Details for: IFIT2

Gene ID: 3433

Symbol: IFIT2

Ensembl ID: ENSG00000119922

Description: interferon induced protein with tetratricopeptide repeats 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 87.1129
    Cell Significance Index: -13.5500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 52.7512
    Cell Significance Index: -13.3800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 30.3523
    Cell Significance Index: -14.3300
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 27.9363
    Cell Significance Index: -14.3700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 11.1683
    Cell Significance Index: -13.7700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.4347
    Cell Significance Index: -11.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5428
    Cell Significance Index: -13.9800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 3.4707
    Cell Significance Index: -10.6600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.8834
    Cell Significance Index: 27.9400
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.8532
    Cell Significance Index: 12.9800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7692
    Cell Significance Index: 694.5000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7092
    Cell Significance Index: 16.3900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.6402
    Cell Significance Index: 13.6400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.6076
    Cell Significance Index: 9.4000
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.5216
    Cell Significance Index: 9.6400
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.4803
    Cell Significance Index: 52.2400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4521
    Cell Significance Index: 73.5400
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.4278
    Cell Significance Index: 25.6800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.3502
    Cell Significance Index: 22.5900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.3247
    Cell Significance Index: 41.6200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2726
    Cell Significance Index: 18.8600
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2430
    Cell Significance Index: 4.3000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2231
    Cell Significance Index: 1.3800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2110
    Cell Significance Index: 40.1500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1622
    Cell Significance Index: 16.0500
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1458
    Cell Significance Index: 16.9900
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: 0.1294
    Cell Significance Index: 1.9500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1293
    Cell Significance Index: 17.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0953
    Cell Significance Index: 129.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0911
    Cell Significance Index: 2.4800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0856
    Cell Significance Index: 4.0300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0473
    Cell Significance Index: 9.4900
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0470
    Cell Significance Index: 1.2600
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0435
    Cell Significance Index: 66.8900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0432
    Cell Significance Index: 1.9600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0399
    Cell Significance Index: 14.3100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0351
    Cell Significance Index: 1.0100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0276
    Cell Significance Index: 0.6900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0224
    Cell Significance Index: 12.2600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0194
    Cell Significance Index: 3.4900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0170
    Cell Significance Index: 31.3700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0107
    Cell Significance Index: 0.5400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0101
    Cell Significance Index: 2.0100
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0057
    Cell Significance Index: 2.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0015
    Cell Significance Index: 2.9000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0017
    Cell Significance Index: -1.2100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0044
    Cell Significance Index: -0.5500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0051
    Cell Significance Index: -0.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0053
    Cell Significance Index: -0.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0056
    Cell Significance Index: -3.5700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0065
    Cell Significance Index: -0.3400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0071
    Cell Significance Index: -5.2100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0148
    Cell Significance Index: -11.1800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0172
    Cell Significance Index: -1.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0221
    Cell Significance Index: -16.3400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0275
    Cell Significance Index: -12.5000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0289
    Cell Significance Index: -16.2900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0303
    Cell Significance Index: -8.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0305
    Cell Significance Index: -19.0600
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0406
    Cell Significance Index: -0.8800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0485
    Cell Significance Index: -7.0500
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: -0.0552
    Cell Significance Index: -0.4500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0593
    Cell Significance Index: -6.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0750
    Cell Significance Index: -12.8200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0807
    Cell Significance Index: -17.0000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0826
    Cell Significance Index: -3.3900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0940
    Cell Significance Index: -12.1500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1083
    Cell Significance Index: -7.2800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1220
    Cell Significance Index: -8.6300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1251
    Cell Significance Index: -13.0300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1354
    Cell Significance Index: -6.3200
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1377
    Cell Significance Index: -4.4100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.1400
    Cell Significance Index: -1.5900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1485
    Cell Significance Index: -11.7600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1503
    Cell Significance Index: -4.2000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1592
    Cell Significance Index: -12.2200
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1627
    Cell Significance Index: -9.9800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1689
    Cell Significance Index: -12.5900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.1692
    Cell Significance Index: -3.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1867
    Cell Significance Index: -4.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1891
    Cell Significance Index: -11.6200
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: -0.1920
    Cell Significance Index: -1.6500
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.2049
    Cell Significance Index: -3.4300
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.2089
    Cell Significance Index: -3.1300
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2102
    Cell Significance Index: -5.3700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2122
    Cell Significance Index: -11.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2268
    Cell Significance Index: -6.5000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2349
    Cell Significance Index: -13.1800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.2452
    Cell Significance Index: -6.5600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2459
    Cell Significance Index: -15.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2719
    Cell Significance Index: -4.6600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2753
    Cell Significance Index: -7.3500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.3028
    Cell Significance Index: -13.4000
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3123
    Cell Significance Index: -6.6800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3283
    Cell Significance Index: -11.5000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.3559
    Cell Significance Index: -2.1500
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.3578
    Cell Significance Index: -13.5500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3734
    Cell Significance Index: -13.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3830
    Cell Significance Index: -12.5400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.3896
    Cell Significance Index: -5.5800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** IFIT2 is a member of the interferon-induced protein family, characterized by its unique tetratricopeptide repeat (TPR) motif. This motif allows for interactions with various proteins, modulating the immune response. IFIT2 is primarily expressed in cells of the immune system, including respiratory basal cells, mural cells, and Kupffer cells, which are involved in the phagocytosis of pathogens. **Pathways and Functions:** IFIT2 is involved in several key pathways, including: 1. **Antiviral Innate Immune Response:** IFIT2 is induced by type I interferons, which are crucial for the defense against viral infections. IFIT2 then interacts with viral proteins, inhibiting their replication and promoting the production of antiviral cytokines. 2. **Apoptotic Mitochondrial Changes:** IFIT2 regulates mitochondrial dynamics, modulating the release of pro-apoptotic factors and promoting cell death in infected cells. 3. **Cytokine Signaling in Immune System:** IFIT2 interacts with cytokine receptors, influencing the production of pro-inflammatory and anti-inflammatory cytokines. 4. **Interferon Alpha/Beta Signaling:** IFIT2 is a key component of the interferon signaling pathway, mediating the transcriptional activation of interferon-stimulated genes (ISGs). **Functions:** IFIT2 has several distinct functions, including: 1. **Viral Inhibition:** IFIT2 directly inhibits viral replication by binding to viral proteins and preventing their interaction with host cells. 2. **Apoptosis Regulation:** IFIT2 modulates mitochondrial dynamics, promoting cell death in infected cells and preventing the spread of viral infections. 3. **Cytokine Regulation:** IFIT2 influences cytokine production, modulating the immune response and preventing excessive inflammation. **Clinical Significance:** Dysregulation of IFIT2 has been implicated in various diseases, including: 1. **Viral Infections:** IFIT2 dysfunction has been linked to the progression of viral infections, such as HIV and influenza. 2. **Cancer:** IFIT2 has been shown to inhibit tumor growth and metastasis, highlighting its potential as a cancer therapeutic target. 3. **Autoimmune Diseases:** IFIT2 dysregulation has been implicated in autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. In conclusion, IFIT2 is a critical component of the innate immune response, playing a vital role in the defense against viral infections and other pathogens. Its dysregulation can have far-reaching consequences for human health, highlighting the need for further research into the mechanisms underlying IFIT2 function and its potential as a therapeutic target.

Genular Protein ID: 4174616661

Symbol: IFIT2_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 2

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 3466167

Title: Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

PubMed ID: 3466167

DOI: 10.1073/pnas.83.23.8929

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 2454816

Title: Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses.

PubMed ID: 2454816

DOI: 10.1111/j.1432-1033.1988.tb14101.x

PubMed ID: 3360121

Title: The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family.

PubMed ID: 3360121

DOI: 10.1016/0014-5793(88)80724-5

PubMed ID: 16973618

Title: Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.

PubMed ID: 16973618

DOI: 10.1074/jbc.m605771200

PubMed ID: 19416887

Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

PubMed ID: 19416887

DOI: 10.1073/pnas.0900818106

PubMed ID: 21190939

Title: The interferon stimulated gene 54 promotes apoptosis.

PubMed ID: 21190939

DOI: 10.1074/jbc.m110.207068

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22825553

Title: Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.

PubMed ID: 22825553

DOI: 10.1038/cr.2012.111

Sequence Information:

  • Length: 472
  • Mass: 54632
  • Checksum: 3CF11319A5008FB9
  • Sequence:
  • MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL 
    KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV 
    KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI 
    ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL 
    EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN 
    LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EDAEYYFQKE 
    FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKSREKEK MKDKLQKIAK 
    MRLSKNGADS EALHVLAFLQ ELNEKMQQAD EDSERGLESG SLIPSASSWN GE

Genular Protein ID: 110294346

Symbol: Q05DN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 412
  • Mass: 48070
  • Checksum: 631B8287A772052F
  • Sequence:
  • MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL 
    KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV 
    KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI 
    ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL 
    EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN 
    LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EEAEYYFQKE 
    FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKKKKKKK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.