Details for: ELF2

Gene ID: 1998

Symbol: ELF2

Ensembl ID: ENSG00000109381

Description: E74 like ETS transcription factor 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 529.5887
    Cell Significance Index: -82.3800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 320.1345
    Cell Significance Index: -81.2000
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 184.8249
    Cell Significance Index: -87.2600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 174.9877
    Cell Significance Index: -71.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 156.1670
    Cell Significance Index: -80.3300
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 74.6903
    Cell Significance Index: -71.3100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 70.3513
    Cell Significance Index: -86.7400
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 30.0837
    Cell Significance Index: -80.5900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 23.5814
    Cell Significance Index: -51.6100
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 22.1882
    Cell Significance Index: -68.1500
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 22.1868
    Cell Significance Index: -87.5500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 5.1830
    Cell Significance Index: 290.8500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 3.4990
    Cell Significance Index: 68.2900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 2.4438
    Cell Significance Index: 187.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.4294
    Cell Significance Index: 482.1200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 2.1824
    Cell Significance Index: 60.9900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.7923
    Cell Significance Index: 359.5400
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.7493
    Cell Significance Index: 107.5200
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.6889
    Cell Significance Index: 24.2900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 1.4317
    Cell Significance Index: 513.5400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 1.1758
    Cell Significance Index: 28.6900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: 1.1486
    Cell Significance Index: 29.5300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.7434
    Cell Significance Index: 134.0100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.7190
    Cell Significance Index: 88.4100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.7113
    Cell Significance Index: 322.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.6147
    Cell Significance Index: 84.4100
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.5147
    Cell Significance Index: 355.9900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.5044
    Cell Significance Index: 320.3700
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.4859
    Cell Significance Index: 25.3100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4690
    Cell Significance Index: 207.3600
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.4470
    Cell Significance Index: 10.7200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.4449
    Cell Significance Index: 19.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.4369
    Cell Significance Index: 28.1900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.4065
    Cell Significance Index: 27.3300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.3988
    Cell Significance Index: 735.4600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3986
    Cell Significance Index: 217.6800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.3816
    Cell Significance Index: 587.4800
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.3767
    Cell Significance Index: 5.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3525
    Cell Significance Index: 13.3500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.3182
    Cell Significance Index: 22.0100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3114
    Cell Significance Index: 2.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.3078
    Cell Significance Index: 579.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.3048
    Cell Significance Index: 414.4300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2725
    Cell Significance Index: 12.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2198
    Cell Significance Index: 41.8400
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.2028
    Cell Significance Index: 4.3400
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1733
    Cell Significance Index: 2.9700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0648
    Cell Significance Index: 6.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0457
    Cell Significance Index: 2.1300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0415
    Cell Significance Index: 5.3200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0185
    Cell Significance Index: 16.7000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0109
    Cell Significance Index: 0.2900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.0050
    Cell Significance Index: -0.0300
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.0460
    Cell Significance Index: -0.7000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0660
    Cell Significance Index: -48.4200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0917
    Cell Significance Index: -15.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0929
    Cell Significance Index: -68.8400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.1019
    Cell Significance Index: -77.1100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1459
    Cell Significance Index: -82.3000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1509
    Cell Significance Index: -17.7900
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1514
    Cell Significance Index: -94.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.1648
    Cell Significance Index: -3.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2144
    Cell Significance Index: -21.9000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.2313
    Cell Significance Index: -33.6200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.2504
    Cell Significance Index: -40.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2546
    Cell Significance Index: -29.6700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2675
    Cell Significance Index: -76.9700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3151
    Cell Significance Index: -14.8100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.3353
    Cell Significance Index: -43.3200
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.3382
    Cell Significance Index: -23.9200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3788
    Cell Significance Index: -28.2300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.3797
    Cell Significance Index: -39.5400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.4132
    Cell Significance Index: -6.9600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.4278
    Cell Significance Index: -49.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.4317
    Cell Significance Index: -90.9300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4318
    Cell Significance Index: -22.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4508
    Cell Significance Index: -28.4100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -0.4606
    Cell Significance Index: -6.8000
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.5357
    Cell Significance Index: -6.6800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.5460
    Cell Significance Index: -14.6300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.6387
    Cell Significance Index: -33.1800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6853
    Cell Significance Index: -24.0800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.7515
    Cell Significance Index: -20.4600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8493
    Cell Significance Index: -24.4700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.8767
    Cell Significance Index: -28.0800
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.9198
    Cell Significance Index: -72.8500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.9356
    Cell Significance Index: -26.8200
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.9438
    Cell Significance Index: -13.9300
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.9642
    Cell Significance Index: -12.1700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9814
    Cell Significance Index: -13.3900
  • Cell Name: type II muscle cell (CL0002212)
    Fold Change: -1.1131
    Cell Significance Index: -17.9600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1944
    Cell Significance Index: -73.2300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.3145
    Cell Significance Index: -45.6800
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -1.4137
    Cell Significance Index: -23.6600
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -1.5038
    Cell Significance Index: -22.8400
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -1.5686
    Cell Significance Index: -16.3400
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -1.6021
    Cell Significance Index: -35.0800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -1.6429
    Cell Significance Index: -34.9900
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -1.6511
    Cell Significance Index: -43.4200
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7499
    Cell Significance Index: -46.8100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ELF2 is a member of the ETS family of transcription factors, which are characterized by their DNA-binding domain and ability to regulate gene expression. Unique to ELF2 is its E74-like domain, which confers specific binding properties to target DNA sequences. The gene is highly expressed in various cell types, including ciliary muscle cells, corneal endothelial cells, and cardiac neurons, highlighting its versatility in regulating cellular development and function. **Pathways and Functions** ELF2's regulatory functions are mediated through its interaction with specific DNA sequences, transcription factors, and co-factors. The gene is involved in various signaling pathways, including: 1. **Cell differentiation**: ELF2 regulates the expression of genes involved in cell differentiation, promoting the development of specific cell types. 2. **Transcriptional regulation**: ELF2 acts as a transcriptional regulator by binding to specific DNA sequences and modulating the activity of RNA polymerase II. 3. **DNA binding**: ELF2's E74-like domain enables it to bind to specific DNA sequences, influencing gene expression and chromatin structure. **Clinical Significance** The dysregulation of ELF2 has been implicated in various diseases, including: 1. **Cancer**: ELF2's role in regulating cell differentiation and transcriptional regulation may contribute to cancer development and progression. 2. **Neurological disorders**: Alterations in ELF2 expression have been linked to neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cardiac disease**: ELF2's involvement in cardiac development and function may contribute to the pathogenesis of cardiac diseases, including heart failure. In conclusion, ELF2 is a multifaceted transcription factor that plays a crucial role in regulating gene expression, cell differentiation, and DNA binding. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the mechanisms underlying ELF2's functions and its potential as a therapeutic target. **Recommendations** 1. **Further research**: Investigate the specific mechanisms by which ELF2 regulates gene expression and transcriptional regulation. 2. **Disease modeling**: Utilize ELF2 as a model to study the pathogenesis of diseases, including cancer, neurological disorders, and cardiac disease. 3. **Therapeutic development**: Explore the potential of ELF2 as a therapeutic target for the treatment of diseases associated with its dysregulation. By elucidating the intricacies of ELF2, we can gain a deeper understanding of its role in regulating gene expression and its potential as a therapeutic target.

Genular Protein ID: 1299572350

Symbol: ELF2_HUMAN

Name: ETS-related transcription factor Elf-2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8756667

Title: Characterization of NERF, a novel transcription factor related to the Ets factor ELF-1.

PubMed ID: 8756667

DOI: 10.1128/mcb.16.9.5091

PubMed ID: 15815621

Title: Generation and annotation of the DNA sequences of human chromosomes 2 and 4.

PubMed ID: 15815621

DOI: 10.1038/nature03466

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10207087

Title: Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21)-positive leukemias.

PubMed ID: 10207087

DOI: 10.1128/mcb.19.5.3635

PubMed ID: 14970218

Title: Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1-mediated transcription of the B cell-specific blk gene.

PubMed ID: 14970218

DOI: 10.1074/jbc.m309074200

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

Sequence Information:

  • Length: 593
  • Mass: 63967
  • Checksum: B67013B453559910
  • Sequence:
  • MTSAVVDSGG TILELSSNGV ENQEESEKVS EYPAVIVEPV PSARLEQGYA AQVLVYDDET 
    YMMQDVAEEQ EVETENVETV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPVEV 
    FVPPCVSTPE FIHAAMRPDV ITETVVEVST EESEPMDTSP IPTSPDSHEP MKKKKVGRKP 
    KTQQSPISNG SPELGIKKKP REGKGNTTYL WEFLLDLLQD KNTCPRYIKW TQREKGIFKL 
    VDSKAVSKLW GKHKNKPDMN YETMGRALRY YYQRGILAKV EGQRLVYQFK DMPKNIVVID 
    DDKSETCNED LAGTTDEKSL ERVSLSAESL LKAASSVRSG KNSSPINCSR AEKGVARVVN 
    ITSPGHDASS RSPTTTASVS ATAAPRTVRV AMQVPVVMTS LGQKISTVAV QSVNAGAPLI 
    TSTSPTTATS PKVVIQTIPT VMPASTENGD KITMQPAKII TIPATQLAQC QLQTKSNLTG 
    SGSINIVGTP LAVRALTPVS IAHGTPVMRL SMPTQQASGQ TPPRVISAVI KGPEVKSEAV 
    AKKQEHDVKT LQLVEEKPAD GNKTVTHVVV VSAPSAIALP VTMKTEGLVT CEK

Genular Protein ID: 1751238371

Symbol: B7Z720_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

Sequence Information:

  • Length: 521
  • Mass: 56133
  • Checksum: A54F8DAA008C164D
  • Sequence:
  • MATSLHEGPT NQLDLLIRAV EASVHSSNAH CTDKTIEAAE ALLHMESPTC LRDSRSPEFI 
    HAAMRPDVIT ETVVEVSTEE SEPMDTSPIP TSPDSHEPMK KKKVGRKPKT QQSPISNGSP 
    ELGIKKKPRE GKGNTTYLWE FLLDLLQDKN TCPRYIKWTQ REKGIFKLVD SKAVSKLWGK 
    HKNKPDMNYE TMGRALRYYY QRGILAKVEG QRLVYQFKDM PKNIVVIDDD KSETCNEDLA 
    GTTDEKSLER VSLSAESLLK AASSVRSGKN SSPINCSRAE KGVARVVNIT SPGHDASSRS 
    PTTTASVSAT AAPRTVRVAM QVPVVMTSLG QKISTVAVQS VNAGAPLITS TSPTTATSPK 
    VVIQTIPTVM PASTENGDKI TMQPAKIITI PATQLAQCQL QTKSNLTGSG SINIVGTPLA 
    VRALTPVSIA HGTPVMRLSM PTQQASGQTP PRVISAVIKG PEVKSEAVAK KQEHDVKTLQ 
    LVEEKPADGN KTVTHVVVVS APSAIALPVT MKTEGLVTCE K

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.