Details for: GRIK3

Gene ID: 2899

Symbol: GRIK3

Ensembl ID: ENSG00000163873

Description: glutamate ionotropic receptor kainate type subunit 3

Associated with

  • Activation of ca-permeable kainate receptor
    (R-HSA-451308)
  • Activation of kainate receptors upon glutamate binding
    (R-HSA-451326)
  • Ionotropic activity of kainate receptors
    (R-HSA-451306)
  • Neuronal system
    (R-HSA-112316)
  • Neurotransmitter receptors and postsynaptic signal transmission
    (R-HSA-112314)
  • Presynaptic function of kainate receptors
    (R-HSA-500657)
  • Transmission across chemical synapses
    (R-HSA-112315)
  • Adenylate cyclase-inhibiting g protein-coupled glutamate receptor signaling pathway
    (GO:0007196)
  • Adenylate cyclase inhibiting g protein-coupled glutamate receptor activity
    (GO:0001640)
  • Axon
    (GO:0030424)
  • Dendrite
    (GO:0030425)
  • Dendrite cytoplasm
    (GO:0032839)
  • Glutamate-gated receptor activity
    (GO:0004970)
  • Glutamate receptor activity
    (GO:0008066)
  • Glutamate receptor signaling pathway
    (GO:0007215)
  • Glutamatergic synapse
    (GO:0098978)
  • G protein-coupled glutamate receptor signaling pathway
    (GO:0007216)
  • Ionotropic glutamate receptor signaling pathway
    (GO:0035235)
  • Kainate selective glutamate receptor activity
    (GO:0015277)
  • Kainate selective glutamate receptor complex
    (GO:0032983)
  • Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
    (GO:0099507)
  • Modulation of chemical synaptic transmission
    (GO:0050804)
  • Monoatomic ion transmembrane transport
    (GO:0034220)
  • Negative regulation of synaptic transmission, glutamatergic
    (GO:0051967)
  • Perikaryon
    (GO:0043204)
  • Plasma membrane
    (GO:0005886)
  • Postsynaptic density membrane
    (GO:0098839)
  • Presynaptic membrane
    (GO:0042734)
  • Regulation of membrane potential
    (GO:0042391)
  • Regulation of postsynaptic membrane potential
    (GO:0060078)
  • Regulation of presynaptic membrane potential
    (GO:0099505)
  • Synaptic transmission, glutamatergic
    (GO:0035249)
  • Terminal bouton
    (GO:0043195)
  • Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
    (GO:1904315)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 8.92
    Marker Score: 4941
  • Cell Name: brainstem motor neuron (CL2000047)
    Fold Change: 3.14
    Marker Score: 1824
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 2.81
    Marker Score: 55969
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 2.55
    Marker Score: 980
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.43
    Marker Score: 2446
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 2.33
    Marker Score: 86058
  • Cell Name: retinal bipolar neuron (CL0000748)
    Fold Change: 2.16
    Marker Score: 18242.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 2.06
    Marker Score: 3909
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 1.88
    Marker Score: 17844
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 1.85
    Marker Score: 15853
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 1.81
    Marker Score: 18721
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 1.75
    Marker Score: 1958
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 1.6
    Marker Score: 15079
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 1.54
    Marker Score: 1924
  • Cell Name: inhibitory interneuron (CL0000498)
    Fold Change: 1.54
    Marker Score: 7132
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 1.53
    Marker Score: 1149
  • Cell Name: neuron (CL0000540)
    Fold Change: 1.45
    Marker Score: 5899
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.42
    Marker Score: 87139
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.32
    Marker Score: 2681
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 1.24
    Marker Score: 1909
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.19
    Marker Score: 2464
  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 1.13
    Marker Score: 1398
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17350
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 1.02
    Marker Score: 355
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.02
    Marker Score: 6754
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48039
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.98
    Marker Score: 587.5
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.97
    Marker Score: 2474
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.95
    Marker Score: 399
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5349
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5285
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.81
    Marker Score: 470
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1263
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: 0.75
    Marker Score: 4036
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.74
    Marker Score: 328
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.73
    Marker Score: 354
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.67
    Marker Score: 351
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.65
    Marker Score: 344.5
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.64
    Marker Score: 175
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.63
    Marker Score: 227
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 194
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.6
    Marker Score: 482
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.58
    Marker Score: 276
  • Cell Name: cerebellar granule cell precursor (CL0002362)
    Fold Change: 0.58
    Marker Score: 323
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.57
    Marker Score: 611
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.55
    Marker Score: 521
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.55
    Marker Score: 605
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.52
    Marker Score: 19933
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.52
    Marker Score: 235
  • Cell Name: astrocyte (CL0000127)
    Fold Change: 0.52
    Marker Score: 447
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.5
    Marker Score: 2099
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.48
    Marker Score: 158
  • Cell Name: CNS interneuron (CL0000402)
    Fold Change: 0.47
    Marker Score: 228
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.46
    Marker Score: 288
  • Cell Name: neuronal brush cell (CL0000555)
    Fold Change: 0.43
    Marker Score: 1428
  • Cell Name: OFF retinal ganglion cell (CL4023033)
    Fold Change: 0.42
    Marker Score: 177
  • Cell Name: meningeal macrophage (CL0000879)
    Fold Change: 0.42
    Marker Score: 117
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.4
    Marker Score: 729
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.38
    Marker Score: 124
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.38
    Marker Score: 99
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.38
    Marker Score: 1089
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.37
    Marker Score: 509
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.34
    Marker Score: 263.5
  • Cell Name: pyramidal neuron (CL0000598)
    Fold Change: 0.34
    Marker Score: 571
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.33
    Marker Score: 370
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.32
    Marker Score: 329
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.3
    Marker Score: 337
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.3
    Marker Score: 701
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.3
    Marker Score: 158
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.29
    Marker Score: 119
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.28
    Marker Score: 170
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.27
    Marker Score: 84
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.27
    Marker Score: 151
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: 0.26
    Marker Score: 65
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.26
    Marker Score: 106
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.25
    Marker Score: 94
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.25
    Marker Score: 87
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.24
    Marker Score: 304
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.24
    Marker Score: 276
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.24
    Marker Score: 108
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.22
    Marker Score: 106
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.22
    Marker Score: 349
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.22
    Marker Score: 128
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: 0.21
    Marker Score: 2140
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.21
    Marker Score: 96
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.21
    Marker Score: 361
  • Cell Name: oligodendrocyte (CL0000128)
    Fold Change: 0.21
    Marker Score: 500
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.19
    Marker Score: 261
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.18
    Marker Score: 83
  • Cell Name: mature astrocyte (CL0002627)
    Fold Change: 0.18
    Marker Score: 116
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.16
    Marker Score: 154
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: 0.16
    Marker Score: 50
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.15
    Marker Score: 186
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.15
    Marker Score: 72
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.15
    Marker Score: 36

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Other Information

**Key characteristics:** * GRIK3 is a ligand-gated ion channel, which means that it opens or closes in response to the binding of a specific ligand. * It is a glutamate receptor, which means that it binds to glutamate, a neurotransmitter that is released by neurons to communicate with other cells. * GRIK3 is a transmembrane protein, which means that it spans the cell membrane and is attached to both the extracellular and intracellular sides. * It is a heterotrimer, which means that it consists of three subunits that are held together by disulfide bonds. **Pathways and functions:** * GRIK3 is involved in a variety of cellular processes, including synaptic plasticity, cognition, and disease. * In the central nervous system, GRIK3 is expressed on the surface of neurons and is primarily expressed in excitatory synapses. * When glutamate binds to GRIK3, it triggers the opening of the channel, which allows calcium ions to flow into the cell. * This influx of calcium ions depolarizes the neuron, which can lead to a variety of cellular responses, including synaptic plasticity and cognition. **Clinical significance:** GRIK3 has been implicated in a number of neurological and psychiatric disorders, including epilepsy, schizophrenia, and autism. Mutations in the GRIK3 gene have been linked to these disorders, suggesting that GRIK3 may play a role in the development of these conditions. **Additional information:** * The GRIK3 gene is located on chromosome 15q2. * It is a relatively large protein, with a molecular weight of approximately 120 kDa. * It is expressed in high levels in the brain, particularly in areas involved in learning and memory. * GRIK3 is a relatively promiscuous ligand, which means that it binds to a variety of different neurotransmitters.

Genular Protein ID: 2350861067

Symbol: GRIK3_HUMAN

Name: Glutamate receptor ionotropic, kainate 3

UniProtKB Accession Codes:

Q13003 A9Z1Z8 B1AMS6 Q13004 Q16136

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 2 CTD 1 ChEBI 4 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 DrugCentral 1 EMBL 9 EPD 1 Ensembl 2 GO 22 Gene3D 3 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 3 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 1 SIGNOR 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7719709

Title: Molecular characterization of the human EAA5 (GluR7) receptor: a high-affinity kainate receptor with novel potential RNA editing sites.

PubMed ID: 7719709

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 8128318

Title: Chromosomal localization of gene for human glutamate receptor subunit-7.

PubMed ID: 8128318

DOI: 10.1007/bf01233385

PubMed ID: 11124978

Title: Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains.

PubMed ID: 11124978

DOI: 10.1523/jneurosci.20-24-09025.2000

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 919
  • Mass: 104037
  • Checksum: 0F68F6CF33E4CE71
  • Sequence:
    • MTAPWRRLRS LVWEYWAGLL VCAFWIPDSR GMPHVIRIGG IFEYADGPNA QVMNAEEHAF 
RFSANIINRN RTLLPNTTLT YDIQRIHFHD SFEATKKACD QLALGVVAIF GPSQGSCTNA 
VQSICNALEV PHIQLRWKHH PLDNKDTFYV NLYPDYASLS HAILDLVQYL KWRSATVVYD 
DSTGLIRLQE LIMAPSRYNI RLKIRQLPID SDDSRPLLKE MKRGREFRII FDCSHTMAAQ 
ILKQAMAMGM MTEYYHFIFT TLDLYALDLE PYRYSGVNLT GFRILNVDNP HVSAIVEKWS 
MERLQAAPRS ESGLLDGVMM TDAALLYDAV HIVSVCYQRA PQMTVNSLQC HRHKAWRFGG 
RFMNFIKEAQ WEGLTGRIVF NKTSGLRTDF DLDIISLKED GLEKVGVWSP ADGLNITEVA 
KGRGPNVTDS LTNRSLIVTT VLEEPFVMFR KSDRTLYGND RFEGYCIDLL KELAHILGFS 
YEIRLVEDGK YGAQDDKGQW NGMVKELIDH KADLAVAPLT ITHVREKAID FSKPFMTLGV 
SILYRKPNGT NPSVFSFLNP LSPDIWMYVL LAYLGVSCVL FVIARFSPYE WYDAHPCNPG 
SEVVENNFTL LNSFWFGMGS LMQQGSELMP KALSTRIIGG IWWFFTLIII SSYTANLAAF 
LTVERMESPI DSADDLAKQT KIEYGAVKDG ATMTFFKKSK ISTFEKMWAF MSSKPSALVK 
NNEEGIQRAL TADYALLMES TTIEYVTQRN CNLTQIGGLI DSKGYGIGTP MGSPYRDKIT 
IAILQLQEED KLHIMKEKWW RGSGCPEEEN KEASALGIQK IGGIFIVLAA GLVLSVLVAV 
GEFVYKLRKT AEREQRSFCS TVADEIRFSL TCQRRVKHKP QPPMMVKTDA VINMHTFNDR 
RLPGKDSMAC STSLAPVFP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.