Details for: GALR1

Gene ID: 2587

Symbol: GALR1

Ensembl ID: ENSG00000166573

Description: galanin receptor 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.6162
    Cell Significance Index: 35.0200
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: 1.1554
    Cell Significance Index: 19.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1465
    Cell Significance Index: 36.7200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.8842
    Cell Significance Index: 19.3600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.7261
    Cell Significance Index: 138.1800
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.3385
    Cell Significance Index: 7.2100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.3199
    Cell Significance Index: 31.6500
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.3023
    Cell Significance Index: 3.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.2851
    Cell Significance Index: 257.4300
  • Cell Name: epithelial cell of thymus (CL0002293)
    Fold Change: 0.2666
    Cell Significance Index: 2.0500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2292
    Cell Significance Index: 13.7600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.2172
    Cell Significance Index: 23.6300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.2124
    Cell Significance Index: 3.3700
  • Cell Name: L5 intratelencephalic projecting glutamatergic neuron (CL4030064)
    Fold Change: 0.2121
    Cell Significance Index: 2.2900
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.1754
    Cell Significance Index: 28.5300
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.1316
    Cell Significance Index: 1.8900
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.1175
    Cell Significance Index: 8.1300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1175
    Cell Significance Index: 3.0900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1004
    Cell Significance Index: 2.5100
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.0895
    Cell Significance Index: 0.7900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0458
    Cell Significance Index: 1.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0322
    Cell Significance Index: 1.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0204
    Cell Significance Index: 9.2700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0198
    Cell Significance Index: 3.9800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.0083
    Cell Significance Index: 0.5100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0035
    Cell Significance Index: 1.2700
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0031
    Cell Significance Index: 0.1100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0002
    Cell Significance Index: 0.3400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0014
    Cell Significance Index: -2.6500
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0020
    Cell Significance Index: -2.7800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0023
    Cell Significance Index: -1.3200
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.0027
    Cell Significance Index: -0.0400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0028
    Cell Significance Index: -0.2900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0032
    Cell Significance Index: -2.0200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0044
    Cell Significance Index: -3.2600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0046
    Cell Significance Index: -3.3600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0047
    Cell Significance Index: -3.5800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0053
    Cell Significance Index: -2.9100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0054
    Cell Significance Index: -1.5500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0056
    Cell Significance Index: -2.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0062
    Cell Significance Index: -3.8700
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0091
    Cell Significance Index: -1.3200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0114
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0116
    Cell Significance Index: -0.2400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0122
    Cell Significance Index: -2.4200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0141
    Cell Significance Index: -1.6100
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0155
    Cell Significance Index: -1.9900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0160
    Cell Significance Index: -2.8800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0167
    Cell Significance Index: -3.5200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0182
    Cell Significance Index: -3.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.0208
    Cell Significance Index: -0.4800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0226
    Cell Significance Index: -0.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0246
    Cell Significance Index: -3.1800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0247
    Cell Significance Index: -1.1500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0250
    Cell Significance Index: -3.4300
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0264
    Cell Significance Index: -3.2500
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.0276
    Cell Significance Index: -0.7500
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0321
    Cell Significance Index: -1.6200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0335
    Cell Significance Index: -1.7400
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: -0.0346
    Cell Significance Index: -0.4200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0352
    Cell Significance Index: -3.6700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0358
    Cell Significance Index: -2.2600
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0389
    Cell Significance Index: -2.3900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: -0.0407
    Cell Significance Index: -0.5900
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0410
    Cell Significance Index: -0.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0433
    Cell Significance Index: -3.2300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0452
    Cell Significance Index: -3.0400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0476
    Cell Significance Index: -3.6500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0484
    Cell Significance Index: -3.1200
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.0488
    Cell Significance Index: -0.6300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0626
    Cell Significance Index: -3.5100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.0651
    Cell Significance Index: -0.6700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0662
    Cell Significance Index: -3.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.0666
    Cell Significance Index: -1.9000
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0696
    Cell Significance Index: -0.9500
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0716
    Cell Significance Index: -2.2800
  • Cell Name: epithelial cell of lacrimal sac (CL1000436)
    Fold Change: -0.0736
    Cell Significance Index: -0.5300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0739
    Cell Significance Index: -3.8800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0739
    Cell Significance Index: -3.2700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0759
    Cell Significance Index: -2.6600
  • Cell Name: rod bipolar cell (CL0000751)
    Fold Change: -0.0794
    Cell Significance Index: -0.9100
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.0832
    Cell Significance Index: -2.6300
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0866
    Cell Significance Index: -2.4200
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.0910
    Cell Significance Index: -3.3400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0932
    Cell Significance Index: -3.5300
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0938
    Cell Significance Index: -1.8300
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1026
    Cell Significance Index: -0.8100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1031
    Cell Significance Index: -2.6500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1033
    Cell Significance Index: -3.5900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.1050
    Cell Significance Index: -1.9400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.1052
    Cell Significance Index: -2.0800
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1059
    Cell Significance Index: -3.1200
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1067
    Cell Significance Index: -3.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.1095
    Cell Significance Index: -2.7900
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1151
    Cell Significance Index: -2.7600
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1158
    Cell Significance Index: -3.0900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1163
    Cell Significance Index: -2.9000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1177
    Cell Significance Index: -2.8500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1194
    Cell Significance Index: -1.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GALR1 is a G protein-coupled receptor (GPCR) that belongs to the class A/1 (rhodopsin-like receptors) family. Its structure and function are characterized by its ability to bind to galanin, a peptide hormone that activates the receptor through a Gαi signaling pathway. This activation leads to a cascade of downstream effects, including the regulation of adenylate cyclase activity, calcium ion concentration, and transcriptional regulation. Notably, GALR1 exhibits both positive and negative regulatory effects on adenylate cyclase activity, depending on the context and cellular environment. **Pathways and Functions:** GALR1's signaling pathways are multifaceted and interconnected, involving various downstream effectors and transcriptional regulators. Key signaling pathways associated with GALR1 include: 1. **Adenylate Cyclase-Activating G Protein-Coupled Receptor Signaling Pathway**: GALR1 activation leads to the stimulation of adenylate cyclase, resulting in increased cAMP levels and downstream effects on cellular processes. 2. **Gαi Signaling Events**: GALR1 binding to galanin triggers the activation of Gαi, which in turn modulates adenylate cyclase activity and regulates calcium ion concentration. 3. **Gpcr Downstream Signaling**: GALR1's signaling is further modulated by downstream effectors, including Gq, Gi, and G12/13, which regulate various cellular processes, including calcium ion concentration and transcriptional regulation. 4. **Neuropeptide Signaling Pathway**: GALR1's interaction with galanin is a key component of the neuropeptide signaling pathway, which plays a critical role in regulating various physiological processes, including pain transmission, mood regulation, and appetite modulation. **Clinical Significance:** GALR1's involvement in various physiological and pathological processes underscores its potential as a therapeutic target for several diseases. Some of the key clinical implications of GALR1 include: 1. **Regulation of Cortisol Secretion**: GALR1's positive regulation of cortisol secretion has implications for the treatment of disorders related to cortisol dysregulation, such as Cushing's syndrome. 2. **Immune Response Modulation**: GALR1's involvement in immune response regulation has implications for the treatment of autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 3. **Neurological Disorders**: GALR1's role in regulating calcium ion concentration and transcriptional regulation has implications for the treatment of neurological disorders, such as Alzheimer's disease and Parkinson's disease. 4. **Cancer**: GALR1's expression in various cancer types, including colon cancer and breast cancer, has implications for the development of targeted therapies. In conclusion, GALR1 is a complex gene with multiple functional signatures, playing a critical role in various physiological and pathological processes. Further research into the mechanisms of GALR1 signaling and its clinical implications will provide valuable insights into the development of novel therapeutic strategies for various diseases.

Genular Protein ID: 3581175607

Symbol: GALR1_HUMAN

Name: Galanin receptor type 1

UniProtKB Accession Codes:

P47211 Q4VBL7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 10 EMDB 2 Ensembl 1 GO 12 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 7524088

Title: Molecular cloning of a functional human galanin receptor.

PubMed ID: 7524088

DOI: 10.1073/pnas.91.21.9780

PubMed ID: 9425310

Title: Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).

PubMed ID: 9425310

DOI: 10.1006/bbrc.1997.7838

PubMed ID: 9367674

Title: Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene.

PubMed ID: 9367674

DOI: 10.1006/geno.1997.4960

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25691535

Title: Galanin pathogenic mutations in temporal lobe epilepsy.

PubMed ID: 25691535

DOI: 10.1093/hmg/ddv060

PubMed ID: 26365466

Title: The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.

PubMed ID: 26365466

DOI: 10.1016/j.bbadis.2015.09.003

Sequence Information:

  • Length: 349
  • Mass: 38953
  • Checksum: A0664227157B3410
  • Sequence:
    • MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG NSLVITVLAR 
SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML 
VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGCIW ALSIAMASPV AYHQGLFHPR 
ASNQTFCWEQ WPDPRHKKAY VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA 
SKKKTAQTVL VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP 
IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.