: 1. **Cadherin binding**: SND1 interacts with cadherins, which are cell adhesion molecules that play a crucial role in maintaining tissue structure and cell-cell interactions. 2. **Cytosol and Dense body**: SND1 is localized to the cytosol and dense bodies, which are organelles involved in protein synthesis and degradation. 3. **Disease and Diseases of signal transduction by growth factor receptors and second messengers**: SND1 is involved in the regulation of cell signaling pathways, including those involved in disease states such as cancer and cardiovascular disease. 4. **Endonuclease activity**: SND1's nuclease domain cleaves RNA molecules, which is essential for RNA metabolism and gene expression regulation. 5. **Extracellular exosome**: SND1 is transported to the extracellular exosome, where it regulates cell signaling and communication. 6. **Melanosome**: SND1 is involved in the regulation of melanosome formation and function. 7. **Oncogenic mapk signaling**: SND1 is involved in the regulation of MAPK signaling pathways, which are critical in cancer development and progression. **Clinical Significance:** SND1 has been implicated in various diseases, including: 1. **Cancer**: SND1 is overexpressed in various types of cancer, including breast, lung, and colon cancer. Its overexpression is associated with poor prognosis and metastasis. 2. **Cardiovascular disease**: SND1 is involved in the regulation of cardiovascular signaling pathways, which are critical in the development of cardiovascular disease. 3. **Neurological disorders**: SND1 is involved in the regulation of neuronal signaling pathways, which are critical in the development of neurological disorders such as Parkinson's disease and Alzheimer's disease. In conclusion, SND1 is a multifunctional gene that plays a critical role in various cellular processes, including cell signaling, transcriptional regulation, and RNA metabolism. Its dysregulation has been implicated in various diseases, including cancer, cardiovascular disease, and neurological disorders. Further research is needed to fully understand the mechanisms by which SND1 regulates cellular processes and to explore its therapeutic potential. **Recommendations:** 1. Further research is needed to elucidate the mechanisms by which SND1 regulates cellular processes. 2. SND1 should be considered as a potential therapeutic target for various diseases, including cancer and cardiovascular disease. 3. SND1's role in RNA metabolism and gene expression regulation should be further investigated to understand its involvement in disease states. **Limitations:** This review highlights the complexity of SND1's role in cellular processes and disease states. However, limitations of this review include: 1. The lack of comprehensive data on SND1's expression and function in different cell types. 2. The limited understanding of SND1's role in disease states, including cancer and cardiovascular disease. 3. The need for further research to fully understand the mechanisms by which SND1 regulates cellular processes. **Future Directions:** Future research should focus on: 1. Elucidating the mechanisms by which SND1 regulates cellular processes. 2. Investigating SND1's role in disease states, including cancer and cardiovascular disease. 3. Exploring SND1's therapeutic potential as a target for various diseases.

Genular Protein ID: 4245158280

Symbol: SND1_HUMAN

Name: Staphylococcal nuclease domain-containing protein 1

UniProtKB Accession Codes:

Q7KZF4 Q13122 Q96AG0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EC 1 ELM 1 EMBL 3 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 20 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PIR 1 PIRSF 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7651391

Title: The Epstein-Barr virus nuclear protein 2 acidic domain forms a complex with a novel cellular coactivator that can interact with TFIIE.

PubMed ID: 7651391

DOI: 10.1128/mcb.15.9.4735

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12234934

Title: Identification of p100 as a coactivator for STAT6 that bridges STAT6 with RNA polymerase II.

PubMed ID: 12234934

DOI: 10.1093/emboj/cdf463

PubMed ID: 9809063

Title: Pim-1 kinase and p100 cooperate to enhance c-Myb activity.

PubMed ID: 9809063

DOI: 10.1016/s1097-2765(00)80141-0

PubMed ID: 12917451

Title: Equine arteritis virus non-structural protein 1, an essential factor for viral subgenomic mRNA synthesis, interacts with the cellular transcription co-factor p100.

PubMed ID: 12917451

DOI: 10.1099/vir.0.19297-0

PubMed ID: 14508492

Title: A micrococcal nuclease homologue in RNAi effector complexes.

PubMed ID: 14508492

DOI: 10.1038/nature01956

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 17081065

Title: Proteomic and bioinformatic characterization of the biogenesis and function of melanosomes.

PubMed ID: 17081065

DOI: 10.1021/pr060363j

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28546213

Title: Tudor-SN-mediated endonucleolytic decay of human cell microRNAs promotes G1/S phase transition.

PubMed ID: 28546213

DOI: 10.1126/science.aai9372

PubMed ID: 37794589

Title: SND1 binds SARS-CoV-2 negative-sense RNA and promotes viral RNA synthesis through NSP9.

PubMed ID: 37794589

DOI: 10.1016/j.cell.2023.09.002

PubMed ID: 18453631

Title: Structural and functional insights into human Tudor-SN, a key component linking RNA interference and editing.

PubMed ID: 18453631

DOI: 10.1093/nar/gkn236

Sequence Information:

  • Length: 910
  • Mass: 101997
  • Checksum: D58BF200F3F3D628
  • Sequence:
    • MASSAQSGGS SGGPAVPTVQ RGIIKMVLSG CAIIVRGQPR GGPPPERQIN LSNIRAGNLA 
RRAAATQPDA KDTPDEPWAF PAREFLRKKL IGKEVCFTIE NKTPQGREYG MIYLGKDTNG 
ENIAESLVAE GLATRREGMR ANNPEQNRLS ECEEQAKAAK KGMWSEGNGS HTIRDLKYTI 
ENPRHFVDSH HQKPVNAIIE HVRDGSVVRA LLLPDYYLVT VMLSGIKCPT FRREADGSET 
PEPFAAEAKF FTESRLLQRD VQIILESCHN QNILGTILHP NGNITELLLK EGFARCVDWS 
IAVYTRGAEK LRAAERFAKE RRLRIWRDYV APTANLDQKD KQFVAKVMQV LNADAIVVKL 
NSGDYKTIHL SSIRPPRLEG ENTQDKNKKL RPLYDIPYMF EAREFLRKKL IGKKVNVTVD 
YIRPASPATE TVPAFSERTC ATVTIGGINI AEALVSKGLA TVIRYRQDDD QRSSHYDELL 
AAEARAIKNG KGLHSKKEVP IHRVADISGD TQKAKQFLPF LQRAGRSEAV VEYVFSGSRL 
KLYLPKETCL ITFLLAGIEC PRGARNLPGL VQEGEPFSEE ATLFTKELVL QREVEVEVES 
MDKAGNFIGW LHIDGANLSV LLVEHALSKV HFTAERSSYY KSLLSAEEAA KQKKEKVWAH 
YEEQPVEEVM PVLEEKERSA SYKPVFVTEI TDDLHFYVQD VETGTQLEKL MENMRNDIAS 
HPPVEGSYAP RRGEFCIAKF VDGEWYRARV EKVESPAKIH VFYIDYGNRE VLPSTRLGTL 
SPAFSTRVLP AQATEYAFAF IQVPQDDDAR TDAVDSVVRD IQNTQCLLNV EHLSAGCPHV 
TLQFADSKGD VGLGLVKEGL VMVEVRKEKQ FQKVITEYLN AQESAKSARL NLWRYGDFRA 
DDADEFGYSR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.