Details for: IFIT2

Gene ID: 3433

Symbol: IFIT2

Ensembl ID: ENSG00000119922

Description: interferon induced protein with tetratricopeptide repeats 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.61
    Marker Score: 2310
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 168946
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 1.46
    Marker Score: 853
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.31
    Marker Score: 1051
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 1.26
    Marker Score: 1257
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71779
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48003.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30403
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 490
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2407
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 444
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2724
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.9
    Marker Score: 360
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5037
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.87
    Marker Score: 313
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5268
  • Cell Name: alternatively activated macrophage (CL0000890)
    Fold Change: 0.85
    Marker Score: 353
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: 0.78
    Marker Score: 247
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.78
    Marker Score: 43355
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.76
    Marker Score: 1236
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 0.76
    Marker Score: 19394
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 574
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.75
    Marker Score: 269
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.73
    Marker Score: 3055
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 654
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.7
    Marker Score: 2712
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.7
    Marker Score: 1715
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.69
    Marker Score: 1346
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171.5
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.65
    Marker Score: 1330
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.65
    Marker Score: 788
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: 0.63
    Marker Score: 368
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.58
    Marker Score: 1378
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.58
    Marker Score: 35732
  • Cell Name: activated CD8-positive, alpha-beta T cell, human (CL0001049)
    Fold Change: 0.57
    Marker Score: 130
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 375
  • Cell Name: non-classical monocyte (CL0000875)
    Fold Change: 0.57
    Marker Score: 1364
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.56
    Marker Score: 357
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.55
    Marker Score: 441
  • Cell Name: blood cell (CL0000081)
    Fold Change: 0.54
    Marker Score: 6240
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.5
    Marker Score: 162
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.49
    Marker Score: 782
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.48
    Marker Score: 501
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.46
    Marker Score: 314
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.45
    Marker Score: 277
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.44
    Marker Score: 4439
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.44
    Marker Score: 390
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.43
    Marker Score: 2635
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.43
    Marker Score: 373
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.43
    Marker Score: 1535
  • Cell Name: nasal mucosa goblet cell (CL0002480)
    Fold Change: 0.43
    Marker Score: 289
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.43
    Marker Score: 732
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.43
    Marker Score: 1028
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.43
    Marker Score: 178
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.42
    Marker Score: 1061
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.42
    Marker Score: 110
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.41
    Marker Score: 599
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.41
    Marker Score: 253
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.41
    Marker Score: 1203
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.41
    Marker Score: 1068
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.41
    Marker Score: 128
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.41
    Marker Score: 721
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.4
    Marker Score: 793
  • Cell Name: plasmacytoid dendritic cell, human (CL0001058)
    Fold Change: 0.39
    Marker Score: 103
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.39
    Marker Score: 655
  • Cell Name: dendritic cell, human (CL0001056)
    Fold Change: 0.38
    Marker Score: 389
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.38
    Marker Score: 513
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.38
    Marker Score: 1202
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.38
    Marker Score: 523.5
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.37
    Marker Score: 184
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 0.37
    Marker Score: 218
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.37
    Marker Score: 230
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.37
    Marker Score: 193
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.37
    Marker Score: 353
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.36
    Marker Score: 472
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.36
    Marker Score: 3576
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.36
    Marker Score: 204
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.36
    Marker Score: 94
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.35
    Marker Score: 90
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 0.35
    Marker Score: 509
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 347
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.34
    Marker Score: 475
  • Cell Name: CD4-positive, alpha-beta cytotoxic T cell (CL0000934)
    Fold Change: 0.34
    Marker Score: 295
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.34
    Marker Score: 106
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.33
    Marker Score: 631
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.33
    Marker Score: 159
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.33
    Marker Score: 177
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.32
    Marker Score: 422
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 0.32
    Marker Score: 301
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: 0.32
    Marker Score: 149
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.32
    Marker Score: 317.5
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.32
    Marker Score: 488
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.31
    Marker Score: 169
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.31
    Marker Score: 319
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.31
    Marker Score: 72
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: 0.31
    Marker Score: 161
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.31
    Marker Score: 295
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.31
    Marker Score: 361

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Other Information

**Key characteristics:** * IFIT2 is a protein with tetratricopeptide repeats. * It is expressed in a variety of cell types, including respiratory epithelial cells, mural cells, and immune cells. * It is a key regulator of the antiviral innate immune response. **Pathways and functions:** * IFIT2 is involved in the regulation of the antiviral innate immune response. * It binds to viral proteins and inhibits their interaction with host proteins. * This prevents the initiation of viral replication and the production of viral proteins. * IFIT2 also modulates the expression of antiviral proteins, including those involved in viral entry and replication. * It also regulates the production of cytokines and chemokines, which are proteins that attract immune cells to the site of infection. **Clinical significance:** * Mutations in the IFIT2 gene have been linked to an increased risk of certain viral infections, such as influenza and HIV. * Therefore, IFIT2 is a potential therapeutic target for the treatment of viral infections. **Other important points:** * IFIT2 is a highly conserved protein, with a similar sequence in mice and humans. * It is a member of the immunoglobulin superfamily, which is a large family of proteins that are involved in the innate immune response. * IFIT2 is a relatively new protein, with most of the sequence being encoded by a single gene.

Genular Protein ID: 4174616661

Symbol: IFIT2_HUMAN

Name: Interferon-induced protein with tetratricopeptide repeats 2

UniProtKB Accession Codes:

P09913 Q5T767

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTC 1 CTD 1 ChiTaRS 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 4 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3466167

Title: Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region.

PubMed ID: 3466167

DOI: 10.1073/pnas.83.23.8929

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 2454816

Title: Regulation of two interferon-inducible human genes by interferon, poly(rI).poly(rC) and viruses.

PubMed ID: 2454816

DOI: 10.1111/j.1432-1033.1988.tb14101.x

PubMed ID: 3360121

Title: The IFI-56K and IFI-54K interferon-inducible human genes belong to the same gene family.

PubMed ID: 3360121

DOI: 10.1016/0014-5793(88)80724-5

PubMed ID: 16973618

Title: Distinct induction patterns and functions of two closely related interferon-inducible human genes, ISG54 and ISG56.

PubMed ID: 16973618

DOI: 10.1074/jbc.m605771200

PubMed ID: 19416887

Title: ISG56 is a negative-feedback regulator of virus-triggered signaling and cellular antiviral response.

PubMed ID: 19416887

DOI: 10.1073/pnas.0900818106

PubMed ID: 21190939

Title: The interferon stimulated gene 54 promotes apoptosis.

PubMed ID: 21190939

DOI: 10.1074/jbc.m110.207068

PubMed ID: 20950130

Title: The ISG56/IFIT1 gene family.

PubMed ID: 20950130

DOI: 10.1089/jir.2010.0101

PubMed ID: 21642987

Title: IFIT1 is an antiviral protein that recognizes 5'-triphosphate RNA.

PubMed ID: 21642987

DOI: 10.1038/ni.2048

PubMed ID: 22814378

Title: N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB.

PubMed ID: 22814378

DOI: 10.1073/pnas.1210303109

PubMed ID: 22825553

Title: Crystal structure of ISG54 reveals a novel RNA binding structure and potential functional mechanisms.

PubMed ID: 22825553

DOI: 10.1038/cr.2012.111

Sequence Information:

  • Length: 472
  • Mass: 54632
  • Checksum: 3CF11319A5008FB9
  • Sequence:
    • MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL 
KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV 
KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI 
ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL 
EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN 
LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EDAEYYFQKE 
FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKSREKEK MKDKLQKIAK 
MRLSKNGADS EALHVLAFLQ ELNEKMQQAD EDSERGLESG SLIPSASSWN GE

Genular Protein ID: 110294346

Symbol: Q05DN2_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q05DN2

Database IDs:

ARBA 3 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Gene3D 1 Genevisible 1 GenomeRNAi 1 InterPro 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SMART 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 412
  • Mass: 48070
  • Checksum: 631B8287A772052F
  • Sequence:
    • MSENNKNSLE SSLRQLKCHF TWNLMEGENS LDDFEDKVFY RTEFQNREFK ATMCNLLAYL 
KHLKGQNEAA LECLRKAEEL IQQEHADQAE IRSLVTWGNY AWVYYHMGRL SDVQIYVDKV 
KHVCEKFSSP YRIESPELDC EEGWTRLKCG GNQNERAKVC FEKALEKKPK NPEFTSGLAI 
ASYRLDNWPP SQNAIDPLRQ AIRLNPDNQY LKVLLALKLH KMREEGEEEG EGEKLVEEAL 
EKAPGVTDVL RSAAKFYRRK DEPDKAIELL KKALEYIPNN AYLHCQIGCC YRAKVFQVMN 
LRENGMYGKR KLLELIGHAV AHLKKADEAN DNLFRVCSIL ASLHALADQY EEAEYYFQKE 
FSKELTPVAK QLLHLRYGNF QLYQMKCEDK AIHHFIEGVK INQKKKKKKK KK

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.