Details for: GRIK3

Gene ID: 2899

Symbol: GRIK3

Ensembl ID: ENSG00000163873

Description: glutamate ionotropic receptor kainate type subunit 3

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Presynaptic function of kainate receptors
    (R-HSA-500657)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway
    (GO:0007196)
  • Adenylate cyclase inhibiting g protein-coupled glutamate receptor activity
    (GO:0001640)
  • Axon
    (GO:0030424)
  • Calcium-mediated signaling
    (GO:0019722)
  • Dendrite
    (GO:0030425)
  • Dendrite cytoplasm
    (GO:0032839)
  • Glutamate-gated calcium ion channel activity
    (GO:0022849)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor activity
    (GO:0008066)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Glutamatergic synapse
    (GO:0098978)
  • G protein-coupled glutamate receptor signaling pathway
    (GO:0007216)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Negative regulation of synaptic transmission, glutamatergic
    (GO:0051967)
  • Perikaryon
    (GO:0043204)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Regulation of membrane potential
    (GO:0042391)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Terminal bouton
    (GO:0043195)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.4385
    Cell Significance Index: 88.4200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 1.3164
    Cell Significance Index: 31.5700
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 1.2710
    Cell Significance Index: 56.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.7955
    Cell Significance Index: 550.1700
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.6804
    Cell Significance Index: 136.4800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.3798
    Cell Significance Index: 7.5100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.2606
    Cell Significance Index: 8.3000
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.1885
    Cell Significance Index: 6.1700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.0231
    Cell Significance Index: 0.4900
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: 0.0150
    Cell Significance Index: 0.2200
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0067
    Cell Significance Index: -2.4100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0080
    Cell Significance Index: -0.4500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0105
    Cell Significance Index: -19.2800
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0107
    Cell Significance Index: -20.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0140
    Cell Significance Index: -21.5100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0163
    Cell Significance Index: -22.1600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0244
    Cell Significance Index: -18.0400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0302
    Cell Significance Index: -19.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0351
    Cell Significance Index: -26.5900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0377
    Cell Significance Index: -21.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0462
    Cell Significance Index: -20.9700
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0594
    Cell Significance Index: -10.7100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0712
    Cell Significance Index: -20.5000
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: -0.0758
    Cell Significance Index: -1.0700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1021
    Cell Significance Index: -20.2700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1166
    Cell Significance Index: -24.5600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1440
    Cell Significance Index: -20.9300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1443
    Cell Significance Index: -24.6400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1467
    Cell Significance Index: -3.6600
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.1501
    Cell Significance Index: -19.2400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1595
    Cell Significance Index: -19.6100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1735
    Cell Significance Index: -22.4200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.1793
    Cell Significance Index: -24.6200
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1986
    Cell Significance Index: -1.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2133
    Cell Significance Index: -24.4400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.2186
    Cell Significance Index: -6.1100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2211
    Cell Significance Index: -23.0200
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2259
    Cell Significance Index: -23.0800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2965
    Cell Significance Index: -22.1000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.3174
    Cell Significance Index: -24.3600
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3422
    Cell Significance Index: -23.0100
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3504
    Cell Significance Index: -5.9900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3524
    Cell Significance Index: -22.2100
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.3566
    Cell Significance Index: -4.5000
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.3849
    Cell Significance Index: -4.4900
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3891
    Cell Significance Index: -13.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.3899
    Cell Significance Index: -18.3300
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3923
    Cell Significance Index: -25.3100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.3935
    Cell Significance Index: -3.7300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4383
    Cell Significance Index: -23.0200
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.5057
    Cell Significance Index: -5.5100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.5159
    Cell Significance Index: -13.2600
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.5351
    Cell Significance Index: -6.9400
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: -0.5937
    Cell Significance Index: -7.1000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5941
    Cell Significance Index: -30.8600
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.6133
    Cell Significance Index: -7.7400
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.6236
    Cell Significance Index: -12.5200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.6264
    Cell Significance Index: -23.7200
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.6732
    Cell Significance Index: -8.9800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.6819
    Cell Significance Index: -23.9600
  • Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
    Fold Change: -0.6879
    Cell Significance Index: -7.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.6964
    Cell Significance Index: -24.2000
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7183
    Cell Significance Index: -17.4000
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.7408
    Cell Significance Index: -21.1400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.7730
    Cell Significance Index: -22.1600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.7759
    Cell Significance Index: -24.5400
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: -0.8055
    Cell Significance Index: -8.3400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.8148
    Cell Significance Index: -24.0000
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.8150
    Cell Significance Index: -11.5800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.8288
    Cell Significance Index: -23.8800
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.8321
    Cell Significance Index: -20.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.8360
    Cell Significance Index: -21.3000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.8885
    Cell Significance Index: -6.0200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.8898
    Cell Significance Index: -23.7600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.9069
    Cell Significance Index: -24.3000
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9152
    Cell Significance Index: -19.1000
  • Cell Name: midget ganglion cell of retina (CL4023188)
    Fold Change: -0.9283
    Cell Significance Index: -9.6700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.9298
    Cell Significance Index: -24.4500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.9437
    Cell Significance Index: -20.3900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.9503
    Cell Significance Index: -23.7400
  • Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
    Fold Change: -0.9518
    Cell Significance Index: -8.9900
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.9696
    Cell Significance Index: -21.2300
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: -0.9708
    Cell Significance Index: -12.6700
  • Cell Name: interneuron (CL0000099)
    Fold Change: -0.9708
    Cell Significance Index: -11.3400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.9710
    Cell Significance Index: -13.3200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.9716
    Cell Significance Index: -16.6500
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.9725
    Cell Significance Index: -24.3100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.9841
    Cell Significance Index: -20.0300
  • Cell Name: basal epithelial cell of prostatic duct (CL0002236)
    Fold Change: -0.9924
    Cell Significance Index: -8.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.9942
    Cell Significance Index: -20.8100
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -1.0465
    Cell Significance Index: -25.5400
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -1.0833
    Cell Significance Index: -18.7300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -1.0898
    Cell Significance Index: -21.4500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -1.1051
    Cell Significance Index: -13.7800
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -1.1078
    Cell Significance Index: -22.0900
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.1436
    Cell Significance Index: -24.4500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -1.1676
    Cell Significance Index: -24.2200
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -1.2135
    Cell Significance Index: -17.2800
  • Cell Name: CD14-positive monocyte (CL0001054)
    Fold Change: -1.2444
    Cell Significance Index: -24.3300
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -1.2446
    Cell Significance Index: -16.5900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** GRIK3 is a subunit of the kainate receptor, a type of glutamate receptor that is involved in the regulation of synaptic transmission. It is characterized by its ability to bind to glutamate, leading to the activation of an ionotropic response. GRIK3 is also known to be involved in the regulation of presynaptic membrane potential and the modulation of postsynaptic membrane potential. Its expression is widespread, with significant presence in various neuronal populations, including brainstem motor neurons, cortical interneurons, and retinal bipolar neurons. **Pathways and Functions:** GRIK3 plays a crucial role in the regulation of synaptic transmission through its involvement in the activation of ca-permeable kainate receptors. This activation leads to the influx of calcium ions into the postsynaptic neuron, which in turn modulates the postsynaptic membrane potential. Additionally, GRIK3 is involved in the regulation of presynaptic membrane potential, influencing the release of neurotransmitters. Its expression is also significant in the regulation of glutamatergic synapses, where it plays a key role in the modulation of synaptic transmission. Furthermore, GRIK3 is involved in the regulation of various signaling pathways, including the adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway. This pathway is involved in the regulation of neuronal excitability and the modulation of synaptic transmission. Additionally, GRIK3 is involved in the regulation of ionotropic activity of kainate receptors, which is critical for the regulation of synaptic transmission. **Clinical Significance:** Dysregulation of GRIK3 has been implicated in various neurological disorders, including epilepsy, schizophrenia, and learning disabilities. For example, mutations in the GRIK3 gene have been associated with familial epilepsy with generalized tonic-clonic seizures. Additionally, GRIK3 has been implicated in the regulation of synaptic plasticity, which is critical for learning and memory. Furthermore, GRIK3 has been shown to play a role in the regulation of neuronal excitability, which is critical for the treatment of various neurological disorders. For example, GRIK3 antagonists have been shown to have potential therapeutic applications in the treatment of epilepsy and schizophrenia. In conclusion, GRIK3 is a crucial component of the glutamatergic system, playing a pivotal role in the regulation of synaptic transmission and neuronal function. Its expression is widespread, with significant presence in various neuronal populations, and its dysregulation has been implicated in various neurological disorders. Further research is needed to fully understand the complexities of GRIK3 and its role in the regulation of synaptic transmission. **References:** * [Insert references to relevant studies and reviews on GRIK3] **Note:** As an expert immunologist, I would like to highlight that GRIK3 is primarily involved in the regulation of synaptic transmission and neuronal function, and its dysregulation has been implicated in various neurological disorders. However, further research is needed to fully understand the complexities of GRIK3 and its role in the regulation of synaptic transmission.

Genular Protein ID: 2350861067

Symbol: GRIK3_HUMAN

Name: Glutamate receptor ionotropic, kainate 3

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 7719709

Title: Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites.

PubMed ID: 7719709

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8128318

Title: Chromosomal localization of gene for human glutamate receptor subunit-7.

PubMed ID: 8128318

DOI: 10.1007/bf01233385

PubMed ID: 11124978

Title: Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.

PubMed ID: 11124978

DOI: 10.1523/jneurosci.20-24-09025.2000

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 919
  • Mass: 104037
  • Checksum: 0F68F6CF33E4CE71
  • Sequence:
  • MTAPWRRLRS LVWEYWAGLL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA QVMNAEEHAF 
    RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD QLALGVVAIF GPSQGSCTNA 
    VQSICNALEV PHIQLRWKHH PLDNKDTFYV NLYPDYASLS HAILDLVQYL KWRSATVVYD 
    DSTGLIRLQE LIMAPSRYNI RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ 
    ILKQAMAMGM MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWS 
    MERLQAAPRS ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC HRHKAWRFGG 
    RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED GLEKVGVWSP ADGLNITEVA 
    KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR KSDRTLYGND RFEGYCIDLL KELAHILGFS 
    YEIRLVEDGK YGAQDDKGQW NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV 
    SILYRKPNGT NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG 
    SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII SSYTANLAAF 
    LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK ISTFEKMWAF MSSKPSALVK 
    NNEEGIQRAL TADYALLMES TTIEYVTQRN CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT 
    IAILQLQEED KLHIMKEKWW RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV 
    GEFVYKLRKT AEREQRSFCS TVADEIRFSL TCQRRVKHKP QPPMMVKTDA VINMHTFNDR 
    RLPGKDSMAC STSLAPVFP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.