Details for: GTF2I

Gene ID: 2969

Symbol: GTF2I

Ensembl ID: ENSG00000263001

Description: general transcription factor IIi

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 270.3005
    Cell Significance Index: -127.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 239.7250
    Cell Significance Index: -97.3900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 221.4002
    Cell Significance Index: -113.8900
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 190.3439
    Cell Significance Index: -127.7300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 102.6454
    Cell Significance Index: -98.0000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 43.3899
    Cell Significance Index: -133.2700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 42.9586
    Cell Significance Index: -115.0800
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.8987
    Cell Significance Index: -43.5500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 10.0812
    Cell Significance Index: 104.3600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 4.7981
    Cell Significance Index: 134.0900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 4.1784
    Cell Significance Index: 234.4700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 3.8187
    Cell Significance Index: 234.7200
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 3.2129
    Cell Significance Index: 39.8500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 3.1894
    Cell Significance Index: 76.4900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 3.1679
    Cell Significance Index: 1136.2600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 3.0315
    Cell Significance Index: 601.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.8694
    Cell Significance Index: 517.2700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.7613
    Cell Significance Index: 339.5300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 2.6087
    Cell Significance Index: 135.8900
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 2.5688
    Cell Significance Index: 19.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.0332
    Cell Significance Index: 1406.2600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.0262
    Cell Significance Index: 406.4500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 1.9970
    Cell Significance Index: 203.9900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 1.8543
    Cell Significance Index: 1012.6800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.7438
    Cell Significance Index: 133.8200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.6801
    Cell Significance Index: 230.7300
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.6798
    Cell Significance Index: 13.0600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 1.6280
    Cell Significance Index: 109.4700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.5779
    Cell Significance Index: 54.8300
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.4926
    Cell Significance Index: 103.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.4738
    Cell Significance Index: 651.6200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.4659
    Cell Significance Index: 64.8400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.3751
    Cell Significance Index: 149.5700
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.3575
    Cell Significance Index: 87.5800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 1.2902
    Cell Significance Index: 48.8600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.1775
    Cell Significance Index: 33.9300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.1038
    Cell Significance Index: 10.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.9677
    Cell Significance Index: 50.8100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.9409
    Cell Significance Index: 24.7400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.8905
    Cell Significance Index: 19.0400
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.8869
    Cell Significance Index: 12.1000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.8340
    Cell Significance Index: 98.3500
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.6237
    Cell Significance Index: 44.1100
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.5777
    Cell Significance Index: 27.1500
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4388
    Cell Significance Index: 56.2500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.3297
    Cell Significance Index: 15.3700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.3259
    Cell Significance Index: 14.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3094
    Cell Significance Index: 16.0700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: 0.2926
    Cell Significance Index: 8.3500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.2922
    Cell Significance Index: 538.9300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2870
    Cell Significance Index: 54.6300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.2832
    Cell Significance Index: 436.0400
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.2239
    Cell Significance Index: 421.5800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1071
    Cell Significance Index: 2.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0924
    Cell Significance Index: 125.6300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0842
    Cell Significance Index: 61.7300
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0719
    Cell Significance Index: 45.6500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0565
    Cell Significance Index: 25.6500
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0562
    Cell Significance Index: 9.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0071
    Cell Significance Index: 0.1900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: -0.0242
    Cell Significance Index: -21.8100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0525
    Cell Significance Index: -5.1900
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0597
    Cell Significance Index: -45.2200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.1181
    Cell Significance Index: -87.4900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1279
    Cell Significance Index: -16.5200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1298
    Cell Significance Index: -18.8700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1299
    Cell Significance Index: -4.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1381
    Cell Significance Index: -10.3000
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1566
    Cell Significance Index: -3.4300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1947
    Cell Significance Index: -109.8100
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.2093
    Cell Significance Index: -130.7100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.2628
    Cell Significance Index: -3.8800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.3051
    Cell Significance Index: -52.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4120
    Cell Significance Index: -118.5400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.5188
    Cell Significance Index: -8.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5219
    Cell Significance Index: -59.7900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.5569
    Cell Significance Index: -35.1000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.5788
    Cell Significance Index: -121.9100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.7779
    Cell Significance Index: -90.6600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.9264
    Cell Significance Index: -96.4600
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.9575
    Cell Significance Index: -57.4800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9986
    Cell Significance Index: -79.0900
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.2025
    Cell Significance Index: -29.3400
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2119
    Cell Significance Index: -28.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.5028
    Cell Significance Index: -25.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.5510
    Cell Significance Index: -49.6800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -1.6578
    Cell Significance Index: -27.9300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -1.7242
    Cell Significance Index: -46.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.8245
    Cell Significance Index: -53.7400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.8480
    Cell Significance Index: -47.2100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.9990
    Cell Significance Index: -122.5600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -2.0907
    Cell Significance Index: -59.9300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -2.1288
    Cell Significance Index: -54.7200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -2.2128
    Cell Significance Index: -32.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.2250
    Cell Significance Index: -33.3400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -2.2809
    Cell Significance Index: -72.1400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -2.4218
    Cell Significance Index: -79.2900
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -2.4515
    Cell Significance Index: -30.5700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -2.4742
    Cell Significance Index: -45.7300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.5511
    Cell Significance Index: -68.2400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** GTF2I exhibits several key characteristics that distinguish it from other transcription factors. Firstly, it is a highly conserved protein, with high sequence similarity across species. This suggests that GTF2I has evolved to play a fundamental role in the regulation of gene expression, a process that is essential for cellular homeostasis. Secondly, GTF2I is a DNA-binding protein that interacts with specific DNA sequences, thereby modulating transcriptional activity. Finally, GTF2I is a RNA polymerase II-specific transcription factor, which implies that it is involved in the regulation of genes that are transcribed by RNA polymerase II. **Pathways and Functions** GTF2I is involved in various cellular pathways and functions, including: 1. **Transcriptional Regulation**: GTF2I regulates the expression of genes involved in cellular processes such as cell growth, differentiation, and survival. 2. **Angiogenesis**: GTF2I negatively regulates angiogenesis, a process that is essential for the formation of new blood vessels. 3. **Cellular Differentiation**: GTF2I is involved in the regulation of cellular differentiation, a process that is critical for the development and function of various cell types. 4. **Immune Response**: GTF2I is expressed in various immune cells, including inhibitory interneurons, which suggests that it may play a role in the regulation of the immune response. **Clinical Significance** GTF2I has been implicated in several human diseases, including: 1. **Angiogenesis-related Disorders**: GTF2I mutations have been associated with angiogenesis-related disorders, such as cancer and vascular diseases. 2. **Neurological Disorders**: GTF2I has been linked to neurological disorders, including autism spectrum disorder and schizophrenia. 3. **Immunological Disorders**: GTF2I is expressed in immune cells and has been implicated in immunological disorders, including autoimmune diseases. In conclusion, GTF2I is a complex transcription factor that plays a critical role in regulating gene expression, cellular differentiation, and the immune response. Its dysregulation has been implicated in various human diseases, highlighting the importance of GTF2I in maintaining cellular homeostasis and overall health. Further research is needed to fully elucidate the functions and clinical significance of GTF2I.

Genular Protein ID: 2191030026

Symbol: GTF2I_HUMAN

Name: General transcription factor II-I

UniProtKB Accession Codes:

P78347 O14743 O15359 O43546 O43588 O43589 Q75M85 Q75M86 Q75M87 Q75M88 Q86U51 Q9BSZ4

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CORUM 1 CPTAC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 5 EvolutionaryTrace 1 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneReviews 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MalaCards 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 2 PIRSF 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 5 Pumba 1 RNAct 1 RefSeq 6 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9384587

Title: Cloning of an inr- and E-box-binding protein, TFII-I, that interacts physically and functionally with USF1.

PubMed ID: 9384587

DOI: 10.1093/emboj/16.23.7091

PubMed ID: 9334314

Title: A multifunctional DNA-binding protein that promotes the formation of serum response factor/homeodomain complexes: identity to TFII-I.

PubMed ID: 9334314

DOI: 10.1101/gad.11.19.2482

PubMed ID: 9012831

Title: BAP-135, a target for Bruton's tyrosine kinase in response to B cell receptor engagement.

PubMed ID: 9012831

DOI: 10.1073/pnas.94.2.604

PubMed ID: 9466987

Title: A duplicated gene in the breakpoint regions of the 7q11.23 Williams-Beuren syndrome deletion encodes the initiator binding protein TFII-I and BAP-135, a phosphorylation target of BTK.

PubMed ID: 9466987

DOI: 10.1093/hmg/7.3.325

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10373551

Title: Regulation of nuclear localization and transcriptional activity of TFII-I by Bruton's tyrosine kinase.

PubMed ID: 10373551

DOI: 10.1128/mcb.19.7.5014

PubMed ID: 11373296

Title: Identification of phosphorylation sites for Bruton's tyrosine kinase within the transcriptional regulator BAP/TFII-I.

PubMed ID: 11373296

DOI: 10.1074/jbc.m103692200

PubMed ID: 12082086

Title: cGMP-dependent protein kinase I beta physically and functionally interacts with the transcriptional regulator TFII-I.

PubMed ID: 12082086

DOI: 10.1074/jbc.m112332200

PubMed ID: 15561718

Title: Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.

PubMed ID: 15561718

DOI: 10.1074/jbc.m411718200

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 16738337

Title: Induction of immunoglobulin heavy-chain transcription through the transcription factor Bright requires TFII-I.

PubMed ID: 16738337

DOI: 10.1128/mcb.02009-05

PubMed ID: 16964243

Title: A probability-based approach for high-throughput protein phosphorylation analysis and site localization.

PubMed ID: 16964243

DOI: 10.1038/nbt1240

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22223895

Title: Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features.

PubMed ID: 22223895

DOI: 10.1074/mcp.m111.015131

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25114211

Title: Mapping of SUMO sites and analysis of SUMOylation changes induced by external stimuli.

PubMed ID: 25114211

DOI: 10.1073/pnas.1413825111

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 25755297

Title: System-wide analysis of SUMOylation dynamics in response to replication stress reveals novel small ubiquitin-like modified target proteins and acceptor lysines relevant for genome stability.

PubMed ID: 25755297

DOI: 10.1074/mcp.o114.044792

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

PubMed ID: 31900622

Title: GPR50-Ctail cleavage and nuclear translocation: a new signal transduction mode for G protein-coupled receptors.

PubMed ID: 31900622

DOI: 10.1007/s00018-019-03440-7

Sequence Information:

  • Length: 998
  • Mass: 112416
  • Checksum: 4CFA2C19002869B9
  • Sequence:
    • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
EESEDPDYYQ YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDSTQHVP 
SETSEDPEVE VTIEDDDYSP PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD 
LRKQVEELFE RKYAQAIKAK GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE 
RILLAKERIR FVIKKHELLN STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE 
ALGSTEAKAV PYQKFEAHPN DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR 
PELLTHSTTE VTQPRTNTPV KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF 
ESNPEFLYVE GLPEGIPFRS PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK 
INTKALQSPK RPRSPGSNSK VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE 
FSFEAWNAKI TDLKQKVENL FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF 
RRPSTFGIPR LEKILRNKAK IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG 
VEDLNIIQVT IPDDDNERLS KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN 
PGCVVVDGMP PGVSFKAPSY LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE 
GPVIQESAEP SQLEVPATEE IKETDGSSQI KQEPDPTW

Genular Protein ID: 804126317

Symbol: A8K9W7_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K9W7

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 1 PeptideAtlas 1 Pfam 1 RefSeq 6 SAM 1 SUPFAM 1

Sequence Information:

  • Length: 978
  • Mass: 110208
  • Checksum: 1FAA4EDECD7724E8
  • Sequence:
    • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
EESEDPDYYQ YNIQGSHHSS EGNEGTEMEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 
PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD LRKQVEELFE RKYAQAIKAK 
GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN 
STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 
DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE VTQPRTNTPV 
KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF ESNPEFLYVG GLPEGIPFRS 
PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK INTKALQSPK RPRSPGSNSK 
VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL 
FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 
IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT IPDDDNERLS 
KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY 
LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE GPVIQESAEP SQLEVPATEE 
IKETDGSSQI KQEPDPTW

Genular Protein ID: 1442034434

Symbol: X5D2J9_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D2J9

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 1 HOGENOM 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PROSITE 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 957
  • Mass: 107970
  • Checksum: E091B620FF633AC8
  • Sequence:
    • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
EESEDPDYYQ YNIQGSHHSS EGNEGTEMEV PAEDDDYSPP SKRPKANELP QPPVPEPANA 
GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG PVTIPYPLFQ SHVEDLYVEG 
LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS TREDLQLDKP ASGVKEEWYA 
RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND LYVEGLPENI PFRSPSWYGI 
PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK EDWNVRITKL RKQVEEIFNL 
KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP TWFGIPRLER IVRGSNKIKF 
VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV PEIEVTVEGP NNNNPQTSAV 
RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF NEKCGEALGL KQAVKVPFAL 
FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI KFIIKKPEMF ETAIKESTSS 
KSPPRKINSS PNVNTTASGV EDLNIIQVTI PDDDNERLSK VEKARQLREQ VNDLFSRKFG 
EAIGMGFPVK VPYRKITINP GCVVVDGMPP GVSFKAPSYL EISSMRRILD SAEFIKFTVI 
RPFPGLVINN QLVDQSESEG PVIQESAEPS QLEVPATEEI KETDGSSQIK QEPDPTW

Genular Protein ID: 2203699117

Symbol: Q499G6_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q499G6

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 GO 3 Gene3D 1 IntAct 1 InterPro 3 KEGG 1 MINT 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSF 1 PROSITE 1 Pfam 1 PharmGKB 1 RefSeq 5 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 976
  • Mass: 110080
  • Checksum: C25BEE75CDED523E
  • Sequence:
    • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
EESEDPDYYQ YNIQGPSETD DVDEKQPLSK PLQGSHHSSE GNEGTEMEVP AEDDDYSPPS 
KRPKANELPQ PPVPEPANAG KRKVREFNFE KWNARITDLR KQVEELFERK YAQAIKAKGP 
VTIPYPLFQS HVEDLYVEGL PEGIPFRRPS TYGIPRLERI LLAKERIRFV IKKHELLNST 
REDLQLDKPA SGVKEEWYAR ITKLRKMVDQ LFCKKFAEAL GSTEAKAVPY QKFEAHPNDL 
YVEGLPENIP FRSPSWYGIP RLEKIIQVGN RIKFVIKRPE LLTHSTTEVT QPRTNTPVKE 
DWNVRITKLR KQVEEIFNLK FAQALGLTEA VKVPYPVFES NPEFLYVEGL PEGIPFRSPT 
WFGIPRLERI VRGSNKIKFV VKKPELVISY LPPGMASKIN TKALQSPKRP RSPGSNSKVP 
EIEVTVEGPN NNNPQTSAVR TPTQTNGSNV PFKPRGREFS FEAWNAKITD LKQKVENLFN 
EKCGEALGLK QAVKVPFALF ESFPEDFYVE GLPEGVPFRR PSTFGIPRLE KILRNKAKIK 
FIIKKPEMFE TAIKESTSSK SPPRKINSSP NVNTTASGVE DLNIIQVTIP DDDNERLSKV 
EKARQLREQV NDLFSRKFGE AIGMGFPVKV PYRKITINRG CVVVDGMPPG VSFKAPSYLE 
ISSMRRILDS AEFIKFTVIR PFPGLVVNNQ LVDQSESEGP VIQESAEPSQ LEVPATEEIK 
ETDGSSQIKQ EPDPTW

Genular Protein ID: 2415940495

Symbol: X5DNP5_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5DNP5

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 4 Gene3D 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PROSITE 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 978
  • Mass: 110280
  • Checksum: 1F006D480F0BE702
  • Sequence:
    • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
EESEDPDYYQ YNIQGSHHSS EGNEGTEMEV PAEDSTQHVP SETSEDPEVE VTIEDDDYSP 
PSKRPKANEL PQPPVPEPAN AGKRKVREFN FEKWNARITD LRKQVEELFE RKYAQAIKAK 
GPVTIPYPLF QSHVEDLYVE GLPEGIPFRR PSTYGIPRLE RILLAKERIR FVIKKHELLN 
STREDLQLDK PASGVKEEWY ARITKLRKMV DQLFCKKFAE ALGSTEAKAV PYQKFEAHPN 
DLYVEGLPEN IPFRSPSWYG IPRLEKIIQV GNRIKFVIKR PELLTHSTTE VTQPRTNTPV 
KEDWNVRITK LRKQVEEIFN LKFAQALGLT EAVKVPYPVF ESNPEFLYVE GLPEGIPFRS 
PTWFGIPRLE RIVRGSNKIK FVVKKPELVI SYLPPGMASK INTKALQSPK RPRSPGSNSK 
VPEIEVTVEG PNNNNPQTSA VRTPTQTNGS NVPFKPRGRE FSFEAWNAKI TDLKQKVENL 
FNEKCGEALG LKQAVKVPFA LFESFPEDFY VEGLPEGVPF RRPSTFGIPR LEKILRNKAK 
IKFIIKKPEM FETAIKESTS SKSPPRKINS SPNVNTTASG VEDLNIIQVT IPDDDNERLS 
KVEKARQLRE QVNDLFSRKF GEAIGMGFPV KVPYRKITIN PGCVVVDGMP PGVSFKAPSY 
LEISSMRRIL DSAEFIKFTV IRPFPGLVIN NQLVDQSESE GPVIQESAEP SQLEVPATEE 
IKETDGSSQI KQEPDPTW

Genular Protein ID: 3067323723

Symbol: X5D939_HUMAN

Name: N/A

UniProtKB Accession Codes:

X5D939

Database IDs:

ARBA 6 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 2 ExpressionAtlas 1 GO 3 Gene3D 1 InterPro 3 NCBI Taxonomy 1 PANTHER 2 PIRSF 1 PROSITE 1 Pfam 1 RefSeq 1 SAM 1 SMR 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 24722188

Title: Protein interaction network of alternatively spliced isoforms from brain links genetic risk factors for autism.

PubMed ID: 24722188

Sequence Information:

  • Length: 977
  • Mass: 110106
  • Checksum: 418D59EC623E6141
  • Sequence:
    • MAQVAMSTLP VEDEESSESR MVVTFLMSAL ESMCKELAKS KAEVACIAVY ETDVFVVGTE 
RGRAFVNTRK DFQKDFVKYC VEEEEKAAEM HKMKSTTQAN RMSVDAVEIE TLRKTVEDYF 
CFCYGKALGK STVVPVPYEK MLRDQSAVVV QGLPEGVAFK HPENYDLATL KWILENKAGI 
SFIIKRPFLE PKKHVGGRVM VTDADRSILS PGGSCGPIKV KTEPTEDSGI SLEMAAVTVK 
EESEDPDYYQ YNIQAGPSET DDVDEKQPLS KPLQGSHHSS EGNEGTEMEV PAEDDDYSPP 
SKRPKANELP QPPVPEPANA GKRKVREFNF EKWNARITDL RKQVEELFER KYAQAIKAKG 
PVTIPYPLFQ SHVEDLYVEG LPEGIPFRRP STYGIPRLER ILLAKERIRF VIKKHELLNS 
TREDLQLDKP ASGVKEEWYA RITKLRKMVD QLFCKKFAEA LGSTEAKAVP YQKFEAHPND 
LYVEGLPENI PFRSPSWYGI PRLEKIIQVG NRIKFVIKRP ELLTHSTTEV TQPRTNTPVK 
EDWNVRITKL RKQVEEIFNL KFAQALGLTE AVKVPYPVFE SNPEFLYVEG LPEGIPFRSP 
TWFGIPRLER IVRGSNKIKF VVKKPELVIS YLPPGMASKI NTKALQSPKR PRSPGSNSKV 
PEIEVTVEGP NNNNPQTSAV RTPTQTNGSN VPFKPRGREF SFEAWNAKIT DLKQKVENLF 
NEKCGEALGL KQAVKVPFAL FESFPEDFYV EGLPEGVPFR RPSTFGIPRL EKILRNKAKI 
KFIIKKPEMF ETAIKESTSS KSPPRKINSS PNVNTTASGV EDLNIIQVTI PDDDNERLSK 
VEKARQLREQ VNDLFSRKFG EAIGMGFPVK VPYRKITINP GCVVVDGMPP GVSFKAPSYL 
EISSMRRILD SAEFIKFTVI RPFPGLVINN QLVDQSESEG PVIQESAEPS QLEVPATEEI 
KETDGSSQIK QEPDPTW

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.