Details for: TNFRSF9

Gene ID: 3604

Symbol: TNFRSF9

Ensembl ID: ENSG00000049249

Description: TNF receptor superfamily member 9

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.6
    Marker Score: 1162
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.25
    Marker Score: 848
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4808
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 1.15
    Marker Score: 659
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.08
    Marker Score: 496
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251802
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 1.03
    Marker Score: 789
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 1.01
    Marker Score: 1434
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71820
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48044
  • Cell Name: basophil (CL0000767)
    Fold Change: 0.99
    Marker Score: 472
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 501
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5316
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 367
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 376
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.89
    Marker Score: 319
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5283
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1260
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 703
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.75
    Marker Score: 390
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.74
    Marker Score: 1394
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.71
    Marker Score: 1444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.71
    Marker Score: 454
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.69
    Marker Score: 344
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.68
    Marker Score: 174
  • Cell Name: CD8-alpha alpha positive, gamma-delta intraepithelial T cell (CL0000802)
    Fold Change: 0.64
    Marker Score: 209
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.63
    Marker Score: 380
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: 0.63
    Marker Score: 350
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 0.59
    Marker Score: 499
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.54
    Marker Score: 144
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.54
    Marker Score: 531
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.51
    Marker Score: 1437
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.46
    Marker Score: 7197
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.44
    Marker Score: 197.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.44
    Marker Score: 139
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 0.44
    Marker Score: 4334
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.44
    Marker Score: 253
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.44
    Marker Score: 715
  • Cell Name: regulatory T cell (CL0000815)
    Fold Change: 0.39
    Marker Score: 426
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.34
    Marker Score: 883
  • Cell Name: CD4-positive, CD25-positive, alpha-beta regulatory T cell (CL0000792)
    Fold Change: 0.3
    Marker Score: 80
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 0.29
    Marker Score: 224
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.28
    Marker Score: 285
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.27
    Marker Score: 15378
  • Cell Name: memory T cell (CL0000813)
    Fold Change: 0.27
    Marker Score: 116
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.26
    Marker Score: 548
  • Cell Name: DN1 thymic pro-T cell (CL0000894)
    Fold Change: 0.26
    Marker Score: 81
  • Cell Name: T-helper 17 cell (CL0000899)
    Fold Change: 0.25
    Marker Score: 166
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.25
    Marker Score: 119
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.23
    Marker Score: 98
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.23
    Marker Score: 73
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 0.22
    Marker Score: 646
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 0.22
    Marker Score: 158
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: leukocyte (CL0000738)
    Fold Change: 0.21
    Marker Score: 123
  • Cell Name: naive regulatory T cell (CL0002677)
    Fold Change: 0.21
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.21
    Marker Score: 72
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.21
    Marker Score: 134
  • Cell Name: natural killer cell (CL0000623)
    Fold Change: 0.21
    Marker Score: 269
  • Cell Name: CD8-positive, alpha-beta memory T cell (CL0000909)
    Fold Change: 0.2
    Marker Score: 170
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.2
    Marker Score: 122
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 0.19
    Marker Score: 99
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.19
    Marker Score: 112
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 0.19
    Marker Score: 362
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.19
    Marker Score: 82
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.18
    Marker Score: 76
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.18
    Marker Score: 201
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 0.18
    Marker Score: 127
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.17
    Marker Score: 98
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.17
    Marker Score: 5736
  • Cell Name: CD8-positive, alpha-beta cytokine secreting effector T cell (CL0000908)
    Fold Change: 0.17
    Marker Score: 72
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 0.16
    Marker Score: 496.5
  • Cell Name: gamma-delta T cell (CL0000798)
    Fold Change: 0.15
    Marker Score: 104
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.15
    Marker Score: 154
  • Cell Name: activated CD4-positive, alpha-beta T cell, human (CL0001043)
    Fold Change: 0.15
    Marker Score: 70
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 101.5
  • Cell Name: CD8-positive, alpha-beta T cell (CL0000625)
    Fold Change: 0.15
    Marker Score: 238
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.15
    Marker Score: 7705
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 144
  • Cell Name: NKp44-negative group 3 innate lymphoid cell, human (CL0001080)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.14
    Marker Score: 31
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 0.13
    Marker Score: 863
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.13
    Marker Score: 48
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.13
    Marker Score: 30
  • Cell Name: CD16-positive, CD56-dim natural killer cell, human (CL0000939)
    Fold Change: 0.13
    Marker Score: 103
  • Cell Name: inflammatory macrophage (CL0000863)
    Fold Change: 0.13
    Marker Score: 41
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.13
    Marker Score: 211
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.13
    Marker Score: 41.5
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.13
    Marker Score: 68
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.13
    Marker Score: 31
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.13
    Marker Score: 29
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.13
    Marker Score: 46
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.13
    Marker Score: 132

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics**: - The TNFRSF9 gene is located on chromosome 15q21.1. - It is a single-exon gene that encodes a protein of 327 amino acids. - The protein is a transmembrane protein that is expressed on the surface of immune cells. - It is a key regulator of T cell development and function. **Pathways and functions**: - The TNFRSF9 gene is involved in a variety of cellular processes, including apoptosis, cytokine signaling, and cell proliferation. - In apoptosis, TNFRSF9 signaling can inhibit apoptosis by promoting the expression of anti-apoptotic proteins. - In cytokine signaling, TNFRSF9 signaling can activate the transcription of genes that promote inflammation and cell growth. - In cell proliferation, TNFRSF9 signaling can promote the proliferation of epithelial cells in the small intestine and colon. **Clinical significance**: - Mutations in the TNFRSF9 gene have been linked to a variety of human diseases, including inflammatory bowel disease, cancer, and autoimmune disorders. - TNFRSF9 inhibitors are being investigated as a potential treatment for these diseases.

Genular Protein ID: 3437521559

Symbol: TNR9_HUMAN

Name: Tumor necrosis factor receptor superfamily member 9

UniProtKB Accession Codes:

Q07011

Database IDs:

ABCD 1 AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CPTAC 1 CPTC 1 ChEMBL 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 ELM 1 EMBL 5 Ensembl 1 ExpressionAtlas 1 GO 7 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 15 PDBsum 12 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8088337

Title: Molecular and biological characterization of human 4-1BB and its ligand.

PubMed ID: 8088337

DOI: 10.1002/eji.1830240943

PubMed ID: 8262389

Title: A receptor induced by lymphocyte activation (ILA): a new member of the human nerve-growth-factor/tumor-necrosis-factor receptor family.

PubMed ID: 8262389

DOI: 10.1016/0378-1119(93)90110-o

PubMed ID: 7622190

Title: Characterization of human homologue of 4-1BB and its ligand.

PubMed ID: 7622190

DOI: 10.1016/0165-2478(94)00227-i

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 9418902

Title: 4-1BB and Ox40 are members of a tumor necrosis factor (TNF)-nerve growth factor receptor subfamily that bind TNF receptor-associated factors and activate nuclear factor kappaB.

PubMed ID: 9418902

DOI: 10.1128/mcb.18.1.558

PubMed ID: 9607925

Title: CD28-independent, TRAF2-dependent costimulation of resting T cells by 4-1BB ligand.

PubMed ID: 9607925

DOI: 10.1084/jem.187.11.1849

PubMed ID: 11804328

Title: A novel leucine-rich repeat protein (LRR-1): potential involvement in 4-1BB-mediated signal transduction.

PubMed ID: 11804328

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 30872117

Title: Immunodeficiency and EBV-induced lymphoproliferation caused by 4-1BB deficiency.

PubMed ID: 30872117

DOI: 10.1016/j.jaci.2019.03.002

Sequence Information:

  • Length: 255
  • Mass: 27899
  • Checksum: F3A563FE5EF00460
  • Sequence:
    • MGNSCYNIVA TLLLVLNFER TRSLQDPCSN CPAGTFCDNN RNQICSPCPP NSFSSAGGQR 
TCDICRQCKG VFRTRKECSS TSNAECDCTP GFHCLGAGCS MCEQDCKQGQ ELTKKGCKDC 
CFGTFNDQKR GICRPWTNCS LDGKSVLVNG TKERDVVCGP SPADLSPGAS SVTPPAPARE 
PGHSPQIISF FLALTSTALL FLLFFLTLRF SVVKRGRKKL LYIFKQPFMR PVQTTQEEDG 
CSCRFPEEEE GGCEL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.