Details for: BPTF

Gene ID: 2186

Symbol: BPTF

Ensembl ID: ENSG00000171634

Description: bromodomain PHD finger transcription factor

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 713.6188
    Cell Significance Index: -111.0000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 411.2861
    Cell Significance Index: -104.3200
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 250.0515
    Cell Significance Index: -118.0600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 237.1158
    Cell Significance Index: -96.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 213.8086
    Cell Significance Index: -109.9800
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 176.0076
    Cell Significance Index: -118.1100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 101.6766
    Cell Significance Index: -97.0800
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 94.0220
    Cell Significance Index: -115.9300
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 41.6278
    Cell Significance Index: -111.5200
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.8932
    Cell Significance Index: -101.0300
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 29.8273
    Cell Significance Index: -117.7000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 25.7198
    Cell Significance Index: -56.2900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.6079
    Cell Significance Index: 258.5700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.6232
    Cell Significance Index: 250.5600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.1035
    Cell Significance Index: 161.6600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.0549
    Cell Significance Index: 606.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 2.7481
    Cell Significance Index: 168.9100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.7117
    Cell Significance Index: 52.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.4950
    Cell Significance Index: 894.9200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4283
    Cell Significance Index: 487.1200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.3906
    Cell Significance Index: 293.9500
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.3894
    Cell Significance Index: 430.7400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.2074
    Cell Significance Index: 61.6900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.1519
    Cell Significance Index: 165.1400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1170
    Cell Significance Index: 290.7200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.1138
    Cell Significance Index: 28.8400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.9227
    Cell Significance Index: 124.0500
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.8753
    Cell Significance Index: 203.9800
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 1.8181
    Cell Significance Index: 1257.4800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.7051
    Cell Significance Index: 931.1900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.4573
    Cell Significance Index: 34.9500
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.2044
    Cell Significance Index: 34.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.1958
    Cell Significance Index: 54.2000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.1921
    Cell Significance Index: 140.5900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1426
    Cell Significance Index: 29.3700
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.0067
    Cell Significance Index: 67.6900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.9755
    Cell Significance Index: 43.1500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.9496
    Cell Significance Index: 419.8200
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.9244
    Cell Significance Index: 7.1300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.8973
    Cell Significance Index: 19.4400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.6642
    Cell Significance Index: 25.1500
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.5692
    Cell Significance Index: 7.0600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.5087
    Cell Significance Index: 957.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.4785
    Cell Significance Index: 8.2000
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3484
    Cell Significance Index: 314.5600
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3428
    Cell Significance Index: 15.9900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3377
    Cell Significance Index: 519.8100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3297
    Cell Significance Index: 42.2600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2787
    Cell Significance Index: 514.0300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.2603
    Cell Significance Index: 118.1200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.2594
    Cell Significance Index: 164.7600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2150
    Cell Significance Index: 4.6000
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.1696
    Cell Significance Index: 230.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1405
    Cell Significance Index: 13.9000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1047
    Cell Significance Index: 3.6800
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0231
    Cell Significance Index: 16.9600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: -0.0028
    Cell Significance Index: -0.5300
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.0064
    Cell Significance Index: -0.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0203
    Cell Significance Index: -3.3000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0291
    Cell Significance Index: -1.3700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1174
    Cell Significance Index: -88.9000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1202
    Cell Significance Index: -89.0600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1973
    Cell Significance Index: -111.2800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2122
    Cell Significance Index: -132.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.2211
    Cell Significance Index: -15.6400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.2236
    Cell Significance Index: -38.1800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.2319
    Cell Significance Index: -12.0500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2385
    Cell Significance Index: -6.3800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2977
    Cell Significance Index: -18.7600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.3186
    Cell Significance Index: -32.5400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3218
    Cell Significance Index: -7.4300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3634
    Cell Significance Index: -46.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.3782
    Cell Significance Index: -54.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4059
    Cell Significance Index: -116.7800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.5635
    Cell Significance Index: -33.8300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5933
    Cell Significance Index: -124.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6646
    Cell Significance Index: -77.4600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7024
    Cell Significance Index: -24.4100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.7083
    Cell Significance Index: -37.1900
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.7648
    Cell Significance Index: -79.6300
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.8460
    Cell Significance Index: -96.9300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.8982
    Cell Significance Index: -19.6700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.9732
    Cell Significance Index: -72.5300
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.0394
    Cell Significance Index: -17.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -1.0656
    Cell Significance Index: -30.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.0827
    Cell Significance Index: -9.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -1.1495
    Cell Significance Index: -32.9500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1749
    Cell Significance Index: -93.0500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.2302
    Cell Significance Index: -33.4900
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.3472
    Cell Significance Index: -19.8900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.4782
    Cell Significance Index: -38.8700
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -1.5849
    Cell Significance Index: -22.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -1.6992
    Cell Significance Index: -45.5300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.7382
    Cell Significance Index: -106.5700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.8279
    Cell Significance Index: -38.9300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.8549
    Cell Significance Index: -31.2500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -1.9006
    Cell Significance Index: -47.5100
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -1.9009
    Cell Significance Index: -27.3400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.9169
    Cell Significance Index: -46.7700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.9729
    Cell Significance Index: -50.4000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** BPTF is a 59-kDa protein that contains a bromodomain, a PHD finger, and a transcriptional activation domain. The bromodomain is responsible for recognizing and binding to acetylated histones, while the PHD finger is involved in DNA binding. The transcriptional activation domain enables BPTF to regulate gene expression by interacting with RNA polymerase II. BPTF is a member of the nucleosome remodeling factor (NURF) complex, which plays a critical role in chromatin remodeling and transcriptional regulation. **Pathways and Functions:** BPTF is involved in various cellular processes, including: 1. **Anterior-Posterior Pattern Specification:** BPTF regulates the expression of genes involved in embryonic development, including those involved in anterior-posterior patterning. 2. **Chromatin Remodeling:** BPTF, as part of the NURF complex, regulates chromatin structure and accessibility, influencing gene expression and transcriptional regulation. 3. **Transcriptional Regulation:** BPTF interacts with RNA polymerase II to regulate transcription, either positively or negatively, depending on the context. 4. **Cellular Response to Nerve Growth Factor Stimulus:** BPTF is involved in regulating the expression of genes involved in neuronal development and function in response to nerve growth factor. **Clinical Significance:** Dysregulation of BPTF has been implicated in various diseases, including: 1. **Neurological Disorders:** Mutations in BPTF have been associated with neurological disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** Aberrant expression of BPTF has been observed in various cancers, including glioblastoma and breast cancer. 3. **Developmental Disorders:** BPTF is essential for normal development, and dysregulation of BPTF has been implicated in developmental disorders, such as Down syndrome. In conclusion, BPTF is a critical gene that plays a central role in regulating transcription and chromatin remodeling. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the functions and clinical significance of this gene.

Genular Protein ID: 1800673508

Symbol: BPTF_HUMAN

Name: Nucleosome-remodeling factor subunit BPTF

UniProtKB Accession Codes:

Q12830 Q6NX67 Q7Z7D6 Q9UIG2

Database IDs:

ABCD 1 AGR 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEMBL 1 ChiTaRS 1 ComplexPortal 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 ELM 1 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 11 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 2 OrthoDB 1 PANTHER 2 PDB 45 PDBsum 45 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 3 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10662542

Title: Identification and characterization of BPTF, a novel bromodomain transcription factor.

PubMed ID: 10662542

DOI: 10.1006/geno.1999.6070

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 7621746

Title: FAC1, a novel gene identified with the monoclonal antibody Alz50, is developmentally regulated in human brain.

PubMed ID: 7621746

DOI: 10.1159/000111270

PubMed ID: 14609955

Title: Isolation of human NURF: a regulator of Engrailed gene expression.

PubMed ID: 14609955

DOI: 10.1093/emboj/cdg582

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9225734

Title: FAC1 expression and localization in motor neurons of developing, adult, and amyotrophic lateral sclerosis spinal cord.

PubMed ID: 9225734

DOI: 10.1006/exnr.1997.6508

PubMed ID: 10403843

Title: DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation.

PubMed ID: 10403843

DOI: 10.1006/bbrc.1999.0986

PubMed ID: 10575013

Title: Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator.

PubMed ID: 10575013

DOI: 10.1074/jbc.274.49.35262

PubMed ID: 10727212

Title: Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity.

PubMed ID: 10727212

DOI: 10.1021/bi992211q

PubMed ID: 15379550

Title: Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein.

PubMed ID: 15379550

DOI: 10.1021/bi0494166

PubMed ID: 15310751

Title: A tissue-specific, naturally occurring human SNF2L variant inactivates chromatin remodeling.

PubMed ID: 15310751

DOI: 10.1074/jbc.m406212200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16728976

Title: A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling.

PubMed ID: 16728976

DOI: 10.1038/nature04815

PubMed ID: 17525332

Title: ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage.

PubMed ID: 17525332

DOI: 10.1126/science.1140321

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25593309

Title: Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination.

PubMed ID: 25593309

DOI: 10.1101/gad.252189.114

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 28942966

Title: Haploinsufficiency of the Chromatin Remodeler BPTF Causes Syndromic Developmental and Speech Delay, Postnatal Microcephaly, and Dysmorphic Features.

PubMed ID: 28942966

DOI: 10.1016/j.ajhg.2017.08.014

PubMed ID: 28801535

Title: Expansion of the ISWI chromatin remodeler family with new active complexes.

PubMed ID: 28801535

DOI: 10.15252/embr.201744011

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 16728978

Title: Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF.

PubMed ID: 16728978

DOI: 10.1038/nature04802

PubMed ID: 18042461

Title: Structural basis for lower lysine methylation state-specific readout by MBT repeats of L3MBTL1 and an engineered PHD finger.

PubMed ID: 18042461

DOI: 10.1016/j.molcel.2007.10.023

PubMed ID: 22464331

Title: Histone recognition and large-scale structural analysis of the human bromodomain family.

PubMed ID: 22464331

DOI: 10.1016/j.cell.2012.02.013

Sequence Information:

  • Length: 3046
  • Mass: 338262
  • Checksum: 37D7206977A8DB09
  • Sequence:
    • MRGRRGRPPK QPAAPAAERC APAPPPPPPP PTSGPIGGLR SRHRGSSRGR WAAAQAEVAP 
KTRLSSPRGG SSSRRKPPPP PPAPPSTSAP GRGGRGGGGG RTGGGGGGGH LARTTAARRA 
VNKVVYDDHE SEEEEEEEDM VSEEEEEEDG DAEETQDSED DEEDEMEEDD DDSDYPEEME 
DDDDDASYCT ESSFRSHSTY SSTPGRRKPR VHRPRSPILE EKDIPPLEFP KSSEDLMVPN 
EHIMNVIAIY EVLRNFGTVL RLSPFRFEDF CAALVSQEQC TLMAEMHVVL LKAVLREEDT 
SNTTFGPADL KDSVNSTLYF IDGMTWPEVL RVYCESDKEY HHVLPYQEAE DYPYGPVENK 
IKVLQFLVDQ FLTTNIAREE LMSEGVIQYD DHCRVCHKLG DLLCCETCSA VYHLECVKPP 
LEEVPEDEWQ CEVCVAHKVP GVTDCVAEIQ KNKPYIRHEP IGYDRSRRKY WFLNRRLIIE 
EDTENENEKK IWYYSTKVQL AELIDCLDKD YWEAELCKIL EEMREEIHRH MDITEDLTNK 
ARGSNKSFLA AANEEILESI RAKKGDIDNV KSPEETEKDK NETENDSKDA EKNREEFEDQ 
SLEKDSDDKT PDDDPEQGKS EEPTEVGDKG NSVSANLGDN TTNATSEETS PSEGRSPVGC 
LSETPDSSNM AEKKVASELP QDVPEEPNKT CESSNTSATT TSIQPNLENS NSSSELNSSQ 
SESAKAADDP ENGERESHTP VSIQEEIVGD FKSEKSNGEL SESPGAGKGA SGSTRIITRL 
RNPDSKLSQL KSQQVAAAAH EANKLFKEGK EVLVVNSQGE ISRLSTKKEV IMKGNINNYF 
KLGQEGKYRV YHNQYSTNSF ALNKHQHRED HDKRRHLAHK FCLTPAGEFK WNGSVHGSKV 
LTISTLRLTI TQLENNIPSS FLHPNWASHR ANWIKAVQMC SKPREFALAL AILECAVKPV 
VMLPIWRESL GHTRLHRMTS IEREEKEKVK KKEKKQEEEE TMQQATWVKY TFPVKHQVWK 
QKGEEYRVTG YGGWSWISKT HVYRFVPKLP GNTNVNYRKS LEGTKNNMDE NMDESDKRKC 
SRSPKKIKIE PDSEKDEVKG SDAAKGADQN EMDISKITEK KDQDVKELLD SDSDKPCKEE 
PMEVDDDMKT ESHVNCQESS QVDVVNVSEG FHLRTSYKKK TKSSKLDGLL ERRIKQFTLE 
EKQRLEKIKL EGGIKGIGKT STNSSKNLSE SPVITKAKEG CQSDSMRQEQ SPNANNDQPE 
DLIQGCSESD SSVLRMSDPS HTTNKLYPKD RVLDDVSIRS PETKCPKQNS IENDIEEKVS 
DLASRGQEPS KSKTKGNDFF IDDSKLASAD DIGTLICKNK KPLIQEESDT IVSSSKSALH 
SSVPKSTNDR DATPLSRAMD FEGKLGCDSE SNSTLENSSD TVSIQDSSEE DMIVQNSNES 
ISEQFRTREQ DVEVLEPLKC ELVSGESTGN CEDRLPVKGT EANGKKPSQQ KKLEERPVNK 
CSDQIKLKNT TDKKNNENRE SEKKGQRTST FQINGKDNKP KIYLKGECLK EISESRVVSG 
NVEPKVNNIN KIIPENDIKS LTVKESAIRP FINGDVIMED FNERNSSETK SHLLSSSDAE 
GNYRDSLETL PSTKESDSTQ TTTPSASCPE SNSVNQVEDM EIETSEVKKV TSSPITSEEE 
SNLSNDFIDE NGLPINKNEN VNGESKRKTV ITEVTTMTST VATESKTVIK VEKGDKQTVV 
SSTENCAKST VTTTTTTVTK LSTPSTGGSV DIISVKEQSK TVVTTTVTDS LTTTGGTLVT 
SMTVSKEYST RDKVKLMKFS RPKKTRSGTA LPSYRKFVTK SSKKSIFVLP NDDLKKLARK 
GGIREVPYFN YNAKPALDIW PYPSPRPTFG ITWRYRLQTV KSLAGVSLML RLLWASLRWD 
DMAAKAPPGG GTTRTETSET EITTTEIIKR RDVGPYGIRS EYCIRKIICP IGVPETPKET 
PTPQRKGLRS SALRPKRPET PKQTGPVIIE TWVAEEELEL WEIRAFAERV EKEKAQAVEQ 
QAKKRLEQQK PTVIATSTTS PTSSTTSTIS PAQKVMVAPI SGSVTTGTKM VLTTKVGSPA 
TVTFQQNKNF HQTFATWVKQ GQSNSGVVQV QQKVLGIIPS STGTSQQTFT SFQPRTATVT 
IRPNTSGSGG TTSNSQVITG PQIRPGMTVI RTPLQQSTLG KAIIRTPVMV QPGAPQQVMT 
QIIRGQPVST AVSAPNTVSS TPGQKSLTSA TSTSNIQSSA SQPPRPQQGQ VKLTMAQLTQ 
LTQGHGGNQG LTVVIQGQGQ TTGQLQLIPQ GVTVLPGPGQ QLMQAAMPNG TVQRFLFTPL 
ATTATTASTT TTTVSTTAAG TGEQRQSKLS PQMQVHQDKT LPPAQSSSVG PAEAQPQTAQ 
PSAQPQPQTQ PQSPAQPEVQ TQPEVQTQTT VSSHVPSEAQ PTHAQSSKPQ VAAQSQPQSN 
VQGQSPVRVQ SPSQTRIRPS TPSQLSPGQQ SQVQTTTSQP IPIQPHTSLQ IPSQGQPQSQ 
PQVQSSTQTL SSGQTLNQVT VSSPSRPQLQ IQQPQPQVIA VPQLQQQVQV LSQIQSQVVA 
QIQAQQSGVP QQIKLQLPIQ IQQSSAVQTH QIQNVVTVQA ASVQEQLQRV QQLRDQQQKK 
KQQQIEIKRE HTLQASNQSE IIQKQVVMKH NAVIEHLKQK KSMTPAEREE NQRMIVCNQV 
MKYILDKIDK EEKQAAKKRK REESVEQKRS KQNATKLSAL LFKHKEQLRA EILKKRALLD 
KDLQIEVQEE LKRDLKIKKE KDLMQLAQAT AVAAPCPPVT PAPPAPPAPP PSPPPPPAVQ 
HTGLLSTPTL PAASQKRKRE EEKDSSSKSK KKKMISTTSK ETKKDTKLYC ICKTPYDESK 
FYIGCDRCQN WYHGRCVGIL QSEAELIDEY VCPQCQSTED AMTVLTPLTE KDYEGLKRVL 
RSLQAHKMAW PFLEPVDPND APDYYGVIKE PMDLATMEER VQRRYYEKLT EFVADMTKIF 
DNCRYYNPSD SPFYQCAEVL ESFFVQKLKG FKASRSHNNK LQSTAS

Genular Protein ID: 4026394178

Symbol: J3QQK4_HUMAN

Name: N/A

UniProtKB Accession Codes:

J3QQK4

Database IDs:

ARBA 10 Antibodypedia 1 Bgee 1 CDD 3 CTD 1 ChiTaRS 1 EMBL 4 Ensembl 2 ExpressionAtlas 1 GO 4 Gene3D 2 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 11 MassIVE 1 NCBI Taxonomy 1 PANTHER 2 PRINTS 1 PROSITE 8 PROSITE-ProRule 2 PeptideAtlas 2 Pfam 4 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 SMART 3 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

Sequence Information:

  • Length: 3158
  • Mass: 350266
  • Checksum: C4C1D599FED5DF68
  • Sequence:
    • MRGRRGRPPK QPAAPAAERC APAPPPPPPP PTSGPIGGLR SRHRGSSRGR WAAAQAEVAP 
KTRLSSPRGG SSSRRKPPPP PPAPPSTSAP GRGGRGGGGG RTGGGGGGGH LARTTAARRA 
VNKVVYDDHE SEEEEEEEDM VSEEEEEEDG DAEETQDSED DEEDEMEEDD DDSDYPEEME 
DDDDDASYCT ESSFRSHSTY SSTPGRRKPR VHRPRSPILE EKDIPPLEFP KSSEDLMVPN 
EHIMNVIAIY EVLRNFGTVL RLSPFRFEDF CAALVSQEQC TLMAEMHVVL LKAVLREEDT 
SNTTFGPADL KDSVNSTLYF IDGMTWPEVL RVYCESDKEY HHVLPYQEAE DYPYGPVENK 
IKVLQFLVDQ FLTTNIAREE LMSEGVIQYD DHCRVCHKLG DLLCCETCSA VYHLECVKPP 
LEEVPEDEWQ CEVCVAHKVP GVTDCVAEIQ KNKPYIRHEP IGYDRSRRKY WFLNRRLIIE 
EDTENENEKK IWYYSTKVQL AELIDCLDKD YWEAELCKIL EEMREEIHRH MDITEDLTNK 
ARGSNKSFLA AANEEILESI RAKKGDIDNV KSPEETEKDK NETENDSKDA EKNREEFEDQ 
SLEKDSDDKT PDDDPEQGKS EEPTEVGDKG NSVSANLGDN TTNATSEETS PSEGRSPVGC 
LSETPDSSNM AEKKVASELP QDVPEEPNKT CESSNTSATT TSIQPNLENS NSSSELNSSQ 
SESAKAADDP ENGERESHTP VSIQEEIVGD FKSEKSNGEL SESPGAGKGA SGSTRIITRL 
RNPDSKLSQL KSQQVAAAAH EANKLFKEGK EVLVVNSQGE ISRLSTKKEV IMKGNINNYF 
KLGQEGKYRV YHNQYSTNSF ALNKHQHRED HDKRRHLAHK FCLTPAGEFK WNGSVHGSKV 
LTISTLRLTI TQLENNIPSS FLHPNWASHR ANWIKAVQMC SKPREFALAL AILECAVKPV 
VMLPIWRESL GHTRLHRMTS IEREEKEKVK KKEKKQEEEE TMQQATWVKY TFPVKHQVWK 
QKGEEYRVTG YGGWSWISKT HVYRFVPKLP GNTNVNYRKS LEGTKNNMDE NMDESDKRKC 
SRSPKKIKIE PDSEKDEVKG SDAAKGADQN EMDISKITEK KDQDVKELLD SDSDKPCKEE 
PMEVDDDMKT ESHVNCQESS QVDVVNVSEG FHLRTSYKKK TKSSKLDGLL ERRIKQFTLE 
EKQRLEKIKL EGGIKGIGKT STNSSKNLSE SPVITKAKEG CQSDSMRQEQ SPNANNDQPE 
DLIQGCSESD SSVLRMSDPS HTTNKLYPKD RVLDDVSIRS PETKCPKQNS IENDIEEKVS 
DLASRGQEPS KSKTKGNDFF IDDSKLASAD DIGTLICKNK KPLIQEESDT IVSSSKSALH 
SSVPKSTNDR DATPLSRAMD FEGKLGCDSE SNSTLENSSD TVSIQDSSEE DMIVQNSNES 
ISEQFRTREQ DVEVLEPLKC ELVSGESTGN CEDRLPVKGT EANGKKPSQQ KKLEERPVNK 
CSDQIKLKNT TDKKNNENRE SEKKGQRTST FQINGKDNKP KIYLKGECLK EISESRVVSG 
NVEPKVNNIN KIIPENDIKS LTVKESAIRP FINGDVIMED FNERNSSETK SHLLSSSDAE 
GNYRDSLETL PSTKESDSTQ TTTPSASCPE SNSVNQVEDM EIETSEVKKV TSSPITSEEE 
SNLSNDFIDE NGLPINKNEN VNGESKRKTV ITEVTTMTST VATESKTVIK VEKGDKQTVV 
SSTENCAKST VTTTTTTVTK LSTPSTGGSV DIISVKEQSK TVVTTTVTDS LTTTGGTLVT 
SMTVSKEYST RDKVKLMKFS RPKKTRSGTA LPSYRKFVTK SSKKSIFVLP NDDLKKLARK 
GGIREVPYFN YNAKPALDIW PYPSPRPTFG ITWRYRLQTV KSLAGVSLML RLLWASLRWD 
DMAAKAPPGG GTTRTETSET EITTTEIIKR RDVGPYGIRS EYCIRKIICP IGVPETPKET 
PTPQRKGLRS SALRPKRPET PKQTGPVIIE TWVAEEELEL WEIRAFAERV EKEKAQAVEQ 
QAKKRLEQQK PTVIATSTTS PTSSTTSTIS PAQKVMVAPI SGSVTTGTKM VLTTKVGSPA 
TVTFQQNKNF HQTFATWVKQ GQSNSATSTA ATSATTIAST GQTFQITGNP VTMAGKVITK 
LPLPANSKIV AVNVPATQGG VVQVQQKVLG IIPSSTGTSQ QTFTSFQPRT ATVTIRPNTS 
GSGGTTSNSQ VITGPQIRPG MTVIRTPLQQ STLGKAIIRT PVMVQPGAPQ QVMTQIIRGQ 
PVSTAVSAPN TVSSTPGQKS LTSATSTSNI QSSASQPPRP QQGQVKLTMA QLTQLTQGHG 
GNQGLTVVIQ GQGQTTGQLQ LIPQGVTVLP GPGQQLMQAA MPNGTVQRFL FTPLATTATT 
ASTTTTTVST TAAGTGEQRQ SKLSPQMQVH QDKTLPPAQS SSVGPAEAQP QTAQPSAQPQ 
PQTQPQSPAQ PEVQTQPEVQ TQTTVSSHVP SEAQPTHAQS SKPQVAAQSQ PQSNVQGQSP 
VRVQSPSQTR IRPSTPSQLS PGQQSQVQTT TSQPIPIQPH TSLQIPSQGQ PQSQPQVQSS 
TQTLSSGQTL NQVTVSSPSR PQLQIQQPQP QVIAVPQLQQ QVQVLSQIQS QVVAQIQAQQ 
SGVPQQIKLQ LPIQIQQSSA VQTHQIQNVV TVQAASVQEQ LQRVQQLRDQ QQKKKQQQIE 
IKREHTLQAS NQSEIIQKQV VMKHNAVIEH LKQKKSMTPA EREENQRMIV CNQVMKYILD 
KIDKEEKQAA KKRKREESVE QKRSKQNATK LSALLFKHKE QLRAEILKKR ALLDKDLQIE 
VQEELKRDLK IKKEKDLMQL AQATAVAAPC PPVTPAPPAP PAPPPSPPPP PAVQHTGLLS 
TPTLPAASQK RKREEEKDSS SKSKKKKMIS TTSKETKKDT KLYCICKTPY DESKFYIGCD 
LCTNWYHGEC VGITEKEAKK MDVYICNDCK RAQEGSSEEL YCICRTPYDE SQFYIGCDRC 
QNWYHGRCVG ILQSEAELID EYVCPQCQST EDAMTVLTPL TEKDYEGLKR VLRSLQAHKM 
AWPFLEPVDP NDAPDYYGVI KEPMDLATME ERVQRRYYEK LTEFVADMTK IFDNCRYYNP 
SDSPFYQCAE VLESFFVQKL KGFKASRSHN NKLQSTAS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.