Details for: GTF2I

Gene ID: 2969

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: GTF2I

Ensembl ID: ENSG00000263001

Description: general transcription factor IIi

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • ciliated epithelial cell CL0000067
    CSI 58.08
    rCSI 51.07%
    PRS 9.28
  • fallopian tube secretory epithelial cell CL4030006
    CSI 54.85
    rCSI 52.8%
    PRS 13.25
  • multi-ciliated epithelial cell CL0005012
    CSI 38.35
    rCSI 38.27%
    PRS 10.93
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 34.91
    rCSI 49.49%
    PRS 11.9
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 32.78
    rCSI 55.03%
    PRS 7.51
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 31.76
    rCSI 82.1%
    PRS 11.93
  • pancreatic A cell CL0000171
    CSI 27.79
    rCSI 29.12%
    PRS 13.68
  • adipocyte CL0000136
    CSI 27.18
    rCSI 34.9%
    PRS 12.84
  • epithelial cell of lung CL0000082
    CSI 27.11
    rCSI 22.47%
    PRS 12.07
  • ciliated cell CL0000064
    CSI 26.87
    rCSI 43.53%
    PRS 13.04
  • retinal ganglion cell CL0000740
    CSI 26.73
    rCSI 59.05%
    PRS 9.22
  • GABAergic amacrine cell CL4030027
    CSI 26.64
    rCSI 91.25%
    PRS 11.37
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 25.19
    rCSI 44.48%
    PRS 7.47
  • sncg GABAergic cortical interneuron CL4023015
    CSI 24.47
    rCSI 39.35%
    PRS 8.23
  • mesodermal cell CL0000222
    CSI 23.37
    rCSI 28.05%
    PRS 12.64
  • VIP GABAergic cortical interneuron CL4023016
    CSI 23.01
    rCSI 27.49%
    PRS 7.36
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 21.43
    rCSI 52.07%
    PRS 7.31
  • stem cell CL0000034
    CSI 21.42
    rCSI 20.65%
    PRS 8.82
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 21.18
    rCSI 50.67%
    PRS 7.02
  • L6b glutamatergic cortical neuron CL4023038
    CSI 19.94
    rCSI 62.33%
    PRS 8.03
  • enteric smooth muscle cell CL0002504
    CSI 19.85
    rCSI 28.33%
    PRS 14.42
  • pancreatic ductal cell CL0002079
    CSI 19.07
    rCSI 37.1%
    PRS 13.06
  • H1 horizontal cell CL0004217
    CSI 18.28
    rCSI 72.39%
    PRS 18.05
  • cardiac muscle cell CL0000746
    CSI 16.9
    rCSI 24.25%
    PRS 9.94
  • pvalb GABAergic cortical interneuron CL4023018
    CSI 16.85
    rCSI 20.96%
    PRS 6.99
  • H2 horizontal cell CL0004218
    CSI 16.02
    rCSI 79.66%
    PRS 13.91
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 15.72
    rCSI 49.15%
    PRS 8.61
  • placental villous trophoblast CL2000060
    CSI 15.43
    rCSI 23.84%
    PRS 11.98
  • hepatic stellate cell CL0000632
    CSI 15.39
    rCSI 57.67%
    PRS 10.83
  • deuterosomal cell CL4033044
    CSI 15.33
    rCSI 51.82%
    PRS 21.53
  • parietal epithelial cell CL1000452
    CSI 15.32
    rCSI 40.94%
    PRS 10.86
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 15.2
    rCSI 57.43%
    PRS 7.65
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 15.16
    rCSI 49.83%
    PRS 6.6
  • epithelial cell CL0000066
    CSI 15.03
    rCSI 23.09%
    PRS 18.19
  • hematopoietic stem cell CL0000037
    CSI 14.95
    rCSI 9.94%
    PRS 15.25
  • ciliated columnar cell of tracheobronchial tree CL0002145
    CSI 14.72
    rCSI 33.54%
    PRS 13.36
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 14.68
    rCSI 52.83%
    PRS 6.98
  • rod bipolar cell CL0000751
    CSI 14.67
    rCSI 26.36%
    PRS 10.67
  • invaginating midget bipolar cell CL4033034
    CSI 14.57
    rCSI 86.04%
    PRS 13.31
  • diffuse bipolar 3a cell CL4033029
    CSI 14.3
    rCSI 97.32%
    PRS 12.76
  • neuroendocrine cell CL0000165
    CSI 13.92
    rCSI 53.84%
    PRS 26.37
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 13.77
    rCSI 71.07%
    PRS 25.1
  • sst GABAergic cortical interneuron CL4023017
    CSI 13.48
    rCSI 17.38%
    PRS 7.87
  • midbrain dopaminergic neuron CL2000097
    CSI 13.36
    rCSI 85.57%
    PRS 19.44
  • S cone cell CL0003050
    CSI 13.03
    rCSI 57.25%
    PRS 9.44
  • diffuse bipolar 6 cell CL4033032
    CSI 12.99
    rCSI 68.28%
    PRS 14.76
  • keratinocyte CL0000312
    CSI 12.73
    rCSI 10.67%
    PRS 15.3
  • M cell of gut CL0000682
    CSI 12.41
    rCSI 13.19%
    PRS 22.71
  • glycinergic amacrine cell CL4030028
    CSI 12.09
    rCSI 31.51%
    PRS 12.61
  • OFFx cell CL4033036
    CSI 12.06
    rCSI 56.71%
    PRS 12.46
  • pancreatic D cell CL0000173
    CSI 12
    rCSI 11.81%
    PRS 13.91
  • small intestine goblet cell CL1000495
    CSI 11.93
    rCSI 26.12%
    PRS 17.05
  • enteroendocrine cell of small intestine CL0009006
    CSI 11.48
    rCSI 25.26%
    PRS 19.62
  • epithelial cell of proximal tubule CL0002306
    CSI 11.07
    rCSI 27.04%
    PRS 12.77
  • intrahepatic cholangiocyte CL0002538
    CSI 10.9
    rCSI 26.15%
    PRS 23.21
  • retinal cone cell CL0000573
    CSI 10.86
    rCSI 17.48%
    PRS 9.84
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 10.84
    rCSI 63.8%
    PRS 7.85
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 10.79
    rCSI 9.74%
    PRS 11.31
  • diffuse bipolar 1 cell CL4033027
    CSI 10.63
    rCSI 79.87%
    PRS 11.43
  • hepatocyte CL0000182
    CSI 10.54
    rCSI 18.86%
    PRS 11.93
  • transit amplifying cell of small intestine CL0009012
    CSI 10.45
    rCSI 45.86%
    PRS 23.82
  • goblet cell CL0000160
    CSI 10.25
    rCSI 9.69%
    PRS 13.37
  • pancreatic epsilon cell CL0005019
    CSI 10.23
    rCSI 47.71%
    PRS 30.4
  • common myeloid progenitor CL0000049
    CSI 10.18
    rCSI 8.23%
    PRS 12.63
  • inhibitory interneuron CL0000498
    CSI 10.12
    rCSI 23.35%
    PRS 10.36
  • flat midget bipolar cell CL4033033
    CSI 10.08
    rCSI 72.03%
    PRS 12.26
  • kidney connecting tubule epithelial cell CL1000768
    CSI 10.01
    rCSI 25.38%
    PRS 9.76
  • diffuse bipolar 3b cell CL4033030
    CSI 9.96
    rCSI 66.08%
    PRS 12.95
  • intestinal tuft cell CL0019032
    CSI 9.93
    rCSI 15.17%
    PRS 14.64
  • medium spiny neuron CL1001474
    CSI 9.82
    rCSI 84.65%
    PRS 4.12
  • lung secretory cell CL1000272
    CSI 9.56
    rCSI 23.67%
    PRS 11.81
  • club cell CL0000158
    CSI 9.4
    rCSI 13.76%
    PRS 14.93
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 9.18
    rCSI 35.75%
    PRS 20.94
  • epicardial adipocyte CL1000309
    CSI 9.02
    rCSI 29.34%
    PRS 15.47
  • mammary gland epithelial cell CL0002327
    CSI 8.87
    rCSI 31.13%
    PRS 23.18
  • renal beta-intercalated cell CL0002201
    CSI 8.85
    rCSI 21.1%
    PRS 15.32
  • epithelial cell of lower respiratory tract CL0002632
    CSI 8.8
    rCSI 6.82%
    PRS 12.19
  • early lymphoid progenitor CL0000936
    CSI 8.7
    rCSI 7.64%
    PRS 14.37
  • endothelial cell of placenta CL0009092
    CSI 8.69
    rCSI 42.82%
    PRS 17.42
  • glutamatergic neuron CL0000679
    CSI 8.63
    rCSI 17.74%
    PRS 13.02
  • nasal mucosa goblet cell CL0002480
    CSI 8.58
    rCSI 9.95%
    PRS 18.88
  • diffuse bipolar 2 cell CL4033028
    CSI 8.52
    rCSI 65.99%
    PRS 12.75
  • pro-B cell CL0000826
    CSI 8.45
    rCSI 7%
    PRS 12.78
  • colon goblet cell CL0009039
    CSI 8.29
    rCSI 19.71%
    PRS 19.27
  • unswitched memory B cell CL0000970
    CSI 8.25
    rCSI 6.94%
    PRS 20.6
  • common lymphoid progenitor CL0000051
    CSI 8.23
    rCSI 11%
    PRS 24.38
  • tuft cell of colon CL0009041
    CSI 7.89
    rCSI 18.39%
    PRS 26.98
  • paneth cell CL0000510
    CSI 7.89
    rCSI 11.65%
    PRS 20.14
  • retina horizontal cell CL0000745
    CSI 7.85
    rCSI 11.97%
    PRS 11.97
  • starburst amacrine cell CL0004232
    CSI 7.48
    rCSI 62.99%
    PRS 12.97
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 7.44
    rCSI 22.94%
    PRS 19.91
  • cardiac endothelial cell CL0010008
    CSI 7.28
    rCSI 29.35%
    PRS 11.37
  • pancreatic PP cell CL0002275
    CSI 7.24
    rCSI 28.84%
    PRS 22.49
  • mononuclear phagocyte CL0000113
    CSI 7.18
    rCSI 15.8%
    PRS 14.12
  • tracheal goblet cell CL1000329
    CSI 6.93
    rCSI 15.14%
    PRS 25.75
  • neuroblast (sensu Vertebrata) CL0000031
    CSI 6.82
    rCSI 8.76%
    PRS 12.44
  • central nervous system neuron CL2000029
    CSI 6.77
    rCSI 49.78%
    PRS 6.52
  • interneuron CL0000099
    CSI 6.77
    rCSI 13.58%
    PRS 9.48
  • inflammatory macrophage CL0000863
    CSI 6.55
    rCSI 11.19%
    PRS 25.68
  • retinal bipolar neuron CL0000748
    CSI 6.43
    rCSI 12.05%
    PRS 9.27
  • elicited macrophage CL0000861
    CSI -6.9
    rCSI -6.3%
    PRS 14.6%
  • CD14-positive monocyte CL0001054
    CSI -6.4
    rCSI -7.9%
    PRS 18.0%
  • foveolar cell of stomach CL0002179
    CSI -5.1
    rCSI -10.9%
    PRS 20.6%
  • CD8-positive, CD28-negative, alpha-beta regulatory T cell CL0000920
    CSI -5.0
    rCSI -10.0%
    PRS 21.2%
  • kidney loop of Henle thick ascending limb epithelial cell CL1001106
    CSI -2.6
    rCSI -22.8%
    PRS 22.8%
  • CD4-positive, alpha-beta memory T cell CL0000897
    CSI -2.4
    rCSI -1.7%
    PRS 17.4%
  • platelet CL0000233
    CSI -2.3
    rCSI -9.5%
    PRS 26.8%
  • granulocyte CL0000094
    CSI -2.1
    rCSI -3.1%
    PRS 16.2%
  • alpha-beta T cell CL0000789
    CSI -1.7
    rCSI -2.0%
    PRS 17.1%
  • contractile cell CL0000183
    CSI -0.6
    rCSI -1.9%
    PRS 9.9%
  • podocyte CL0000653
    CSI -0.5
    rCSI -2.3%
    PRS 12.6%
  • vasa recta descending limb cell CL1001285
    CSI -0.4
    rCSI -3.3%
    PRS 50.0%
  • lung macrophage CL1001603
    CSI -0.2
    rCSI -0.4%
    PRS 14.5%
  • tracheobronchial smooth muscle cell CL0019019
    CSI -0.1
    rCSI -0.2%
    PRS 16.9%
  • syncytiotrophoblast cell CL0000525
    CSI 0.1
    rCSI 0.2%
    PRS 24.9%
  • mesenchymal lymphangioblast CL0005021
    CSI 0.1
    rCSI 1.9%
    PRS 55.6%
  • brain vascular cell CL4023072
    CSI 0.1
    rCSI 0.8%
    PRS 12.2%
  • odontoblast CL0000060
    CSI 0.1
    rCSI 1.8%
    PRS 54.4%
  • Merkel cell CL0000242
    CSI 0.1
    rCSI 2.6%
    PRS 71.4%
  • colon macrophage CL0009038
    CSI 0.1
    rCSI 0.6%
    PRS 26.4%
  • epithelial cell of urethra CL1000296
    CSI 0.1
    rCSI 3.3%
    PRS 40.4%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.2
    rCSI 1.7%
    PRS 17.8%
  • cytotoxic T cell CL0000910
    CSI 0.2
    rCSI 0.9%
    PRS 18.7%
  • erythroblast CL0000765
    CSI 0.2
    rCSI 0.4%
    PRS 21.1%
  • glial cell CL0000125
    CSI 0.2
    rCSI 0.9%
    PRS 13.0%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.2
    rCSI 1.6%
    PRS 25.0%
  • metallothionein-positive alveolar macrophage CL4033042
    CSI 0.3
    rCSI 2.7%
    PRS 48.3%
  • lung pericyte CL0009089
    CSI 0.3
    rCSI 0.8%
    PRS 15.3%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.3
    rCSI 0.8%
    PRS 19.8%
  • bronchiolar smooth muscle cell CL4033017
    CSI 0.3
    rCSI 4.5%
    PRS 39.7%
  • regular ventricular cardiac myocyte CL0002131
    CSI 0.3
    rCSI 2.0%
    PRS 10.0%
  • basal-myoepithelial cell of mammary gland CL0002324
    CSI 0.3
    rCSI 0.6%
    PRS 27.8%
  • cerebellar neuron CL1001611
    CSI 0.3
    rCSI 3.0%
    PRS 5.2%
  • erythroid progenitor cell CL0000038
    CSI 0.4
    rCSI 2.0%
    PRS 19.8%
  • mesenchymal cell CL0008019
    CSI 0.4
    rCSI 0.9%
    PRS 13.0%
  • paneth cell of colon CL0009009
    CSI 0.4
    rCSI 3.5%
    PRS 36.1%
  • mesenchymal stem cell CL0000134
    CSI 0.4
    rCSI 3.9%
    PRS 23.1%
  • kidney connecting tubule principal cell CL4030018
    CSI 0.4
    rCSI 2.8%
    PRS 66.0%
  • eye photoreceptor cell CL0000287
    CSI 0.4
    rCSI 4.3%
    PRS 32.1%
  • blood vessel smooth muscle cell CL0019018
    CSI 0.4
    rCSI 3.1%
    PRS 13.2%
  • effector CD4-positive, alpha-beta T cell CL0001044
    CSI 0.4
    rCSI 1.1%
    PRS 18.6%
  • squamous epithelial cell CL0000076
    CSI 0.4
    rCSI 0.9%
    PRS 16.2%
  • collagen secreting cell CL0000667
    CSI 0.4
    rCSI 2.3%
    PRS 44.9%
  • dendritic cell, human CL0001056
    CSI 0.4
    rCSI 0.6%
    PRS 14.9%
  • serotonergic neuron CL0000850
    CSI 0.5
    rCSI 2.1%
    PRS 5.1%
  • myeloid dendritic cell, human CL0001057
    CSI 0.5
    rCSI 2.9%
    PRS 40.0%
  • group 2 innate lymphoid cell CL0001069
    CSI 0.5
    rCSI 2.8%
    PRS 42.7%
  • germinal center B cell CL0000844
    CSI 0.5
    rCSI 1.6%
    PRS 31.6%
  • alveolar adventitial fibroblast CL4028006
    CSI 0.5
    rCSI 0.9%
    PRS 12.8%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 0.6
    rCSI 3.9%
    PRS 14.3%
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 0.6
    rCSI 0.4%
    PRS 11.6%
  • alternatively activated macrophage CL0000890
    CSI 0.6
    rCSI 0.8%
    PRS 19.5%
  • myelocyte CL0002193
    CSI 0.6
    rCSI 4.0%
    PRS 40.5%
  • CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell CL0000915
    CSI 0.7
    rCSI 2.9%
    PRS 44.0%
  • lung microvascular endothelial cell CL2000016
    CSI 0.7
    rCSI 13.2%
    PRS 39.8%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 0.7
    rCSI 0.9%
    PRS 17.9%
  • mucus secreting cell CL0000319
    CSI 0.7
    rCSI 1.1%
    PRS 16.5%
  • macroglial cell CL0000126
    CSI 0.7
    rCSI 1.8%
    PRS 18.1%
  • promonocyte CL0000559
    CSI 0.7
    rCSI 1.2%
    PRS 17.1%
  • renal principal cell CL0005009
    CSI 0.7
    rCSI 1.9%
    PRS 17.0%
  • kidney epithelial cell CL0002518
    CSI 0.8
    rCSI 1.4%
    PRS 30.1%
  • keratocyte CL0002363
    CSI 0.8
    rCSI 1.9%
    PRS 19.1%
  • fibroblast of breast CL4006000
    CSI 0.8
    rCSI 3.3%
    PRS 32.7%
  • neural progenitor cell CL0011020
    CSI 0.8
    rCSI 3.6%
    PRS 12.5%
  • myeloid dendritic cell CL0000782
    CSI 0.8
    rCSI 1.2%
    PRS 18.8%
  • CD34-positive, CD56-positive, CD117-positive common innate lymphoid precursor, human CL0001074
    CSI 0.9
    rCSI 10.0%
    PRS 47.6%
  • dopaminergic neuron CL0000700
    CSI 0.9
    rCSI 4.9%
    PRS 5.2%
  • eosinophil CL0000771
    CSI 0.9
    rCSI 5.8%
    PRS 33.0%
  • megakaryocyte CL0000556
    CSI 0.9
    rCSI 3.9%
    PRS 23.0%
  • pancreatic stellate cell CL0002410
    CSI 0.9
    rCSI 5.4%
    PRS 19.2%
  • transitional stage B cell CL0000818
    CSI 0.9
    rCSI 3.0%
    PRS 35.6%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 1.0
    rCSI 1.2%
    PRS 15.0%
  • muscle cell CL0000187
    CSI 1.0
    rCSI 2.0%
    PRS 29.7%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 1.0
    rCSI 0.7%
    PRS 15.4%
  • OFF-bipolar cell CL0000750
    CSI 1.0
    rCSI 1.4%
    PRS 20.8%
  • tracheobronchial serous cell CL0019001
    CSI 1.0
    rCSI 4.4%
    PRS 24.5%
  • pulmonary artery endothelial cell CL1001568
    CSI 1.0
    rCSI 1.4%
    PRS 19.5%
  • small pre-B-II cell CL0000954
    CSI 1.1
    rCSI 1.0%
    PRS 26.4%
  • antibody secreting cell CL0000946
    CSI 1.1
    rCSI 4.7%
    PRS 49.9%
  • conjunctival epithelial cell CL1000432
    CSI 1.1
    rCSI 1.7%
    PRS 12.8%
  • skin fibroblast CL0002620
    CSI 1.1
    rCSI 1.0%
    PRS 20.7%
  • class switched memory B cell CL0000972
    CSI 1.1
    rCSI 0.8%
    PRS 21.5%
  • basket cell CL0000118
    CSI 1.1
    rCSI 7.1%
    PRS 5.8%
  • renal alpha-intercalated cell CL0005011
    CSI 1.1
    rCSI 1.5%
    PRS 17.0%
  • CD4-positive helper T cell CL0000492
    CSI 1.1
    rCSI 0.9%
    PRS 17.7%
  • colonocyte CL1000347
    CSI 1.1
    rCSI 1.6%
    PRS 17.6%
  • transit amplifying cell of colon CL0009011
    CSI 1.2
    rCSI 1.4%
    PRS 15.1%
  • hair follicular keratinocyte CL2000092
    CSI 1.2
    rCSI 21.6%
    PRS 49.4%
  • Bergmann glial cell CL0000644
    CSI 1.3
    rCSI 1.7%
    PRS 13.0%
  • acinar cell of salivary gland CL0002623
    CSI 1.3
    rCSI 29.6%
    PRS 22.9%
  • intermediate monocyte CL0002393
    CSI 1.3
    rCSI 2.0%
    PRS 12.6%
  • Langerhans cell CL0000453
    CSI 1.3
    rCSI 2.0%
    PRS 22.3%
  • bronchial goblet cell CL1000312
    CSI 1.3
    rCSI 5.3%
    PRS 28.0%
  • effector CD8-positive, alpha-beta T cell CL0001050
    CSI 1.3
    rCSI 1.0%
    PRS 16.7%
  • vasa recta ascending limb cell CL1001131
    CSI 1.4
    rCSI 6.1%
    PRS 45.7%
  • primitive red blood cell CL0002355
    CSI 1.4
    rCSI 7.4%
    PRS 23.9%
  • serous secreting cell CL0000313
    CSI 1.4
    rCSI 6.9%
    PRS 49.9%
  • central memory CD4-positive, alpha-beta T cell CL0000904
    CSI 1.4
    rCSI 0.8%
    PRS 17.6%
  • effector memory CD8-positive, alpha-beta T cell, terminally differentiated CL0001062
    CSI 1.5
    rCSI 7.3%
    PRS 16.7%
  • retinal blood vessel endothelial cell CL0002585
    CSI 1.5
    rCSI 2.3%
    PRS 14.0%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary General Transcription Factor IIi, encoded by the [GTF2I](/details-gene/2969) gene, is a multifunctional phosphoprotein that acts as a core component of the transcription machinery. It plays a crucial role in initiating transcription by RNA polymerase II through its DNA and protein binding activities. While broadly expressed, its significance is particularly pronounced in specialized cell types, including various [ciliated epithelial cells](/details-cell/CL0000067) and [fallopian tube secretory epithelial cells](/details-cell/CL4030006), as well as specific neuronal and endocrine populations. Clinically, heterozygous deletion of [GTF2I](/details-gene/2969) is associated with the multisystem neurodevelopmental disorder Williams-Beuren syndrome ([OMIM: 601679](https://omim.org/entry/601679)). ## Cellular Roles and Expression Landscape The expression profile of [GTF2I](/details-gene/2969) indicates a foundational role in cellular transcription, with particularly high significance in specialized, functionally active cell types. **Overall**, the gene shows its highest Cell Significance Index (CSI) in epithelial lineages, especially those involved in barrier function, secretion, and motility. Top-ranking cells include [ciliated epithelial cell](/details-cell/CL0000067) (CSI: 58.08), [fallopian tube secretory epithelial cell](/details-cell/CL4030006) (CSI: 54.85), and [multi-ciliated epithelial cell](/details-cell/CL0005012) (CSI: 38.35). This pattern extends to other specialized epithelial cells, such as those in the kidney's loop of Henle and lung epithelia, suggesting a key role in maintaining the transcriptional programs of these highly differentiated tissues. Additionally, [GTF2I](/details-gene/2969) is a significant factor in certain neuronal populations, like [lamp5 GABAergic cortical interneurons](/details-cell/CL4023011), and endocrine cells, such as [pancreatic A cells](/details-cell/CL0000171). In stark contrast, [GTF2I](/details-gene/2969) displays low to negative CSI values across numerous hematopoietic lineages. It is a notable anti-marker for myeloid cells, including [elicited macrophage](/details-cell/CL0000861) (CSI: -6.88) and [CD14-positive monocyte](/details-cell/CL0001054) (CSI: -6.35), as well as for various T cell subsets. This suggests that while [GTF2I](/details-gene/2969) is a general transcription factor, its function may be less central or perhaps superseded by lineage-specific factors in the context of mature immune cell identity and function. This finding is interesting given literature describing its role as a phosphorylation target of Bruton's tyrosine kinase in B cell receptor signaling ([Link](https://doi.org/10.1073/pnas.94.2.604)), which may point to context- or cell-subset-specific roles within the immune system not captured in this broad overview. ## Pathways and Molecular Function Functionally, [GTF2I](/details-gene/2969) is integral to the regulation of gene expression. Gene Ontology annotations confirm its role in [Positive regulation of transcription by rna polymerase ii ([GO:0045944](https://www.ebi.ac.uk/QuickGO/term/GO:0045944))](https://www.ebi.ac.uk/QuickGO/term/GO:0045944) and the core process of [Transcription by rna polymerase ii ([GO:0006366](https://www.ebi.ac.uk/QuickGO/term/GO:0006366))](https://www.ebi.ac.uk/QuickGO/term/GO:0006366). Its molecular activities are characterized by [Dna binding ([GO:0003677](https://www.ebi.ac.uk/QuickGO/term/GO:0003677))](https://www.ebi.ac.uk/QuickGO/term/GO:0003677), [Dna-binding transcription factor activity ([GO:0003700](https://www.ebi.ac.uk/QuickGO/term/GO:0003700))](https://www.ebi.ac.uk/QuickGO/term/GO:0003700), and [Protein binding ([GO:0005515](https://www.ebi.ac.uk/QuickGO/term/GO:0005515))](https://www.ebi.ac.uk/QuickGO/term/GO:0005515), reflecting its ability to interact with both the initiator (Inr) element of core promoters and other regulatory proteins like USF1 ([Link](https://doi.org/10.1093/emboj/16.23.7091)). The protein is localized to the [Nucleus ([GO:0005634](https://www.ebi.ac.uk/QuickGO/term/GO:0005634))](https://www.ebi.ac.uk/QuickGO/term/GO:0005634) and [Cytoplasm ([GO:0005737](https://www.ebi.ac.uk/QuickGO/term/GO:0005737))](https://www.ebi.ac.uk/QuickGO/term/GO:0005737), indicating that its activity may be regulated through nucleocytoplasmic shuttling, a process known to be influenced by signaling pathways such as BTK activation ([Link](https://doi.org/10.1128/mcb.19.7.5014)). An additional annotated function is the [Negative regulation of angiogenesis ([GO:0016525](https://www.ebi.ac.uk/QuickGO/term/GO:0016525))](https://www.ebi.ac.uk/QuickGO/term/GO:0016525), suggesting broader roles in tissue homeostasis beyond basal transcription. ## Research Directions The data highlights a distinct expression pattern for [GTF2I](/details-gene/2969), pointing towards specialized functions that warrant further investigation. **Proposed Hypotheses:** 1. The exceptionally high significance of [GTF2I](/details-gene/2969) in [ciliated](/details-cell/CL0000067) and [secretory epithelial cells](/details-cell/CL4030006) suggests it orchestrates a specific transcriptional program essential for cellular differentiation and function in these tissues, such as ciliogenesis or mucin production, which goes beyond its general housekeeping role. 2. The marked lack of significance of [GTF2I](/details-gene/2969) in mature myeloid and T-lymphoid lineages suggests its expression is actively suppressed or its function is made redundant by lineage-defining transcription factors to maintain specific immune cell identities. **Experimental Approach:** To test the first hypothesis regarding the role of [GTF2I](/details-gene/2969) in epithelial specialization, one could utilize an air-liquid interface (ALI) culture model with primary human bronchial epithelial cells. Knockdown of [GTF2I](/details-gene/2969) using CRISPR interference (CRISPRi) prior to differentiation could be performed. The subsequent effects on epithelial differentiation could be quantified by immunofluorescence microscopy for ciliary (e.g., acetylated tubulin) and secretory cell (e.g., MUC5AC) markers. RNA-sequencing of the knockdown cells would identify downstream target genes, revealing the specific pathways regulated by [GTF2I](/details-gene/2969) in this context. **Therapeutic Potential:** As a core transcription factor, [GTF2I](/details-gene/2969) presents a challenging therapeutic target due to the high risk of off-target effects. Its haploinsufficiency is causative for Williams-Beuren syndrome, indicating that systemic inhibition would likely be pathogenic. Therefore, strategies aimed at inhibiting its function would be unsuitable for most conditions. In specific malignancies where [GTF2I](/details-gene/2969) may be part of an oncogenic fusion protein or is aberrantly overexpressed, targeting its specific protein-protein interactions could be a viable, albeit complex, strategy. Therapeutic activation to address haploinsufficiency is currently beyond the scope of conventional drug development.

Genular Protein ID: 2191030026

Symbol: GTF2I_HUMAN

Name: General transcription factor II-I

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 9384587

Title: Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1.

PubMed ID: 9384587

DOI: 10.1093/emboj/16.23.7091

PubMed ID: 9334314

Title: A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.

PubMed ID: 9334314

DOI: 10.1101/gad.11.19.2482

PubMed ID: 9012831

Title: BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.

PubMed ID: 9012831

DOI: 10.1073/pnas.94.2.604

PubMed ID: 9466987

Title: A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK.

PubMed ID: 9466987

DOI: 10.1093/hmg/7.3.325

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373551

Title: Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase.

PubMed ID: 10373551

DOI: 10.1128/mcb.19.7.5014

PubMed ID: 11373296

Title: Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.

PubMed ID: 11373296

DOI: 10.1074/jbc.m103692200

PubMed ID: 12082086

Title: cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.

PubMed ID: 12082086

DOI: 10.1074/jbc.m112332200

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16738337

Title: Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.

PubMed ID: 16738337

DOI: 10.1128/mcb.02009-05

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31900622

Title: GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.

PubMed ID: 31900622

DOI: 10.1007/s00018-019-03440-7

Sequence Information:

  • Length: 998
  • Mass: 112416
  • Checksum: 4CFA2C19002869B9
  • Sequence:
  • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
    RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
    CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
    SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
    EESEDPDYYQ YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDSTQHVP 
    SETSEDPEVE VTIEDDDYSP PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD 
    LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE 
    RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE 
    ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR 
    PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 
    ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK 
    INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE 
    FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF 
    RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG 
    VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 
    PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE 
    GPVIQESAEP SQLEVPATEE IKETDGSSQI KQEPDPTW

Genular Protein ID: 804126317

Symbol: A8K9W7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 978
  • Mass: 110208
  • Checksum: 1FAA4EDECD7724E8
  • Sequence:
  • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
    RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
    CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
    SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
    EESEDPDYYQ YNIQGSHHSS EGNEGTEMEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 
    PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD LRKQVEELFE RKYAQAIKAK 
    GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN 
    STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 
    DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE VTQPRTNTPV 
    KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF ESNPEFLYVG GLPEGIPFRS 
    PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK INTKALQSPK RPRSPGSNSK 
    VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL 
    FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 
    IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT IPDDDNERLS 
    KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY 
    LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE GPVIQESAEP SQLEVPATEE 
    IKETDGSSQI KQEPDPTW

Genular Protein ID: 1442034434

Symbol: X5D2J9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 957
  • Mass: 107970
  • Checksum: E091B620FF633AC8
  • Sequence:
  • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
    RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
    CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
    SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
    EESEDPDYYQ YNIQGSHHSS EGNEGTEMEV PAEDDDYSPP SKRPKANELP QPPVPEPANA 
    GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG PVTIPYPLFQ SHVEDLYVEG 
    LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS TREDLQLDKP ASGVKEEWYA 
    RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND LYVEGLPENI PFRSPSWYGI 
    PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK EDWNVRITKL RKQVEEIFNL 
    KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP TWFGIPRLER IVRGSNKIKF 
    VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV PEIEVTVEGP NNNNPQTSAV 
    RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF NEKCGEALGL KQAVKVPFAL 
    FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI KFIIKKPEMF ETAIKESTSS 
    KSPPRKINSS PNVNTTASGV EDLNIIQVTI PDDDNERLSK VEKARQLREQ VNDLFSRKFG 
    EAIGMGFPVK VPYRKITINP GCVVVDGMPP GVSFKAPSYL EISSMRRILD SAEFIKFTVI 
    RPFPGLVINN QLVDQSESEG PVIQESAEPS QLEVPATEEI KETDGSSQIK QEPDPTW

Genular Protein ID: 2203699117

Symbol: Q499G6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 976
  • Mass: 110080
  • Checksum: C25BEE75CDED523E
  • Sequence:
  • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
    RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
    CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
    SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
    EESEDPDYYQ YNIQGPSETD DVDEKQPLSK PLQGSHHSSE GNEGTEMEVP AEDDDYSPPS 
    KRPKANELPQ PPVPEPANAG KRKVREFNFE KWNARITDLR KQVEELFERK YAQAIKAKGP 
    VTIPYPLFQS HVEDLYVEGL PEGIPFRRPS TYGIPRLERI LLAKERIRFV IKKHELLNST 
    REDLQLDKPA SGVKEEWYAR ITKLRKMVDQ LFCKKFAEAL GSTEAKAVPY QKFEAHPNDL 
    YVEGLPENIP FRSPSWYGIP RLEKIIQVGN RIKFVIKRPE LLTHSTTEVT QPRTNTPVKE 
    DWNVRITKLR KQVEEIFNLK FAQALGLTEA VKVPYPVFES NPEFLYVEGL PEGIPFRSPT 
    WFGIPRLERI VRGSNKIKFV VKKPELVISY LPPGMASKIN TKALQSPKRP RSPGSNSKVP 
    EIEVTVEGPN NNNPQTSAVR TPTQTNGSNV PFKPRGREFS FEAWNAKITD LKQKVENLFN 
    EKCGEALGLK QAVKVPFALF ESFPEDFYVE GLPEGVPFRR PSTFGIPRLE KILRNKAKIK 
    FIIKKPEMFE TAIKESTSSK SPPRKINSSP NVNTTASGVE DLNIIQVTIP DDDNERLSKV 
    EKARQLREQV NDLFSRKFGE AIGMGFPVKV PYRKITINRG CVVVDGMPPG VSFKAPSYLE 
    ISSMRRILDS AEFIKFTVIR PFPGLVVNNQ LVDQSESEGP VIQESAEPSQ LEVPATEEIK 
    ETDGSSQIKQ EPDPTW

Genular Protein ID: 2415940495

Symbol: X5DNP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 978
  • Mass: 110280
  • Checksum: 1F006D480F0BE702
  • Sequence:
  • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
    RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
    CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
    SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
    EESEDPDYYQ YNIQGSHHSS EGNEGTEMEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 
    PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD LRKQVEELFE RKYAQAIKAK 
    GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN 
    STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 
    DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE VTQPRTNTPV 
    KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF ESNPEFLYVE GLPEGIPFRS 
    PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK INTKALQSPK RPRSPGSNSK 
    VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL 
    FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 
    IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT IPDDDNERLS 
    KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY 
    LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE GPVIQESAEP SQLEVPATEE 
    IKETDGSSQI KQEPDPTW

Genular Protein ID: 3067323723

Symbol: X5D939_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 977
  • Mass: 110106
  • Checksum: 418D59EC623E6141
  • Sequence:
  • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
    RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
    CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
    SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
    EESEDPDYYQ YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDDDYSPP 
    SKRPKANELP QPPVPEPANA GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG 
    PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS 
    TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND 
    LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK 
    EDWNVRITKL RKQVEEIFNL KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP 
    TWFGIPRLER IVRGSNKIKF VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV 
    PEIEVTVEGP NNNNPQTSAV RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF 
    NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI 
    KFIIKKPEMF ETAIKESTSS KSPPRKINSS PNVNTTASGV EDLNIIQVTI PDDDNERLSK 
    VEKARQLREQ VNDLFSRKFG EAIGMGFPVK VPYRKITINP GCVVVDGMPP GVSFKAPSYL 
    EISSMRRILD SAEFIKFTVI RPFPGLVINN QLVDQSESEG PVIQESAEPS QLEVPATEEI 
    KETDGSSQIK QEPDPTW