Details for: NAGA

Gene ID: 4668

Symbol: NAGA

Ensembl ID: ENSG00000198951

Description: alpha-N-acetylgalactosaminidase

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 71.3619
    Cell Significance Index: -11.1000
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 45.7729
    Cell Significance Index: -11.6100
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 30.8672
    Cell Significance Index: -12.5400
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 26.4199
    Cell Significance Index: -13.5900
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 13.1344
    Cell Significance Index: -12.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 9.9679
    Cell Significance Index: -12.2900
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.9797
    Cell Significance Index: -13.3400
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.7083
    Cell Significance Index: -11.3900
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.2032
    Cell Significance Index: -12.6400
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 1.7408
    Cell Significance Index: -3.8100
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 1.6475
    Cell Significance Index: 10.9300
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 1.1162
    Cell Significance Index: 20.6300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8944
    Cell Significance Index: 807.5500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.8595
    Cell Significance Index: 51.6000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.7674
    Cell Significance Index: 83.4700
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7148
    Cell Significance Index: 19.1200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.6273
    Cell Significance Index: 102.0200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.3857
    Cell Significance Index: 10.3400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.3633
    Cell Significance Index: 18.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2933
    Cell Significance Index: 20.2900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2671
    Cell Significance Index: 2.4600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.2490
    Cell Significance Index: 6.6500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2175
    Cell Significance Index: 41.3900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.2114
    Cell Significance Index: 27.1000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.2014
    Cell Significance Index: 9.3900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1879
    Cell Significance Index: 25.8100
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1786
    Cell Significance Index: 3.8700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1628
    Cell Significance Index: 16.1000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.1575
    Cell Significance Index: 28.4000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.1491
    Cell Significance Index: 6.7600
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.1409
    Cell Significance Index: 4.0600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.1337
    Cell Significance Index: 3.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.1326
    Cell Significance Index: 72.4100
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.1288
    Cell Significance Index: 0.8000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.1270
    Cell Significance Index: 15.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1219
    Cell Significance Index: 2.0400
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0840
    Cell Significance Index: 37.1500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0746
    Cell Significance Index: 2.3900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0705
    Cell Significance Index: 2.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0623
    Cell Significance Index: 12.3600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.0553
    Cell Significance Index: 1.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.0368
    Cell Significance Index: 6.2800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.0359
    Cell Significance Index: 4.1000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0198
    Cell Significance Index: 3.9700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0178
    Cell Significance Index: 0.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.0152
    Cell Significance Index: 1.7900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0127
    Cell Significance Index: 4.5700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0095
    Cell Significance Index: 0.9700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0040
    Cell Significance Index: 0.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0035
    Cell Significance Index: 2.4200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0005
    Cell Significance Index: -0.8500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0014
    Cell Significance Index: -1.0700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0039
    Cell Significance Index: -2.4200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.0800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0074
    Cell Significance Index: -11.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0089
    Cell Significance Index: -6.7300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0093
    Cell Significance Index: -12.6100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0106
    Cell Significance Index: -6.0000
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0114
    Cell Significance Index: -8.3900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0148
    Cell Significance Index: -9.3900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0164
    Cell Significance Index: -0.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0212
    Cell Significance Index: -9.6000
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0244
    Cell Significance Index: -5.1400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.0260
    Cell Significance Index: -0.3900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0263
    Cell Significance Index: -7.5600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0276
    Cell Significance Index: -3.5700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0292
    Cell Significance Index: -2.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0390
    Cell Significance Index: -4.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0401
    Cell Significance Index: -0.8400
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0405
    Cell Significance Index: -2.5500
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0494
    Cell Significance Index: -0.4000
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0564
    Cell Significance Index: -8.2000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0586
    Cell Significance Index: -3.7800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0640
    Cell Significance Index: -3.0100
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0680
    Cell Significance Index: -7.9300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0791
    Cell Significance Index: -2.3300
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0861
    Cell Significance Index: -6.0900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.0871
    Cell Significance Index: -0.9900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1091
    Cell Significance Index: -3.0500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1124
    Cell Significance Index: -6.3100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1138
    Cell Significance Index: -11.8500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1202
    Cell Significance Index: -6.0700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1265
    Cell Significance Index: -9.7100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.1314
    Cell Significance Index: -1.3600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1349
    Cell Significance Index: -8.2700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.1400
    Cell Significance Index: -1.9100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1537
    Cell Significance Index: -9.4500
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1624
    Cell Significance Index: -6.6500
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1625
    Cell Significance Index: -12.8700
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.1762
    Cell Significance Index: -4.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1799
    Cell Significance Index: -4.7300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1814
    Cell Significance Index: -12.2000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.1844
    Cell Significance Index: -2.9300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1975
    Cell Significance Index: -10.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2234
    Cell Significance Index: -11.7300
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2442
    Cell Significance Index: -10.8000
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2871
    Cell Significance Index: -10.5400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2886
    Cell Significance Index: -10.9300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.2894
    Cell Significance Index: -3.4500
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2897
    Cell Significance Index: -3.7100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Enzymatic Activity:** NAGA is a glycosidase enzyme that hydrolyzes alpha-galactosidic bonds, leading to the breakdown of glycosides and glycolipids. 2. **Widespread Expression:** NAGA is expressed in various cell types, including immune cells (e.g., monocytes, macrophages), endothelial cells, neurons, and trophoblasts. 3. **Cell-Specific Expression:** NAGA's expression is cell-specific, with significant differences in expression levels among various cell types. 4. **Signaling Pathways:** NAGA is involved in signaling pathways, including protein homodimerization activity and carbohydrate catabolic processes. **Pathways and Functions:** 1. **Glycolipid Catabolism:** NAGA plays a crucial role in the breakdown of glycolipids, which are essential components of cellular membranes and extracellular matrices. 2. **Glycoside Catabolism:** NAGA is involved in the breakdown of glycosides, which are important components of cellular metabolism. 3. **Alpha-Galactosidase Activity:** NAGA's enzymatic activity is essential for the breakdown of alpha-galactosidic bonds in glycosides and glycolipids. 4. **Protein Homodimerization Activity:** NAGA is involved in protein homodimerization, which is a critical process in cellular signaling and regulation. 5. **Carbohydrate Catabolic Process:** NAGA is involved in carbohydrate catabolism, which is essential for energy metabolism and cellular homeostasis. **Clinical Significance:** 1. **Immunological Disorders:** NAGA's role in immune cell function and regulation makes it a potential target for the treatment of immunological disorders, such as autoimmune diseases and cancer. 2. **Neurological Disorders:** NAGA's expression in neurons and its involvement in protein homodimerization activity make it a potential target for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 3. **Cancer:** NAGA's expression in cancer cells and its involvement in glycolipid catabolism make it a potential target for the treatment of cancer. 4. **Infectious Diseases:** NAGA's role in immune cell function and regulation makes it a potential target for the treatment of infectious diseases, such as tuberculosis and HIV. In conclusion, NAGA is a multifunctional enzyme that plays a crucial role in various cellular processes, including glycolipid catabolism, glycoside catabolism, and protein homodimerization activity. Its widespread expression across various cell types and its involvement in immune response and other cellular processes make it an attractive target for the treatment of various diseases. Further research is needed to fully elucidate the functions and significance of NAGA in human health and disease.

Genular Protein ID: 2289887013

Symbol: NAGAB_HUMAN

Name: Alpha-galactosidase B

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 2174888

Title: Human alpha-N-acetylgalactosaminidase-molecular cloning, nucleotide sequence, and expression of a full-length cDNA. Homology with human alpha-galactosidase A suggests evolution from a common ancestral gene.

PubMed ID: 2174888

DOI: 10.1016/s0021-9258(18)45818-8

PubMed ID: 1646157

Title: Structural organization and complete sequence of the human alpha-N-acetylgalactosaminidase gene: homology with the alpha-galactosidase A gene provides evidence for evolution from a common ancestral gene.

PubMed ID: 1646157

DOI: 10.1016/0888-7543(91)90493-x

PubMed ID: 2551294

Title: Molecular cloning of a full-length cDNA for human alpha-N-acetylgalactosaminidase (alpha-galactosidase B).

PubMed ID: 2551294

DOI: 10.1016/0006-291x(89)91149-2

PubMed ID: 2372288

Title: Molecular cloning of two species of cDNAs for human alpha-N-acetylgalactosaminidase and expression in mammalian cells.

PubMed ID: 2372288

DOI: 10.1016/0006-291x(90)91264-s

PubMed ID: 15461802

Title: A genome annotation-driven approach to cloning the human ORFeome.

PubMed ID: 15461802

DOI: 10.1186/gb-2004-5-10-r84

PubMed ID: 10591208

Title: The DNA sequence of human chromosome 22.

PubMed ID: 10591208

DOI: 10.1038/990031

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2256909

Title: Photolabeling of the alpha-neuraminidase/beta-galactosidase complex from human placenta with a photoreactive neuraminidase inhibitor.

PubMed ID: 2256909

DOI: 10.1016/s0006-291x(05)81014-9

PubMed ID: 1418679

Title: An investigation into the glycolipid metabolism of alpha-N-acetylgalactosaminidase-deficient fibroblasts using native and artificial glycolipids.

PubMed ID: 1418679

DOI: 10.1515/bchm3.1992.373.2.989

PubMed ID: 9741689

Title: Degradation of blood group A glycolipid A-6-2 by normal and mutant human skin fibroblasts.

PubMed ID: 9741689

PubMed ID: 17693683

Title: Quantitative phosphoproteome profiling of Wnt3a-mediated signaling network: indicating the involvement of ribonucleoside-diphosphate reductase M2 subunit phosphorylation at residue serine 20 in canonical Wnt signal transduction.

PubMed ID: 17693683

DOI: 10.1074/mcp.m700120-mcp200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 19683538

Title: The 1.9 A structure of human alpha-N-acetylgalactosaminidase: the molecular basis of Schindler and Kanzaki diseases.

PubMed ID: 19683538

DOI: 10.1016/j.jmb.2009.08.021

PubMed ID: 2243144

Title: Schindler disease: the molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes an infantile neuroaxonal dystrophy.

PubMed ID: 2243144

DOI: 10.1172/jci114901

PubMed ID: 8040340

Title: The molecular lesion in the alpha-N-acetylgalactosaminidase gene that causes angiokeratoma corporis diffusum with glycopeptiduria.

PubMed ID: 8040340

DOI: 10.1172/jci117404

PubMed ID: 8782044

Title: Human alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency: new mutations and the paradox between genotype and phenotype.

PubMed ID: 8782044

DOI: 10.1136/jmg.33.6.458

PubMed ID: 11251574

Title: A new case of alpha-N-acetylgalactosaminidase deficiency with angiokeratoma corporis diffusum, with Meniere's syndrome and without mental retardation.

PubMed ID: 11251574

DOI: 10.1046/j.1365-2133.2001.04028.x

Sequence Information:

  • Length: 411
  • Mass: 46565
  • Checksum: 781A0728C0B29CD9
  • Sequence:
  • MLLKTVLLLG HVAQVLMLDN GLLQTPPMGW LAWERFRCNI NCDEDPKNCI SEQLFMEMAD 
    RMAQDGWRDM GYTYLNIDDC WIGGRDASGR LMPDPKRFPH GIPFLADYVH SLGLKLGIYA 
    DMGNFTCMGY PGTTLDKVVQ DAQTFAEWKV DMLKLDGCFS TPEERAQGYP KMAAALNATG 
    RPIAFSCSWP AYEGGLPPRV NYSLLADICN LWRNYDDIQD SWWSVLSILN WFVEHQDILQ 
    PVAGPGHWND PDMLLIGNFG LSLEQSRAQM ALWTVLAAPL LMSTDLRTIS AQNMDILQNP 
    LMIKINQDPL GIQGRRIHKE KSLIEVYMRP LSNKASALVF FSCRTDMPYR YHSSLGQLNF 
    TGSVIYEAQD VYSGDIISGL RDETNFTVII NPSGVVMWYL YPIKNLEMSQ Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.