Details for: TRA2A

Gene ID: 29896

Symbol: TRA2A

Ensembl ID: ENSG00000164548

Description: transformer 2 alpha homolog

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 531.4853
    Cell Significance Index: -82.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 315.2655
    Cell Significance Index: -79.9700
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 188.5191
    Cell Significance Index: -77.6600
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 182.1984
    Cell Significance Index: -86.0200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 179.8861
    Cell Significance Index: -73.0800
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 162.0186
    Cell Significance Index: -83.3400
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 128.4905
    Cell Significance Index: -86.2200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 77.2250
    Cell Significance Index: -73.7300
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 71.5435
    Cell Significance Index: -88.2100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.3114
    Cell Significance Index: -81.2000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.9035
    Cell Significance Index: -76.4900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.7823
    Cell Significance Index: -89.9000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 19.5149
    Cell Significance Index: -42.7100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 3.7544
    Cell Significance Index: 210.6800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 3.5736
    Cell Significance Index: 95.4200
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.8790
    Cell Significance Index: 39.2800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 2.4659
    Cell Significance Index: 494.6600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.1896
    Cell Significance Index: 141.2700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1322
    Cell Significance Index: 423.1400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 2.0444
    Cell Significance Index: 39.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.0239
    Cell Significance Index: 56.5600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.9002
    Cell Significance Index: 681.5600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8025
    Cell Significance Index: 110.7900
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.6769
    Cell Significance Index: 48.0700
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.3691
    Cell Significance Index: 188.0200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.2317
    Cell Significance Index: 157.9000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.2010
    Cell Significance Index: 130.6400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.1855
    Cell Significance Index: 524.1300
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.0754
    Cell Significance Index: 30.9900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.0426
    Cell Significance Index: 80.0100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.8682
    Cell Significance Index: 30.1700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.8474
    Cell Significance Index: 462.7700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.8011
    Cell Significance Index: 37.6500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.7909
    Cell Significance Index: 93.2700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.7658
    Cell Significance Index: 39.8900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.7416
    Cell Significance Index: 8.8400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7245
    Cell Significance Index: 89.0900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7111
    Cell Significance Index: 128.2000
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.6976
    Cell Significance Index: 16.7300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.6956
    Cell Significance Index: 18.9400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6028
    Cell Significance Index: 36.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.5946
    Cell Significance Index: 39.9800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.4748
    Cell Significance Index: 12.4900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4601
    Cell Significance Index: 20.3500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3890
    Cell Significance Index: 14.7300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.3814
    Cell Significance Index: 26.9700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3775
    Cell Significance Index: 710.7600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.3172
    Cell Significance Index: 19.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.3078
    Cell Significance Index: 195.4600
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.3069
    Cell Significance Index: 5.2600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2354
    Cell Significance Index: 23.2900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.1993
    Cell Significance Index: 90.4600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1528
    Cell Significance Index: 5.3700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.1426
    Cell Significance Index: 219.5000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.1305
    Cell Significance Index: 16.8600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.1252
    Cell Significance Index: 230.8100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0838
    Cell Significance Index: 15.9600
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.0609
    Cell Significance Index: 4.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0607
    Cell Significance Index: 82.5900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0167
    Cell Significance Index: 2.8500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0121
    Cell Significance Index: 0.6300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0296
    Cell Significance Index: -21.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0412
    Cell Significance Index: -25.7100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0504
    Cell Significance Index: -38.1700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0704
    Cell Significance Index: -51.6000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1117
    Cell Significance Index: -1.8700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1131
    Cell Significance Index: -5.2800
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1158
    Cell Significance Index: -6.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1179
    Cell Significance Index: -66.5000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.1694
    Cell Significance Index: -3.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.1758
    Cell Significance Index: -28.6000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1901
    Cell Significance Index: -8.6200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1954
    Cell Significance Index: -19.9600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2611
    Cell Significance Index: -37.9600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2767
    Cell Significance Index: -58.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2782
    Cell Significance Index: -80.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4865
    Cell Significance Index: -55.7400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.4886
    Cell Significance Index: -56.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.5600
    Cell Significance Index: -63.9200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.6502
    Cell Significance Index: -67.7100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.6707
    Cell Significance Index: -17.2400
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.7022
    Cell Significance Index: -18.8200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7390
    Cell Significance Index: -21.0900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.7691
    Cell Significance Index: -16.3800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.8712
    Cell Significance Index: -12.5100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.9587
    Cell Significance Index: -20.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9698
    Cell Significance Index: -76.8100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -1.0158
    Cell Significance Index: -25.9500
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.0262
    Cell Significance Index: -6.2000
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -1.1540
    Cell Significance Index: -9.4100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.1590
    Cell Significance Index: -24.2600
  • Cell Name: peg cell (CL4033014)
    Fold Change: -1.2111
    Cell Significance Index: -27.9800
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.2257
    Cell Significance Index: -18.1000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.2357
    Cell Significance Index: -75.7600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.3888
    Cell Significance Index: -30.4100
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: -1.3911
    Cell Significance Index: -12.8100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.4568
    Cell Significance Index: -46.6600
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -1.4625
    Cell Significance Index: -27.0300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -1.4846
    Cell Significance Index: -43.6000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -1.5843
    Cell Significance Index: -51.8700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TRA2A is a member of the transformer family, which is characterized by its ability to regulate RNA splicing and processing. The gene is specifically expressed in various cell types, including taste receptor cells, skeletal muscle satellite stem cells, and fibroblasts from the mammary gland. This widespread expression suggests that TRA2A plays a crucial role in maintaining cellular homeostasis and function. Furthermore, the gene's involvement in spliceosomal complexes and its ability to regulate mRNA splicing via the spliceosome highlight its importance in post-transcriptional gene regulation. **Pathways and Functions:** TRA2A is involved in several key pathways, including: 1. **Intracellular membrane-bounded organelle**: TRA2A is localized to various organelles, including the nucleus, nucleolus, and nucleoplasm, suggesting its involvement in regulating gene expression and cellular processes. 2. **mRNA splicing**: TRA2A regulates mRNA splicing via the spliceosome, a complex that plays a critical role in removing introns and joining exons to form mature mRNA molecules. 3. **Positive regulation of mRNA splicing**: TRA2A acts as a positive regulator of mRNA splicing, enhancing the efficiency of the spliceosome and resulting in the production of correctly spliced mRNA molecules. 4. **Protein binding and RNA binding**: TRA2A interacts with proteins and RNA molecules, influencing the stability, localization, and translation of mRNAs. **Clinical Significance:** While TRA2A's exact clinical significance remains unclear, its expression in various cell types and its involvement in RNA splicing and processing suggest potential implications for human diseases. For instance: 1. **Cancer**: Dysregulation of TRA2A expression has been linked to various cancers, including breast cancer, where it may contribute to tumor progression and metastasis. 2. **Neurological disorders**: TRA2A's involvement in RNA splicing and processing may also impact neurological disorders, such as neurodegenerative diseases, where aberrant RNA splicing can contribute to disease pathology. 3. **Developmental disorders**: TRA2A's expression in embryonic stem cells and its role in regulating gene expression may also contribute to developmental disorders, such as congenital anomalies. In conclusion, TRA2A is a multifaceted gene that plays a critical role in regulating RNA splicing and processing. Its widespread expression in various cell types and its involvement in key pathways highlight its importance in maintaining cellular homeostasis and function. Further research is needed to elucidate the clinical significance of TRA2A and its potential implications for human diseases.

Genular Protein ID: 3743179675

Symbol: TRA2A_HUMAN

Name: Transformer-2 protein homolog A

UniProtKB Accession Codes:

Q13595 B4DQI6 B4DUA9 E9PD75

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 3 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 3 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 4 Pumba 1 RNAct 1 RefSeq 7 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8799144

Title: A human homologue of the Drosophila sex determination factor transformer-2 has conserved splicing regulatory functions.

PubMed ID: 8799144

DOI: 10.1073/pnas.93.17.9004

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9546399

Title: Human Tra2 proteins are sequence-specific activators of pre-mRNA splicing.

PubMed ID: 9546399

DOI: 10.1016/s0092-8674(00)81153-8

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 282
  • Mass: 32689
  • Checksum: EDB5ABE7BEA023FD
  • Sequence:
    • MSDVEENNFE GRESRSQSKS PTGTPARVKS ESRSGSRSPS RVSKHSESHS RSRSKSRSRS 
RRHSHRRYTR SRSHSHSHRR RSRSRSYTPE YRRRRSRSHS PMSNRRRHTG SRANPDPNTC 
LGVFGLSLYT TERDLREVFS RYGPLSGVNV VYDQRTGRSR GFAFVYFERI DDSKEAMERA 
NGMELDGRRI RVDYSITKRA HTPTPGIYMG RPTHSGGGGG GGGGGGGGGG GRRRDSYYDR 
GYDRGYDRYE DYDYRYRRRS PSPYYSRYRS RSRSRSYSPR RY

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.