Details for: CCL19

Gene ID: 6363

Symbol: CCL19

Ensembl ID: ENSG00000172724

Description: C-C motif chemokine ligand 19

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 11.8404
    Cell Significance Index: 67.8900
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 9.8491
    Cell Significance Index: -4.6500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 8.8368
    Cell Significance Index: -3.5900
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 3.8039
    Cell Significance Index: 31.4600
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 3.5468
    Cell Significance Index: 56.2700
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.3165
    Cell Significance Index: 29.2700
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 1.9200
    Cell Significance Index: 5.7100
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 1.1489
    Cell Significance Index: 17.4500
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.7835
    Cell Significance Index: 9.2600
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.4541
    Cell Significance Index: 5.2300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.4439
    Cell Significance Index: 196.2800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.2327
    Cell Significance Index: 3.6000
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.2169
    Cell Significance Index: 1.0700
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.1704
    Cell Significance Index: 2.0100
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.0885
    Cell Significance Index: 1.5200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.0660
    Cell Significance Index: 0.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.0118
    Cell Significance Index: 0.1000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0069
    Cell Significance Index: 0.8800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0041
    Cell Significance Index: 0.2100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.0034
    Cell Significance Index: 0.2400
  • Cell Name: muscle cell (CL0000187)
    Fold Change: -0.0021
    Cell Significance Index: -0.0200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0044
    Cell Significance Index: -8.0500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.9000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0052
    Cell Significance Index: -3.3000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0057
    Cell Significance Index: -4.3200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0060
    Cell Significance Index: -8.1200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0068
    Cell Significance Index: -3.8200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0074
    Cell Significance Index: -3.3400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0077
    Cell Significance Index: -0.2100
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0078
    Cell Significance Index: -1.5500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0105
    Cell Significance Index: -5.7600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0107
    Cell Significance Index: -0.0900
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0139
    Cell Significance Index: -0.5700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0144
    Cell Significance Index: -4.1300
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0163
    Cell Significance Index: -2.9400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0211
    Cell Significance Index: -3.0700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0226
    Cell Significance Index: -2.3100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0233
    Cell Significance Index: -4.9000
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.0238
    Cell Significance Index: -0.4200
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0263
    Cell Significance Index: -5.2800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0267
    Cell Significance Index: -3.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0278
    Cell Significance Index: -4.7500
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0326
    Cell Significance Index: -3.8500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0411
    Cell Significance Index: -4.7100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0412
    Cell Significance Index: -5.6600
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0453
    Cell Significance Index: -2.3600
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.0501
    Cell Significance Index: -0.7300
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0565
    Cell Significance Index: -7.3000
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.0684
    Cell Significance Index: -0.4300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0716
    Cell Significance Index: -0.6900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0737
    Cell Significance Index: -4.5200
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: -0.0748
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0772
    Cell Significance Index: -5.1900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0777
    Cell Significance Index: -5.9700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0860
    Cell Significance Index: -1.8000
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.0894
    Cell Significance Index: -3.1100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1094
    Cell Significance Index: -8.1600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1105
    Cell Significance Index: -3.2600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1116
    Cell Significance Index: -3.1200
  • Cell Name: duct epithelial cell (CL0000068)
    Fold Change: -0.1150
    Cell Significance Index: -1.5900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1195
    Cell Significance Index: -5.5700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1236
    Cell Significance Index: -7.6000
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1258
    Cell Significance Index: -7.0600
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1307
    Cell Significance Index: -3.3600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1329
    Cell Significance Index: -4.8800
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1350
    Cell Significance Index: -1.3100
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: -0.1356
    Cell Significance Index: -1.6100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.1377
    Cell Significance Index: -2.3100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.1427
    Cell Significance Index: -2.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1430
    Cell Significance Index: -6.7200
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1468
    Cell Significance Index: -4.3100
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1484
    Cell Significance Index: -5.2000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1530
    Cell Significance Index: -5.0100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1562
    Cell Significance Index: -6.9100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1567
    Cell Significance Index: -4.2000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1642
    Cell Significance Index: -4.1000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1642
    Cell Significance Index: -1.7900
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1643
    Cell Significance Index: -2.3900
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1670
    Cell Significance Index: -5.3200
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: -0.1682
    Cell Significance Index: -1.8800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1749
    Cell Significance Index: -4.6700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1812
    Cell Significance Index: -4.6300
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1817
    Cell Significance Index: -6.8800
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1822
    Cell Significance Index: -5.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1859
    Cell Significance Index: -5.3300
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1892
    Cell Significance Index: -4.8200
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1916
    Cell Significance Index: -4.6400
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: -0.1948
    Cell Significance Index: -1.8500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1989
    Cell Significance Index: -6.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.2037
    Cell Significance Index: -4.4600
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2061
    Cell Significance Index: -5.1400
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: -0.2087
    Cell Significance Index: -2.2500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2093
    Cell Significance Index: -5.0200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2133
    Cell Significance Index: -3.4600
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2174
    Cell Significance Index: -1.9700
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2186
    Cell Significance Index: -4.0400
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.2227
    Cell Significance Index: -4.4400
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -0.2245
    Cell Significance Index: -4.3900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CCL19 is a small, secreted protein that belongs to the C-C chemokine family. It is characterized by its ability to bind to the CCR7 receptor, which is a G-protein coupled receptor that plays a critical role in the chemotaxis of immune cells. CCL19 is also known for its ability to induce the production of various cytokines and chemokines, including interleukin-12 (IL-12), tumor necrosis factor-alpha (TNF-alpha), and prostaglandin E2 (PGE2). Additionally, CCL19 has been shown to regulate the maturation and differentiation of dendritic cells, which are essential for the initiation of immune responses. **Pathways and Functions** CCL19 is involved in several signaling pathways that regulate immune responses, including: 1. **Chemokine-mediated signaling pathway**: CCL19 binds to the CCR7 receptor, which activates a G-protein coupled receptor signaling pathway that regulates the migration of immune cells. 2. **Cytokine signaling in immune system**: CCL19 induces the production of IL-12, TNF-alpha, and PGE2, which are essential cytokines that regulate the immune response. 3. **G protein-coupled receptor signaling pathway**: CCL19 binds to the CCR7 receptor, which activates a G-protein coupled receptor signaling pathway that regulates the migration of immune cells. 4. **Cell communication**: CCL19 regulates the communication between immune cells, including dendritic cells, T cells, and monocytes. 5. **Cell maturation and differentiation**: CCL19 regulates the maturation and differentiation of dendritic cells, which are essential for the initiation of immune responses. **Clinical Significance** CCL19 has been implicated in various immune-related disorders, including: 1. **Autoimmune diseases**: CCL19 has been shown to contribute to the development of autoimmune diseases, such as multiple sclerosis and rheumatoid arthritis. 2. **Cancer**: CCL19 has been implicated in the progression of various cancers, including melanoma and lung cancer. 3. **Infectious diseases**: CCL19 has been shown to contribute to the pathogenesis of infectious diseases, such as HIV and tuberculosis. 4. **Allergic diseases**: CCL19 has been implicated in the development of allergic diseases, such as asthma and allergic rhinitis. In summary, CCL19 is a chemokine that plays a critical role in regulating immune responses by facilitating the migration of immune cells to sites of infection or inflammation. Its dysregulation has been implicated in various immune-related disorders, making it a potential target for the development of therapeutic interventions.

Genular Protein ID: 1989087361

Symbol: CCL19_HUMAN

Name: C-C motif chemokine 19

UniProtKB Accession Codes:

Q99731 O00697 O00736

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 50 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 3 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 neXtProt 1

Citations:

PubMed ID: 9013939

Title: Identification through bioinformatics of two new macrophage proinflammatory human chemokines: MIP-3alpha and MIP-3beta.

PubMed ID: 9013939

PubMed ID: 9153236

Title: Molecular cloning of a novel human CC chemokine EBI1-ligand chemokine that is a specific functional ligand for EBI1, CCR7.

PubMed ID: 9153236

DOI: 10.1074/jbc.272.21.13803

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9498785

Title: CK beta-11/macrophage inflammatory protein-3 beta/EBI1-ligand chemokine is an efficacious chemoattractant for T and B cells.

PubMed ID: 9498785

PubMed ID: 23341447

Title: Beta-arrestin recruitment and G protein signaling by the atypical human chemokine decoy receptor CCX-CKR.

PubMed ID: 23341447

DOI: 10.1074/jbc.m112.406108

PubMed ID: 27044744

Title: The Anti-inflammatory Protein TSG-6 Regulates Chemokine Function by Inhibiting Chemokine/Glycosaminoglycan Interactions.

PubMed ID: 27044744

DOI: 10.1074/jbc.m116.720953

Sequence Information:

  • Length: 98
  • Mass: 10993
  • Checksum: 0D2516DB2EB1C81B
  • Sequence:
    • MALLLALSLL VLWTSPAPTL SGTNDAEDCC LSVTQKPIPG YIVRNFHYLL IKDGCRVPAV 
VFTTLRGRQL CAPPDQPWVE RIIQRLQRTS AKMKRRSS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.