Details for: ELF1

Gene ID: 1997

Symbol: ELF1

Ensembl ID: ENSG00000120690

Description: E74 like ETS transcription factor 1

Associated with

  • Gene expression (transcription)
    (R-HSA-74160)
  • Generic transcription pathway
    (R-HSA-212436)
  • Rna polymerase ii transcription
    (R-HSA-73857)
  • Runx1 regulates transcription of genes involved in bcr signaling
    (R-HSA-8939245)
  • Runx1 regulates transcription of genes involved in interleukin signaling
    (R-HSA-8939247)
  • Transcriptional regulation by runx1
    (R-HSA-8878171)
  • Cell differentiation
    (GO:0030154)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity
    (GO:0003700)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Negative regulation of t cell receptor signaling pathway
    (GO:0050860)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Regulation of cytokine production
    (GO:0001817)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 431.9644
    Cell Significance Index: -67.1900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 208.0480
    Cell Significance Index: -52.7700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 168.6986
    Cell Significance Index: -68.5400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 157.6497
    Cell Significance Index: -74.4300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 145.6885
    Cell Significance Index: -74.9400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 111.1588
    Cell Significance Index: -74.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 72.7054
    Cell Significance Index: -69.4200
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 57.8366
    Cell Significance Index: -71.3100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 24.9621
    Cell Significance Index: -66.8700
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 20.4659
    Cell Significance Index: -62.8600
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.7022
    Cell Significance Index: -43.1200
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 18.5578
    Cell Significance Index: -73.2300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.1511
    Cell Significance Index: 84.1400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 3.0986
    Cell Significance Index: 237.7900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.8290
    Cell Significance Index: 182.5200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.8196
    Cell Significance Index: 55.0300
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.2592
    Cell Significance Index: 448.3400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.0110
    Cell Significance Index: 237.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 1.8183
    Cell Significance Index: 50.8200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.7393
    Cell Significance Index: 213.8600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.6665
    Cell Significance Index: 300.4200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.3766
    Cell Significance Index: 37.4700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.2563
    Cell Significance Index: 23.2200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1768
    Cell Significance Index: 30.2500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.1350
    Cell Significance Index: 7.6900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.9317
    Cell Significance Index: 43.7900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.9025
    Cell Significance Index: 45.6100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.7637
    Cell Significance Index: 417.0800
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.7609
    Cell Significance Index: 336.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6672
    Cell Significance Index: 91.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5426
    Cell Significance Index: 88.2600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.4861
    Cell Significance Index: 36.2300
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.4624
    Cell Significance Index: 6.6500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4339
    Cell Significance Index: 47.2000
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.4290
    Cell Significance Index: 6.1600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.4120
    Cell Significance Index: 11.8700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.3933
    Cell Significance Index: 74.8400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.2828
    Cell Significance Index: 14.6900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.2580
    Cell Significance Index: 5.5900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.2574
    Cell Significance Index: 6.2800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.2392
    Cell Significance Index: 30.9000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.1572
    Cell Significance Index: 1.9800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1517
    Cell Significance Index: 15.0100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.1406
    Cell Significance Index: 4.1300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.1381
    Cell Significance Index: 27.7000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.1054
    Cell Significance Index: 5.4900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0953
    Cell Significance Index: 16.2700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0713
    Cell Significance Index: 3.2300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0558
    Cell Significance Index: 7.1500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0550
    Cell Significance Index: 3.8900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0441
    Cell Significance Index: 15.8300
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0383
    Cell Significance Index: 26.4700
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 0.0298
    Cell Significance Index: 0.1800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0266
    Cell Significance Index: 16.8900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0240
    Cell Significance Index: 44.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0231
    Cell Significance Index: 43.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0134
    Cell Significance Index: 20.6400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0034
    Cell Significance Index: 1.5300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -0.0092
    Cell Significance Index: -0.0800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0188
    Cell Significance Index: -13.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0294
    Cell Significance Index: -18.3400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0304
    Cell Significance Index: -41.3100
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0396
    Cell Significance Index: -1.3900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0525
    Cell Significance Index: -39.7600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0575
    Cell Significance Index: -42.1300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0588
    Cell Significance Index: -2.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0841
    Cell Significance Index: -2.4100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0975
    Cell Significance Index: -55.0000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1020
    Cell Significance Index: -10.4200
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1067
    Cell Significance Index: -5.9900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1726
    Cell Significance Index: -4.6300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1906
    Cell Significance Index: -3.2100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1940
    Cell Significance Index: -40.8700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1978
    Cell Significance Index: -5.2900
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -0.2108
    Cell Significance Index: -2.2400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2138
    Cell Significance Index: -61.5300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2338
    Cell Significance Index: -33.9800
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2414
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3651
    Cell Significance Index: -41.8300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.3792
    Cell Significance Index: -44.1900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.3902
    Cell Significance Index: -5.7600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4438
    Cell Significance Index: -50.6600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4925
    Cell Significance Index: -6.7200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5523
    Cell Significance Index: -14.1100
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.5734
    Cell Significance Index: -5.0900
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.5878
    Cell Significance Index: -13.5800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -0.6162
    Cell Significance Index: -3.7900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6629
    Cell Significance Index: -69.0200
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.7421
    Cell Significance Index: -18.5500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.7751
    Cell Significance Index: -52.1200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.8067
    Cell Significance Index: -55.7900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.8219
    Cell Significance Index: -50.5200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.8556
    Cell Significance Index: -67.7600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.8579
    Cell Significance Index: -18.2700
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9621
    Cell Significance Index: -14.2000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.0956
    Cell Significance Index: -67.1700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1876
    Cell Significance Index: -74.8500
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2546
    Cell Significance Index: -17.8600
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: -1.2866
    Cell Significance Index: -21.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.3180
    Cell Significance Index: -58.3000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ELF1 is a transcription factor that belongs to the ETS family, characterized by the presence of a DNA-binding domain and a transcriptional activation function. It is highly expressed in various cell types, including T cells, B cells, cardiac myocytes, and conjunctival epithelial cells. ELF1 shares homology with other ETS transcription factors, such as ETS1 and ETS2, and is involved in regulating gene expression through specific DNA sequences. **Pathways and Functions:** ELF1 is implicated in several critical pathways and functions, including: 1. **Immune Response:** ELF1 plays a crucial role in regulating T cell receptor signaling, cytokine production, and transcriptional regulation by Runx1, a transcription factor that controls the expression of genes involved in B cell receptor signaling and interleukin signaling. 2. **Cell Differentiation:** ELF1 is involved in the differentiation of T cells, including alpha-beta memory T cells and DN3 thymocytes, through the regulation of transcriptional programs that govern cell fate decisions. 3. **Chromatin Remodeling:** ELF1 interacts with chromatin-modifying enzymes to regulate chromatin structure and facilitate gene expression. 4. **Transcriptional Regulation:** ELF1 binds to specific DNA sequences and recruits RNA polymerase II to activate transcription, thereby regulating the expression of target genes. **Clinical Significance:** The dysregulation of ELF1 has been implicated in various diseases, including: 1. **Autoimmune Disorders:** ELF1 has been shown to play a role in the regulation of T cell responses and cytokine production, making it a potential target for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 2. **Cancer:** ELF1 has been implicated in the regulation of tumor cell growth, invasion, and metastasis, suggesting its potential as a therapeutic target in cancer therapy. 3. **Cardiac Disease:** ELF1 has been shown to regulate cardiac myocyte differentiation and function, making it a potential target for the treatment of cardiac diseases, such as heart failure. In conclusion, ELF1 is a critical ETS transcription factor that plays a pivotal role in regulating immune response, cell differentiation, and transcriptional programs. Its dysregulation has been implicated in various diseases, highlighting the need for further research into its role in human health and disease.

Genular Protein ID: 3617871947

Symbol: ELF1_HUMAN

Name: ETS-related transcription factor Elf-1

UniProtKB Accession Codes:

P32519 B4E2I5 E9PDQ9 Q8N6F6 Q9UDE1

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 13 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 Reactome 2 RefSeq 10 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1527846

Title: A novel Ets-related transcription factor, Elf-1, binds to human immunodeficiency virus type 2 regulatory elements that are required for inducible trans activation in T cells.

PubMed ID: 1527846

DOI: 10.1128/jvi.66.10.5890-5897.1992

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15057823

Title: The DNA sequence and analysis of human chromosome 13.

PubMed ID: 15057823

DOI: 10.1038/nature02379

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 1545787

Title: Cis-acting sequences required for inducible interleukin-2 enhancer function bind a novel Ets-related protein, Elf-1.

PubMed ID: 1545787

DOI: 10.1128/mcb.12.3.1043-1053.1992

PubMed ID: 8493578

Title: Regulation of the Ets-related transcription factor Elf-1 by binding to the retinoblastoma protein.

PubMed ID: 8493578

DOI: 10.1126/science.8493578

PubMed ID: 8756667

Title: Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.

PubMed ID: 8756667

DOI: 10.1128/mcb.16.9.5091

PubMed ID: 9524226

Title: Cloning of a novel human ELF-1-related ETS transcription factor, ELFR, its characterization and chromosomal assignment relative to ELF-1.

PubMed ID: 9524226

DOI: 10.1016/s0378-1119(98)00022-5

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 619
  • Mass: 67498
  • Checksum: FA0A51B3965616F3
  • Sequence:
    • MAAVVQQNDL VFEFASNVME DERQLGDPAI FPAVIVEHVP GADILNSYAG LACVEEPNDM 
ITESSLDVAE EEIIDDDDDD ITLTVEASCH DGDETIETIE AAEALLNMDS PGPMLDEKRI 
NNNIFSSPED DMVVAPVTHV SVTLDGIPEV METQQVQEKY ADSPGASSPE QPKRKKGRKT 
KPPRPDSPAT TPNISVKKKN KDGKGNTIYL WEFLLALLQD KATCPKYIKW TQREKGIFKL 
VDSKAVSRLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK EMPKDLIYIN 
DEDPSSSIES SDPSLSSSAT SNRNQTSRSR VSSSPGVKGG ATTVLKPGNS KAAKPKDPVE 
VAQPSEVLRT VQPTQSPYPT QLFRTVHVVQ PVQAVPEGEA ARTSTMQDET LNSSVQSIRT 
IQAPTQVPVV VSPRNQQLHT VTLQTVPLTT VIASTDPSAG TGSQKFILQA IPSSQPMTVL 
KENVMLQSQK AGSPPSIVLG PAQVQQVLTS NVQTICNGTV SVASSPSFSA TAPVVTFSPR 
SSQLVAHPPG TVITSVIKTQ ETKTLTQEVE KKESEDHLKE NTEKTEQQPQ PYVMVVSSSN 
GFTSQVAMKQ NELLEPNSF

Genular Protein ID: 1327458552

Symbol: Q6MZZ4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6MZZ4

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 HOGENOM 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 RuleBase 1 SAM 1 SUPFAM 1 UCSC 1

Citations:

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

Sequence Information:

  • Length: 361
  • Mass: 38996
  • Checksum: 65B581B0CD936677
  • Sequence:
    • MNYETMGRAL RYYYQRGILA KVEGQRLVYQ FKEMPKDLIY INDEDPSSSI ESSDPSLSSS 
ATSNRNQTSR SRVSSSPGVK GGATTVLKPG NSKAAKPKDP VEVAQPSEVL RTVQPTQSPY 
PTQLFRTVHV VQPVQAVPEG EAARTSTMQD ETLNSSVQSI RTIQAPTQVP VVVSPRNQQL 
HTVTLQTVPL TTVIASTDPS AGTGSQKFIL QAIPSSQPMT VLKENVMLQS QKAGSPPSIV 
LGPAQVQQVL TSNVQTICNG TVSVASSPSF SATAPVVTFS PRSSQLVAHP PGTVITSVIK 
TQETKTLTQE VEKKESEDHL KENTEKTEQQ PQPYVMVVSS SNGFTSQVAM KQNELLEPNS 
F

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.