Details for: GRK6

Gene ID: 2870

Symbol: GRK6

Ensembl ID: ENSG00000198055

Description: G protein-coupled receptor kinase 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 1.56
    Marker Score: 779
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 1.49
    Marker Score: 896
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 1.41
    Marker Score: 609
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 1.39
    Marker Score: 3893
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 1.34
    Marker Score: 1256
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 1.33
    Marker Score: 1315
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.32
    Marker Score: 2504
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 1.32
    Marker Score: 1238
  • Cell Name: central memory CD8-positive, alpha-beta T cell (CL0000907)
    Fold Change: 1.32
    Marker Score: 3211
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 1.24
    Marker Score: 377
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.19
    Marker Score: 2805
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.19
    Marker Score: 714
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 1.19
    Marker Score: 391
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.18
    Marker Score: 416
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 1.16
    Marker Score: 375
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.11
    Marker Score: 2718.5
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.08
    Marker Score: 60671
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 1.08
    Marker Score: 3144
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 1.07
    Marker Score: 1581
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.06
    Marker Score: 16582
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 1.05
    Marker Score: 615
  • Cell Name: central memory CD4-positive, alpha-beta T cell (CL0000904)
    Fold Change: 1.05
    Marker Score: 1132
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 1.05
    Marker Score: 1162
  • Cell Name: memory regulatory T cell (CL0002678)
    Fold Change: 1.03
    Marker Score: 361
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.03
    Marker Score: 322
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 1.03
    Marker Score: 902
  • Cell Name: Unknown (CL0000548)
    Fold Change: 1.03
    Marker Score: 747.5
  • Cell Name: CD16-negative, CD56-bright natural killer cell, human (CL0000938)
    Fold Change: 1.01
    Marker Score: 825
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71687
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 1
    Marker Score: 889
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47911
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.99
    Marker Score: 2012.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30392
  • Cell Name: IgG plasmablast (CL0000982)
    Fold Change: 0.96
    Marker Score: 266
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.96
    Marker Score: 9522
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 0.96
    Marker Score: 725
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.95
    Marker Score: 293
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.94
    Marker Score: 2395
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.93
    Marker Score: 779
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.92
    Marker Score: 476
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.92
    Marker Score: 724
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.91
    Marker Score: 432
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.91
    Marker Score: 1209
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.91
    Marker Score: 2190
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.9
    Marker Score: 2697
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 0.9
    Marker Score: 579
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.89
    Marker Score: 603
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 0.88
    Marker Score: 3784
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.88
    Marker Score: 643
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.86
    Marker Score: 7392
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: 0.86
    Marker Score: 2135
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: 0.85
    Marker Score: 471
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.85
    Marker Score: 307
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.84
    Marker Score: 4788
  • Cell Name: IgA plasmablast (CL0000984)
    Fold Change: 0.82
    Marker Score: 215
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 0.81
    Marker Score: 349
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.8
    Marker Score: 48967.5
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.8
    Marker Score: 8221.5
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.8
    Marker Score: 8063.5
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.79
    Marker Score: 20179
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.78
    Marker Score: 2466
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.78
    Marker Score: 312
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.77
    Marker Score: 266
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.76
    Marker Score: 40445
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.76
    Marker Score: 2245
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.75
    Marker Score: 438
  • Cell Name: IgM plasma cell (CL0000986)
    Fold Change: 0.73
    Marker Score: 254
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.73
    Marker Score: 193
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.72
    Marker Score: 372
  • Cell Name: ILC1, human (CL0001077)
    Fold Change: 0.72
    Marker Score: 182
  • Cell Name: effector memory CD8-positive, alpha-beta T cell (CL0000913)
    Fold Change: 0.72
    Marker Score: 441
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 0.71
    Marker Score: 411
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.71
    Marker Score: 365
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.71
    Marker Score: 184
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2938
  • Cell Name: B-1b B cell (CL0000821)
    Fold Change: 0.7
    Marker Score: 161
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.69
    Marker Score: 8003
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.69
    Marker Score: 499
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.68
    Marker Score: 155
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.67
    Marker Score: 991
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.67
    Marker Score: 293
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 0.67
    Marker Score: 1193
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.67
    Marker Score: 442
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.67
    Marker Score: 167
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.67
    Marker Score: 422
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.66
    Marker Score: 134
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.66
    Marker Score: 148
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.66
    Marker Score: 145
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.66
    Marker Score: 413
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.66
    Marker Score: 129
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.66
    Marker Score: 140
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.66
    Marker Score: 153
  • Cell Name: progenitor cell of endocrine pancreas (CL0002351)
    Fold Change: 0.66
    Marker Score: 143
  • Cell Name: CD4-positive helper T cell (CL0000492)
    Fold Change: 0.65
    Marker Score: 712
  • Cell Name: intermediate monocyte (CL0002393)
    Fold Change: 0.65
    Marker Score: 226
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.65
    Marker Score: 381.5

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Other Information

**Key characteristics** * GRK6 is a protein that is encoded by the GRK6_HUMAN gene. * It is a kinase that is localized to the cytoplasm. * It is a key downstream effector of GPCRs. * It plays a role in the regulation of GPCR signaling pathways. **Pathways and functions** * GRK6 is a downstream effector of GPCRs. * It is involved in the regulation of GPCR signaling pathways in a variety of cell types. * It is involved in the regulation of cell growth, differentiation, and apoptosis. * It is involved in the regulation of inflammation. **Clinical significance** GRK6 is a potential therapeutic target for a variety of diseases. For example, it is a target for cancer therapy, as it is expressed in high levels in many types of cancer cells. Inhibition of GRK6 has been shown to inhibit cancer cell growth and metastasis. **Additional information** * GRK6 is a member of the GPCR kinase family of proteins. * It is a multi-domain protein that is composed of three different subunits. * It is activated by G proteins. * It is a key regulator of GPCR signaling pathways.

Genular Protein ID: 399754056

Symbol: GRK6_HUMAN

Name: G protein-coupled receptor kinase 6

UniProtKB Accession Codes:

P43250 O60541 Q13652

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 CarbonylDB 1 ChEBI 9 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EC 2 EMBL 6 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 11 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GuidetoPHARMACOLOGY 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 3 PIR 1 PRINTS 1 PRO 1 PROSITE 5 PROSITE-ProRule 4 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 3 Pumba 1 RNAct 1 Reactome 1 RefSeq 3 Rhea 3 SIGNOR 1 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 SwissPalm 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8366096

Title: Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

PubMed ID: 8366096

DOI: 10.1016/s0021-9258(19)36546-9

PubMed ID: 10506199

Title: The GRK4 subfamily of G protein-coupled receptor kinases. Alternative splicing, gene organization, and sequence conservation.

PubMed ID: 10506199

DOI: 10.1074/jbc.274.41.29381

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 8415712

Title: Identification of additional members of human G-protein-coupled receptor kinase multigene family.

PubMed ID: 8415712

DOI: 10.1073/pnas.90.20.9398

PubMed ID: 7961702

Title: Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

PubMed ID: 7961702

DOI: 10.1016/s0021-9258(18)46852-4

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19801552

Title: G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway.

PubMed ID: 19801552

DOI: 10.1074/jbc.m109.047456

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 20048153

Title: Site-specific phosphorylation of CXCR4 is dynamically regulated by multiple kinases and results in differential modulation of CXCR4 signaling.

PubMed ID: 20048153

DOI: 10.1074/jbc.m109.091173

PubMed ID: 16613860

Title: The structure of G protein-coupled receptor kinase (GRK)-6 defines a second lineage of GRKs.

PubMed ID: 16613860

DOI: 10.1074/jbc.m601327200

PubMed ID: 20729810

Title: Molecular basis for activation of G protein-coupled receptor kinases.

PubMed ID: 20729810

DOI: 10.1038/emboj.2010.206

PubMed ID: 17344846

Title: Patterns of somatic mutation in human cancer genomes.

PubMed ID: 17344846

DOI: 10.1038/nature05610

Sequence Information:

  • Length: 576
  • Mass: 65991
  • Checksum: 3BF8C3B1CDE2BD74
  • Sequence:
    • MELENIVANT VLLKAREGGG GNRKGKSKKW RQMLQFPHIS QCEELRLSLE RDYHSLCERQ 
PIGRLLFREF CATRPELSRC VAFLDGVAEY EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE 
VPRQLVTNCT QRLEQGPCKD LFQELTRLTH EYLSVAPFAD YLDSIYFNRF LQWKWLERQP 
VTKNTFRQYR VLGKGGFGEV CACQVRATGK MYACKKLEKK RIKKRKGEAM ALNEKQILEK 
VNSRFVVSLA YAYETKDALC LVLTLMNGGD LKFHIYHMGQ AGFPEARAVF YAAEICCGLE 
DLHRERIVYR DLKPENILLD DHGHIRISDL GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE 
RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK KIKREEVERL VKEVPEEYSE RFSPQARSLC 
SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI 
EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP WQNEMVETEC FQELNVFGLD GSVPPDLDWK 
GQPPAPPKKG LLQRLFSRQD CCGNCSDSEE ELPTRL

Genular Protein ID: 2624740912

Symbol: B3KPS5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KPS5

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChEBI 1 DNASU 1 EMBL 2 GO 4 Gene3D 3 GenomeRNAi 1 InterPro 9 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PIRSR 1 PRINTS 1 PROSITE 8 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 RefSeq 1 RuleBase 1 SAM 1 SMART 3 SUPFAM 2

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 559
  • Mass: 63752
  • Checksum: 4173C98156202BDE
  • Sequence:
    • MPHPCALGLW TQQLPSLPTE RDYHSLCERQ PIGRLLFREF CATRPELSRC VAFLDGVAEY 
EVTPDDKRKA CGRQLTQNFL SHTGPDLIPE VPRQLVTNCT QRLEQGPCKD LFQELTRLTH 
EYLSVAPFAD YLDSIYFNRF LQWKWLERQP VTKNTFRQYR VLGKGGFGEV CACQVRATGK 
MYACKKLEKK RIKKRKGEAM ALNEKQILEK VNSRFVVSLA YAYETKDALC LVLTLMNGGD 
LKFHIYHMGQ AGFPEARAVF YAAEICCGLE DLHRERIVYR DLKPENILLD DHGHIRISDL 
GLAVHVPEGQ TIKGRVGTVG YMAPEVVKNE RYTFSPDWWA LGCLLYEMIA GQSPFQQRKK 
KIKREEVERL VKEVPEEYSE RFSPQARSLC SQLLCKDPAE RLGCRGGSAR EVKEHPLFKK 
LNFKRLGAGM LEPPFKPDPQ AIYCKDVLDI EQFSTVKGVE LEPTDQDFYQ KFATGSVPIP 
WQNEMVETEC FQELNVFGLD GSVPPDLDWK GQPPAPPKKG LLQRLFSRQR IAVETAATAR 
KSSPPASSPQ PEAPTSSWR

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.