Details for: SLC25A3

Gene ID: 5250

Symbol: SLC25A3

Ensembl ID: ENSG00000075415

Description: solute carrier family 25 member 3

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 775.8515
    Cell Significance Index: -120.6800
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 417.1999
    Cell Significance Index: -105.8200
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 355.5306
    Cell Significance Index: -146.4600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 316.3637
    Cell Significance Index: -128.5300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 306.7423
    Cell Significance Index: -144.8200
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 277.3213
    Cell Significance Index: -142.6500
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 216.8483
    Cell Significance Index: -145.5100
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 136.4661
    Cell Significance Index: -130.2900
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 113.4509
    Cell Significance Index: -139.8800
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 37.3031
    Cell Significance Index: -147.2000
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 37.2659
    Cell Significance Index: -99.8300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 32.9127
    Cell Significance Index: -101.0900
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 21.7035
    Cell Significance Index: -47.5000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 5.6356
    Cell Significance Index: 262.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 5.6303
    Cell Significance Index: 195.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 5.3407
    Cell Significance Index: 58.0600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 5.3080
    Cell Significance Index: 249.4700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 5.0837
    Cell Significance Index: 106.4100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 4.3889
    Cell Significance Index: 310.4000
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 4.1669
    Cell Significance Index: 268.8300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 4.0643
    Cell Significance Index: 52.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 3.8420
    Cell Significance Index: 1698.6400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 3.8203
    Cell Significance Index: 469.7400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.8198
    Cell Significance Index: 524.5700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.8039
    Cell Significance Index: 109.0400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 3.7954
    Cell Significance Index: 99.8000
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.7660
    Cell Significance Index: 444.1300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.6889
    Cell Significance Index: 2014.6200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.5503
    Cell Significance Index: 640.0000
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 3.5153
    Cell Significance Index: 103.2400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.2248
    Cell Significance Index: 416.6200
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1907
    Cell Significance Index: 25.4800
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.8054
    Cell Significance Index: 76.3600
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.7383
    Cell Significance Index: 143.7700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 2.6742
    Cell Significance Index: 30.3800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.6013
    Cell Significance Index: 193.8700
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 2.3923
    Cell Significance Index: 306.6800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 2.1324
    Cell Significance Index: 423.1800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.9682
    Cell Significance Index: 18.1300
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.9391
    Cell Significance Index: 44.8000
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 1.7914
    Cell Significance Index: 38.8100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.7729
    Cell Significance Index: 47.3400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 1.3933
    Cell Significance Index: 237.9100
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.2914
    Cell Significance Index: 127.7500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.2241
    Cell Significance Index: 63.5900
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.0674
    Cell Significance Index: 214.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.8292
    Cell Significance Index: 23.8900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.7524
    Cell Significance Index: 679.3800
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 0.7158
    Cell Significance Index: 13.2300
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.5888
    Cell Significance Index: 95.7600
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5513
    Cell Significance Index: 104.9200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.4786
    Cell Significance Index: 350.9300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.3414
    Cell Significance Index: 122.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2633
    Cell Significance Index: 199.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.2371
    Cell Significance Index: 12.3500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.2198
    Cell Significance Index: 3.8900
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0947
    Cell Significance Index: 1.5900
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0442
    Cell Significance Index: 1.2400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0347
    Cell Significance Index: 1.2200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0045
    Cell Significance Index: 8.4400
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0492
    Cell Significance Index: -90.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0511
    Cell Significance Index: -37.8500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0736
    Cell Significance Index: -45.9800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0784
    Cell Significance Index: -120.6800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0807
    Cell Significance Index: -8.2400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0912
    Cell Significance Index: -7.2200
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1040
    Cell Significance Index: -66.0500
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.1146
    Cell Significance Index: -79.2400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.1206
    Cell Significance Index: -163.9200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1659
    Cell Significance Index: -34.9400
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1765
    Cell Significance Index: -20.1500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1880
    Cell Significance Index: -106.0000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2024
    Cell Significance Index: -91.8800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.2824
    Cell Significance Index: -17.8000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2928
    Cell Significance Index: -22.4700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.4362
    Cell Significance Index: -125.5200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5468
    Cell Significance Index: -13.9700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5771
    Cell Significance Index: -66.1200
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6691
    Cell Significance Index: -97.2600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6953
    Cell Significance Index: -18.6300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.7307
    Cell Significance Index: -33.1200
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.8151
    Cell Significance Index: -95.0000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.9422
    Cell Significance Index: -57.9100
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0537
    Cell Significance Index: -59.1300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -1.2577
    Cell Significance Index: -17.1600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -1.2721
    Cell Significance Index: -87.9700
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -1.2907
    Cell Significance Index: -41.3400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.3574
    Cell Significance Index: -141.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.4750
    Cell Significance Index: -99.1800
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: -1.7565
    Cell Significance Index: -10.8100
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: -1.8011
    Cell Significance Index: -26.5900
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -2.0507
    Cell Significance Index: -12.3900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -2.2822
    Cell Significance Index: -61.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.3360
    Cell Significance Index: -143.2200
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -2.3445
    Cell Significance Index: -35.1300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -2.4358
    Cell Significance Index: -20.4600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -2.5517
    Cell Significance Index: -26.4200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.6886
    Cell Significance Index: -79.1900
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -2.7216
    Cell Significance Index: -46.6400
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -2.7369
    Cell Significance Index: -121.0600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Inorganic Phosphate Transporter**: The SLC25A3 protein is a phosphate transporter that facilitates the transport of inorganic phosphate ions across cellular membranes. 2. **Mitochondrial Localization**: The protein is localized to the mitochondrial inner membrane, suggesting a role in mitochondrial phosphate homeostasis. 3. **Proton Symporter Activity**: SLC25A3 exhibits phosphate:proton symporter activity, indicating that it can co-transport phosphate ions with protons across the membrane. 4. **Widespread Tissue Expression**: The gene is expressed in various tissues, including fibroblasts, mesodermal cells, kidney loop of Henle epithelial cells, and hematopoietic stem cells. **Pathways and Functions:** 1. **Mitochondrial Phosphate Homeostasis**: SLC25A3 plays a crucial role in maintaining mitochondrial phosphate homeostasis by regulating the transport of phosphate ions across the mitochondrial inner membrane. 2. **Energy Metabolism**: The protein is involved in energy metabolism by facilitating the transport of phosphate ions, which is essential for ATP synthesis and energy production. 3. **DNA Synthesis**: SLC25A3 is required for DNA synthesis and repair by regulating the availability of phosphate ions. 4. **Cell Signaling**: The protein is involved in cell signaling pathways, including the regulation of cell growth, differentiation, and survival. 5. **Extracellular Phosphate Transport**: SLC25A3 can also transport phosphate ions across the plasma membrane, regulating extracellular phosphate homeostasis. **Clinical Significance:** 1. **Phosphate Metabolism Disorders**: Mutations in the SLC25A3 gene have been associated with phosphate metabolism disorders, including hypophosphatemia (low phosphate levels) and hyperphosphatemia (high phosphate levels). 2. **Renal Impairment**: SLC25A3 has been implicated in renal impairment, as it plays a crucial role in phosphate homeostasis in the kidney. 3. **Hematopoietic Disorders**: The protein is required for hematopoiesis, and mutations in SLC25A3 have been associated with hematopoietic disorders, including anemia and leukopenia. 4. **Cancer**: SLC25A3 has been implicated in cancer, as it is involved in cell growth, differentiation, and survival pathways. In conclusion, the SLC25A3 gene plays a critical role in maintaining phosphate homeostasis within cells, and its dysfunction has been implicated in various diseases, including phosphate metabolism disorders, renal impairment, hematopoietic disorders, and cancer. Further research is needed to fully understand the mechanisms by which SLC25A3 regulates phosphate homeostasis and its clinical significance.

Genular Protein ID: 3884645496

Symbol: S25A3_HUMAN

Name: Phosphate transport protein

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8144629

Title: The sequences of human and bovine genes of the phosphate carrier from mitochondria contain evidence of alternatively spliced forms.

PubMed ID: 8144629

DOI: 10.1016/s0021-9258(17)34081-4

PubMed ID: 1777677

Title: Nucleotide sequence of a human heart cDNA encoding the mitochondrial phosphate carrier.

PubMed ID: 1777677

DOI: 10.3109/10425179109039683

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14654843

Title: Proteomic characterization of the human centrosome by protein correlation profiling.

PubMed ID: 14654843

DOI: 10.1038/nature02166

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 29237729

Title: The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis.

PubMed ID: 29237729

DOI: 10.1074/jbc.ra117.000265

PubMed ID: 17273968

Title: Mitochondrial phosphate-carrier deficiency: a novel disorder of oxidative phosphorylation.

PubMed ID: 17273968

DOI: 10.1086/511788

Sequence Information:

  • Length: 362
  • Mass: 40095
  • Checksum: 78714C85931B22D5
  • Sequence:
  • MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VEEQYSCDYG 
    SGRFFILCGL GGIISCGTTH TALVPLDLVK CRMQVDPQKY KGIFNGFSVT LKEDGVRGLA 
    KGWAPTFLGY SMQGLCKFGF YEVFKVLYSN MLGEENTYLW RTSLYLAASA SAEFFADIAL 
    APMEAAKVRI QTQPGYANTL RDAAPKMYKE EGLKAFYKGV APLWMRQIPY TMMKFACFER 
    TVEALYKFVV PKPRSECSKP EQLVVTFVAG YIAGVFCAIV SHPADSVVSV LNKEKGSSAS 
    LVLKRLGFKG VWKGLFARII MIGTLTALQW FIYDSVKVYF RLPRPPPPEM PESLKKKLGL 
    TQ

Genular Protein ID: 1927830628

Symbol: Q6MZF9_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 52
  • Mass: 5516
  • Checksum: B67A9A9DDFDEBE25
  • Sequence:
  • MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VE

Genular Protein ID: 433538248

Symbol: A0A024RBE8_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 26871637

Title: Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing.

PubMed ID: 26871637

DOI: 10.1016/j.cell.2016.01.029

Sequence Information:

  • Length: 361
  • Mass: 39959
  • Checksum: 43AD380B15553DA6
  • Sequence:
  • MFSSVAHLAR ANPFNTPHLQ LVHDGLGDLR SSSPGPTGQP RRPRNLAAAA VEEYSCEFGS 
    AKYYALCGFG GVLSCGLTHT AVVPLDLVKC RMQVDPQKYK GIFNGFSVTL KEDGVRGLAK 
    GWAPTFLGYS MQGLCKFGFY EVFKVLYSNM LGEENTYLWR TSLYLAASAS AEFFADIALA 
    PMEAAKVRIQ TQPGYANTLR DAAPKMYKEE GLKAFYKGVA PLWMRQIPYT MMKFACFERT 
    VEALYKFVVP KPRSECSKPE QLVVTFVAGY IAGVFCAIVS HPADSVVSVL NKEKGSSASL 
    VLKRLGFKGV WKGLFARIIM IGTLTALQWF IYDSVKVYFR LPRPPPPEMP ESLKKKLGLT 
    Q

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.