Gene GALR1 - ENSG00000166573 | NCBI Gene ID: 2587

Details for: GALR1

Gene ID: 2587

Symbol: GALR1

Ensembl ID: ENSG00000166573

Description: galanin receptor 1

Associated with

Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Peptide ligand-binding receptors
(R-HSA-375276)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-activating g protein-coupled receptor signaling pathway
(GO:0007189)
Galanin receptor activity
(GO:0004966)
G protein-coupled peptide receptor activity
(GO:0008528)
Membrane
(GO:0016020)
Negative regulation of adenylate cyclase activity
(GO:0007194)
Neuropeptide binding
(GO:0042923)
Neuropeptide signaling pathway
(GO:0007218)
Peptide hormone binding
(GO:0017046)
Plasma membrane
(GO:0005886)
Positive regulation of cortisol secretion
(GO:0051464)
Positive regulation of cytosolic calcium ion concentration
(GO:0007204)
Positive regulation of transcription by rna polymerase ii
(GO:0045944)
Protein binding
(GO:0005515)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: colon goblet cell (CL0009039)
Fold Change: 1.62
Marker Score: 1175
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 1.47
Marker Score: 2778
Cell Name: granulocyte monocyte progenitor cell (CL0000557)
Fold Change: 1.38
Marker Score: 874
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.35
Marker Score: 2737
Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
Fold Change: 1.27
Marker Score: 859
Cell Name: goblet cell (CL0000160)
Fold Change: 1.16
Marker Score: 7693
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: 1.15
Marker Score: 4822
Cell Name: transit amplifying cell of colon (CL0009011)
Fold Change: 1.1
Marker Score: 506
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71835
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48059
Cell Name: erythrocyte (CL0000232)
Fold Change: 1
Marker Score: 552
Cell Name: tuft cell of colon (CL0009041)
Fold Change: 0.99
Marker Score: 512
Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
Fold Change: 0.98
Marker Score: 465
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30409
Cell Name: transit amplifying cell of small intestine (CL0009012)
Fold Change: 0.98
Marker Score: 406
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2413
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: 0.94
Marker Score: 377
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5354
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2741
Cell Name: epithelial cell of small intestine (CL0002254)
Fold Change: 0.91
Marker Score: 328
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5290
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 0.87
Marker Score: 1070
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 0.84
Marker Score: 507
Cell Name: early T lineage precursor (CL0002425)
Fold Change: 0.83
Marker Score: 635
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 0.83
Marker Score: 12987
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 0.8
Marker Score: 6839
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 0.79
Marker Score: 1645
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1267
Cell Name: brush cell (CL0002204)
Fold Change: 0.78
Marker Score: 711
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.77
Marker Score: 400
Cell Name: gut absorptive cell (CL0000677)
Fold Change: 0.73
Marker Score: 465
Cell Name: neutrophil progenitor cell (CL0000834)
Fold Change: 0.7
Marker Score: 180
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: 0.67
Marker Score: 1481
Cell Name: cardiac neuron (CL0010022)
Fold Change: 0.65
Marker Score: 812
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 0.62
Marker Score: 326.5
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.56
Marker Score: 444
Cell Name: intestinal tuft cell (CL0019032)
Fold Change: 0.55
Marker Score: 175
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.54
Marker Score: 240
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.52
Marker Score: 172
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.49
Marker Score: 2934
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.47
Marker Score: 222
Cell Name: supporting cell (CL0000630)
Fold Change: 0.46
Marker Score: 856
Cell Name: hematopoietic stem cell (CL0000037)
Fold Change: 0.38
Marker Score: 199
Cell Name: smooth muscle cell of prostate (CL1000487)
Fold Change: 0.33
Marker Score: 83
Cell Name: common myeloid progenitor (CL0000049)
Fold Change: 0.31
Marker Score: 82
Cell Name: fraction A pre-pro B cell (CL0002045)
Fold Change: 0.31
Marker Score: 311
Cell Name: neuron (CL0000540)
Fold Change: 0.23
Marker Score: 936
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: 0.23
Marker Score: 65
Cell Name: acinar cell (CL0000622)
Fold Change: 0.21
Marker Score: 146
Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
Fold Change: 0.2
Marker Score: 85
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.2
Marker Score: 62
Cell Name: neural cell (CL0002319)
Fold Change: 0.2
Marker Score: 95
Cell Name: enteroendocrine cell of colon (CL0009042)
Fold Change: 0.19
Marker Score: 66
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: 0.19
Marker Score: 1580
Cell Name: chromaffin cell (CL0000166)
Fold Change: 0.18
Marker Score: 260
Cell Name: mast cell (CL0000097)
Fold Change: 0.18
Marker Score: 106
Cell Name: megakaryocyte (CL0000556)
Fold Change: 0.18
Marker Score: 100
Cell Name: paneth cell of epithelium of small intestine (CL1000343)
Fold Change: 0.17
Marker Score: 43
Cell Name: plasma cell (CL0000786)
Fold Change: 0.17
Marker Score: 191.5
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.17
Marker Score: 59
Cell Name: kidney collecting duct principal cell (CL1001431)
Fold Change: 0.17
Marker Score: 426
Cell Name: granulosa cell (CL0000501)
Fold Change: 0.17
Marker Score: 1692
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.16
Marker Score: 96
Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
Fold Change: 0.15
Marker Score: 51
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 0.15
Marker Score: 9235
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: 0.14
Marker Score: 48
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.13
Marker Score: 303
Cell Name: osteoclast (CL0000092)
Fold Change: 0.13
Marker Score: 63
Cell Name: squamous epithelial cell (CL0000076)
Fold Change: 0.13
Marker Score: 86
Cell Name: respiratory basal cell (CL0002633)
Fold Change: 0.12
Marker Score: 175.5
Cell Name: precursor B cell (CL0000817)
Fold Change: 0.12
Marker Score: 78
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 0.11
Marker Score: 51
Cell Name: pancreatic A cell (CL0000171)
Fold Change: 0.11
Marker Score: 110
Cell Name: nasal mucosa goblet cell (CL0002480)
Fold Change: 0.11
Marker Score: 71
Cell Name: pro-B cell (CL0000826)
Fold Change: 0.11
Marker Score: 102
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.11
Marker Score: 34
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.1
Marker Score: 91
Cell Name: parietal epithelial cell (CL1000452)
Fold Change: 0.1
Marker Score: 35
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.09
Marker Score: 33
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 0.09
Marker Score: 143.5
Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
Fold Change: 0.09
Marker Score: 5192
Cell Name: pericyte (CL0000669)
Fold Change: 0.09
Marker Score: 51
Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
Fold Change: 0.09
Marker Score: 168
Cell Name: macrophage (CL0000235)
Fold Change: 0.08
Marker Score: 92
Cell Name: keratocyte (CL0002363)
Fold Change: 0.08
Marker Score: 19
Cell Name: mature alpha-beta T cell (CL0000791)
Fold Change: 0.08
Marker Score: 4326
Cell Name: astrocyte (CL0000127)
Fold Change: 0.08
Marker Score: 69
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.08
Marker Score: 23
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.08
Marker Score: 20
Cell Name: mature NK T cell (CL0000814)
Fold Change: 0.08
Marker Score: 35
Cell Name: epithelial cell (CL0000066)
Fold Change: 0.08
Marker Score: 120
Cell Name: B cell (CL0000236)
Fold Change: 0.07
Marker Score: 70
Cell Name: Purkinje cell (CL0000121)
Fold Change: 0.07
Marker Score: 2467
Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
Fold Change: 0.07
Marker Score: 40
Cell Name: melanocyte (CL0000148)
Fold Change: 0.07
Marker Score: 28
Cell Name: fibroblast (CL0000057)
Fold Change: 0.07
Marker Score: 66
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.07
Marker Score: 158
Cell Name: skin fibroblast (CL0002620)
Fold Change: 0.07
Marker Score: 17
Cell Name: neuroendocrine cell (CL0000165)
Fold Change: 0.06
Marker Score: 25
Cell Name: enterocyte of epithelium of large intestine (CL0002071)
Fold Change: 0.06
Marker Score: 64

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**Key characteristics:** * GALR1 is a member of the class a/1 (rhodopsin-like receptors) of G protein-coupled receptors. * It is a transmembrane protein with seven transmembrane domains and a cytoplasmic tail. * It is expressed in the plasma membrane of cells. * It is a negative regulator of adenylate cyclase activity. * It is involved in the regulation of cortisol secretion, cytosolic calcium ion concentration, and transcription. **Pathways and functions:** * GALR1 is a key regulator of the adenylate cyclase-activating g protein-coupled receptor (GPCR) signaling pathway. * It is activated by neuropeptides, which are released by neurons. * Activation of GALR1 leads to the inhibition of adenylate cyclase, which is an enzyme that is responsible for the production of cyclic AMP (cAMP). * cAMP is a second messenger that regulates a variety of cellular processes, including cell growth, differentiation, and metabolism. * The inhibition of adenylate cyclase by GALR1 helps to maintain the levels of cyclic GMP (cGMP), which is an allosteric activator of adenylate cyclase. * cGMP is involved in a variety of cellular processes, including cardiac contraction, smooth muscle relaxation, and vascular tone. **Clinical significance:** GALR1 gene mutations have been linked to a number of human diseases, including autism, schizophrenia, and heart failure. These mutations can disrupt the normal function of GALR1, leading to the development of these diseases. **Additional information:** * GALR1 is a promising target for the treatment of a variety of diseases, including cancer and pain. * There are a number of drugs that target GALR1, which are being tested in clinical trials for the treatment of cancer and other diseases.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

Galanin receptor type 1

Genular Protein ID: 3581175607

Symbol: GALR1_HUMAN

Name: Galanin receptor type 1

UniProtKB Accession Codes:

P47211 Q4VBL7

Database IDs:

Citations:

PubMed ID: 7524088

Title: Molecular cloning of a functional human galanin receptor.

PubMed ID: 7524088

DOI: 10.1073/pnas.91.21.9780

PubMed ID: 9425310

Title: Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R).

PubMed ID: 9425310

DOI: 10.1006/bbrc.1997.7838

PubMed ID: 9367674

Title: Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene.

PubMed ID: 9367674

DOI: 10.1006/geno.1997.4960

PubMed ID: 16177791

Title: DNA sequence and analysis of human chromosome 18.

PubMed ID: 16177791

DOI: 10.1038/nature03983

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 25691535

Title: Galanin pathogenic mutations in temporal lobe epilepsy.

PubMed ID: 25691535

DOI: 10.1093/hmg/ddv060

PubMed ID: 26365466

Title: The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity.

PubMed ID: 26365466

DOI: 10.1016/j.bbadis.2015.09.003

Sequence Information:

Length: 349
Mass: 38953
Checksum: A0664227157B3410
Sequence:

MELAVGNLSE GNASWPEPPA PEPGPLFGIG VENFVTLVVF GLIFALGVLG NSLVITVLAR 
SKPGKPRSTT NLFILNLSIA DLAYLLFCIP FQATVYALPT WVLGAFICKF IHYFFTVSML 
VSIFTLAAMS VDRYVAIVHS RRSSSLRVSR NALLGVGCIW ALSIAMASPV AYHQGLFHPR 
ASNQTFCWEQ WPDPRHKKAY VVCTFVFGYL LPLLLICFCY AKVLNHLHKK LKNMSKKSEA 
SKKKTAQTVL VVVVVFGISW LPHHIIHLWA EFGVFPLTPA SFLFRITAHC LAYSNSSVNP 
IIYAFLSENF RKAYKQVFKC HIRKDSHLSD TKESKSRIDT PPSTNCTHV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.

Details for: GALR1

Associated with

Cells (max top 100)

Other Information

Molecular cloning of a functional human galanin receptor. PubMed ID: 7524088

Cloning, chromosomal location, and transcriptional regulation of the human galanin-1 receptor gene (GALN1R). PubMed ID: 9425310

Structural organization of the mouse and human GALR1 galanin receptor genes (Galnr and GALNR) and chromosomal localization of the mouse gene. PubMed ID: 9367674

DNA sequence and analysis of human chromosome 18. PubMed ID: 16177791

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Galanin pathogenic mutations in temporal lobe epilepsy. PubMed ID: 25691535

The zinc binding receptor GPR39 interacts with 5-HT1A and GalR1 to form dynamic heteroreceptor complexes with signaling diversity. PubMed ID: 26365466