Details for: ELF2

Gene ID: 1998

Symbol: ELF2

Ensembl ID: ENSG00000109381

Description: E74 like ETS transcription factor 2

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 3.12
    Marker Score: 6,852
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 3.04
    Marker Score: 1,771
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 2.95
    Marker Score: 3,969
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 2.91
    Marker Score: 7,290
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 2.83
    Marker Score: 3,528
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 2.7
    Marker Score: 3,105
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 2.64
    Marker Score: 3,200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 2.61
    Marker Score: 46,305
  • Cell Name: regular ventricular cardiac myocyte (CL0002131)
    Fold Change: 2.52
    Marker Score: 56,295
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 2.52
    Marker Score: 1,502
  • Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
    Fold Change: 2.47
    Marker Score: 12,943
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 2.44
    Marker Score: 713
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 2.43
    Marker Score: 1,597
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 2.4
    Marker Score: 1,404
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 2.39
    Marker Score: 4,600
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 2.39
    Marker Score: 1,295
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.39
    Marker Score: 2,703
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 2.34
    Marker Score: 979
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.31
    Marker Score: 3,360
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 2.29
    Marker Score: 3,224
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: 2.27
    Marker Score: 48,476
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 2.26
    Marker Score: 1,189
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 2.24
    Marker Score: 1,688
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 2.19
    Marker Score: 7,340
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 2.19
    Marker Score: 2,416
  • Cell Name: epithelial cell of lower respiratory tract (CL0002632)
    Fold Change: 2.16
    Marker Score: 9,013
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 2.11
    Marker Score: 16,160
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 2.1
    Marker Score: 5,034
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 2.08
    Marker Score: 657
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 2.08
    Marker Score: 31,033
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 2.07
    Marker Score: 78,784
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 2.07
    Marker Score: 8,650
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: 2
    Marker Score: 1,778
  • Cell Name: alveolar type 2 fibroblast cell (CL4028006)
    Fold Change: 2
    Marker Score: 1,110
  • Cell Name: A2 amacrine cell (CL0004219)
    Fold Change: 1.99
    Marker Score: 632
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 1.98
    Marker Score: 66,798
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 1.96
    Marker Score: 500
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 1.96
    Marker Score: 8,125
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 1.93
    Marker Score: 6,334
  • Cell Name: fat cell (CL0000136)
    Fold Change: 1.92
    Marker Score: 1,072
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 1.89
    Marker Score: 1,453
  • Cell Name: epithelial cell of prostate (CL0002231)
    Fold Change: 1.89
    Marker Score: 1,309
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 1.86
    Marker Score: 2,007
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 1.83
    Marker Score: 1,957
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 1.82
    Marker Score: 1,737
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 1.82
    Marker Score: 66,975
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.81
    Marker Score: 1,786
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 1.8
    Marker Score: 895
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.77
    Marker Score: 108,982
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 1.77
    Marker Score: 603
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 1.77
    Marker Score: 35,203
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.77
    Marker Score: 6,836
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 1.75
    Marker Score: 479
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 1.74
    Marker Score: 552
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.71
    Marker Score: 3,603
  • Cell Name: mature microglial cell (CL0002629)
    Fold Change: 1.7
    Marker Score: 614
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.69
    Marker Score: 27,209
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.68
    Marker Score: 817
  • Cell Name: cholangiocyte (CL1000488)
    Fold Change: 1.67
    Marker Score: 626
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.67
    Marker Score: 17,275
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 1.67
    Marker Score: 1,096
  • Cell Name: basal cell (CL0000646)
    Fold Change: 1.66
    Marker Score: 2,149
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.64
    Marker Score: 425
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.64
    Marker Score: 6,665
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 1.63
    Marker Score: 948
  • Cell Name: podocyte (CL0000653)
    Fold Change: 1.63
    Marker Score: 603
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 1.63
    Marker Score: 2,304
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.62
    Marker Score: 7,476
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: 1.6
    Marker Score: 482
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 1.59
    Marker Score: 1,379
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 1.59
    Marker Score: 1,671
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 1.58
    Marker Score: 1,911
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 1.56
    Marker Score: 1,656
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 1.55
    Marker Score: 871
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.55
    Marker Score: 14,740
  • Cell Name: regular atrial cardiac myocyte (CL0002129)
    Fold Change: 1.55
    Marker Score: 5,505
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 1.55
    Marker Score: 446
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 1.55
    Marker Score: 965
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.54
    Marker Score: 13,223
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.54
    Marker Score: 482
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 1.53
    Marker Score: 618
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: 1.5
    Marker Score: 564
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 1.48
    Marker Score: 1,363
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.48
    Marker Score: 354
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: 1.46
    Marker Score: 764
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.46
    Marker Score: 1,805
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: 1.46
    Marker Score: 9,377
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 1.46
    Marker Score: 7,832
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 1.44
    Marker Score: 433
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 1.43
    Marker Score: 520
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.42
    Marker Score: 612
  • Cell Name: neural cell (CL0002319)
    Fold Change: 1.42
    Marker Score: 684
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 1.42
    Marker Score: 449
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.41
    Marker Score: 3,331
  • Cell Name: taste receptor cell (CL0000209)
    Fold Change: 1.41
    Marker Score: 1,217
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.41
    Marker Score: 453
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.4
    Marker Score: 7,550
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 1.4
    Marker Score: 1,502
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.4
    Marker Score: 2,160
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.4
    Marker Score: 690

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ELF2 is a member of the ETS family of transcription factors, which are characterized by their DNA-binding domain and ability to regulate gene expression. Unique to ELF2 is its E74-like domain, which confers specific binding properties to target DNA sequences. The gene is highly expressed in various cell types, including ciliary muscle cells, corneal endothelial cells, and cardiac neurons, highlighting its versatility in regulating cellular development and function. **Pathways and Functions** ELF2's regulatory functions are mediated through its interaction with specific DNA sequences, transcription factors, and co-factors. The gene is involved in various signaling pathways, including: 1. **Cell differentiation**: ELF2 regulates the expression of genes involved in cell differentiation, promoting the development of specific cell types. 2. **Transcriptional regulation**: ELF2 acts as a transcriptional regulator by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 3. **DNA binding**: ELF2's E74-like domain enables it to bind to specific DNA sequences, influencing gene expression and chromatin structure. **Clinical Significance** The dysregulation of ELF2 has been implicated in various diseases, including: 1. **Cancer**: ELF2's role in regulating cell differentiation and transcriptional regulation may contribute to cancer development and progression. 2. **Neurological disorders**: Alterations in ELF2 expression have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiac disease**: ELF2's involvement in cardiac development and function may contribute to the pathogenesis of cardiac diseases, including heart failure. In conclusion, ELF2 is a multifaceted transcription factor that plays a crucial role in regulating gene expression, cell differentiation, and DNA binding. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying ELF2's functions and its potential as a therapeutic target. **Recommendations** 1. **Further research**: Investigate the specific mechanisms by which ELF2 regulates gene expression and transcriptional regulation. 2. **Disease modeling**: Utilize ELF2 as a model to study the pathogenesis of diseases, including cancer, neurological disorders, and cardiac disease. 3. **Therapeutic development**: Explore the potential of ELF2 as a therapeutic target for the treatment of diseases associated with its dysregulation. By elucidating the intricacies of ELF2, we can gain a deeper understanding of its role in regulating gene expression and its potential as a therapeutic target.

Genular Protein ID: 1299572350

Symbol: ELF2_HUMAN

Name: ETS-related transcription factor Elf-2

UniProtKB Accession Codes:

Q15723 E9PCX3 Q15724 Q15725 Q6P1K5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 5 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 12 EPD 1 Ensembl 6 ExpressionAtlas 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 6 Pumba 1 RNAct 1 Reactome 1 RefSeq 7 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8756667

Title: Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.

PubMed ID: 8756667

DOI: 10.1128/mcb.16.9.5091

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 14970218

Title: Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.

PubMed ID: 14970218

DOI: 10.1074/jbc.m309074200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

Sequence Information:

  • Length: 593
  • Mass: 63967
  • Checksum: B67013B453559910
  • Sequence:
    • MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA AQVLVYDDET 
YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPVEV 
FVPPCVSTPE FIHAAMRPDV ITETVVEVST EESEPMDTSP IPTSPDSHEP MKKKKVGRKP 
KTQQSPISNG SPELGIKKKP REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL 
VDSKAVSKLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID 
DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR AEKGVARVVN 
ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS LGQKISTVAV QSVNAGAPLI 
TSTSPTTATS PKVVIQTIPT VMPASTENGD KITMQPAKII TIPATQLAQC QLQTKSNLTG 
SGSINIVGTP LAVRALTPVS IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV 
AKKQEHDVKT LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK

Genular Protein ID: 1751238371

Symbol: B7Z720_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z720

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 6 ExpressionAtlas 1 GO 4 Gene3D 1 GenomeRNAi 1 IntAct 1 InterPro 5 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 4 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 1 SMR 1 SUPFAM 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 521
  • Mass: 56133
  • Checksum: A54F8DAA008C164D
  • Sequence:
    • MATSLHEGPT NQLDLLIRAV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPEFI 
HAAMRPDVIT ETVVEVSTEE SEPMDTSPIP TSPDSHEPMK KKKVGRKPKT QQSPISNGSP 
ELGIKKKPRE GKGNTTYLWE FLLDLLQDKN TCPRYIKWTQ REKGIFKLVD SKAVSKLWGK 
HKNKPDMNYE TMGRALRYYY QRGILAKVEG QRLVYQFKDM PKNIVVIDDD KSETCNEDLA 
GTTDEKSLER VSLSAESLLK AASSVRSGKN SSPINCSRAE KGVARVVNIT SPGHDASSRS 
PTTTASVSAT AAPRTVRVAM QVPVVMTSLG QKISTVAVQS VNAGAPLITS TSPTTATSPK 
VVIQTIPTVM PASTENGDKI TMQPAKIITI PATQLAQCQL QTKSNLTGSG SINIVGTPLA 
VRALTPVSIA HGTPVMRLSM PTQQASGQTP PRVISAVIKG PEVKSEAVAK KQEHDVKTLQ 
LVEEKPADGN KTVTHVVVVS APSAIALPVT MKTEGLVTCE K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.