Details for: NAGA
Associated with
Cells (max top 100)
(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)
- Cell Name: polychromatophilic erythroblast (CL0000550)
Fold Change: 71.3619
Cell Significance Index: -11.1000 - Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
Fold Change: 45.7729
Cell Significance Index: -11.6100 - Cell Name: mucosal type mast cell (CL0000485)
Fold Change: 30.8672
Cell Significance Index: -12.5400 - Cell Name: peripheral blood mononuclear cell (CL2000001)
Fold Change: 26.4199
Cell Significance Index: -13.5900 - Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 13.1344
Cell Significance Index: -12.5400 - Cell Name: orthochromatic erythroblast (CL0000552)
Fold Change: 9.9679
Cell Significance Index: -12.2900 - Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
Fold Change: 4.9797
Cell Significance Index: -13.3400 - Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
Fold Change: 3.7083
Cell Significance Index: -11.3900 - Cell Name: stromal cell of bone marrow (CL0010001)
Fold Change: 3.2032
Cell Significance Index: -12.6400 - Cell Name: epidermal Langerhans cell (CL0002457)
Fold Change: 1.7408
Cell Significance Index: -3.8100 - Cell Name: late promyelocyte (CL0002151)
Fold Change: 1.6475
Cell Significance Index: 10.9300 - Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 1.1162
Cell Significance Index: 20.6300 - Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.8944
Cell Significance Index: 807.5500 - Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.8595
Cell Significance Index: 51.6000 - Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.7674
Cell Significance Index: 83.4700 - Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7148
Cell Significance Index: 19.1200 - Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.6273
Cell Significance Index: 102.0200 - Cell Name: cortical cell of adrenal gland (CL0002097)
Fold Change: 0.3857
Cell Significance Index: 10.3400 - Cell Name: bladder urothelial cell (CL1001428)
Fold Change: 0.3633
Cell Significance Index: 18.8700 - Cell Name: microfold cell of epithelium of small intestine (CL1000353)
Fold Change: 0.2933
Cell Significance Index: 20.2900 - Cell Name: umbrella cell of urothelium (CL4030056)
Fold Change: 0.2671
Cell Significance Index: 2.4600 - Cell Name: placental villous trophoblast (CL2000060)
Fold Change: 0.2490
Cell Significance Index: 6.6500 - Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.2175
Cell Significance Index: 41.3900 - Cell Name: odontoblast (CL0000060)
Fold Change: 0.2114
Cell Significance Index: 27.1000 - Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: 0.2014
Cell Significance Index: 9.3900 - Cell Name: stromal cell of ovary (CL0002132)
Fold Change: 0.1879
Cell Significance Index: 25.8100 - Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.1786
Cell Significance Index: 3.8700 - Cell Name: colon goblet cell (CL0009039)
Fold Change: 0.1628
Cell Significance Index: 16.1000 - Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: 0.1575
Cell Significance Index: 28.4000 - Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.1491
Cell Significance Index: 6.7600 - Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 0.1409
Cell Significance Index: 4.0600 - Cell Name: basal cell of prostate epithelium (CL0002341)
Fold Change: 0.1337
Cell Significance Index: 3.6400 - Cell Name: cell in vitro (CL0001034)
Fold Change: 0.1326
Cell Significance Index: 72.4100 - Cell Name: extravillous trophoblast (CL0008036)
Fold Change: 0.1288
Cell Significance Index: 0.8000 - Cell Name: basal cell of urothelium (CL1000486)
Fold Change: 0.1270
Cell Significance Index: 15.6100 - Cell Name: mesenchymal cell (CL0008019)
Fold Change: 0.1219
Cell Significance Index: 2.0400 - Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: 0.0840
Cell Significance Index: 37.1500 - Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 0.0746
Cell Significance Index: 2.3900 - Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
Fold Change: 0.0705
Cell Significance Index: 2.0700 - Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.0623
Cell Significance Index: 12.3600 - Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: 0.0553
Cell Significance Index: 1.9200 - Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: 0.0368
Cell Significance Index: 6.2800 - Cell Name: pancreatic endocrine cell (CL0008024)
Fold Change: 0.0359
Cell Significance Index: 4.1000 - Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.0198
Cell Significance Index: 3.9700 - Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.0178
Cell Significance Index: 0.6300 - Cell Name: tonsil germinal center B cell (CL2000006)
Fold Change: 0.0152
Cell Significance Index: 1.7900 - Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 0.0127
Cell Significance Index: 4.5700 - Cell Name: abnormal cell (CL0001061)
Fold Change: 0.0095
Cell Significance Index: 0.9700 - Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 0.0040
Cell Significance Index: 0.0900 - Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 0.0035
Cell Significance Index: 2.4200 - Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0005
Cell Significance Index: -0.8500 - Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0014
Cell Significance Index: -1.0700 - Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.0039
Cell Significance Index: -2.4200 - Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0044
Cell Significance Index: -8.0800 - Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0074
Cell Significance Index: -11.3200 - Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0089
Cell Significance Index: -6.7300 - Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0093
Cell Significance Index: -12.6100 - Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.0106
Cell Significance Index: -6.0000 - Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
Fold Change: -0.0114
Cell Significance Index: -8.3900 - Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.0148
Cell Significance Index: -9.3900 - Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: -0.0164
Cell Significance Index: -0.3400 - Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.0212
Cell Significance Index: -9.6000 - Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.0244
Cell Significance Index: -5.1400 - Cell Name: paneth cell of colon (CL0009009)
Fold Change: -0.0260
Cell Significance Index: -0.3900 - Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.0263
Cell Significance Index: -7.5600 - Cell Name: lactocyte (CL0002325)
Fold Change: -0.0276
Cell Significance Index: -3.5700 - Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
Fold Change: -0.0292
Cell Significance Index: -2.1800 - Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.0390
Cell Significance Index: -4.4700 - Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -0.0401
Cell Significance Index: -0.8400 - Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -0.0405
Cell Significance Index: -2.5500 - Cell Name: myeloid leukocyte (CL0000766)
Fold Change: -0.0494
Cell Significance Index: -0.4000 - Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.0564
Cell Significance Index: -8.2000 - Cell Name: early pro-B cell (CL0002046)
Fold Change: -0.0586
Cell Significance Index: -3.7800 - Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -0.0640
Cell Significance Index: -3.0100 - Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.0680
Cell Significance Index: -7.9300 - Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -0.0791
Cell Significance Index: -2.3300 - Cell Name: sebum secreting cell (CL0000317)
Fold Change: -0.0861
Cell Significance Index: -6.0900 - Cell Name: endothelial cell of venule (CL1000414)
Fold Change: -0.0871
Cell Significance Index: -0.9900 - Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.1091
Cell Significance Index: -3.0500 - Cell Name: retinal progenitor cell (CL0002672)
Fold Change: -0.1124
Cell Significance Index: -6.3100 - Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.1138
Cell Significance Index: -11.8500 - Cell Name: fibro/adipogenic progenitor cell (CL0009099)
Fold Change: -0.1202
Cell Significance Index: -6.0700 - Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.1265
Cell Significance Index: -9.7100 - Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: -0.1314
Cell Significance Index: -1.3600 - Cell Name: intestinal tuft cell (CL0019032)
Fold Change: -0.1349
Cell Significance Index: -8.2700 - Cell Name: conjunctival epithelial cell (CL1000432)
Fold Change: -0.1400
Cell Significance Index: -1.9100 - Cell Name: forebrain neuroblast (CL1000042)
Fold Change: -0.1537
Cell Significance Index: -9.4500 - Cell Name: neuron associated cell (CL0000095)
Fold Change: -0.1624
Cell Significance Index: -6.6500 - Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
Fold Change: -0.1625
Cell Significance Index: -12.8700 - Cell Name: peg cell (CL4033014)
Fold Change: -0.1762
Cell Significance Index: -4.0700 - Cell Name: granulosa cell (CL0000501)
Fold Change: -0.1799
Cell Significance Index: -4.7300 - Cell Name: hippocampal granule cell (CL0001033)
Fold Change: -0.1814
Cell Significance Index: -12.2000 - Cell Name: keratocyte (CL0002363)
Fold Change: -0.1844
Cell Significance Index: -2.9300 - Cell Name: lung endothelial cell (CL1001567)
Fold Change: -0.1975
Cell Significance Index: -10.2900 - Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.2234
Cell Significance Index: -11.7300 - Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: -0.2442
Cell Significance Index: -10.8000 - Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -0.2871
Cell Significance Index: -10.5400 - Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: -0.2886
Cell Significance Index: -10.9300 - Cell Name: retinal rod cell (CL0000604)
Fold Change: -0.2894
Cell Significance Index: -3.4500 - Cell Name: interstitial cell of ovary (CL0002094)
Fold Change: -0.2897
Cell Significance Index: -3.7100
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Other Information
Genular Protein ID: 2289887013
Symbol: NAGAB_HUMAN
Name: Alpha-galactosidase B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 2174888
Title: Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene.
PubMed ID: 2174888
PubMed ID: 1646157
Title: Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha-galactosidase A gene provides evidence for evolution from a common ancestral gene.
PubMed ID: 1646157
PubMed ID: 2551294
Title: Molecular cloning of a full-length cDNA for human alpha-N-acetylgalactosaminidase (alpha-galactosidase B).
PubMed ID: 2551294
PubMed ID: 2372288
Title: Molecular cloning of two species of cDNAs for human alpha-N-acetylgalactosaminidase and expression in mammalian cells.
PubMed ID: 2372288
PubMed ID: 15461802
Title: A genome annotation-driven approach to cloning the human ORFeome.
PubMed ID: 15461802
PubMed ID: 10591208
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 2256909
Title: Photolabeling of the alpha-neuraminidase/beta-galactosidase complex from human placenta with a photoreactive neuraminidase inhibitor.
PubMed ID: 2256909
PubMed ID: 1418679
Title: An investigation into the glycolipid metabolism of alpha-N-acetylgalactosaminidase-deficient fibroblasts using native and artificial glycolipids.
PubMed ID: 1418679
PubMed ID: 9741689
Title: Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.
PubMed ID: 9741689
PubMed ID: 17693683
Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.
PubMed ID: 17693683
PubMed ID: 19159218
Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.
PubMed ID: 19159218
DOI: 10.1021/pr8008012
PubMed ID: 25944712
Title: N-terminome analysis of the human mitochondrial proteome.
PubMed ID: 25944712
PubMed ID: 19683538
Title: The 1.9 A structure of human alpha-N-acetylgalactosaminidase: the molecular basis of Schindler and Kanzaki diseases.
PubMed ID: 19683538
PubMed ID: 2243144
Title: Schindler disease: the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy.
PubMed ID: 2243144
DOI: 10.1172/jci114901
PubMed ID: 8040340
Title: The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria.
PubMed ID: 8040340
DOI: 10.1172/jci117404
PubMed ID: 8782044
Title: Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and phenotype.
PubMed ID: 8782044
DOI: 10.1136/jmg.33.6.458
PubMed ID: 11251574
Title: A new case of alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum, with Meniere's syndrome and without mental retardation.
PubMed ID: 11251574
Sequence Information:
- Length: 411
- Mass: 46565
- Checksum: 781A0728C0B29CD9
- Sequence:
MLLKTVLLLG HVAQVLMLDN GLLQTPPMGW LAWERFRCNI NCDEDPKNCI SEQLFMEMAD RMAQDGWRDM GYTYLNIDDC WIGGRDASGR LMPDPKRFPH GIPFLADYVH SLGLKLGIYA DMGNFTCMGY PGTTLDKVVQ DAQTFAEWKV DMLKLDGCFS TPEERAQGYP KMAAALNATG RPIAFSCSWP AYEGGLPPRV NYSLLADICN LWRNYDDIQD SWWSVLSILN WFVEHQDILQ PVAGPGHWND PDMLLIGNFG LSLEQSRAQM ALWTVLAAPL LMSTDLRTIS AQNMDILQNP LMIKINQDPL GIQGRRIHKE KSLIEVYMRP LSNKASALVF FSCRTDMPYR YHSSLGQLNF TGSVIYEAQD VYSGDIISGL RDETNFTVII NPSGVVMWYL YPIKNLEMSQ Q
Database document:
This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.