Details for: NCOR1

Gene ID: 9611

Symbol: NCOR1

Ensembl ID: ENSG00000141027

Description: nuclear receptor corepressor 1

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 3.23
    Marker Score: 3,910
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 3.13
    Marker Score: 4,216
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 3.11
    Marker Score: 13,010
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 3.02
    Marker Score: 7,558
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 2.95
    Marker Score: 2,273
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 2.95
    Marker Score: 6,470
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 2.76
    Marker Score: 2,387
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 2.72
    Marker Score: 1,321
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.72
    Marker Score: 1,433
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.71
    Marker Score: 5,211
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 2.65
    Marker Score: 1,546
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.64
    Marker Score: 3,192
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.64
    Marker Score: 56,275
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.63
    Marker Score: 3,024
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2.62
    Marker Score: 1,459
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 2.62
    Marker Score: 2,823
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.6
    Marker Score: 760
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.59
    Marker Score: 10,815
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2.56
    Marker Score: 2,270
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.52
    Marker Score: 44,693
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 2.5
    Marker Score: 24,766
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.48
    Marker Score: 55,432
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 2.47
    Marker Score: 1,292
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 2.39
    Marker Score: 1,663
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 2.39
    Marker Score: 968
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 2.38
    Marker Score: 686
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.37
    Marker Score: 748
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.35
    Marker Score: 561
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 2.35
    Marker Score: 2,236
  • Cell Name: fat cell (CL0000136)
    Fold Change: 2.34
    Marker Score: 1,310
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.34
    Marker Score: 2,920
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 2.34
    Marker Score: 1,542
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 2.34
    Marker Score: 10,828
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.34
    Marker Score: 46,525
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.34
    Marker Score: 88,722
  • Cell Name: podocyte (CL0000653)
    Fold Change: 2.33
    Marker Score: 862
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.32
    Marker Score: 34,715
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.31
    Marker Score: 1,351
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 2.31
    Marker Score: 1,441
  • Cell Name: subcutaneous fat cell (CL0002521)
    Fold Change: 2.29
    Marker Score: 838
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.29
    Marker Score: 36,791
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.29
    Marker Score: 17,544
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 2.29
    Marker Score: 1,982
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 2.28
    Marker Score: 1,133
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.27
    Marker Score: 1,231
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 2.27
    Marker Score: 1,121
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.26
    Marker Score: 2,562
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 2.26
    Marker Score: 717
  • Cell Name: basal cell (CL0000646)
    Fold Change: 2.26
    Marker Score: 2,914
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.26
    Marker Score: 920
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 2.23
    Marker Score: 568
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.19
    Marker Score: 2,420
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.19
    Marker Score: 916
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 2.18
    Marker Score: 788
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 2.17
    Marker Score: 758
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 2.17
    Marker Score: 810
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.16
    Marker Score: 5,181
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 2.16
    Marker Score: 3,062
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.15
    Marker Score: 1,283
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.14
    Marker Score: 79,126
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 2.14
    Marker Score: 1,624
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.14
    Marker Score: 24,918
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 2.14
    Marker Score: 7,021
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 2.14
    Marker Score: 72,273
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 2.14
    Marker Score: 630
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 2.13
    Marker Score: 740
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 2.12
    Marker Score: 8,810
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 2.12
    Marker Score: 916
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 2.11
    Marker Score: 1,413
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.11
    Marker Score: 462
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 2.1
    Marker Score: 2,229
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 2.1
    Marker Score: 1,926
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.1
    Marker Score: 4,260
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 2.09
    Marker Score: 2,277
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.05
    Marker Score: 20,762
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 2.04
    Marker Score: 5,649
  • Cell Name: hepatocyte (CL0000182)
    Fold Change: 2.04
    Marker Score: 1,393
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 2.03
    Marker Score: 690
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 2.03
    Marker Score: 7,838
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.03
    Marker Score: 2,447
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 2.02
    Marker Score: 2,032
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.02
    Marker Score: 2,129
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.02
    Marker Score: 6,374
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.02
    Marker Score: 462
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.01
    Marker Score: 6,324
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2
    Marker Score: 5,624
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2
    Marker Score: 1,460
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 2
    Marker Score: 727
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2
    Marker Score: 1,887
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 1.99
    Marker Score: 3,630
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.99
    Marker Score: 18,739
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.99
    Marker Score: 122,335
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 1.98
    Marker Score: 2,737
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 1.98
    Marker Score: 1,991
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 1.97
    Marker Score: 1,676
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 1.97
    Marker Score: 3,438
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.96
    Marker Score: 2,885
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 1.96
    Marker Score: 103,540
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.96
    Marker Score: 4,086
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.95
    Marker Score: 737

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Transcriptional Corepressor**: NCOR1 acts as a transcriptional corepressor, binding to nuclear receptors, transcription factors, and other proteins to modulate their activity and regulate gene expression. 2. **Multifunctional Protein**: NCOR1 interacts with various proteins, including nuclear receptors, transcription factors, and histone deacetylases, to regulate cellular processes. 3. **Wide-Tissue Expression**: NCOR1 is expressed in different tissues and cell types, including lens epithelial cells, skeletal muscle fibers, and renal principal cells. 4. **Regulation of Metabolic Pathways**: NCOR1 plays a crucial role in regulating metabolic pathways, including lipid metabolism, glycolysis, and fatty acid metabolism. 5. **Developmental Regulation**: NCOR1 is involved in regulating developmental processes, including the activation of anterior Hox genes in hindbrain development during early embryogenesis. **Pathways and Functions** 1. **Notch Signaling Pathway**: NCOR1 interacts with Notch receptors to regulate their signaling activity and control cell fate decisions. 2. **Nuclear Receptor Signaling Pathway**: NCOR1 binds to nuclear receptors, modulating their activity and regulating gene expression. 3. **Histone Deacetylase Complex**: NCOR1 interacts with histone deacetylases to regulate chromatin structure and gene expression. 4. **Circadian Clock**: NCOR1 plays a role in regulating the circadian clock by interacting with clock proteins. 5. **Mitochondrial Biogenesis**: NCOR1 regulates mitochondrial biogenesis by interacting with transcription factors and histone deacetylases. **Clinical Significance** 1. **Pervasive Developmental Disorders**: NCOR1 mutations have been associated with pervasive developmental disorders, including Rett syndrome. 2. **Cancer**: NCOR1 is overexpressed in certain types of cancer, including breast and lung cancer, and is involved in regulating tumor growth and progression. 3. **Metabolic Disorders**: NCOR1 plays a crucial role in regulating metabolic pathways, and its dysregulation has been implicated in metabolic disorders, including obesity and diabetes. 4. **Neurological Disorders**: NCOR1 is involved in regulating neuronal development and function, and its dysregulation has been implicated in neurological disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, NCOR1 is a multifunctional protein that plays a crucial role in regulating various cellular processes, including gene expression, signaling pathways, and development. Its dysregulation has been implicated in various diseases, including pervasive developmental disorders, cancer, metabolic disorders, and neurological disorders. Further research is needed to fully understand the mechanisms of NCOR1 and its role in human disease.

Genular Protein ID: 1881303346

Symbol: NCOR1_HUMAN

Name: Nuclear receptor corepressor 1

UniProtKB Accession Codes:

O75376 B3DLF8 E9PGV6 Q86YY0 Q9UPV5 Q9UQ18

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CORUM 1 CPTC 1 CTD 1 CarbonylDB 1 ChEMBL 1 ChiTaRS 1 DIP 1 DNASU 1 DisGeNET 1 DrugCentral 1 ELM 1 EMBL 8 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 24 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 IDEAL 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 23 PDBsum 18 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 22 RefSeq 4 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9724795

Title: ETO, fusion partner in t(8;21) acute myeloid leukemia, represses transcription by interaction with the human N-CoR/mSin3/HDAC1 complex.

PubMed ID: 9724795

DOI: 10.1073/pnas.95.18.10860

PubMed ID: 10470851

Title: Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10470851

DOI: 10.1093/dnares/6.3.197

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10444336

Title: Localization of the human nuclear receptor co-repressor (hN-CoR) gene between the CMT1A and the SMS critical regions of chromosome 17p11.2.

PubMed ID: 10444336

DOI: 10.1006/geno.1998.5694

PubMed ID: 9328355

Title: Transcriptional activation and repression by RORalpha, an orphan nuclear receptor required for cerebellar development.

PubMed ID: 9328355

DOI: 10.1210/mend.11.11.0002

PubMed ID: 11013263

Title: A novel nuclear receptor corepressor complex, N-CoR, contains components of the mammalian SWI/SNF complex and the corepressor KAP-1.

PubMed ID: 11013263

DOI: 10.1074/jbc.m007864200

PubMed ID: 11533236

Title: ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain.

PubMed ID: 11533236

DOI: 10.1128/mcb.21.19.6470-6483.2001

PubMed ID: 11931768

Title: The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2.

PubMed ID: 11931768

DOI: 10.1016/s1097-2765(02)00468-9

PubMed ID: 12590135

Title: The histone deacetylase 9 gene encodes multiple protein isoforms.

PubMed ID: 12590135

DOI: 10.1074/jbc.m212935200

PubMed ID: 14525983

Title: DACH1 inhibits transforming growth factor-beta signaling through binding Smad4.

PubMed ID: 14525983

DOI: 10.1074/jbc.m310021200

PubMed ID: 14527417

Title: N-CoR mediates DNA methylation-dependent repression through a methyl CpG binding protein Kaiso.

PubMed ID: 14527417

DOI: 10.1016/j.molcel.2003.08.008

PubMed ID: 15454082

Title: MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation.

PubMed ID: 15454082

DOI: 10.1016/j.cell.2004.09.014

PubMed ID: 16024779

Title: JMJD2A is a novel N-CoR-interacting protein and is involved in repression of the human transcription factor achaete scute-like homologue 2 (ASCL2/Hash2).

PubMed ID: 16024779

DOI: 10.1128/mcb.25.15.6404-6414.2005

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17452463

Title: Regulation of P-TEFb elongation complex activity by CDK9 acetylation.

PubMed ID: 17452463

DOI: 10.1128/mcb.00857-06

PubMed ID: 17519354

Title: Novel regulatory role for human Acf1 in transcriptional repression of vitamin D3 receptor-regulated genes.

PubMed ID: 17519354

DOI: 10.1210/me.2007-0095

PubMed ID: 18220336

Title: Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis.

PubMed ID: 18220336

DOI: 10.1021/pr0705441

PubMed ID: 18691976

Title: Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle.

PubMed ID: 18691976

DOI: 10.1016/j.molcel.2008.07.007

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 20812024

Title: FBI-1 functions as a novel AR co-repressor in prostate cancer cells.

PubMed ID: 20812024

DOI: 10.1007/s00018-010-0511-7

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23911289

Title: A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters.

PubMed ID: 23911289

DOI: 10.1016/j.celrep.2013.06.016

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 23372760

Title: Structural and functional analysis of the DEAF-1 and BS69 MYND domains.

PubMed ID: 23372760

DOI: 10.1371/journal.pone.0054715

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 28698609

Title: Functional analyses of a novel missense and other mutations of the vitamin D receptor in association with alopecia.

PubMed ID: 28698609

DOI: 10.1038/s41598-017-05081-x

PubMed ID: 20543827

Title: A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor.

PubMed ID: 20543827

DOI: 10.1038/nsmb.1855

Sequence Information:

  • Length: 2440
  • Mass: 270210
  • Checksum: 1647FE060373A125
  • Sequence:
    • MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ 
QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ 
RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE 
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY 
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR 
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ 
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM 
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL 
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE 
KEDSKENTKE KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA 
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA 
QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE DEDIEASNEE 
ENPEDSEVEA VKPSEDSPEN ATSRGNTEPA VELEPTTETA PSTSPSLAVP STKPAEDESV 
ETQVNDSISA ETAEQMDVDQ QEHSAEEGSV CDPPPATKAD SVDVEVRVPE NHASKVEGDN 
TKERDLDRAS EKVEPRDEDL VVAQQINAQR PEPQSDNDSS ATCSADEDVD GEPERQRMFP 
MDSKPSLLNP TGSILVSSPL KPNPLDLPQL QHRAAVIPPM VSCTPCNIPI GTPVSGYALY 
QRHIKAMHES ALLEEQRQRQ EQIDLECRSS TSPCGTSKSP NREWEVLQPA PHQVITNLPE 
GVRLPTTRPT RPPPPLIPSS KTTVASEKPS FIMGGSISQG TPGTYLTSHN QASYTQETPK 
PSVGSISLGL PRQQESAKSA TLPYIKQEEF SPRSQNSQPE GLLVRAQHEG VVRGTAGAIQ 
EGSITRGTPT SKISVESIPS LRGSITQGTP ALPQTGIPTE ALVKGSISRM PIEDSSPEKG 
REEAASKGHV IYEGKSGHIL SYDNIKNARE GTRSPRTAHE ISLKRSYESV EGNIKQGMSM 
RESPVSAPLE GLICRALPRG SPHSDLKERT VLSGSIMQGT PRATTESFED GLKYPKQIKR 
ESPPIRAFEG AITKGKPYDG ITTIKEMGRS IHEIPRQDIL TQESRKTPEV VQSTRPIIEG 
SISQGTPIKF DNNSGQSAIK HNVKSLITGP SKLSRGMPPL EIVPENIKVV ERGKYEDVKA 
GETVRSRHTS VVSSGPSVLR STLHEAPKAQ LSPGIYDDTS ARRTPVSYQN TMSRGSPMMN 
RTSDVTISSN KSTNHERKST LTPTQRESIP AKSPVPGVDP VVSHSPFDPH HRGSTAGEVY 
RSHLPTHLDP AMPFHRALDP AAAAYLFQRQ LSPTPGYPSQ YQLYAMENTR QTILNDYITS 
QQMQVNLRPD VARGLSPREQ PLGLPYPATR GIIDLTNMPP TILVPHPGGT STPPMDRITY 
IPGTQITFPP RPYNSASMSP GHPTHLAAAA SAERERERER EKERERERIA AASSDLYLRP 
GSEQPGRPGS HGYVRSPSPS VRTQETMLQQ RPSVFQGTNG TSVITPLDPT AQLRIMPLPA 
GGPSISQGLP ASRYNTAADA LAALVDAAAS APQMDVSKTK ESKHEAARLE ENLRSRSAAV 
SEQQQLEQKT LEVEKRSVQC LYTSSAFPSG KPQPHSSVVY SEAGKDKGPP PKSRYEEELR 
TRGKTTITAA NFIDVIITRQ IASDKDARER GSQSSDSSSS LSSHRYETPS DAIEVISPAS 
SPAPPQEKLQ TYQPEVVKAN QAENDPTRQY EGPLHHYRPQ QESPSPQQQL PPSSQAEGMG 
QVPRTHRLIT LADHICQIIT QDFARNQVSS QTPQQPPTST FQNSPSALVS TPVRTKTSNR 
YSPESQAQSV HHQRPGSRVS PENLVDKSRG SRPGKSPERS HVSSEPYEPI SPPQVPVVHE 
KQDSLLLLSQ RGAEPAEQRN DARSPGSISY LPSFFTKLEN TSPMVKSKKQ EIFRKLNSSG 
GGDSDMAAAQ PGTEIFNLPA VTTSGSVSSR GHSFADPASN LGLEDIIRKA LMGSFDDKVE 
DHGVVMSQPM GVVPGTANTS VVTSGETRRE EGDPSPHSGG VCKPKLISKS NSRKSKSPIP 
GQGYLGTERP SSVSSVHSEG DYHRQTPGWA WEDRPSSTGS TQFPYNPLTM RMLSSTPPTP 
IACAPSAVNQ AAPHQQNRIW EREPAPLLSA QYETLSDSDD

Genular Protein ID: 639529386

Symbol: A0A994J5B8_HUMAN

Name: N/A

UniProtKB Accession Codes:

A0A994J5B8

Database IDs:

ARBA 3 CDD 1 CTD 1 EMBL 2 EPD 1 Ensembl 2 GO 1 Gene3D 3 GeneTree 1 HGNC 1 InterPro 5 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 6 Pfam 2 Proteomes 2 RefSeq 1 SAM 1 SMART 1 SMR 1 SUPFAM 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 2466
  • Mass: 272880
  • Checksum: ECABCA0D8CE3C02C
  • Sequence:
    • MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ 
QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ 
RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE 
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY 
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TGVPARRMMK NQVMRKKLIL 
FFKRRNHARK QREQKICQRY DQLMEAWEKK VDRIENNPRR KAKESKTREY YEKQFPEIRK 
QREQQERFQR VGQRGAGLSA TIARSEHEIS EIIDGLSEQE NNEKQMRQLS VIPPMMFDAE 
QRRVKFINMN GLMEDPMKVY KDRQFMNVWT DHEKEIFKDK FIQHPKNFGL IASYLERKSV 
PDCVLYYYLT KKNENYKALV RRNYGKRRGR NQQQIARPSQ EEKVEEKEED KAEKTEKKEE 
EKKDEEEKDE KEDSKENTKE KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT 
NEAAAASAAA AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI 
AKMVGTKSEA QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE 
DEDIEASNEE ENPEDSEGAE NSSDTESAPS PSPVEAVKPS EDSPENATSR GNTEPAVELE 
PTTETAPSTS PSLAVPSTKP AEDESVETQV NDSISAETAE QMDVDQQEHS AEEGSVCDPP 
PATKADSVDV EVRVPENHAS KVEGDNTKER DLDRASEKVE PRDEDLVVAQ QINAQRPEPQ 
SDNDSSATCS ADEDVDGEPE RQRMFPMDSK PSLLNPTGSI LVSSPLKPNP LDLPQLQHRA 
AVIPPMVSCT PCNIPIGTPV SGYALYQRHI KAMHESALLE EQRQRQEQID LECRSSTSPC 
GTSKSPNREW EVLQPAPHQV ITNLPEGVRL PTTRPTRPPP PLIPSSKTTV ASEKPSFIMG 
GSISQGTPGT YLTSHNQASY TQETPKPSVG SISLGLPRQQ ESAKSATLPY IKQEEFSPRS 
QNSQPEGLLV RAQHEGVVRG TAGAIQEGSI TRGTPTSKIS VESIPSLRGS ITQGTPALPQ 
TGIPTEALVK GSISRMPIED SSPEKGREEA ASKGHVIYEG KSGHILSYDN IKNAREGTRS 
PRTAHEISLK RSYESVEGNI KQGMSMRESP VSAPLEGLIC RALPRGSPHS DLKERTVLSG 
SIMQGTPRAT TESFEDGLKY PKQIKRESPP IRAFEGAITK GKPYDGITTI KEMGRSIHEI 
PRQDILTQES RKTPEVVQST RPIIEGSISQ GTPIKFDNNS GQSAIKHNVK SLITGPSKLS 
RGMPPLEIVP ENIKVVERGK YEDVKAGETV RSRHTSVVSS GPSVLRSTLH EAPKAQLSPG 
IYDDTSARRT PVSYQNTMSR GSPMMNRTSD VTISSNKSTN HERKSTLTPT QRESIPAKSP 
VPGVDPVVSH SPFDPHHRGS TAGEVYRSHL PTHLDPAMPF HRALDPAAAA YLFQRQLSPT 
PGYPSQYQLY AMENTRQTIL NDYITSQQMQ VNLRPDVARG LSPREQPLGL PYPATRGIID 
LTNMPPTILV PHPGGTSTPP MDRITYIPGT QITFPPRPYN SASMSPGHPT HLAAAASAER 
EREREREKER ERERIAAASS DLYLRPGSEQ PGRPGSHGYV RSPSPSVRTQ ETMLQQRPSV 
FQGTNGTSVI TPLDPTAQLR IMPLPAGGPS ISQGLPASRY NTAADALAAL VDAAASAPQM 
DVSKTKESKH EAARLEENLR SRSAAVSEQQ QLEQKTLEVE KRSVQCLYTS SAFPSGKPQP 
HSSVVYSEAG KDKGPPPKSR YEEELRTRGK TTITAANFID VIITRQIASD KDARERGSQS 
SDSSSSLSSH RYETPSDAIE VISPASSPAP PQEKLQTYQP EVVKANQAEN DPTRQYEGPL 
HHYRPQQESP SPQQQLPPSS QAEGMGQVPR THRLITLADH ICQIITQDFA RNQVSSQTPQ 
QPPTSTFQNS PSALVSTPVR TKTSNRYSPE SQAQSVHHQR PGSRVSPENL VDKSRGSRPG 
KSPERSHVSS EPYEPISPPQ VPVVHEKQDS LLLLSQRGAE PAEQRNDARS PGSISYLPSF 
FTKLENTSPM VKSKKQEIFR KLNSSGGGDS DMAAAQPGTE IFNLPAVTTS GSVSSRGHSF 
ADPASNLGLE DIIRKALMGS FDDKVEDHGV VMSQPMGVVP GTANTSVVTS GETRREEGDP 
SPHSGGVCKP KLISKSNSRK SKSPIPGQGY LGTERPSSVS SVHSEGDYHR QTPGWAWEDR 
PSSTGSTQFP YNPLTMRMLS STPPTPIACA PSAVNQAAPH QQNRIWEREP APLLSAQYET 
LSDSDD

Genular Protein ID: 2532973506

Symbol: Q6PGR4_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6PGR4

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 2 Genevisible 1 GenomeRNAi 1 InterPro 4 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 2 PeptideAtlas 1 Pfam 2 RefSeq 2 SAM 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 518
  • Mass: 60737
  • Checksum: 1AAFB739707E550F
  • Sequence:
    • MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ 
QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ 
RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE 
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY 
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR 
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ 
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM 
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL 
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVKKKK

Genular Protein ID: 2433731457

Symbol: H0Y459_HUMAN

Name: N/A

UniProtKB Accession Codes:

H0Y459

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 CDD 1 CTD 1 ChiTaRS 1 EMBL 2 EPD 1 Ensembl 3 GO 2 Gene3D 3 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 PANTHER 2 PROSITE 6 Pfam 2 Proteomes 2 ProteomicsDB 1 RefSeq 7 SAM 1 SMART 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

Sequence Information:

  • Length: 2514
  • Mass: 277995
  • Checksum: 186AD4C676A9EB5D
  • Sequence:
    • MSSSGYPPNQ GAFSTEQSRY PPHSVQYTFP NTRHQQEFAV PDYRSSHLEV SQASQLLQQQ 
QQQQLRRRPS LLSEFHPGSD RPQERRTSYE PFHPGPSPVD HDSLESKRPR LEQVSDSHFQ 
RVSAAVLPLV HPLPEGLRAS ADAKKDPAFG GKHEAPSSPI SGQPCGDDQN ASPSKLSKEE 
LIQSMDRVDR EIAKVEQQIL KLKKKQQQLE EEAAKPPEPE KPVSPPPVEQ KHRSIVQIIY 
DENRKKAEEA HKIFEGLGPK VELPLYNQPS DTKVYHENIK TNQVMRKKLI LFFKRRNHAR 
KQREQKICQR YDQLMEAWEK KVDRIENNPR RKAKESKTRE YYEKQFPEIR KQREQQERFQ 
RVGQRGAGLS ATIARSEHEI SEIIDGLSEQ ENNEKQMRQL SVIPPMMFDA EQRRVKFINM 
NGLMEDPMKV YKDRQFMNVW TDHEKEIFKD KFIQHPKNFG LIASYLERKS VPDCVLYYYL 
TKKNENYKAL VRRNYGKRRG RNQQIARPSQ EEKVEEKEED KAEKTEKKEE EKKDEEEKDE 
KEDSKENTKE KDKIDGTAEE TEEREQATPR GRKTANSQGR RKGRITRSMT NEAAAASAAA 
AAATEEPPPP LPPPPEPIST EPVETSRWTE EEMEVAKKGL VEHGRNWAAI AKMVGTKSEA 
QCKNFYFNYK RRHNLDNLLQ QHKQKTSRKP REERDVSQCE SVASTVSAQE DEDIEASNEE 
ENPEDSEGAE NSSDTESAPS PSPVEAVKPS EDSPENATSR GNTEPAVELE PTTETAPSTS 
PSLAVPSTKP AEDESVETQV NDSISAETAE QMDVDQQEHS AEEGSVCDPP PATKADSVDV 
EVRVPENHAS KVEGDNTKER DLDRASEKVE PRDEDLVVAQ QINAQRPEPQ SDNDSSATCS 
ADEDVDGEPE RQRMFPMDSK PSLLNPTGSI LVSSPLKPNP LDLPQLQHRA AVIPPMVSCT 
PCNIPIGTPV SGYALYQRHI KAMHESALLE EQRQRQEQID LECRSSTSPC GTSKSPNREW 
EGKSVAYMPY AEVKRALEQE AQMHNTAARS ASPCRLSPRE VSKAAPQPDM SAARYSVPPV 
LQPAPHQVIT NLPEGVRLPT TRPTRPPPPL IPSSKTTVAS EKPSFIMGGS ISQGTPGTYL 
TSHNQASYTQ ETPKPSVGSI SLGLPRQQES AKSATLPYIK QEEFSPRSQN SQPEGLLVRA 
QHEGVVRGTA GAIQEGSITR GTPTSKISVE SIPSLRGSIT QGTPALPQTG IPTEALVKGS 
ISRMPIEDSS PEKGREEAAS KGHVIYEGKS GHILSYDNIK NAREGTRSPR TAHEISLKRS 
YESVEGNIKQ GMSMRESPVS APLEGLICRA LPRGSPHSDL KERTVLSGSI MQGTPRATTE 
SFEDGLKYPK QIKRESPPIR AFEGAITKGK PYDGITTIKE MGRSIHEIPR QDILTQESRK 
TPEVVQSTRP IIEGSISQGT PIKFDNNSGQ SAIKHNVKSL ITGPSKLSRG MPPLEIVPEN 
IKVVERGKYE DVKAGETVRS RHTSVVSSGP SVLRSTLHEA PKAQLSPGIY DDTSARRTPV 
SYQNTMSRGS PMMNRTSDVT ISSNKSTNHE RKSTLTPTQR ESIPAKSPVP GVDPVVSHSP 
FDPHHRGSTA GEVYRSHLPT HLDPAMPFHR ALDPAAAAYL FQRQLSPTPG YPSQYQLYAM 
ENTRQTILND YITSQQMQVN LRPDVARGLS PREQPLGLPY PATRGIIDLT NMPPTILVPH 
PGGTSTPPMD RITYIPGTQI TFPPRPYNSA SMSPGHPTHL AAAASAERER EREREKERER 
ERIAAASSDL YLRPGSEQPG RPGSHGYVRS PSPSVRTQET MLQQRPSVFQ GTNGTSVITP 
LDPTAQLRIM PLPAGGPSIS QGLPASRYNT AADALAALVD AAASAPQMDV SKTKESKHEA 
ARLEENLRSR SAAVSEQQQL EQKTLEVEKR SVQCLYTSSA FPSGKPQPHS SVVYSEAGKD 
KGPPPKSRYE EELRTRGKTT ITAANFIDVI ITRQIASDKD ARERGSQSSD SSSSLSSHRY 
ETPSDAIEVI SPASSPAPPQ EKLQTYQPEV VKANQAENDP TRQYEGPLHH YRPQQESPSP 
QQQLPPSSQA EGMGQVPRTH RLITLADHIC QIITQDFARN QVSSQTPQQP PTSTFQNSPS 
ALVSTPVRTK TSNRYSPESQ AQSVHHQRPG SRVSPENLVD KSRGSRPGKS PERSHVSSEP 
YEPISPPQVP VVHEKQDSLL LLSQRGAEPA EQRNDARSPG SISYLPSFFT KLENTSPMVK 
SKKQEIFRKL NSSGGGDSDM AAAQPGTEIF NLPAVTTSGS VSSRGHSFAD PASNLGLEDI 
IRKALMGSFD DKVEDHGVVM SQPMGVVPGT ANTSVVTSGE TRREEGDPSP HSGGVCKPKL 
ISKSNSRKSK SPIPGQGYLG TERPSSVSSV HSEGDYHRQT PGWAWEDRPS STGSTQFPYN 
PLTMRMLSST PPTPIACAPS AVNQAAPHQQ NRIWEREPAP LLSAQYETLS DSDD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.