Details for: MAP1LC3B
Gene ID: 81631
Gene Type: Protein-coding - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.
Symbol: MAP1LC3B
Ensembl ID: ENSG00000140941
Description: microtubule associated protein 1 light chain 3 beta
Cell Significance Landscape
Associated with
Significant Cells
Cell Significance Index (CSI) scores for the chosen context(s)
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CSI 71.43rCSI 48.12%PRS 5.48
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CSI 67.78rCSI 65.18%PRS 9.82
-
CSI 60.76rCSI 46.81%PRS 4.07
-
CSI 39.42rCSI 52.4%PRS 4.93
-
CSI 38.59rCSI 76.94%PRS 7.74
-
CSI 36.52rCSI 49.76%PRS 4.08
-
CSI 36.47rCSI 91.37%PRS 15.1
-
CSI 34.84rCSI 67.75%PRS 4.6
-
CSI 31.72rCSI 38.62%PRS 5.71
-
CSI 31.53rCSI 36.1%PRS 9.39
-
CSI 27.01rCSI 24.8%PRS 5.15
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CSI 25.08rCSI 38.75%PRS 4.23
-
CSI 24.94rCSI 47.07%PRS 5.62
-
CSI 24.93rCSI 21.92%PRS 3.26
-
CSI 24.61rCSI 70.27%PRS 8.01
-
CSI 24.57rCSI 25.74%PRS 4.21
-
CSI 22.88rCSI 28.31%PRS 3.95
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CSI 22.66rCSI 18.76%PRS 4.5
-
CSI 22.31rCSI 18.7%PRS 5.42
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CSI 21.56rCSI 22.91%PRS 8.07
-
CSI 21.22rCSI 46.97%PRS 4.23
-
CSI 21.06rCSI 18.31%PRS 5.56
-
CSI 19.12rCSI 55.08%PRS 9.21
-
CSI 16.92rCSI 16.64%PRS 4.93
-
CSI 16.79rCSI 11.19%PRS 12.69
-
CSI 16.38rCSI 29.77%PRS 6.91
-
CSI 16.38rCSI 28.02%PRS 9.87
-
CSI 14.73rCSI 22.46%PRS 4.22
-
CSI 13.97rCSI 22.52%PRS 7.34
-
CSI 13.55rCSI 10.07%PRS 6.75
-
CSI 12.79rCSI 44.89%PRS 8.21
-
CSI 12.59rCSI 20.27%PRS 3.49
-
CSI 12.19rCSI 10.68%PRS 6.1
-
CSI 12.19rCSI 39.1%PRS 6.81
-
CSI 12.13rCSI 83.28%PRS 8.99
-
CSI 11.97rCSI 26.43%PRS 3.26
-
CSI 11.92rCSI 58.74%PRS 6.11
-
CSI 11.9rCSI 20.97%PRS 4.84
-
CSI 11.57rCSI 49.98%PRS 8.8
-
CSI 11.41rCSI 45.43%PRS 8.07
-
CSI 10.67rCSI 10.28%PRS 2.38
-
CSI 10.1rCSI 58.76%PRS 6.78
-
CSI 9.33rCSI 9.77%PRS 4.83
-
CSI 9.26rCSI 25.45%PRS 7.55
-
CSI 9.07rCSI 54.9%PRS 10.63
-
CSI 8.97rCSI 9.62%PRS 4.16
-
CSI 8.78rCSI 11.5%PRS 6.32
-
CSI 8.43rCSI 12.72%PRS 4.43
-
CSI 8.35rCSI 11.92%PRS 5.13
-
CSI 8.33rCSI 15.9%PRS 11.08
-
CSI 8.23rCSI 23.83%PRS 5.11
-
CSI 8.16rCSI 10.26%PRS 6.94
-
CSI 8.15rCSI 10.38%PRS 5.26
-
CSI 7.83rCSI 23.37%PRS 12.31
-
CSI 7.17rCSI 38.67%PRS 8.94
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CSI 7.14rCSI 10.1%PRS 6.78
-
CSI 7.11rCSI 16.55%PRS 11.03
-
CSI 6.78rCSI 10.36%PRS 7.93
-
CSI 6.69rCSI 4.95%PRS 4.23
-
CSI 6.36rCSI 12.03%PRS 10.18
-
CSI 6.18rCSI 4.31%PRS 4.76
-
CSI 6.06rCSI 9.99%PRS 5.26
-
CSI 6.01rCSI 9.17%PRS 4.5
-
CSI 5.96rCSI 17.6%PRS 5.75
-
CSI 5.86rCSI 9.36%PRS 4.91
-
CSI 5.78rCSI 8.88%PRS 5.24
-
CSI 5.76rCSI 4.96%PRS 7.48
-
CSI 5.74rCSI 8.82%PRS 6.51
-
CSI 5.57rCSI 8.52%PRS 5.22
-
CSI 5.55rCSI 60.42%PRS 8.6
-
CSI 5.44rCSI 6.83%PRS 5.73
-
CSI 5.32rCSI 15.42%PRS 3.95
-
CSI 5.18rCSI 24.16%PRS 11.34
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CSI 5.11rCSI 4.62%PRS 3.97
-
CSI 5rCSI 8.56%PRS 6.03
-
CSI 4.98rCSI 3.73%PRS 13.7
-
CSI 4.92rCSI 6.76%PRS 9.76
-
CSI 4.91rCSI 16.08%PRS 14.21
-
CSI 4.73rCSI 11.23%PRS 6.07
-
CSI 4.65rCSI 3.49%PRS 4.65
-
CSI 4.62rCSI 3.86%PRS 14.8
-
CSI 4.39rCSI 4.09%PRS 4.52
-
CSI 4.33rCSI 18.22%PRS 12.43
-
CSI 4.33rCSI 3.8%PRS 5.05
-
CSI 4.31rCSI 3.39%PRS 5.37
-
CSI 4.23rCSI 9.65%PRS 4.18
-
CSI 4.05rCSI 7.8%PRS 10.4
-
CSI 3.98rCSI 14.13%PRS 7.43
-
CSI 3.93rCSI 3.26%PRS 4.24
-
CSI 3.79rCSI 29.72%PRS 10.69
-
CSI 3.74rCSI 89.52%PRS 17.21
-
CSI 3.73rCSI 17.24%PRS 9.92
-
CSI 3.64rCSI 5.22%PRS 6.31
-
CSI 3.64rCSI 4.67%PRS 4.47
-
CSI 3.56rCSI 5.14%PRS 6.28
-
CSI 3.54rCSI 3.5%PRS 19.93
-
CSI 3.5rCSI 9.45%PRS 5.88
-
CSI 3.42rCSI 6.27%PRS 29.27
-
CSI 3.42rCSI 2.38%PRS 6.57
-
CSI 3.38rCSI 22.19%PRS 11.95
-
CSI -9.0rCSI -55.9%PRS 3.7%
-
CSI -8.3rCSI -30.0%PRS 2.5%
-
CSI -8.2rCSI -18.1%PRS 4.9%
-
CSI -6.1rCSI -13.6%PRS 2.9%
-
CSI -5.3rCSI -8.5%PRS 3.1%
-
CSI -4.7rCSI -34.4%PRS 2.2%
-
CSI -4.6rCSI -8.5%PRS 3.5%
-
CSI -3.6rCSI -4.0%PRS 5.2%
-
CSI -3.1rCSI -7.1%PRS 4.4%
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CSI -2.8rCSI -5.1%PRS 4.4%
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CSI -2.8rCSI -2.7%PRS 7.3%
-
CSI -2.7rCSI -3.8%PRS 4.3%
-
CSI -2.6rCSI -3.0%PRS 7.3%
-
CSI -2.4rCSI -5.8%PRS 8.6%
-
CSI -2.0rCSI -3.5%PRS 6.0%
-
CSI -1.8rCSI -4.9%PRS 5.4%
-
CSI -1.8rCSI -4.5%PRS 4.6%
-
CSI -1.4rCSI -2.6%PRS 7.2%
-
CSI -1.3rCSI -4.3%PRS 3.3%
-
CSI -1.3rCSI -3.2%PRS 3.6%
-
CSI -1.2rCSI -3.0%PRS 5.7%
-
CSI -1.2rCSI -6.9%PRS 3.0%
-
CSI -0.7rCSI -1.8%PRS 2.7%
-
CSI -0.7rCSI -0.6%PRS 7.1%
-
CSI -0.6rCSI -1.0%PRS 4.5%
-
CSI -0.6rCSI -0.7%PRS 7.9%
-
CSI -0.6rCSI -2.5%PRS 16.7%
-
CSI -0.5rCSI -2.6%PRS 32.7%
-
CSI -0.4rCSI -2.5%PRS 6.9%
-
CSI -0.2rCSI -0.9%PRS 2.9%
-
CSI -0.2rCSI -0.4%PRS 14.4%
-
CSI -0.2rCSI -0.8%PRS 4.6%
-
CSI -0.1rCSI -0.4%PRS 7.7%
-
CSI -0.1rCSI -0.7%PRS 27.2%
-
CSI 0.0rCSI -0.1%PRS 3.2%
-
CSI 0.0rCSI 0.1%PRS 7.5%
-
CSI 0.0rCSI 0.1%PRS 2.5%
-
CSI 0.0rCSI 1.2%PRS 53.5%
-
CSI 0.0rCSI 0.4%PRS 14.5%
-
CSI 0.1rCSI 0.1%PRS 2.7%
-
CSI 0.1rCSI 0.2%PRS 2.9%
-
CSI 0.1rCSI 1.0%PRS 16.0%
-
CSI 0.1rCSI 1.4%PRS 10.9%
-
CSI 0.1rCSI 0.7%PRS 31.0%
-
CSI 0.1rCSI 0.9%PRS 18.6%
-
CSI 0.1rCSI 0.5%PRS 12.5%
-
CSI 0.1rCSI 0.8%PRS 7.1%
-
CSI 0.2rCSI 0.8%PRS 10.9%
-
CSI 0.2rCSI 0.3%PRS 9.3%
-
CSI 0.2rCSI 0.2%PRS 4.6%
-
CSI 0.2rCSI 0.4%PRS 10.0%
-
CSI 0.2rCSI 1.0%PRS 14.3%
-
CSI 0.2rCSI 1.2%PRS 15.3%
-
CSI 0.2rCSI 1.2%PRS 24.2%
-
CSI 0.2rCSI 0.5%PRS 7.3%
-
CSI 0.2rCSI 5.4%PRS 26.0%
-
CSI 0.3rCSI 0.5%PRS 9.0%
-
CSI 0.3rCSI 1.7%PRS 15.6%
-
CSI 0.3rCSI 2.1%PRS 20.6%
-
CSI 0.3rCSI 1.5%PRS 9.0%
-
CSI 0.3rCSI 0.5%PRS 2.7%
-
CSI 0.3rCSI 0.2%PRS 4.4%
-
CSI 0.3rCSI 2.9%PRS 20.3%
-
CSI 0.3rCSI 1.1%PRS 5.6%
-
CSI 0.3rCSI 1.3%PRS 10.1%
-
CSI 0.3rCSI 2.4%PRS 8.6%
-
CSI 0.3rCSI 1.5%PRS 24.5%
-
CSI 0.4rCSI 1.1%PRS 5.5%
-
CSI 0.4rCSI 1.6%PRS 8.8%
-
CSI 0.4rCSI 0.6%PRS 4.6%
-
CSI 0.4rCSI 0.4%PRS 3.8%
-
CSI 0.4rCSI 0.7%PRS 13.7%
-
CSI 0.4rCSI 1.7%PRS 3.9%
-
CSI 0.4rCSI 1.4%PRS 4.0%
-
CSI 0.4rCSI 2.7%PRS 17.0%
-
CSI 0.4rCSI 2.4%PRS 21.6%
-
CSI 0.4rCSI 1.6%PRS 22.8%
-
CSI 0.5rCSI 1.7%PRS 7.5%
-
CSI 0.5rCSI 1.3%PRS 22.0%
-
CSI 0.5rCSI 9.6%PRS 4.6%
-
CSI 0.5rCSI 4.3%PRS 27.8%
-
CSI 0.5rCSI 2.8%PRS 24.7%
-
CSI 0.5rCSI 0.4%PRS 8.1%
-
CSI 0.5rCSI 1.0%PRS 5.1%
-
CSI 0.5rCSI 0.6%PRS 4.5%
-
CSI 0.5rCSI 1.0%PRS 11.0%
-
CSI 0.5rCSI 0.4%PRS 5.3%
-
CSI 0.5rCSI 7.3%PRS 3.5%
-
CSI 0.5rCSI 1.2%PRS 5.9%
-
CSI 0.5rCSI 3.2%PRS 25.1%
-
CSI 0.5rCSI 1.3%PRS 6.9%
-
CSI 0.6rCSI 0.9%PRS 11.6%
-
CSI 0.6rCSI 1.9%PRS 20.6%
-
CSI 0.6rCSI 0.7%PRS 6.8%
-
CSI 0.6rCSI 2.9%PRS 5.9%
-
CSI 0.6rCSI 0.7%PRS 7.6%
-
CSI 0.6rCSI 2.6%PRS 18.1%
-
CSI 0.6rCSI 0.9%PRS 7.3%
-
CSI 0.6rCSI 1.1%PRS 4.3%
-
CSI 0.6rCSI 1.4%PRS 8.7%
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration
Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.
Legend:
- Query Gene
-
Node Color (Target Cell CSI, relative to current network):
- Very High
- High
- Medium
- Low
- Very Low
- CSI N/A
- Node Size: Proportional to Target Cell CSI magnitude
- STRING PPI Edge
- Shared Pathway Edge (ONTOLOGY)
Other Information
This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.
Genular Protein ID: 1941761350
Symbol: MLP3B_HUMAN
Name: Autophagy-related protein LC3 B
UniProtKB Accession Codes:
Database IDs:
Citations:
PubMed ID: 12932674
Title: Gene expression profiles in human non-small and small-cell lung cancers.
PubMed ID: 12932674
PubMed ID: 14713272
Title: The gene expression profiling of sporadic pheochromocytoma and novel full-length cDNAs cloning.
PubMed ID: 14713272
PubMed ID: 12740394
Title: Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.
PubMed ID: 12740394
PubMed ID: 14702039
Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.
PubMed ID: 14702039
DOI: 10.1038/ng1285
PubMed ID: 15489334
Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).
PubMed ID: 15489334
DOI: 10.1101/gr.2596504
PubMed ID: 15187094
Title: HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.
PubMed ID: 15187094
PubMed ID: 15355958
Title: Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.
PubMed ID: 15355958
PubMed ID: 15325588
Title: LC3 conjugation system in mammalian autophagy.
PubMed ID: 15325588
PubMed ID: 15095872
Title: Caldendrin but not calmodulin binds to light chain 3 of MAP1A/B: an association with the microtubule cytoskeleton highlighting exclusive binding partners for neuronal Ca(2+)-sensor proteins.
PubMed ID: 15095872
PubMed ID: 17580304
Title: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.
PubMed ID: 17580304
PubMed ID: 20818167
Title: Synthetic substrates for measuring activity of autophagy proteases: autophagins (Atg4).
PubMed ID: 20818167
PubMed ID: 20418806
Title: LC3 and GATE-16/GABARAP subfamilies are both essential yet act differently in autophagosome biogenesis.
PubMed ID: 20418806
PubMed ID: 20529957
Title: Ubiquilin functions in autophagy and is degraded by chaperone-mediated autophagy.
PubMed ID: 20529957
DOI: 10.1093/hmg/ddq231
PubMed ID: 20100911
Title: FYCO1 is a Rab7 effector that binds to LC3 and PI3P to mediate microtubule plus end-directed vesicle transport.
PubMed ID: 20100911
PubMed ID: 20562859
Title: Network organization of the human autophagy system.
PubMed ID: 20562859
DOI: 10.1038/nature09204
PubMed ID: 21383079
Title: OATL1, a novel autophagosome-resident Rab33B-GAP, regulates autophagosomal maturation.
PubMed ID: 21383079
PubMed ID: 22948227
Title: MAPK15/ERK8 stimulates autophagy by interacting with LC3 and GABARAP proteins.
PubMed ID: 22948227
DOI: 10.4161/auto.21857
PubMed ID: 22311637
Title: Identification of autophagosome-associated proteins and regulators by quantitative proteomic analysis and genetic screens.
PubMed ID: 22311637
PubMed ID: 22354992
Title: Rab GTPase-activating proteins in autophagy: regulation of endocytic and autophagy pathways by direct binding to human ATG8 modifiers.
PubMed ID: 22354992
DOI: 10.1128/mcb.06717-11
PubMed ID: 22922758
Title: Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
PubMed ID: 22922758
PubMed ID: 22470510
Title: DOR/Tp53inp2 and Tp53inp1 constitute a metazoan gene family encoding dual regulators of autophagy and transcription.
PubMed ID: 22470510
PubMed ID: 23112293
Title: The Legionella effector RavZ inhibits host autophagy through irreversible Atg8 deconjugation.
PubMed ID: 23112293
PubMed ID: 23721406
Title: Arginine68 is an essential residue for the C-terminal cleavage of human Atg8 family proteins.
PubMed ID: 23721406
PubMed ID: 23459205
Title: Ubiquilin4 is an adaptor protein that recruits Ubiquilin1 to the autophagy machinery.
PubMed ID: 23459205
PubMed ID: 23209295
Title: Modulation of serines 17 and 24 in the LC3-interacting region of Bnip3 determines pro-survival mitophagy versus apoptosis.
PubMed ID: 23209295
PubMed ID: 24089205
Title: Autophagy promotes primary ciliogenesis by removing OFD1 from centriolar satellites.
PubMed ID: 24089205
DOI: 10.1038/nature12606
PubMed ID: 24668264
Title: Structural determinants in GABARAP required for the selective binding and recruitment of ALFY to LC3B-positive structures.
PubMed ID: 24668264
PubMed ID: 25215947
Title: AMBRA1 is able to induce mitophagy via LC3 binding, regardless of PARKIN and p62/SQSTM1.
PubMed ID: 25215947
DOI: 10.1038/cdd.2014.139
PubMed ID: 25684205
Title: CUL3-KBTBD6/KBTBD7 ubiquitin ligase cooperates with GABARAP proteins to spatially restrict TIAM1-RAC1 signaling.
PubMed ID: 25684205
PubMed ID: 26040720
Title: Regulation of endoplasmic reticulum turnover by selective autophagy.
PubMed ID: 26040720
DOI: 10.1038/nature14498
PubMed ID: 26451915
Title: The Autophagy Receptor TAX1BP1 and the Molecular Motor Myosin VI Are Required for Clearance of Salmonella Typhimurium by Autophagy.
PubMed ID: 26451915
PubMed ID: 28017329
Title: Prohibitin 2 Is an Inner Mitochondrial Membrane Mitophagy Receptor.
PubMed ID: 28017329
PubMed ID: 29458288
Title: Delipidation of mammalian Atg8-family proteins by each of the four ATG4 proteases.
PubMed ID: 29458288
PubMed ID: 29420192
Title: Mechanism of Stx17 recruitment to autophagosomes via IRGM and mammalian Atg8 proteins.
PubMed ID: 29420192
PubMed ID: 30143514
Title: TRIM16 controls assembly and degradation of protein aggregates by modulating the p62-NRF2 axis and autophagy.
PubMed ID: 30143514
PubMed ID: 30661429
Title: Redundancy of human ATG4 protease isoforms in autophagy and LC3/GABARAP processing revealed in cells.
PubMed ID: 30661429
PubMed ID: 31315929
Title: Human ATG4 autophagy proteases counteract attachment of ubiquitin-like LC3/GABARAP proteins to other cellular proteins.
PubMed ID: 31315929
PubMed ID: 30420355
Title: LC3 and STRAP regulate actin filament assembly by JMY during autophagosome formation.
PubMed ID: 30420355
PubMed ID: 31006538
Title: Intrinsically disordered protein TEX264 mediates ER-phagy.
PubMed ID: 31006538
PubMed ID: 31006537
Title: TEX264 is an endoplasmic reticulum-resident ATG8-interacting protein critical for ER remodeling during nutrient stress.
PubMed ID: 31006537
PubMed ID: 32315611
Title: A DNM2 Centronuclear Myopathy Mutation Reveals a Link between Recycling Endosome Scission and Autophagy.
PubMed ID: 32315611
PubMed ID: 33499712
Title: Mammalian BCAS3 and C16orf70 associate with the phagophore assembly site in response to selective and non-selective autophagy.
PubMed ID: 33499712
PubMed ID: 31722778
Title: LIR motifs and the membrane-targeting domain are complementary in the function of RavZ.
PubMed ID: 31722778
PubMed ID: 31091447
Title: The Glycoprotein and Nucleocapsid Protein of Hantaviruses Manipulate Autophagy Flux to Restrain Host Innate Immune Responses.
PubMed ID: 31091447
PubMed ID: 33783314
Title: The BAX-binding protein MOAP1 associates with LC3 and promotes closure of the phagophore.
PubMed ID: 33783314
PubMed ID: 34338405
Title: Role of FAM134 paralogues in endoplasmic reticulum remodeling, ER-phagy, and Collagen quality control.
PubMed ID: 34338405
PubMed ID: 33909989
Title: Non-canonical autophagy drives alternative ATG8 conjugation to phosphatidylserine.
PubMed ID: 33909989
PubMed ID: 36758105
Title: Structural basis for regulation of apoptosis and autophagy by the BIRC6/SMAC complex.
PubMed ID: 36758105
PubMed ID: 15857831
Title: Solution structure of microtubule-associated protein light chain 3 and identification of its functional subdomains.
PubMed ID: 15857831
PubMed ID: 18524774
Title: Structural basis for sorting mechanism of p62 in selective autophagy.
PubMed ID: 18524774
PubMed ID: 24290141
Title: Structural basis of the autophagy-related LC3/Atg13 LIR complex: recognition and interaction mechanism.
PubMed ID: 24290141
PubMed ID: 28668392
Title: A novel conformation of the LC3-interacting region motif revealed by the structure of a complex between LC3B and RavZ.
PubMed ID: 28668392
PubMed ID: 28395732
Title: Elucidation of the anti-autophagy mechanism of the Legionella effector RavZ using semisynthetic LC3 proteins.
PubMed ID: 28395732
DOI: 10.7554/elife.23905
Sequence Information:
- Length: 125
- Mass: 14688
- Checksum: BB141DEC7653E83F
- Sequence:
MPSEKTFKQR RTFEQRVEDV RLIREQHPTK IPVIIERYKG EKQLPVLDKT KFLVPDHVNM SELIKIIRRR LQLNANQAFF LLVNGHSMVS VSTPISEVYE SEKDEDGFLY MVYASQETFG MKLSV