P2RY12 | ENSG00000169313 | NCBI 64805

Details for: P2RY12

Gene ID: 64805

Symbol: P2RY12

Ensembl ID: ENSG00000169313

Description: purinergic receptor P2Y12

Associated with

Adp signalling through p2y purinoceptor 12
(R-HSA-392170)
Class a/1 (rhodopsin-like receptors)
(R-HSA-373076)
G alpha (i) signalling events
(R-HSA-418594)
Gpcr downstream signalling
(R-HSA-388396)
Gpcr ligand binding
(R-HSA-500792)
Nucleotide-like (purinergic) receptors
(R-HSA-418038)
P2y receptors
(R-HSA-417957)
Platelet activation, signaling and aggregation
(R-HSA-76002)
Signal amplification
(R-HSA-392518)
Signaling by gpcr
(R-HSA-372790)
Signal transduction
(R-HSA-162582)
Adenylate cyclase-inhibiting g protein-coupled receptor signaling pathway
(GO:0007193)
Calcium-mediated signaling
(GO:0019722)
Calcium-mediated signaling using extracellular calcium source
(GO:0035585)
Cell body membrane
(GO:0044298)
Cell projection membrane
(GO:0031253)
Cell projection organization
(GO:0030030)
Cell surface
(GO:0009986)
Cellular response to atp
(GO:0071318)
Cerebral cortex radial glia-guided migration
(GO:0021801)
Establishment of localization in cell
(GO:0051649)
G protein-coupled adenosine receptor activity
(GO:0001609)
G protein-coupled adenosine receptor signaling pathway
(GO:0001973)
G protein-coupled adp receptor activity
(GO:0001621)
G protein-coupled purinergic nucleotide receptor activity
(GO:0045028)
G protein-coupled purinergic nucleotide receptor signaling pathway
(GO:0035589)
G protein-coupled receptor signaling pathway
(GO:0007186)
Guanyl-nucleotide exchange factor activity
(GO:0005085)
Hemostasis
(GO:0007599)
Lamellipodium assembly
(GO:0030032)
Membrane
(GO:0016020)
Monoatomic ion transport
(GO:0006811)
Phospholipase c-activating g protein-coupled receptor signaling pathway
(GO:0007200)
Plasma membrane
(GO:0005886)
Platelet activation
(GO:0030168)
Platelet aggregation
(GO:0070527)
Positive regulation of cell adhesion mediated by integrin
(GO:0033630)
Positive regulation of chemotaxis
(GO:0050921)
Positive regulation of integrin activation by cell surface receptor linked signal transduction
(GO:0033626)
Positive regulation of microglial cell migration
(GO:1904141)
Positive regulation of monoatomic ion transport
(GO:0043270)
Positive regulation of phosphatidylinositol 3-kinase/protein kinase b signal transduction
(GO:0051897)
Positive regulation of ruffle assembly
(GO:1900029)
Regulation of chemotaxis
(GO:0050920)
Regulation of microglial cell migration
(GO:1904139)
Response to axon injury
(GO:0048678)
Substrate-dependent cell migration, cell extension
(GO:0006930)
Visual system development
(GO:0150063)

Other Information

Proteins

P2Y purinoceptor 12
A8K7T1_HUMAN

Genular Protein ID: 2907335515

Symbol: P2Y12_HUMAN

Name: P2Y purinoceptor 12

UniProtKB Accession Codes:

Q9H244 D3DNJ5 Q546J7

Database IDs:

Citations:

PubMed ID: 11196645

Title: Identification of the platelet ADP receptor targeted by antithrombotic drugs.

PubMed ID: 11196645

DOI: 10.1038/35051599

PubMed ID: 11104774

Title: ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999.

PubMed ID: 11104774

DOI: 10.1074/jbc.m009718200

PubMed ID: 11502873

Title: Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y1 receptor.

PubMed ID: 11502873

PubMed ID: 12044878

Title: Identification of G protein-coupled receptor genes from the human genome sequence.

PubMed ID: 12044878

DOI: 10.1016/s0014-5793(02)02775-8

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 24670650

Title: Structure of the human P2Y12 receptor in complex with an antithrombotic drug.

PubMed ID: 24670650

DOI: 10.1038/nature13083

PubMed ID: 24784220

Title: Agonist-bound structure of the human P2Y12 receptor.

PubMed ID: 24784220

DOI: 10.1038/nature13288

PubMed ID: 12578987

Title: Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding.

PubMed ID: 12578987

DOI: 10.1073/pnas.0437879100

PubMed ID: 25428217

Title: Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis.

PubMed ID: 25428217

DOI: 10.1182/blood-2013-07-517896

Sequence Information:

Length: 342
Mass: 39439
Checksum: 8553D2746C89176D
Sequence:

MQAVDNLTSA PGNTSLCTRD YKITQVLFPL LYTVLFFVGL ITNGLAMRIF FQIRSKSNFI 
IFLKNTVISD LLMILTFPFK ILSDAKLGTG PLRTFVCQVT SVIFYFTMYI SISFLGLITI 
DRYQKTTRPF KTSNPKNLLG AKILSVVIWA FMFLLSLPNM ILTNRQPRDK NVKKCSFLKS 
EFGLVWHEIV NYICQVIFWI NFLIVIVCYT LITKELYRSY VRTRGVGKVP RKKVNVKVFI 
IIAVFFICFV PFHFARIPYT LSQTRDVFDC TAENTLFYVK ESTLWLTSLN ACLDPFIYFF 
LCKSFRNSLI SMLKCPNSAT SLSQDNRKKE QDGGDPNEET PM

Genular Protein ID: 1888626019

Symbol: A8K7T1_HUMAN

Name: N/A

UniProtKB Accession Codes:

A8K7T1

Database IDs:

Sequence Information:

Length: 342
Mass: 39487
Checksum: F25A35603C891779
Sequence:

MQAVDNLTSA PGNTSLCTRD YKITQVLFPL LYTVLFFVGL ITNGLAMRIF FQIRSKSNFI 
IFLKNTVISD LLMILTFPFK ILSDAKLGTG PLRTFVCQVT SVIFYFTMYI SISFLGLITI 
DRYQKTTRPF KTSNPKNLLG AKILSVVIWA FMFLLSLPNM ILTNRQPRDK NVKKCSFLKS 
EFGLVWHEIV NYICQVIFWI NFLIFIVCYT LITKELYRSY VRTRGVGKVP RKKVNVKVFI 
IIAVFFICFV PFHFARIPYT LSQTRDVFDC TAENTLFYVK ESTLWLTSLN ACLDPFIYFF 
LCKSFRNSLI SMLKCPNSAT SLSQDNRKKE QDGGDPNEET PM

The gene details are incomplete or unavailable at the moment.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: P2RY12

Associated with

Other Information

Identification of the platelet ADP receptor targeted by antithrombotic drugs. PubMed ID: 11196645

ADP is the cognate ligand for the orphan G protein-coupled receptor SP1999. PubMed ID: 11104774

Molecular cloning of the platelet P2T(AC) ADP receptor: pharmacological comparison with another ADP receptor, the P2Y1 receptor. PubMed ID: 11502873

Identification of G protein-coupled receptor genes from the human genome sequence. PubMed ID: 12044878

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Structure of the human P2Y12 receptor in complex with an antithrombotic drug. PubMed ID: 24670650

Agonist-bound structure of the human P2Y12 receptor. PubMed ID: 24784220

Molecular bases of defective signal transduction in the platelet P2Y12 receptor of a patient with congenital bleeding. PubMed ID: 12578987

Identification of a new dysfunctional platelet P2Y12 receptor variant associated with bleeding diathesis. PubMed ID: 25428217