Details for: UBR5

Gene ID: 51366

Symbol: UBR5

Ensembl ID: ENSG00000104517

Description: ubiquitin protein ligase E3 component n-recognin 5

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 546.7220
    Cell Significance Index: -85.0400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 333.1843
    Cell Significance Index: -84.5100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 185.2114
    Cell Significance Index: -87.4400
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 167.3325
    Cell Significance Index: -67.9800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 157.6445
    Cell Significance Index: -81.0900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 71.5166
    Cell Significance Index: -68.2800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 70.2235
    Cell Significance Index: -86.5800
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.8303
    Cell Significance Index: -82.5900
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 26.0756
    Cell Significance Index: -80.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 22.8869
    Cell Significance Index: -50.0900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.2222
    Cell Significance Index: -87.6900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.8379
    Cell Significance Index: 271.4800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 4.4432
    Cell Significance Index: 114.2100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.1669
    Cell Significance Index: 243.0200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.8845
    Cell Significance Index: 1034.6300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.8557
    Cell Significance Index: 566.7300
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.7466
    Cell Significance Index: 168.8200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.7047
    Cell Significance Index: 542.5600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 2.3655
    Cell Significance Index: 56.7300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.1999
    Cell Significance Index: 42.9400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.1908
    Cell Significance Index: 356.3100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 2.1111
    Cell Significance Index: 93.3800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 2.0915
    Cell Significance Index: 79.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.0216
    Cell Significance Index: 139.8100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.5805
    Cell Significance Index: 44.1700
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.5122
    Cell Significance Index: 1045.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.4340
    Cell Significance Index: 96.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.2872
    Cell Significance Index: 67.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0769
    Cell Significance Index: 117.1400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 1.0455
    Cell Significance Index: 1968.6200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8641
    Cell Significance Index: 24.9000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.8570
    Cell Significance Index: 20.9100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.8351
    Cell Significance Index: 23.8300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.8021
    Cell Significance Index: 98.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7974
    Cell Significance Index: 143.7600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.7830
    Cell Significance Index: 35.4900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7210
    Cell Significance Index: 327.2500
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6496
    Cell Significance Index: 586.5300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.6103
    Cell Significance Index: 387.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.5484
    Cell Significance Index: 11.8800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5013
    Cell Significance Index: 30.1000
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.4651
    Cell Significance Index: 254.0100
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3949
    Cell Significance Index: 728.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3710
    Cell Significance Index: 571.1400
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.3429
    Cell Significance Index: 9.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3413
    Cell Significance Index: 46.8700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3169
    Cell Significance Index: 5.4300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.2975
    Cell Significance Index: 35.0900
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.2387
    Cell Significance Index: 324.5400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.2297
    Cell Significance Index: 101.5700
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.2030
    Cell Significance Index: 2.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1230
    Cell Significance Index: 2.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0745
    Cell Significance Index: 3.5000
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0225
    Cell Significance Index: 2.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0155
    Cell Significance Index: -0.5500
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0376
    Cell Significance Index: -0.5400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0424
    Cell Significance Index: -31.4200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0681
    Cell Significance Index: -49.9000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0720
    Cell Significance Index: -44.9600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1073
    Cell Significance Index: -18.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1101
    Cell Significance Index: -62.1100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1115
    Cell Significance Index: -84.3900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1283
    Cell Significance Index: -13.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.1948
    Cell Significance Index: -37.0800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.2315
    Cell Significance Index: -29.6800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2432
    Cell Significance Index: -35.3500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2564
    Cell Significance Index: -73.7700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2626
    Cell Significance Index: -55.3200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2628
    Cell Significance Index: -13.6500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2842
    Cell Significance Index: -13.2500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3089
    Cell Significance Index: -36.0000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3105
    Cell Significance Index: -40.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.3143
    Cell Significance Index: -9.0100
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.3316
    Cell Significance Index: -7.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3884
    Cell Significance Index: -25.0600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.4302
    Cell Significance Index: -43.9400
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.5647
    Cell Significance Index: -42.0900
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6148
    Cell Significance Index: -70.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.6244
    Cell Significance Index: -71.5400
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.6628
    Cell Significance Index: -9.7900
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.7603
    Cell Significance Index: -53.7700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.7812
    Cell Significance Index: -4.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.7982
    Cell Significance Index: -10.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.8138
    Cell Significance Index: -51.2900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.8681
    Cell Significance Index: -21.7000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.9054
    Cell Significance Index: -47.5400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9187
    Cell Significance Index: -72.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.0031
    Cell Significance Index: -21.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0940
    Cell Significance Index: -67.0700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.1473
    Cell Significance Index: -36.7500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.2370
    Cell Significance Index: -25.6600
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.2479
    Cell Significance Index: -21.0200
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.2799
    Cell Significance Index: -15.9600
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -1.3230
    Cell Significance Index: -18.5000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -1.3250
    Cell Significance Index: -26.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.3434
    Cell Significance Index: -36.5700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -1.3659
    Cell Significance Index: -20.1600
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.3680
    Cell Significance Index: -44.7900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -1.3811
    Cell Significance Index: -43.9900
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -1.4914
    Cell Significance Index: -22.6900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** UBR5 is a member of the HECT (heterochronic excess) family of ubiquitin ligases, characterized by its ability to recognize specific ubiquitin chains and transfer them to target proteins. The n-recognin domain of UBR5 is responsible for binding to these ubiquitin chains, allowing for efficient recognition and transfer. UBR5 is also known to interact with various proteins, including Smoothened signaling pathway components, Wnt signaling pathway components, and proteins involved in DNA damage response and repair. These interactions highlight the complex regulatory network mediated by UBR5. **Pathways and Functions:** UBR5 is involved in various cellular pathways, including: 1. **Protein Quality Control**: UBR5 regulates protein degradation by the UPS, ensuring the removal of damaged or misfolded proteins and maintaining protein homeostasis. 2. **Cell Cycle Progression**: UBR5 is involved in regulating cell cycle progression by targeting proteins involved in the cell cycle machinery for degradation. 3. **Gene Expression**: UBR5 influences gene expression by regulating the degradation of transcriptional regulators and other proteins involved in gene expression. 4. **DNA Damage Response**: UBR5 interacts with proteins involved in DNA damage response and repair, highlighting its role in maintaining genomic stability. 5. **Immune Response**: UBR5 is highly expressed in immune cells, suggesting its involvement in regulating immune cell function and responding to pathogens. **Clinical Significance:** Dysregulation of UBR5 has been implicated in various diseases, including cancer, neurodegenerative disorders, and autoimmune diseases. For example: 1. **Cancer**: UBR5 is often overexpressed in cancer cells, contributing to tumorigenesis and cancer progression. 2. **Neurodegenerative Disorders**: UBR5 has been linked to neurodegenerative disorders, such as Alzheimer's disease and Parkinson's disease, where its dysregulation contributes to protein aggregation and neuronal degeneration. 3. **Autoimmune Diseases**: UBR5 is involved in regulating immune cell function, and its dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, UBR5 is a critical component of the ubiquitin-proteasome system, regulating protein quality control, cell cycle progression, and gene expression. Its dysregulation has been implicated in various diseases, highlighting the importance of understanding its role in maintaining cellular homeostasis and responding to environmental cues.

Genular Protein ID: 1710493613

Symbol: UBR5_HUMAN

Name: E3 ubiquitin-protein ligase, HECT domain-containing 1

UniProtKB Accession Codes:

O95071 B2RP24 J3KMW7 O94970 Q9NPL3

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 2 CORUM 1 CTD 1 ChEBI 12 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DisProt 1 EC 1 ELM 1 EMBL 6 EMDB 10 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 31 Gene3D 6 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 11 PDBsum 11 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10030672

Title: Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs.

PubMed ID: 10030672

DOI: 10.1038/sj.onc.1202249

PubMed ID: 11714696

Title: Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response.

PubMed ID: 11714696

DOI: 10.1074/jbc.m104347200

PubMed ID: 10048485

Title: Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10048485

DOI: 10.1093/dnares/5.6.355

PubMed ID: 12168954

Title: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.

PubMed ID: 12168954

DOI: 10.1093/dnares/9.3.99

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12011095

Title: EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response.

PubMed ID: 12011095

DOI: 10.1074/jbc.m203527200

PubMed ID: 15592455

Title: Immunoaffinity profiling of tyrosine phosphorylation in cancer cells.

PubMed ID: 15592455

DOI: 10.1038/nbt1046

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19287380

Title: Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase.

PubMed ID: 19287380

DOI: 10.1038/ncb1848

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21127351

Title: Transcription factor IIS cooperates with the E3 ligase UBR5 to ubiquitinate the CDK9 subunit of the positive transcription elongation factor B.

PubMed ID: 21127351

DOI: 10.1074/jbc.m110.176628

PubMed ID: 21924388

Title: Identification of phosphorylation sites on the E3 ubiquitin ligase UBR5/EDD.

PubMed ID: 21924388

DOI: 10.1016/j.jprot.2011.08.023

PubMed ID: 21118991

Title: The EDD E3 ubiquitin ligase ubiquitinates and up-regulates beta-catenin.

PubMed ID: 21118991

DOI: 10.1091/mbc.e10-05-0440

PubMed ID: 21726808

Title: Acetylation regulates gluconeogenesis by promoting PEPCK1 degradation via recruiting the UBR5 ubiquitin ligase.

PubMed ID: 21726808

DOI: 10.1016/j.molcel.2011.04.028

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22884692

Title: TRIP12 and UBR5 Suppress Spreading of Chromatin Ubiquitylation at Damaged Chromosomes.

PubMed ID: 22884692

DOI: 10.1016/j.cell.2012.06.039

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24656813

Title: Phosphorylation-dependent PIH1D1 interactions define substrate specificity of the R2TP cochaperone complex.

PubMed ID: 24656813

DOI: 10.1016/j.celrep.2014.03.013

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 29033132

Title: Assembly and function of heterotypic ubiquitin chains in cell-cycle and protein quality control.

PubMed ID: 29033132

DOI: 10.1016/j.cell.2017.09.040

PubMed ID: 28689657

Title: Wnt-dependent inactivation of the Groucho/TLE co-repressor by the HECT E3 ubiquitin ligase Hyd/UBR5.

PubMed ID: 28689657

DOI: 10.1016/j.molcel.2017.06.009

PubMed ID: 29441057

Title: Stability of the HTLV-1 Antisense-Derived Protein, HBZ, Is Regulated by the E3 Ubiquitin-Protein Ligase, UBR5.

PubMed ID: 29441057

DOI: 10.3389/fmicb.2018.00080

PubMed ID: 29378950

Title: K63 ubiquitylation triggers proteasomal degradation by seeding branched ubiquitin chains.

PubMed ID: 29378950

DOI: 10.1073/pnas.1716673115

PubMed ID: 33208877

Title: Identification of the HECT E3 ligase UBR5 as a regulator of MYC degradation using a CRISPR/Cas9 screen.

PubMed ID: 33208877

DOI: 10.1038/s41598-020-76960-z

PubMed ID: 35217622

Title: Role of ubiquitin-protein ligase UBR5 in the disassembly of mitotic checkpoint complexes.

PubMed ID: 35217622

DOI: 10.1073/pnas.2121478119

PubMed ID: 37478862

Title: Orphan quality control shapes network dynamics and gene expression.

PubMed ID: 37478862

DOI: 10.1016/j.cell.2023.06.015

PubMed ID: 11287654

Title: X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein.

PubMed ID: 11287654

DOI: 10.1073/pnas.071552198

PubMed ID: 17897937

Title: Structural basis of ubiquitin recognition by the ubiquitin-associated (UBA) domain of the ubiquitin ligase EDD.

PubMed ID: 17897937

DOI: 10.1074/jbc.m705655200

PubMed ID: 23027739

Title: Structure of the HECT C-lobe of the UBR5 E3 ubiquitin ligase.

PubMed ID: 23027739

DOI: 10.1107/s1744309112036937

PubMed ID: 37040767

Title: Structure of the human UBR5 E3 ubiquitin ligase.

PubMed ID: 37040767

DOI: 10.1016/j.str.2023.03.010

PubMed ID: 37409633

Title: Cryo-EM structure of the chain-elongating E3 ubiquitin ligase UBR5.

PubMed ID: 37409633

DOI: 10.15252/embj.2022113348

PubMed ID: 37478846

Title: UBR5 forms ligand-dependent complexes on chromatin to regulate nuclear hormone receptor stability.

PubMed ID: 37478846

DOI: 10.1016/j.molcel.2023.06.028

PubMed ID: 37620400

Title: Structural snapshots along K48-linked ubiquitin chain formation by the HECT E3 UBR5.

PubMed ID: 37620400

DOI: 10.1038/s41589-023-01414-2

Sequence Information:

  • Length: 2799
  • Mass: 309352
  • Checksum: 871300DB404FF561
  • Sequence:
    • MTSIHFVVHP LPGTEDQLND RLREVSEKLN KYNLNSHPPL NVLEQATIKQ CVVGPNHAAF 
LLEDGRVCRI GFSVQPDRLE LGKPDNNDGS KLNSNSGAGR TSRPGRTSDS PWFLSGSETL 
GRLAGNTLGS RWSSGVGGSG GGSSGRSSAG ARDSRRQTRV IRTGRDRGSG LLGSQPQPVI 
PASVIPEELI SQAQVVLQGK SRSVIIRELQ RTNLDVNLAV NNLLSRDDED GDDGDDTASE 
SYLPGEDLMS LLDADIHSAH PSVIIDADAM FSEDISYFGY PSFRRSSLSR LGSSRVLLLP 
LERDSELLRE RESVLRLRER RWLDGASFDN ERGSTSKEGE PNLDKKNTPV QSPVSLGEDL 
QWWPDKDGTK FICIGALYSE LLAVSSKGEL YQWKWSESEP YRNAQNPSLH HPRATFLGLT 
NEKIVLLSAN SIRATVATEN NKVATWVDET LSSVASKLEH TAQTYSELQG ERIVSLHCCA 
LYTCAQLENS LYWWGVVPFS QRKKMLEKAR AKNKKPKSSA GISSMPNITV GTQVCLRNNP 
LYHAGAVAFS ISAGIPKVGV LMESVWNMND SCRFQLRSPE SLKNMEKASK TTEAKPESKQ 
EPVKTEMGPP PSPASTCSDA SSIASSASMP YKRRRSTPAP KEEEKVNEEQ WSLREVVFVE 
DVKNVPVGKV LKVDGAYVAV KFPGTSSNTN CQNSSGPDAD PSSLLQDCRL LRIDELQVVK 
TGGTPKVPDC FQRTPKKLCI PEKTEILAVN VDSKGVHAVL KTGNWVRYCI FDLATGKAEQ 
ENNFPTSSIA FLGQNERNVA IFTAGQESPI ILRDGNGTIY PMAKDCMGGI RDPDWLDLPP 
ISSLGMGVHS LINLPANSTI KKKAAVIIMA VEKQTLMQHI LRCDYEACRQ YLMNLEQAVV 
LEQNLQMLQT FISHRCDGNR NILHACVSVC FPTSNKETKE EEEAERSERN TFAERLSAVE 
AIANAISVVS SNGPGNRAGS SSSRSLRLRE MMRRSLRAAG LGRHEAGASS SDHQDPVSPP 
IAPPSWVPDP PAMDPDGDID FILAPAVGSL TTAATGTGQG PSTSTIPGPS TEPSVVESKD 
RKANAHFILK LLCDSVVLQP YLRELLSAKD ARGMTPFMSA VSGRAYPAAI TILETAQKIA 
KAEISSSEKE EDVFMGMVCP SGTNPDDSPL YVLCCNDTCS FTWTGAEHIN QDIFECRTCG 
LLESLCCCTE CARVCHKGHD CKLKRTSPTA YCDCWEKCKC KTLIAGQKSA RLDLLYRLLT 
ATNLVTLPNS RGEHLLLFLV QTVARQTVEH CQYRPPRIRE DRNRKTASPE DSDMPDHDLE 
PPRFAQLALE RVLQDWNALK SMIMFGSQEN KDPLSASSRI GHLLPEEQVY LNQQSGTIRL 
DCFTHCLIVK CTADILLLDT LLGTLVKELQ NKYTPGRREE AIAVTMRFLR SVARVFVILS 
VEMASSKKKN NFIPQPIGKC KRVFQALLPY AVEELCNVAE SLIVPVRMGI ARPTAPFTLA 
STSIDAMQGS EELFSVEPLP PRPSSDQSSS SSQSQSSYII RNPQQRRISQ SQPVRGRDEE 
QDDIVSADVE EVEVVEGVAG EEDHHDEQEE HGEENAEAEG QHDEHDEDGS DMELDLLAAA 
ETESDSESNH SNQDNASGRR SVVTAATAGS EAGASSVPAF FSEDDSQSND SSDSDSSSSQ 
SDDIEQETFM LDEPLERTTN SSHANGAAQA PRSMQWAVRN TQHQRAASTA PSSTSTPAAS 
SAGLIYIDPS NLRRSGTIST SAAAAAAALE ASNASSYLTS ASSLARAYSI VIRQISDLMG 
LIPKYNHLVY SQIPAAVKLT YQDAVNLQNY VEEKLIPTWN WMVSIMDSTE AQLRYGSALA 
SAGDPGHPNH PLHASQNSAR RERMTAREEA SLRTLEGRRR ATLLSARQGM MSARGDFLNY 
ALSLMRSHND EHSDVLPVLD VCSLKHVAYV FQALIYWIKA MNQQTTLDTP QLERKRTREL 
LELGIDNEDS EHENDDDTNQ SATLNDKDDD SLPAETGQNH PFFRRSDSMT FLGCIPPNPF 
EVPLAEAIPL ADQPHLLQPN ARKEDLFGRP SQGLYSSSAS SGKCLMEVTV DRNCLEVLPT 
KMSYAANLKN VMNMQNRQKK EGEEQPVLPE ETESSKPGPS AHDLAAQLKS SLLAEIGLTE 
SEGPPLTSFR PQCSFMGMVI SHDMLLGRWR LSLELFGRVF MEDVGAEPGS ILTELGGFEV 
KESKFRREME KLRNQQSRDL SLEVDRDRDL LIQQTMRQLN NHFGRRCATT PMAVHRVKVT 
FKDEPGEGSG VARSFYTAIA QAFLSNEKLP NLECIQNANK GTHTSLMQRL RNRGERDRER 
EREREMRRSS GLRAGSRRDR DRDFRRQLSI DTRPFRPASE GNPSDDPEPL PAHRQALGER 
LYPRVQAMQP AFASKITGML LELSPAQLLL LLASEDSLRA RVDEAMELII AHGRENGADS 
ILDLGLVDSS EKVQQENRKR HGSSRSVVDM DLDDTDDGDD NAPLFYQPGK RGFYTPRPGK 
NTEARLNCFR NIGRILGLCL LQNELCPITL NRHVIKVLLG RKVNWHDFAF FDPVMYESLR 
QLILASQSSD ADAVFSAMDL AFAIDLCKEE GGGQVELIPN GVNIPVTPQN VYEYVRKYAE 
HRMLVVAEQP LHAMRKGLLD VLPKNSLEDL TAEDFRLLVN GCGEVNVQML ISFTSFNDES 
GENAEKLLQF KRWFWSIVEK MSMTERQDLV YFWTSSPSLP ASEEGFQPMP SITIRPPDDQ 
HLPTANTCIS RLYVPLYSSK QILKQKLLLA IKTKNFGFV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.