Details for: TNFRSF9

Gene ID: 3604

Symbol: TNFRSF9

Ensembl ID: ENSG00000049249

Description: TNF receptor superfamily member 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 26.1660
    Cell Significance Index: -4.0700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 16.0462
    Cell Significance Index: -4.0700
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 10.1660
    Cell Significance Index: -4.1300
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 4.2187
    Cell Significance Index: 25.2800
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 0.9149
    Cell Significance Index: -2.8100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.8196
    Cell Significance Index: 12.6800
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 0.7191
    Cell Significance Index: 11.8500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: 0.6944
    Cell Significance Index: 11.9300
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.2890
    Cell Significance Index: 2.9500
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.2783
    Cell Significance Index: 3.9900
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.2749
    Cell Significance Index: 2.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.1776
    Cell Significance Index: 4.7500
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 0.0738
    Cell Significance Index: 0.7400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0516
    Cell Significance Index: 1.4800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0415
    Cell Significance Index: 4.8400
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.0126
    Cell Significance Index: 0.3700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0008
    Cell Significance Index: 0.1700
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.0000
    Cell Significance Index: 0.0000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0015
    Cell Significance Index: -2.8100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0016
    Cell Significance Index: -0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0024
    Cell Significance Index: -4.3500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0030
    Cell Significance Index: -1.3300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0035
    Cell Significance Index: -5.3500
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0036
    Cell Significance Index: -2.7400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0039
    Cell Significance Index: -5.3500
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0048
    Cell Significance Index: -2.6200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0057
    Cell Significance Index: -4.1600
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0060
    Cell Significance Index: -3.8400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0060
    Cell Significance Index: -4.4800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0069
    Cell Significance Index: -0.8800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0080
    Cell Significance Index: -4.5200
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0092
    Cell Significance Index: -4.1800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0096
    Cell Significance Index: -5.9900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0103
    Cell Significance Index: -1.1800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0106
    Cell Significance Index: -2.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0124
    Cell Significance Index: -3.5800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0140
    Cell Significance Index: -2.5300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0194
    Cell Significance Index: -2.6700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0220
    Cell Significance Index: -2.2500
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.0222
    Cell Significance Index: -0.4100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0238
    Cell Significance Index: -4.0700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0244
    Cell Significance Index: -3.5500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0251
    Cell Significance Index: -3.0900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0287
    Cell Significance Index: -6.0500
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0327
    Cell Significance Index: -4.2200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0350
    Cell Significance Index: -1.5200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0363
    Cell Significance Index: -4.2800
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0364
    Cell Significance Index: -1.8900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0368
    Cell Significance Index: -2.3200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0392
    Cell Significance Index: -4.0800
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0412
    Cell Significance Index: -2.0800
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0447
    Cell Significance Index: -2.1000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0474
    Cell Significance Index: -3.0600
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0496
    Cell Significance Index: -2.0300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0557
    Cell Significance Index: -4.1500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0571
    Cell Significance Index: -4.3800
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0576
    Cell Significance Index: -3.8800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0602
    Cell Significance Index: -3.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0614
    Cell Significance Index: -0.8800
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.0684
    Cell Significance Index: -1.0000
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.0728
    Cell Significance Index: -0.9200
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: -0.0733
    Cell Significance Index: -0.7800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0734
    Cell Significance Index: -4.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0795
    Cell Significance Index: -4.1400
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0800
    Cell Significance Index: -4.4900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0821
    Cell Significance Index: -2.1100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0855
    Cell Significance Index: -2.3900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0893
    Cell Significance Index: -4.6900
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.0960
    Cell Significance Index: -1.6300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0982
    Cell Significance Index: -3.4400
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: -0.0996
    Cell Significance Index: -0.4600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1017
    Cell Significance Index: -4.5000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1027
    Cell Significance Index: -3.2700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1042
    Cell Significance Index: -3.4100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1068
    Cell Significance Index: -4.9800
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1105
    Cell Significance Index: -2.9600
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1123
    Cell Significance Index: -2.8000
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1196
    Cell Significance Index: -4.5300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1218
    Cell Significance Index: -4.4700
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.1222
    Cell Significance Index: -0.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1263
    Cell Significance Index: -4.3900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1266
    Cell Significance Index: -4.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.1272
    Cell Significance Index: -2.1800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1273
    Cell Significance Index: -3.4000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.1290
    Cell Significance Index: -3.5100
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: -0.1340
    Cell Significance Index: -1.3900
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1371
    Cell Significance Index: -2.8700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1377
    Cell Significance Index: -3.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1383
    Cell Significance Index: -3.4500
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: -0.1414
    Cell Significance Index: -0.8200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1426
    Cell Significance Index: -4.2000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1469
    Cell Significance Index: -2.9900
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: -0.1485
    Cell Significance Index: -0.8100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1510
    Cell Significance Index: -4.3500
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: -0.1551
    Cell Significance Index: -1.8300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1563
    Cell Significance Index: -4.1100
  • Cell Name: T cell (CL0000084)
    Fold Change: -0.1567
    Cell Significance Index: -1.8500
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1580
    Cell Significance Index: -3.4600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1583
    Cell Significance Index: -3.4200
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -0.1584
    Cell Significance Index: -2.7300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** TNFRSF9 is a single-pass transmembrane receptor protein that belongs to the tumor necrosis factor receptor superfamily. The gene is characterized by its high expression in various cell types, including colon goblet cells, intestinal crypt stem cells, and exhausted T cells. TNFRSF9 is also expressed in the central nervous system, where it is involved in regulating GABAergic interneuron function. The gene's ability to interact with multiple signaling pathways, including the non-canonical NF-κB pathway, highlights its versatility in mediating diverse cellular responses. **Pathways and Functions:** TNFRSF9 is involved in several critical cellular processes, including: 1. **Apoptotic Process:** TNFRSF9 can induce apoptosis in certain cell types, such as intestinal epithelial cells, by activating the non-canonical NF-κB pathway. 2. **Cytokine Signaling in Immune System:** TNFRSF9 interacts with TNF-α and other cytokines to modulate immune responses, particularly in the context of T cell activation and proliferation. 3. **Regulation of Cell Population Proliferation:** TNFRSF9 can inhibit cell proliferation in certain cell types, such as intestinal crypt stem cells, by activating the non-canonical NF-κB pathway. 4. **Tnfr2 Non-Canonical NF-κB Pathway:** TNFRSF9 interacts with TNF-2 to activate the non-canonical NF-κB pathway, which is involved in regulating immune responses and cell proliferation. **Clinical Significance:** TNFRSF9's involvement in various cellular processes makes it a potential therapeutic target in several diseases, including: 1. **Autoimmune Diseases:** Dysregulation of TNFRSF9 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, highlighting its potential as a therapeutic target. 2. **Cancer:** TNFRSF9's role in regulating cell proliferation and apoptosis makes it a potential target for cancer therapy. 3. **Neurological Disorders:** TNFRSF9's involvement in regulating GABAergic interneuron function makes it a potential therapeutic target for neurological disorders, such as epilepsy and Alzheimer's disease. In conclusion, TNFRSF9 is a multifaceted gene involved in various cellular processes, including immune regulation, apoptosis, and cell proliferation. Its high expression in diverse cell types and interactions with multiple signaling pathways underscore its significance in maintaining tissue homeostasis and responding to environmental cues. Further research is needed to fully elucidate the functions and clinical significance of TNFRSF9.

Genular Protein ID: 3437521559

Symbol: TNR9_HUMAN

Name: Tumor necrosis factor receptor superfamily member 9

UniProtKB Accession Codes:

Q07011

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 CTD 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 13 PDBsum 13 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8088337

Title: Molecular and biological characterization of human 4-1BB and its ligand.

PubMed ID: 8088337

DOI: 10.1002/eji.1830240943

PubMed ID: 8262389

Title: A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.

PubMed ID: 8262389

DOI: 10.1016/0378-1119(93)90110-o

PubMed ID: 7622190

Title: Characterization of human homologue of 4-1BB and its ligand.

PubMed ID: 7622190

DOI: 10.1016/0165-2478(94)00227-i

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9418902

Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

PubMed ID: 9418902

DOI: 10.1128/mcb.18.1.558

PubMed ID: 9607925

Title: CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.

PubMed ID: 9607925

DOI: 10.1084/jem.187.11.1849

PubMed ID: 11804328

Title: A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction.

PubMed ID: 11804328

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30872117

Title: Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.

PubMed ID: 30872117

DOI: 10.1016/j.jaci.2019.03.002

Sequence Information:

  • Length: 255
  • Mass: 27899
  • Checksum: F3A563FE5EF00460
  • Sequence:
    • MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP NSFSSAGGQR 
TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS MCEQDCKQGQ ELTKKGCKDC 
CFGTFNDQKR GICRPWTNCS LDGKSVLVNG TKERDVVCGP SPADLSPGAS SVTPPAPARE 
PGHSPQIISF FLALTSTALL FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG 
CSCRFPEEEE GGCEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.