Details for: VPS13C

Gene ID: 54832

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: VPS13C

Ensembl ID: ENSG00000129003

Description: vacuolar protein sorting 13 homolog C

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • pvalb GABAergic cortical interneuron CL4023018
    CSI 67.96
    rCSI 84.54%
    PRS 7.89
  • sst GABAergic cortical interneuron CL4023017
    CSI 58.47
    rCSI 75.38%
    PRS 8.9
  • lamp5 GABAergic cortical interneuron CL4023011
    CSI 55.1
    rCSI 92.48%
    PRS 8.49
  • VIP GABAergic cortical interneuron CL4023016
    CSI 55.03
    rCSI 65.73%
    PRS 8.29
  • sncg GABAergic cortical interneuron CL4023015
    CSI 41.66
    rCSI 67%
    PRS 9.27
  • L2/3-6 intratelencephalic projecting glutamatergic neuron CL4023040
    CSI 36.21
    rCSI 88%
    PRS 8.27
  • differentiation-committed oligodendrocyte precursor CL4023059
    CSI 35.34
    rCSI 64.21%
    PRS 11.74
  • retinal ganglion cell CL0000740
    CSI 34.12
    rCSI 75.37%
    PRS 10.33
  • caudal ganglionic eminence derived cortical interneuron CL4023064
    CSI 31.35
    rCSI 55.37%
    PRS 8.42
  • chandelier pvalb GABAergic cortical interneuron CL4023036
    CSI 30.53
    rCSI 95.49%
    PRS 9.71
  • L6b glutamatergic cortical neuron CL4023038
    CSI 27.76
    rCSI 86.75%
    PRS 9.05
  • L5 extratelencephalic projecting glutamatergic cortical neuron CL4023041
    CSI 24.65
    rCSI 88.69%
    PRS 7.91
  • near-projecting glutamatergic cortical neuron CL4023012
    CSI 23.31
    rCSI 88.11%
    PRS 8.67
  • duct epithelial cell CL0000068
    CSI 20.9
    rCSI 30.58%
    PRS 15.18
  • kidney loop of Henle thin descending limb epithelial cell CL1001111
    CSI 19.24
    rCSI 27.28%
    PRS 13.42
  • Hofbauer cell CL3000001
    CSI 17.79
    rCSI 33.59%
    PRS 17.9
  • neuron CL0000540
    CSI 17.59
    rCSI 46.84%
    PRS 11.52
  • L2/3 intratelencephalic projecting glutamatergic neuron CL4030059
    CSI 16.89
    rCSI 36.63%
    PRS 8.4
  • kidney loop of Henle thin ascending limb epithelial cell CL1001107
    CSI 15.7
    rCSI 40.59%
    PRS 13.42
  • CD14-low, CD16-positive monocyte CL0002396
    CSI 15.68
    rCSI 12.08%
    PRS 13.1
  • corticothalamic-projecting glutamatergic cortical neuron CL4023013
    CSI 15.51
    rCSI 91.33%
    PRS 8.9
  • central nervous system macrophage CL0000878
    CSI 15.41
    rCSI 51.07%
    PRS 13.66
  • lung ciliated cell CL1000271
    CSI 13.99
    rCSI 16.17%
    PRS 10.51
  • retinal cone cell CL0000573
    CSI 13.91
    rCSI 22.38%
    PRS 11.06
  • H1 horizontal cell CL0004217
    CSI 13.53
    rCSI 53.59%
    PRS 19.98
  • chondrocyte CL0000138
    CSI 13.07
    rCSI 20.79%
    PRS 12.25
  • central nervous system neuron CL2000029
    CSI 12.86
    rCSI 94.53%
    PRS 7.65
  • helper T cell CL0000912
    CSI 12.85
    rCSI 18.17%
    PRS 19.92
  • Bergmann glial cell CL0000644
    CSI 12.15
    rCSI 16.63%
    PRS 14.47
  • kidney interstitial alternatively activated macrophage CL1000695
    CSI 12.09
    rCSI 31.51%
    PRS 13.23
  • mature B cell CL0000785
    CSI 11.38
    rCSI 9.9%
    PRS 17.79
  • kidney connecting tubule epithelial cell CL1000768
    CSI 11.27
    rCSI 28.59%
    PRS 10.95
  • renal principal cell CL0005009
    CSI 10.39
    rCSI 26.99%
    PRS 18.93
  • H2 horizontal cell CL0004218
    CSI 10.2
    rCSI 50.7%
    PRS 15.37
  • oligodendrocyte precursor cell CL0002453
    CSI 10.02
    rCSI 22.04%
    PRS 8.7
  • pancreatic A cell CL0000171
    CSI 9.02
    rCSI 9.45%
    PRS 15.37
  • enteroendocrine cell of small intestine CL0009006
    CSI 8.82
    rCSI 19.42%
    PRS 21.96
  • GABAergic amacrine cell CL4030027
    CSI 8.4
    rCSI 28.79%
    PRS 12.59
  • brush cell of tracheobronchial tree CL0002075
    CSI 8.33
    rCSI 24.72%
    PRS 20.74
  • blood vessel smooth muscle cell CL0019018
    CSI 8.23
    rCSI 66.95%
    PRS 14.82
  • microglial cell CL0000129
    CSI 7.85
    rCSI 31.61%
    PRS 33.59
  • T follicular helper cell CL0002038
    CSI 7.66
    rCSI 5.74%
    PRS 23.27
  • S cone cell CL0003050
    CSI 7.66
    rCSI 33.65%
    PRS 11.15
  • small intestine goblet cell CL1000495
    CSI 7.48
    rCSI 16.39%
    PRS 19.16
  • ciliated epithelial cell CL0000067
    CSI 7.21
    rCSI 6.34%
    PRS 10.41
  • tuft cell of colon CL0009041
    CSI 6.87
    rCSI 16.01%
    PRS 29.6
  • L5/6 near-projecting glutamatergic neuron CL4030067
    CSI 6.37
    rCSI 20.95%
    PRS 7.8
  • ON parasol ganglion cell CL4033052
    CSI 6.21
    rCSI 88.07%
    PRS 10.3
  • retina horizontal cell CL0000745
    CSI 6.05
    rCSI 9.23%
    PRS 13.39
  • diffuse bipolar 6 cell CL4033032
    CSI 5.34
    rCSI 28.1%
    PRS 16.36
  • astrocyte of the cerebral cortex CL0002605
    CSI 5.18
    rCSI 11.61%
    PRS 8.85
  • medium spiny neuron CL1001474
    CSI 5.14
    rCSI 44.25%
    PRS 5.32
  • ciliated cell CL0000064
    CSI 5.13
    rCSI 8.31%
    PRS 14.57
  • oligodendrocyte CL0000128
    CSI 5.08
    rCSI 15.02%
    PRS 10.5
  • respiratory hillock cell CL4030023
    CSI 5
    rCSI 8.91%
    PRS 24.3
  • CD14-positive, CD16-negative classical monocyte CL0002057
    CSI 4.94
    rCSI 29.92%
    PRS 31.9
  • rod bipolar cell CL0000751
    CSI 4.72
    rCSI 8.48%
    PRS 12.01
  • pancreatic PP cell CL0002275
    CSI 4.61
    rCSI 18.34%
    PRS 25.22
  • ON midget ganglion cell CL4033046
    CSI 4.47
    rCSI 91.02%
    PRS 11.04
  • endothelial cell of pericentral hepatic sinusoid CL0019022
    CSI 4.43
    rCSI 13.66%
    PRS 21.74
  • unswitched memory B cell CL0000970
    CSI 4.37
    rCSI 3.68%
    PRS 23.14
  • activated type II NK T cell CL0000931
    CSI 4.31
    rCSI 4.85%
    PRS 23.07
  • lung endothelial cell CL1001567
    CSI 4.01
    rCSI 9.35%
    PRS 33.86
  • naive B cell CL0000788
    CSI 3.84
    rCSI 3.29%
    PRS 24.73
  • L4 intratelencephalic projecting glutamatergic neuron CL4030063
    CSI 3.81
    rCSI 9.11%
    PRS 8.22
  • diffuse bipolar 3a cell CL4033029
    CSI 3.72
    rCSI 25.31%
    PRS 14.21
  • direct pathway medium spiny neuron CL4023026
    CSI 3.68
    rCSI 88.16%
    PRS 6.7
  • indirect pathway medium spiny neuron CL4023029
    CSI 3.64
    rCSI 87.87%
    PRS 7.64
  • intermediate monocyte CL0002393
    CSI 3.63
    rCSI 5.48%
    PRS 14.25
  • pancreatic acinar cell CL0002064
    CSI 3.45
    rCSI 4.59%
    PRS 15.71
  • lung secretory cell CL1000272
    CSI 3.37
    rCSI 8.33%
    PRS 13.27
  • blood vessel endothelial cell CL0000071
    CSI 3.29
    rCSI 6.83%
    PRS 14.35
  • plasmacytoid dendritic cell, human CL0001058
    CSI 3.27
    rCSI 2.29%
    PRS 15.12
  • memory B cell CL0000787
    CSI 3.24
    rCSI 3.2%
    PRS 52.13
  • BEST4+ enteroycte CL4030026
    CSI 3.13
    rCSI 3.89%
    PRS 15.18
  • mucosal invariant T cell CL0000940
    CSI 3.05
    rCSI 2.47%
    PRS 23.04
  • glutamatergic neuron CL0000679
    CSI 3.05
    rCSI 6.27%
    PRS 14.43
  • myeloid dendritic cell, human CL0001057
    CSI 3.03
    rCSI 17.05%
    PRS 44.49
  • invaginating midget bipolar cell CL4033034
    CSI 3.02
    rCSI 17.85%
    PRS 14.86
  • CD16-negative, CD56-bright natural killer cell, human CL0000938
    CSI 2.99
    rCSI 2.24%
    PRS 40.55
  • CD4-positive, alpha-beta thymocyte CL0000810
    CSI 2.98
    rCSI 2.39%
    PRS 25.97
  • colon goblet cell CL0009039
    CSI 2.97
    rCSI 7.06%
    PRS 21.58
  • neural crest cell CL0011012
    CSI 2.89
    rCSI 2.29%
    PRS 9.89
  • acinar cell of salivary gland CL0002623
    CSI 2.89
    rCSI 67.24%
    PRS 26.16
  • cerebral cortex endothelial cell CL1001602
    CSI 2.87
    rCSI 4.97%
    PRS 10.94
  • ependymal cell CL0000065
    CSI 2.84
    rCSI 5.76%
    PRS 6.4
  • glycinergic amacrine cell CL4030028
    CSI 2.8
    rCSI 7.29%
    PRS 14.11
  • pancreatic D cell CL0000173
    CSI 2.78
    rCSI 2.74%
    PRS 15.65
  • transitional stage B cell CL0000818
    CSI 2.78
    rCSI 9.11%
    PRS 39.21
  • B cell CL0000236
    CSI 2.78
    rCSI 3.72%
    PRS 54.64
  • multi-ciliated epithelial cell CL0005012
    CSI 2.78
    rCSI 2.77%
    PRS 12.28
  • parietal epithelial cell CL1000452
    CSI 2.77
    rCSI 7.4%
    PRS 12.04
  • hepatic stellate cell CL0000632
    CSI 2.72
    rCSI 10.18%
    PRS 12.22
  • adipocyte CL0000136
    CSI 2.7
    rCSI 3.47%
    PRS 14.25
  • pulmonary capillary endothelial cell CL4028001
    CSI 2.55
    rCSI 4.86%
    PRS 22.89
  • keratocyte CL0002363
    CSI 2.55
    rCSI 6.12%
    PRS 21.51
  • endothelial cell of vascular tree CL0002139
    CSI 2.54
    rCSI 13.91%
    PRS 23.97
  • alpha-beta T cell CL0000789
    CSI 2.54
    rCSI 2.98%
    PRS 19.15
  • interstitial cell of Cajal CL0002088
    CSI 2.53
    rCSI 3.22%
    PRS 16.72
  • myeloid dendritic cell CL0000782
    CSI 2.49
    rCSI 3.61%
    PRS 21.25
  • activated CD4-positive, alpha-beta T cell CL0000896
    CSI -5.4
    rCSI -5.0%
    PRS 26.1%
  • peripheral nervous system neuron CL2000032
    CSI -3.6
    rCSI -4.8%
    PRS 12.8%
  • regular ventricular cardiac myocyte CL0002131
    CSI -2.7
    rCSI -16.9%
    PRS 11.3%
  • neuroblast (sensu Vertebrata) CL0000031
    CSI -2.5
    rCSI -3.3%
    PRS 14.0%
  • Langerhans cell CL0000453
    CSI -1.8
    rCSI -2.8%
    PRS 25.2%
  • cerebellar neuron CL1001611
    CSI -1.4
    rCSI -12.7%
    PRS 6.8%
  • pulmonary ionocyte CL0017000
    CSI -1.0
    rCSI -1.2%
    PRS 18.1%
  • brain vascular cell CL4023072
    CSI -0.4
    rCSI -3.8%
    PRS 14.5%
  • lung pericyte CL0009089
    CSI -0.2
    rCSI -0.4%
    PRS 17.2%
  • extravillous trophoblast CL0008036
    CSI -0.1
    rCSI -0.1%
    PRS 12.6%
  • mesenchymal stem cell CL0000134
    CSI 0.0
    rCSI 0.2%
    PRS 25.9%
  • cytotoxic T cell CL0000910
    CSI 0.1
    rCSI 0.4%
    PRS 20.9%
  • lymphoid lineage restricted progenitor cell CL0000838
    CSI 0.1
    rCSI 0.3%
    PRS 23.5%
  • lung microvascular endothelial cell CL2000016
    CSI 0.1
    rCSI 1.4%
    PRS 43.5%
  • intestinal crypt stem cell of colon CL0009043
    CSI 0.1
    rCSI 0.6%
    PRS 26.2%
  • vein endothelial cell of respiratory system CL4033008
    CSI 0.1
    rCSI 0.6%
    PRS 28.0%
  • pancreatic stellate cell CL0002410
    CSI 0.1
    rCSI 0.6%
    PRS 21.6%
  • deuterosomal cell CL4033044
    CSI 0.1
    rCSI 0.4%
    PRS 23.7%
  • erythroid progenitor cell CL0000038
    CSI 0.1
    rCSI 0.7%
    PRS 22.1%
  • mucus secreting cell CL0000319
    CSI 0.1
    rCSI 0.2%
    PRS 18.5%
  • placental villous trophoblast CL2000060
    CSI 0.1
    rCSI 0.2%
    PRS 13.5%
  • intestinal epithelial cell CL0002563
    CSI 0.1
    rCSI 0.1%
    PRS 15.0%
  • type EC enteroendocrine cell CL0000577
    CSI 0.1
    rCSI 0.5%
    PRS 23.5%
  • diffuse bipolar 1 cell CL4033027
    CSI 0.1
    rCSI 1.1%
    PRS 13.0%
  • promonocyte CL0000559
    CSI 0.2
    rCSI 0.3%
    PRS 19.3%
  • collagen secreting cell CL0000667
    CSI 0.2
    rCSI 0.9%
    PRS 48.1%
  • diffuse bipolar 2 cell CL4033028
    CSI 0.2
    rCSI 1.4%
    PRS 14.4%
  • endothelial cell of uterus CL0009095
    CSI 0.2
    rCSI 1.3%
    PRS 38.6%
  • alveolar adventitial fibroblast CL4028006
    CSI 0.2
    rCSI 0.3%
    PRS 14.4%
  • cone retinal bipolar cell CL0000752
    CSI 0.2
    rCSI 2.6%
    PRS 49.8%
  • tracheobronchial serous cell CL0019001
    CSI 0.2
    rCSI 0.9%
    PRS 27.2%
  • erythroblast CL0000765
    CSI 0.2
    rCSI 0.6%
    PRS 23.4%
  • serotonergic neuron CL0000850
    CSI 0.2
    rCSI 1.0%
    PRS 6.5%
  • natural T-regulatory cell CL0000903
    CSI 0.2
    rCSI 0.4%
    PRS 38.8%
  • skeletal muscle satellite stem cell CL0008011
    CSI 0.2
    rCSI 1.0%
    PRS 39.1%
  • cardiac blood vessel endothelial cell CL0010006
    CSI 0.2
    rCSI 1.7%
    PRS 16.0%
  • central memory CD8-positive, alpha-beta T cell CL0000907
    CSI 0.2
    rCSI 0.2%
    PRS 17.3%
  • starburst amacrine cell CL0004232
    CSI 0.2
    rCSI 2.0%
    PRS 14.3%
  • basal cell of epithelium of trachea CL1000348
    CSI 0.3
    rCSI 1.8%
    PRS 42.8%
  • respiratory basal cell CL0002633
    CSI 0.3
    rCSI 0.3%
    PRS 16.9%
  • granulocyte monocyte progenitor cell CL0000557
    CSI 0.3
    rCSI 0.2%
    PRS 16.1%
  • tracheobronchial smooth muscle cell CL0019019
    CSI 0.3
    rCSI 0.5%
    PRS 19.0%
  • paneth cell of epithelium of small intestine CL1000343
    CSI 0.3
    rCSI 0.8%
    PRS 22.2%
  • enteroendocrine cell of colon CL0009042
    CSI 0.3
    rCSI 1.3%
    PRS 37.5%
  • erythroid lineage cell CL0000764
    CSI 0.3
    rCSI 1.8%
    PRS 33.0%
  • hematopoietic multipotent progenitor cell CL0000837
    CSI 0.3
    rCSI 0.7%
    PRS 22.8%
  • CD8-positive, alpha-beta memory T cell, CD45RO-positive CL0001203
    CSI 0.3
    rCSI 0.4%
    PRS 18.7%
  • flat midget bipolar cell CL4033033
    CSI 0.3
    rCSI 2.2%
    PRS 13.9%
  • enterocyte of epithelium of small intestine CL1000334
    CSI 0.3
    rCSI 4.9%
    PRS 35.2%
  • P/D1 enteroendocrine cell CL0002268
    CSI 0.3
    rCSI 1.8%
    PRS 35.1%
  • corneal epithelial cell CL0000575
    CSI 0.3
    rCSI 1.0%
    PRS 25.4%
  • eosinophil CL0000771
    CSI 0.4
    rCSI 2.4%
    PRS 36.7%
  • muscle cell CL0000187
    CSI 0.4
    rCSI 0.8%
    PRS 32.8%
  • pancreatic epsilon cell CL0005019
    CSI 0.4
    rCSI 1.8%
    PRS 33.6%
  • intraepithelial lymphocyte CL0002496
    CSI 0.4
    rCSI 1.1%
    PRS 54.1%
  • common dendritic progenitor CL0001029
    CSI 0.4
    rCSI 0.5%
    PRS 18.4%
  • epicardial adipocyte CL1000309
    CSI 0.4
    rCSI 1.4%
    PRS 17.4%
  • enteroglial cell CL4040002
    CSI 0.4
    rCSI 2.2%
    PRS 25.5%
  • kidney distal convoluted tubule epithelial cell CL1000849
    CSI 0.4
    rCSI 4.6%
    PRS 19.7%
  • antibody secreting cell CL0000946
    CSI 0.4
    rCSI 1.9%
    PRS 55.0%
  • enterocyte of epithelium of large intestine CL0002071
    CSI 0.4
    rCSI 2.3%
    PRS 25.2%
  • intrahepatic cholangiocyte CL0002538
    CSI 0.4
    rCSI 1.1%
    PRS 25.9%
  • forebrain radial glial cell CL0013000
    CSI 0.5
    rCSI 1.5%
    PRS 20.8%
  • T-helper 1 cell CL0000545
    CSI 0.5
    rCSI 0.8%
    PRS 37.2%
  • professional antigen presenting cell CL0000145
    CSI 0.5
    rCSI 1.6%
    PRS 50.5%
  • vasa recta descending limb cell CL1001285
    CSI 0.5
    rCSI 3.8%
    PRS 54.3%
  • macroglial cell CL0000126
    CSI 0.5
    rCSI 1.2%
    PRS 19.8%
  • microcirculation associated smooth muscle cell CL0008035
    CSI 0.5
    rCSI 1.5%
    PRS 16.3%
  • tissue-resident macrophage CL0000864
    CSI 0.5
    rCSI 2.4%
    PRS 29.3%
  • acinar cell CL0000622
    CSI 0.5
    rCSI 0.8%
    PRS 18.9%
  • T-helper 17 cell CL0000899
    CSI 0.5
    rCSI 0.4%
    PRS 25.4%
  • small pre-B-II cell CL0000954
    CSI 0.5
    rCSI 0.5%
    PRS 29.6%
  • stromal cell of ovary CL0002132
    CSI 0.5
    rCSI 1.5%
    PRS 23.7%
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 0.6
    rCSI 0.7%
    PRS 20.2%
  • CD4-positive, CD25-positive, alpha-beta regulatory T cell CL0000792
    CSI 0.6
    rCSI 0.6%
    PRS 22.6%
  • basophil CL0000767
    CSI 0.6
    rCSI 1.2%
    PRS 29.1%
  • respiratory suprabasal cell CL4033048
    CSI 0.6
    rCSI 0.8%
    PRS 16.6%
  • regular atrial cardiac myocyte CL0002129
    CSI 0.6
    rCSI 1.9%
    PRS 15.3%
  • myeloid lineage restricted progenitor cell CL0000839
    CSI 0.6
    rCSI 3.2%
    PRS 28.0%
  • common myeloid progenitor CL0000049
    CSI 0.6
    rCSI 0.5%
    PRS 14.3%
  • lung neuroendocrine cell CL1000223
    CSI 0.6
    rCSI 0.9%
    PRS 16.5%
  • effector memory CD4-positive, alpha-beta T cell CL0000905
    CSI 0.6
    rCSI 0.9%
    PRS 34.2%
  • megakaryocyte-erythroid progenitor cell CL0000050
    CSI 0.6
    rCSI 0.6%
    PRS 12.8%
  • elicited macrophage CL0000861
    CSI 0.6
    rCSI 0.6%
    PRS 16.5%
  • neuroendocrine cell CL0000165
    CSI 0.6
    rCSI 2.4%
    PRS 29.4%
  • CD1c-positive myeloid dendritic cell CL0002399
    CSI 0.6
    rCSI 0.8%
    PRS 17.0%
  • stromal cell CL0000499
    CSI 0.6
    rCSI 1.8%
    PRS 20.3%
  • ionocyte CL0005006
    CSI 0.6
    rCSI 0.7%
    PRS 13.2%
  • common lymphoid progenitor CL0000051
    CSI 0.7
    rCSI 0.9%
    PRS 27.4%
  • respiratory goblet cell CL0002370
    CSI 0.7
    rCSI 7.1%
    PRS 27.5%
  • bronchial goblet cell CL1000312
    CSI 0.7
    rCSI 2.6%
    PRS 31.0%
  • colonocyte CL1000347
    CSI 0.7
    rCSI 1.0%
    PRS 19.7%
  • innate lymphoid cell CL0001065
    CSI 0.7
    rCSI 1.4%
    PRS 21.7%
  • granulocyte CL0000094
    CSI 0.7
    rCSI 1.1%
    PRS 18.2%
  • alveolar macrophage CL0000583
    CSI 0.7
    rCSI 1.2%
    PRS 16.8%
  • club cell CL0000158
    CSI 0.7
    rCSI 1.0%
    PRS 16.7%
  • dopaminergic neuron CL0000700
    CSI 0.7
    rCSI 4.1%
    PRS 6.5%
  • luminal epithelial cell of mammary gland CL0002326
    CSI 0.7
    rCSI 1.3%
    PRS 22.0%
  • OFFx cell CL4033036
    CSI 0.7
    rCSI 3.5%
    PRS 14.3%
  • midbrain dopaminergic neuron CL2000097
    CSI 0.7
    rCSI 4.8%
    PRS 21.5%

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

Comma-separated if multiple.
Comma-separated if multiple.

Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary Vacuolar protein sorting 13 homolog C ([VPS13C](/details-gene/54832)) is a protein-coding gene located on chromosome 15q22.2. It functions primarily as a lipid transport protein, mediating the transfer of lipids at membrane contact sites between organelles. Functional annotations highlight its crucial role in processes such as '[Lipid transport](/details-go/GO:0006869)', '[Mitochondrion organization](/details-go/GO:0007005)', and '[Golgi to endosome transport](/details-go/GO:0006895)'. **Overall**, expression data reveals that [VPS13C](/details-gene/54832) is a highly significant marker in the central nervous system, showing prominent expression in various subtypes of cortical neurons, including '[pvalb GABAergic cortical interneuron](/details-cell/CL4023018)' and '[sst GABAergic cortical interneuron](/details-cell/CL4023017)'. Clinically, loss-of-function mutations in [VPS13C](/details-gene/54832) are associated with a form of early-onset, autosomal-recessive parkinsonism ([Link](https://doi.org/10.1016/j.ajhg.2016.01.014)). ## Cellular Roles and Expression Landscape The expression profile of [VPS13C](/details-gene/54832) establishes it as a key gene within the central nervous system, with a particularly specialized role in cortical neuronal populations. **Overall**, it demonstrates the highest significance in several subtypes of inhibitory interneurons, such as '[pvalb GABAergic cortical interneuron](/details-cell/CL4023018)' (CSI: 67.96), '[sst GABAergic cortical interneuron](/details-cell/CL4023017)' (CSI: 58.47), and '[VIP GABAergic cortical interneuron](/details-cell/CL4023016)' (CSI: 55.03). Its expression is also significant in excitatory neurons, including '[L2/3-6 intratelencephalic projecting glutamatergic neuron](/details-cell/CL4023040)' (CSI: 36.21), and in glial cells like '[differentiation-committed oligodendrocyte precursor](/details-cell/CL4023059)' (CSI: 35.34). The specificity of this expression pattern is underscored by its notably low significance in cell types outside the nervous system. For instance, [VPS13C](/details-gene/54832) is an anti-marker for immune cells like '[activated CD4-positive, alpha-beta T cell](/details-cell/CL0000896)' (CSI: -5.39) and muscle cells such as '[regular ventricular cardiac myocyte](/details-cell/CL0002131)' (CSI: -2.70). This restricted expression landscape suggests that the functions of [VPS13C](/details-gene/54832) are highly tailored to the complex organelle and lipid trafficking demands of neuronal and specific glial cells. ## Pathways and Molecular Function The molecular functions of [VPS13C](/details-gene/54832) are centered on intracellular trafficking and organelle maintenance, which are critical for neuronal health. The gene product is involved in '[Lipid transport](/details-go/GO:0006869)', a function mediated by its localization at sites of close apposition between the '[Endoplasmic reticulum membrane](/details-go/GO:0005789)' and other organelles like the '[Mitochondrial outer membrane](/details-go/GO:0005741)', '[Lysosomal membrane](/details-go/GO:0005765)', and '[Late endosome membrane](/details-go/GO:0031902)' ([Link](https://doi.org/10.1083/jcb.201807019)). This lipid transport capability is integral to '[Mitochondrion organization](/details-go/GO:0007005)' and is directly implicated in the process of mitochondrial quality control. Specifically, [VPS13C](/details-gene/54832) is annotated for the '[Negative regulation of type 2 mitophagy](/details-go/GO:1905090)'. Its dysfunction is known to impair the clearance of damaged mitochondria, leading to cellular stress and degeneration, which is consistent with its pathogenic role in Parkinson's disease ([Link](https://doi.org/10.1016/j.ajhg.2016.01.014)). Furthermore, its involvement in '[Golgi to endosome transport](/details-go/GO:0006895)' and its localization to '[Dense core granule membrane](/details-go/GO:0032127)' suggest a potential role in the secretory pathway and neurotransmitter vesicle trafficking, processes vital for synaptic function in the neurons where it is highly expressed. ## Research Directions The specific expression of [VPS13C](/details-gene/54832) in neurons and its established link to mitochondrial dysfunction and neurodegeneration present several avenues for future research. **Proposed Hypotheses:** 1. **Neuronal Susceptibility in Parkinsonism:** The high expression of [VPS13C](/details-gene/54832) in specific cortical interneurons suggests these cells may be particularly vulnerable to its loss of function. We hypothesize that disruption of [VPS13C](/details-gene/54832)-mediated ER-mitochondria lipid transport in '[pvalb GABAergic cortical interneuron](/details-cell/CL4023018)' leads to bioenergetic failure and excitotoxicity, contributing to the specific circuit dysfunctions observed in early-onset Parkinsonism. 2. **Role in Synaptic Plasticity:** Given its association with dense core granules and endosomes, we hypothesize that [VPS13C](/details-gene/54832) is essential for maintaining the lipid composition of synaptic vesicle membranes, thereby regulating neurotransmitter release efficiency and synaptic plasticity. Its dysregulation could impair neuronal communication long before overt neurodegeneration occurs. **Key Experimental Approach:** To test the first hypothesis regarding neuronal susceptibility, a compelling approach would be to utilize human induced pluripotent stem cells (iPSCs) from patients with [VPS13C](/details-gene/54832) mutations. These iPSCs could be differentiated into cortical organoids containing diverse neuronal subtypes, including GABAergic interneurons. Advanced imaging techniques, such as live-cell microscopy with fluorescent lipid probes and mitochondrial reporters, could then be used to directly visualize lipid transfer defects and subsequent mitochondrial dysfunction (e.g., morphology changes, membrane potential loss) specifically within the PVALB-positive interneuron population compared to other neuronal types within the same organoid. **Therapeutic Potential:** As loss-of-function mutations in [VPS13C](/details-gene/54832) cause disease, the therapeutic strategy would be aimed at **activation** or functional restoration. Its intracellular localization as a lipid transporter makes it a challenging target for antibodies. Therefore, promising therapeutic avenues could include gene therapy approaches to reintroduce a functional copy of [VPS13C](/details-gene/54832) into affected neuronal populations. Alternatively, the development of small molecules that can stabilize the mutant protein or enhance its residual lipid transport activity could offer a viable pharmacological strategy.

Genular Protein ID: 188485766

Symbol: VP13C_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15498460

Title: Analysis of the human VPS13 gene family.

PubMed ID: 15498460

DOI: 10.1016/j.ygeno.2004.04.012

PubMed ID: 10718198

Title: Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro.

PubMed ID: 10718198

DOI: 10.1093/dnares/7.1.65

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 26942284

Title: Loss of mitochondrial morphology, transmembrane potential, and respiration function in autosomal-recessive parkinsonism causes mitochondrial dysfunction and increases PINK1/Parkin-dependent mitophagy.

PubMed ID: 26942284

DOI: 10.1016/j.ajhg.2016.01.014

PubMed ID: 25787250

Title: Neomorphic effects of recurrent somatic mutations in Yin Yang 1 in insulin-producing adenomas.

PubMed ID: 25787250

DOI: 10.1073/pnas.1503696112

PubMed ID: 30093493

Title: VPS13A and VPS13C are lipid transport proteins differentially localized at ER contact sites.

PubMed ID: 30093493

DOI: 10.1083/jcb.201807019

Sequence Information:

  • Length: 3753
  • Mass: 422390
  • Checksum: 8B51A6778A89F639
  • Sequence:
  • MVLESVVADL LNRFLGDYVE NLNKSQLKLG IWGGNVALDN LQIKENALSE LDVPFKVKAG 
    QIDKLTLKIP WKNLYGEAVV ATLEGLYLLV VPGASIKYDA VKEEKSLQDV KQKELSRIEE 
    ALQKAAEKGT HSGEFIYGLE NFVYKDIKPG RKRKKHKKHF KKPFKGLDRS KDKPKEAKKD 
    TFVEKLATQV IKNVQVKITD IHIKYEDDVT DPKRPLSFGV TLGELSLLTA NEHWTPCILN 
    EADKIIYKLI RLDSLSAYWN VNCSMSYQRS REQILDQLKN EILTSGNIPP NYQYIFQPIS 
    ASAKLYMNPY AESELKTPKL DCNIEIQNIA IELTKPQYLS MIDLLESVDY MVRNAPYRKY 
    KPYLPLHTNG RRWWKYAIDS VLEVHIRRYT QMWSWSNIKK HRQLLKSYKI AYKNKLTQSK 
    VSEEIQKEIQ DLEKTLDVFN IILARQQAQV EVIRSGQKLR KKSADTGEKR GGWFSGLWGK 
    KESKKKDEES LIPETIDDLM TPEEKDKLFT AIGYSESTHN LTLPKQYVAH IMTLKLVSTS 
    VTIRENKNIP EILKIQIIGL GTQVSQRPGA QALKVEAKLE HWYITGLRQQ DIVPSLVASI 
    GDTTSSLLKI KFETNPEDSP ADQTLIVQSQ PVEVIYDAKT VNAVVEFFQS NKGLDLEQIT 
    SATLMKLEEI KERTATGLTH IIETRKVLDL RINLKPSYLV VPQTGFHHEK SDLLILDFGT 
    FQLNSKDQGL QKTTNSSLEE IMDKAYDKFD VEIKNVQLLF ARAEETWKKC RFQHPSTMHI 
    LQPMDIHVEL AKAMVEKDIR MARFKVSGGL PLMHVRISDQ KMKDVLYLMN SIPLPQKSSA 
    QSPERQVSSI PIISGGTKGL LGTSLLLDTV ESESDDEYFD AEDGEPQTCK SMKGSELKKA 
    AEVPNEELIN LLLKFEIKEV ILEFTKQQKE EDTILVFNVT QLGTEATMRT FDLTVVSYLK 
    KISLDYHEIE GSKRKPLHLI SSSDKPGLDL LKVEYIKADK NGPSFQTAFG KTEQTVKVAF 
    SSLNLLLQTQ ALVASINYLT TIIPSDDQSI SVAKEVQIST EKQQKNSTLP KAIVSSRDSD 
    IIDFRLFAKL NAFCVIVCNE KNNIAEIKIQ GLDSSLSLQS RKQSLFARLE NIIVTDVDPK 
    TVHKKAVSIM GNEVFRFNLD LYPDATEGDL YTDMSKVDGV LSLNVGCIQI VYLHKFLMSL 
    LNFLNNFQTA KESLSAATAQ AAERAATSVK DLAQRSFRVS INIDLKAPVI VIPQSSISTN 
    AVVVDLGLIR VHNQFSLVSD EDYLNPPVID RMDVQLTKLT LYRTVIQPGI YHPDIQLLHP 
    INLEFLVNRN LAASWYHKVP VVEIKGHLDS MNVSLNQEDL NLLFRILTEN LCEGTEDLDK 
    VKPRVQETGE IKEPLEISIS QDVHDSKNTL TTGVEEIRSV DIINMLLNFE IKEVVVTLMK 
    KSEKKGRPLH ELNVLQLGME AKVKTYDMTA KAYLKKISMQ CFDFTDSKGE PLHIINSSNV 
    TDEPLLKMLL TKADSDGPEF KTIHDSTKQR LKVSFASLDL VLHLEALLSF MDFLSSAAPF 
    SEPSSSEKES ELKPLVGESR SIAVKAVSSN ISQKDVFDLK ITAELNAFNV FVCDQKCNIA 
    DIKIHGMDAS ISVKPKQTDV FARLKDIIVM NVDLQSIHKK AVSILGDEVF RFQLTLYPDA 
    TEGEAYADMS KVDGKLSFKV GCIQIVYVHK FFMSLLNFLN NFQTAKEALS TATVQAAERA 
    ASSMKDLAQK SFRLLMDINL KAPVIIIPQS SVSPNAVIAD LGLIRVENKF SLVPMEHYSL 
    PPVIDKMNIE LTQLKLSRTI LQASLPQNDI EILKPVNMLL SIQRNLAAAW YVQIPGMEIK 
    GKLKPMQVAL SEDDLTVLMK ILLENLGEAS SQPSPTQSVQ ETVRVRKVDV SSVPDHLKEQ 
    EDWTDSKLSM NQIVSLQFDF HFESLSIILY NNDINQESGV AFHNDSFQLG ELRLHLMASS 
    GKMFKDGSMN VSVKLKTCTL DDLREGIERA TSRMIDRKND QDNNSSMIDI SYKQDKNGSQ 
    IDAVLDKLYV CASVEFLMTV ADFFIKAVPQ SPENVAKETQ ILPRQTATGK VKIEKDDSVR 
    PNMTLKAMIT DPEVVFVASL TKADAPALTA SFQCNLSLST SKLEQMMEAS VRDLKVLACP 
    FLREKRGKNI TTVLQPCSLF MEKCTWASGK QNINIMVKEF IIKISPIILN TVLTIMAALS 
    PKTKEDGSKD TSKEMENLWG IKSINDYNTW FLGVDTATEI TESFKGIEHS LIEENCGVVV 
    ESIQVTLECG LGHRTVPLLL AESKFSGNIK NWTSLMAAVA DVTLQVHYYN EIHAVWEPLI 
    ERVEGKRQWN LRLDVKKNPV QDKSLLPGDD FIPEPQMAIH ISSGNTMNIT ISKSCLNVFN 
    NLAKGFSEGT ASTFDYSLKD RAPFTVKNAV GVPIKVKPNC NLRVMGFPEK SDIFDVDAGQ 
    NLELEYASMV PSSQGNLSIL SRQESSFFTL TIVPHGYTEV ANIPVARPGR RLYNVRNPNA 
    SHSDSVLVQI DATEGNKVIT LRSPLQIKNH FSIAFIIYKF VKNVKLLERI GIARPEEEFH 
    VPLDSYRCQL FIQPAGILEH QYKESTTYIS WKEELHRSRE VRCMLQCPSV EVSFLPLIVN 
    TVALPDELSY ICTHGEDWDV AYIIHLYPSL TLRNLLPYSL RYLLEGTAET HELAEGSTAD 
    VLHSRISGEI MELVLVKYQG KNWNGHFRIR DTLPEFFPVC FSSDSTEVTT VDLSVHVRRI 
    GSRMVLSVFS PYWLINKTTR VLQYRSEDIH VKHPADFRDI ILFSFKKKNI FTKNKVQLKI 
    STSAWSSSFS LDTVGSYGCV KCPANNMEYL VGVSIKMSSF NLSRIVTLTP FCTIANKSSL 
    ELEVGEIASD GSMPTNKWNY IASSECLPFW PESLSGKLCV RVVGCEGSSK PFFYNRQDNG 
    TLLSLEDLNG GILVDVNTAE HSTVITFSDY HEGSAPALIM NHTPWDILTY KQSGSPEEMV 
    LLPRQARLFA WADPTGTRKL TWTYAANVGE HDLLKDGCGQ FPYDANIQIH WVSFLDGRQR 
    VLLFTDDVAL VSKALQAEEM EQADYEITLS LHSLGLSLVN NESKQEVSYI GITSSGVVWE 
    VKPKQKWKPF SQKQIILLEQ SYQKHQISRD HGWIKLDNNF EVNFDKDPME MRLPIRSPIK 
    RDFLSGIQIE FKQSSHQRSL RARLYWLQVD NQLPGAMFPV VFHPVAPPKS IALDSEPKPF 
    IDVSVITRFN EYSKVLQFKY FMVLIQEMAL KIDQGFLGAI IALFTPTTDP EAERRRTKLI 
    QQDIDALNAE LMETSMTDMS ILSFFEHFHI SPVKLHLSLS LGSGGEESDK EKQEMFAVHS 
    VNLLLKSIGA TLTDVDDLIF KLAYYEIRYQ FYKRDQLIWS VVRHYSEQFL KQMYVLVLGL 
    DVLGNPFGLI RGLSEGVEAL FYEPFQGAVQ GPEEFAEGLV IGVRSLFGHT VGGAAGVVSR 
    ITGSVGKGLA AITMDKEYQQ KRREELSRQP RDFGDSLARG GKGFLRGVVG GVTGIITKPV 
    EGAKKEGAAG FFKGIGKGLV GAVARPTGGI VDMASSTFQG IQRAAESTEE VSSLRPPRLI 
    HEDGIIRPYD RQESEGSDLL ENHIKKLEGE TYRYHCAIPG SKKTILMVTN RRVLCIKEVE 
    ILGLMCVDWQ CPFEDFVFPP SVSENVLKIS VKEQGLFHKK DSANQGCVRK VYLKDTATAE 
    RACNAIEDAQ STRQQQKLMK QSSVRLLRPQ LPS