Details for: MSRB1

Gene ID: 51734

Symbol: MSRB1

Ensembl ID: ENSG00000198736

Description: methionine sulfoxide reductase B1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 95.2135
    Cell Significance Index: -14.8100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 48.2567
    Cell Significance Index: -12.2400
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 37.2377
    Cell Significance Index: -15.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 34.4190
    Cell Significance Index: -16.2500
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 30.8426
    Cell Significance Index: -15.8700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 24.2913
    Cell Significance Index: -16.3000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 12.2470
    Cell Significance Index: -15.1000
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 4.8477
    Cell Significance Index: 38.7100
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.8379
    Cell Significance Index: -12.9600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.9001
    Cell Significance Index: -15.3900
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 2.2405
    Cell Significance Index: 18.8200
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.9272
    Cell Significance Index: 35.6200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.4815
    Cell Significance Index: 88.9400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 1.3111
    Cell Significance Index: 152.7900
  • Cell Name: liver dendritic cell (CL2000055)
    Fold Change: 1.2112
    Cell Significance Index: 3.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8475
    Cell Significance Index: 137.8300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.7100
    Cell Significance Index: 36.8800
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 0.6389
    Cell Significance Index: 5.4900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5519
    Cell Significance Index: 105.0200
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.5402
    Cell Significance Index: 487.7200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.5199
    Cell Significance Index: 51.4300
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.5126
    Cell Significance Index: 4.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.3890
    Cell Significance Index: 77.2000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.3727
    Cell Significance Index: 63.6400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.3257
    Cell Significance Index: 4.8800
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: 0.3254
    Cell Significance Index: 7.9400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.3234
    Cell Significance Index: 176.6300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.3044
    Cell Significance Index: 41.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2984
    Cell Significance Index: 10.3700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.2649
    Cell Significance Index: 7.7800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.2612
    Cell Significance Index: 47.0800
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.2559
    Cell Significance Index: 1.5900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.2490
    Cell Significance Index: 18.5600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2257
    Cell Significance Index: 10.2300
  • Cell Name: hepatoblast (CL0005026)
    Fold Change: 0.2099
    Cell Significance Index: 3.5300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.2086
    Cell Significance Index: 14.7500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.2070
    Cell Significance Index: 25.4500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1888
    Cell Significance Index: 83.4700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.1832
    Cell Significance Index: 8.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.1825
    Cell Significance Index: 8.5100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.1721
    Cell Significance Index: 2.5400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1593
    Cell Significance Index: 4.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.1279
    Cell Significance Index: 16.4000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1094
    Cell Significance Index: 2.3700
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.1026
    Cell Significance Index: 2.7400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0977
    Cell Significance Index: 1.1100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0945
    Cell Significance Index: 11.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0744
    Cell Significance Index: 4.8000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0594
    Cell Significance Index: 41.1000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 0.0447
    Cell Significance Index: 0.2800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0352
    Cell Significance Index: 0.7500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.0248
    Cell Significance Index: 18.7400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0228
    Cell Significance Index: 0.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 0.0150
    Cell Significance Index: 0.7900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0016
    Cell Significance Index: -1.1800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0033
    Cell Significance Index: -0.1700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0049
    Cell Significance Index: -9.2700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0051
    Cell Significance Index: -0.5200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0098
    Cell Significance Index: -18.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0118
    Cell Significance Index: -18.2300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0128
    Cell Significance Index: -0.4500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0131
    Cell Significance Index: -17.8700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0168
    Cell Significance Index: -12.4500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0179
    Cell Significance Index: -0.3000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0186
    Cell Significance Index: -0.7600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0201
    Cell Significance Index: -11.3500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0202
    Cell Significance Index: -12.8400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0246
    Cell Significance Index: -11.1500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0306
    Cell Significance Index: -19.0900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0317
    Cell Significance Index: -11.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0346
    Cell Significance Index: -6.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0360
    Cell Significance Index: -4.6500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0378
    Cell Significance Index: -10.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0454
    Cell Significance Index: -1.2700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0481
    Cell Significance Index: -1.3100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.0560
    Cell Significance Index: -1.4300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0819
    Cell Significance Index: -6.4900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0820
    Cell Significance Index: -17.2800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0824
    Cell Significance Index: -9.4400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.0840
    Cell Significance Index: -2.2100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0885
    Cell Significance Index: -12.8600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1092
    Cell Significance Index: -8.3800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1142
    Cell Significance Index: -3.0600
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1173
    Cell Significance Index: -1.6000
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1236
    Cell Significance Index: -0.9500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1236
    Cell Significance Index: -1.2800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1352
    Cell Significance Index: -14.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1379
    Cell Significance Index: -8.6900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1815
    Cell Significance Index: -3.8000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1879
    Cell Significance Index: -4.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1991
    Cell Significance Index: -5.8700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2045
    Cell Significance Index: -11.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.2157
    Cell Significance Index: -13.2300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2657
    Cell Significance Index: -13.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.2952
    Cell Significance Index: -2.0000
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3167
    Cell Significance Index: -8.1400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3325
    Cell Significance Index: -12.2100
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.3440
    Cell Significance Index: -5.8000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3495
    Cell Significance Index: -7.2500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3518
    Cell Significance Index: -15.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MSRB1 belongs to the family of methionine sulfoxide reductases, which play a vital role in maintaining protein integrity by reducing oxidized methionine residues. The enzyme has a unique structure, consisting of two subunits, with one subunit having a catalytic domain and the other subunit containing a zinc-binding site. MSRB1 is also known to interact with other proteins, including actin-binding proteins, which suggests its involvement in cytoskeletal dynamics. **Pathways and Functions:** MSRB1 is involved in several cellular processes, including: 1. **Protein repair:** MSRB1 reduces oxidized methionine residues, restoring the native conformation of proteins and maintaining their function. 2. **Actin cytoskeleton dynamics:** MSRB1 interacts with actin-binding proteins, regulating cytoskeletal organization and cell movement. 3. **Innate immune response:** MSRB1 has been shown to play a role in the innate immune response, particularly in the repair of damaged tissues and the regulation of immune cell function. 4. **Metabolism of proteins:** MSRB1 is involved in the degradation of oxidized proteins, which is essential for maintaining protein homeostasis. **Clinical Significance:** The clinical significance of MSRB1 is multifaceted: 1. **Neurodegenerative diseases:** Mutations in MSRB1 have been linked to neurodegenerative disorders, such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). 2. **Cancer:** MSRB1 has been implicated in cancer development and progression, particularly in the context of oxidative stress and DNA damage. 3. **Autoimmune diseases:** MSRB1 has been shown to play a role in the development of autoimmune diseases, such as rheumatoid arthritis and lupus. 4. **Infectious diseases:** MSRB1 has been implicated in the pathogenesis of infectious diseases, such as tuberculosis and malaria. In conclusion, MSRB1 is a complex enzyme with multiple functions, including protein repair, actin cytoskeleton dynamics, and innate immune response. Its clinical significance is far-reaching, with implications for neurodegenerative diseases, cancer, autoimmune diseases, and infectious diseases. Further research is needed to fully elucidate the role of MSRB1 in human health and disease.

Genular Protein ID: 1978681000

Symbol: MSRB1_HUMAN

Name: Methionine-R-sulfoxide reductase B1

UniProtKB Accession Codes:

Q9NZV6 Q96RX6 Q9BTV2 Q9P0B1

Database IDs:

AGR 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChEBI 15 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EC 2 EMBL 6 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 8 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10608886

Title: Novel selenoproteins identified in silico and in vivo by using a conserved RNA structural motif.

PubMed ID: 10608886

DOI: 10.1074/jbc.274.53.38147

PubMed ID: 11042152

Title: Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.

PubMed ID: 11042152

DOI: 10.1101/gr.140200

PubMed ID: 11157797

Title: Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16.

PubMed ID: 11157797

DOI: 10.1093/hmg/10.4.339

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 26138980

Title: SELENOPROTEINS. CRL2 aids elimination of truncated selenoproteins produced by failed UGA/Sec decoding.

PubMed ID: 26138980

DOI: 10.1126/science.aab0515

Sequence Information:

  • Length: 116
  • Mass: 12760
  • Checksum: 812B033BE02B7C0E
  • Sequence:
    • MSFCSFFGGE VFQNHFEPGV YVCAKCGYEL FSSRSKYAHS SPWPAFTETI HADSVAKRPE 
HNRSEALKVS CGKCGNGLGH EFLNDGPKPG QSRFUIFSSS LKFVPKGKET SASQGH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.