Details for: CUBN

Gene ID: 8029

Symbol: CUBN

Ensembl ID: ENSG00000107611

Description: cubilin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 66.4437
    Cell Significance Index: -10.3400
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 39.7605
    Cell Significance Index: -10.0900
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 23.0642
    Cell Significance Index: -9.3700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 3.8281
    Cell Significance Index: -10.2600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 3.1431
    Cell Significance Index: 25.1000
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 2.9974
    Cell Significance Index: -6.5600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.6229
    Cell Significance Index: -10.3500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 1.5784
    Cell Significance Index: 88.5700
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 1.2773
    Cell Significance Index: 13.2300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.9470
    Cell Significance Index: 339.6800
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.7153
    Cell Significance Index: 7.4100
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.6335
    Cell Significance Index: 5.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.5482
    Cell Significance Index: 70.2800
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4424
    Cell Significance Index: 43.7700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4277
    Cell Significance Index: 81.3900
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: 0.3747
    Cell Significance Index: 14.1900
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.3730
    Cell Significance Index: 3.1700
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.3646
    Cell Significance Index: 10.5100
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.3597
    Cell Significance Index: 7.0200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: 0.2661
    Cell Significance Index: 11.7700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2555
    Cell Significance Index: 15.3400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2468
    Cell Significance Index: 49.5000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: 0.1734
    Cell Significance Index: 11.6600
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1581
    Cell Significance Index: 2.2200
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: 0.1521
    Cell Significance Index: 12.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.1330
    Cell Significance Index: 84.5000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.1312
    Cell Significance Index: 26.0300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.1305
    Cell Significance Index: 2.7900
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: 0.0988
    Cell Significance Index: 44.8500
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0895
    Cell Significance Index: 168.6100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0834
    Cell Significance Index: 128.3300
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.0827
    Cell Significance Index: 9.0000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0776
    Cell Significance Index: 143.2000
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0560
    Cell Significance Index: 1.4000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.0548
    Cell Significance Index: 0.6900
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0526
    Cell Significance Index: 47.4900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0516
    Cell Significance Index: 35.6800
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0514
    Cell Significance Index: 3.5600
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0440
    Cell Significance Index: 59.7900
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.0404
    Cell Significance Index: 0.5800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0183
    Cell Significance Index: 1.1300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.0140
    Cell Significance Index: 0.2400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0104
    Cell Significance Index: 5.6900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0054
    Cell Significance Index: 0.9700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0041
    Cell Significance Index: 2.9700
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0037
    Cell Significance Index: 0.0800
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0023
    Cell Significance Index: 0.0800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0051
    Cell Significance Index: -0.7400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0086
    Cell Significance Index: -0.2200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0093
    Cell Significance Index: -4.0900
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0115
    Cell Significance Index: -0.5200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0119
    Cell Significance Index: -0.1800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0133
    Cell Significance Index: -9.8800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0142
    Cell Significance Index: -10.7700
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0176
    Cell Significance Index: -10.9800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0185
    Cell Significance Index: -10.4400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0190
    Cell Significance Index: -3.1000
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0217
    Cell Significance Index: -6.2300
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0231
    Cell Significance Index: -3.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0244
    Cell Significance Index: -0.3500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.0278
    Cell Significance Index: -0.7400
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0357
    Cell Significance Index: -4.3900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0370
    Cell Significance Index: -6.3100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0386
    Cell Significance Index: -1.2400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0412
    Cell Significance Index: -3.1600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0413
    Cell Significance Index: -2.5300
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.0452
    Cell Significance Index: -0.9900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0468
    Cell Significance Index: -4.7800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0510
    Cell Significance Index: -10.7400
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0613
    Cell Significance Index: -6.3800
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0626
    Cell Significance Index: -7.2900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0646
    Cell Significance Index: -3.0100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0725
    Cell Significance Index: -8.3100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0759
    Cell Significance Index: -9.8100
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.0824
    Cell Significance Index: -0.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0874
    Cell Significance Index: -10.3100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.1027
    Cell Significance Index: -7.2600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1152
    Cell Significance Index: -7.2600
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1153
    Cell Significance Index: -7.4400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1209
    Cell Significance Index: -3.4500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1236
    Cell Significance Index: -5.8100
  • Cell Name: hippocampal astrocyte (CL0002604)
    Fold Change: -0.1266
    Cell Significance Index: -1.7700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1272
    Cell Significance Index: -2.7100
  • Cell Name: astrocyte of the cerebral cortex (CL0002605)
    Fold Change: -0.1359
    Cell Significance Index: -2.3500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1382
    Cell Significance Index: -10.3000
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1468
    Cell Significance Index: -1.7100
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.1490
    Cell Significance Index: -7.8200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1493
    Cell Significance Index: -3.5800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -0.1504
    Cell Significance Index: -1.8700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1539
    Cell Significance Index: -4.3000
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -0.1589
    Cell Significance Index: -0.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1633
    Cell Significance Index: -5.7200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1657
    Cell Significance Index: -8.6100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.1669
    Cell Significance Index: -3.3500
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1672
    Cell Significance Index: -8.7100
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1728
    Cell Significance Index: -4.3100
  • Cell Name: corneal endothelial cell (CL0000132)
    Fold Change: -0.1729
    Cell Significance Index: -2.6300
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1796
    Cell Significance Index: -5.8800
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1881
    Cell Significance Index: -5.9900
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2050
    Cell Significance Index: -4.4300

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** CUBN is a large transmembrane receptor protein with a molecular weight of approximately 460 kDa. It is composed of multiple extracellular and intracellular domains, which interact with various ligands, including cobalamin, vitamin D, and lipoproteins. CUBN is characterized by its ability to bind to cobalamin and facilitate its uptake into enterocytes, thereby regulating the availability of this essential nutrient. The receptor is also involved in the regulation of vitamin D metabolism, with CUBN binding to vitamin D and facilitating its transport into cells. **Pathways and Functions** CUBN is involved in several key pathways, including: 1. **Cobalamin transport**: CUBN binds to cobalamin and facilitates its uptake into enterocytes, where it is then transported to the bloodstream. 2. **Vitamin D metabolism**: CUBN binds to vitamin D and facilitates its transport into cells, where it is then converted into its active form, 1,25-dihydroxyvitamin D. 3. **Lipoprotein clearance**: CUBN binds to lipoproteins and facilitates their clearance from the plasma, thereby regulating lipid metabolism. 4. **Receptor-mediated endocytosis**: CUBN is involved in the regulation of receptor-mediated endocytosis, a process by which cells internalize ligands bound to receptors. **Clinical Significance** Dysregulation of CUBN has been implicated in several diseases, including: 1. **Cobalamin deficiency**: Defects in CUBN have been linked to cobalamin deficiency, a condition characterized by impaired vitamin B12 absorption and metabolism. 2. **Vitamin D deficiency**: CUBN is also involved in the regulation of vitamin D metabolism, and defects in the receptor have been linked to vitamin D deficiency. 3. **Kidney disease**: CUBN is expressed in the kidney and is involved in the regulation of lipoprotein clearance. Defects in CUBN have been linked to kidney disease. 4. **Neurological disorders**: CUBN is expressed in the brain and is involved in the regulation of vitamin D metabolism. Defects in CUBN have been linked to neurological disorders, including multiple sclerosis and Parkinson's disease. In conclusion, CUBN is a critical receptor protein involved in the transport of cobalamin and vitamin D, as well as the clearance of lipoproteins from the plasma. Dysregulation of CUBN has been implicated in several diseases related to cobalamin and vitamin D metabolism, and further research is needed to fully understand the role of this receptor in human health and disease.

Genular Protein ID: 1729558410

Symbol: CUBN_HUMAN

Name: 460 kDa receptor

UniProtKB Accession Codes:

O60494 B0YIZ4 Q5VTA6 Q96RU9

Database IDs:

AGR 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 3 CORUM 1 CTD 1 ChEBI 19 ChiTaRS 1 ComplexPortal 1 DIP 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 7 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 29 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 10 KEGG 1 MANE-Select 1 MIM 5 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PIR 1 PRO 1 PROSITE 6 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 5 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 3 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9572993

Title: The human intrinsic factor-vitamin B12 receptor, cubilin: molecular characterization and chromosomal mapping of the gene to 10p within the autosomal recessive megaloblastic anemia (MGA1) region.

PubMed ID: 9572993

PubMed ID: 15164054

Title: The DNA sequence and comparative analysis of human chromosome 10.

PubMed ID: 15164054

DOI: 10.1038/nature02462

PubMed ID: 10371504

Title: The intrinsic factor-vitamin B12 receptor, cubilin, is a high-affinity apolipoprotein A-I receptor facilitating endocytosis of high-density lipoprotein.

PubMed ID: 10371504

DOI: 10.1038/9504

PubMed ID: 10080186

Title: Mutations in CUBN, encoding the intrinsic factor-vitamin B12 receptor, cubilin, cause hereditary megaloblastic anaemia 1.

PubMed ID: 10080186

DOI: 10.1038/6831

PubMed ID: 11717447

Title: Cubilin dysfunction causes abnormal metabolism of the steroid hormone 25(OH) vitamin D(3).

PubMed ID: 11717447

DOI: 10.1073/pnas.241516998

PubMed ID: 11606717

Title: Megalin-dependent cubilin-mediated endocytosis is a major pathway for the apical uptake of transferrin in polarized epithelia.

PubMed ID: 11606717

DOI: 10.1073/pnas.211291398

PubMed ID: 14576052

Title: The functional cobalamin (vitamin B12)-intrinsic factor receptor is a novel complex of cubilin and amnionless.

PubMed ID: 14576052

DOI: 10.1182/blood-2003-08-2852

PubMed ID: 17124247

Title: Identification of the ligands of protein interaction domains through a functional approach.

PubMed ID: 17124247

DOI: 10.1074/mcp.m600289-mcp200

PubMed ID: 29402915

Title: Amnionless-mediated glycosylation is crucial for cell surface targeting of cubilin in renal and intestinal cells.

PubMed ID: 29402915

DOI: 10.1038/s41598-018-20731-4

PubMed ID: 31613795

Title: Human C-terminal CUBN variants associate with chronic proteinuria and normal renal function.

PubMed ID: 31613795

DOI: 10.1172/jci129937

PubMed ID: 20237569

Title: Structural basis for receptor recognition of vitamin-B(12)-intrinsic factor complexes.

PubMed ID: 20237569

DOI: 10.1038/nature08874

PubMed ID: 30523278

Title: Structural assembly of the megadalton-sized receptor for intestinal vitamin B12 uptake and kidney protein reabsorption.

PubMed ID: 30523278

DOI: 10.1038/s41467-018-07468-4

PubMed ID: 10887099

Title: Cubilin P1297L mutation associated with hereditary megaloblastic anemia 1 causes impaired recognition of intrinsic factor-vitamin B(12) by cubilin.

PubMed ID: 10887099

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

PubMed ID: 17668238

Title: Imerslund-Graesbeck syndrome in a 15-year-old German girl caused by compound heterozygous mutations in CUBN.

PubMed ID: 17668238

DOI: 10.1007/s00431-007-0571-3

PubMed ID: 21355061

Title: CUBN is a gene locus for albuminuria.

PubMed ID: 21355061

DOI: 10.1681/asn.2010060598

PubMed ID: 21248752

Title: Exome sequencing identifies frequent mutation of the SWI/SNF complex gene PBRM1 in renal carcinoma.

PubMed ID: 21248752

DOI: 10.1038/nature09639

PubMed ID: 23114252

Title: Linkage disequilibrium analysis reveals an albuminuria risk haplotype containing three missense mutations in the cubilin gene with striking differences among European and African ancestry populations.

PubMed ID: 23114252

DOI: 10.1186/1471-2369-13-142

PubMed ID: 24156255

Title: Detailed investigations of proximal tubular function in Imerslund-Graesbeck syndrome.

PubMed ID: 24156255

DOI: 10.1186/1471-2350-14-111

Sequence Information:

  • Length: 3623
  • Mass: 398736
  • Checksum: 8D602663C6D4751F
  • Sequence:
    • MMNMSLPFLW SLLTLLIFAE VNGEAGELEL QRQKRSINLQ QPRMATERGN LVFLTGSAQN 
IEFRTGSLGK IKLNDEDLSE CLHQIQKNKE DIIELKGSAI GLPQNISSQI YQLNSKLVDL 
ERKFQGLQQT VDKKVCSSNP CQNGGTCLNL HDSFFCICPP QWKGPLCSAD VNECEIYSGT 
PLSCQNGGTC VNTMGSYSCH CPPETYGPQC ASKYDDCEGG SVARCVHGIC EDLMREQAGE 
PKYSCVCDAG WMFSPNSPAC TLDRDECSFQ PGPCSTLVQC FNTQGSFYCG ACPTGWQGNG 
YICEDINECE INNGGCSVAP PVECVNTPGS SHCQACPPGY QGDGRVCTLT DICSVSNGGC 
HPDASCSSTL GSLPLCTCLP GYTGNGYGPN GCVQLSNICL SHPCLNGQCI DTVSGYFCKC 
DSGWTGVNCT ENINECLSNP CLNGGTCVDG VDSFSCECTR LWTGALCQVP QQVCGESLSG 
INGSFSYRSP DVGYVHDVNC FWVIKTEMGK VLRITFTFFR LESMDNCPHE FLQVYDGDSS 
SAFQLGRFCG SSLPHELLSS DNALYFHLYS EHLRNGRGFT VRWETQQPEC GGILTGPYGS 
IKSPGYPGNY PPGRDCVWIV VTSPDLLVTF TFGTLSLEHH DDCNKDYLEI RDGPLYQDPL 
LGKFCTTFSV PPLQTTGPFA RIHFHSDSQI SDQGFHITYL TSPSDLRCGG NYTDPEGELF 
LPELSGPFTH TRQCVYMMKQ PQGEQIQINF THVELQCQSD SSQNYIEVRD GETLLGKVCG 
NGTISHIKSI TNSVWIRFKI DASVEKASFR AVYQVACGDE LTGEGVIRSP FFPNVYPGER 
TCRWTIHQPQ SQVILLNFTV FEIGSSAHCE TDYVEIGSSS ILGSPENKKY CGTDIPSFIT 
SVYNFLYVTF VKSSSTENHG FMAKFSAEDL ACGEILTEST GTIQSPGHPN VYPHGINCTW 
HILVQPNHLI HLMFETFHLE FHYNCTNDYL EVYDTDSETS LGRYCGKSIP PSLTSSGNSL 
MLVFVTDSDL AYEGFLINYE AISAATACLQ DYTDDLGTFT SPNFPNNYPN NWECIYRITV 
RTGQLIAVHF TNFSLEEAIG NYYTDFLEIR DGGYEKSPLL GIFYGSNLPP TIISHSNKLW 
LKFKSDQIDT RSGFSAYWDG SSTGCGGNLT TSSGTFISPN YPMPYYHSSE CYWWLKSSHG 
SAFELEFKDF HLEHHPNCTL DYLAVYDGPS SNSHLLTQLC GDEKPPLIRS SGDSMFIKLR 
TDEGQQGRGF KAEYRQTCEN VVIVNQTYGI LESIGYPNPY SENQHCNWTI RATTGNTVNY 
TFLAFDLEHH INCSTDYLEL YDGPRQMGRY CGVDLPPPGS TTSSKLQVLL LTDGVGRREK 
GFQMQWFVYG CGGELSGATG SFSSPGFPNR YPPNKECIWY IRTDPGSSIQ LTIHDFDVEY 
HSRCNFDVLE IYGGPDFHSP RIAQLCTQRS PENPMQVSST GNELAIRFKT DLSINGRGFN 
ASWQAVTGGC GGIFQAPSGE IHSPNYPSPY RSNTDCSWVI RVDRNHRVLL NFTDFDLEPQ 
DSCIMAYDGL SSTMSRLART CGREQLANPI VSSGNSLFLR FQSGPSRQNR GFRAQFRQAC 
GGHILTSSFD TVSSPRFPAN YPNNQNCSWI IQAQPPLNHI TLSFTHFELE RSTTCARDFV 
EILDGGHEDA PLRGRYCGTD MPHPITSFSS ALTLRFVSDS SISAGGFHTT VTASVSACGG 
TFYMAEGIFN SPGYPDIYPP NVECVWNIVS SPGNRLQLSF ISFQLEDSQD CSRDFVEIRE 
GNATGHLVGR YCGNSFPLNY SSIVGHTLWV RFISDGSGSG TGFQATFMKI FGNDNIVGTH 
GKVASPFWPE NYPHNSNYQW TVNVNASHVV HGRILEMDIE EIQNCYYDKL RIYDGPSIHA 
RLIGAYCGTQ TESFSSTGNS LTFHFYSDSS ISGKGFLLEW FAVDAPDGVL PTIAPGACGG 
FLRTGDAPVF LFSPGWPDSY SNRVDCTWLI QAPDSTVELN ILSLDIESHR TCAYDSLVIR 
DGDNNLAQQL AVLCGREIPG PIRSTGEYMF IRFTSDSSVT RAGFNASFHK SCGGYLHADR 
GIITSPKYPE TYPSNLNCSW HVLVQSGLTI AVHFEQPFQI PNGDSSCNQG DYLVLRNGPD 
ICSPPLGPPG GNGHFCGSHA SSTLFTSDNQ MFVQFISDHS NEGQGFKIKY EAKSLACGGN 
VYIHDADSAG YVTSPNHPHN YPPHADCIWI LAAPPETRIQ LQFEDRFDIE VTPNCTSNYL 
ELRDGVDSDA PILSKFCGTS LPSSQWSSGE VMYLRFRSDN SPTHVGFKAK YSIAQCGGRV 
PGQSGVVESI GHPTLPYRDN LFCEWHLQGL SGHYLTISFE DFNLQNSSGC EKDFVEIWDN 
HTSGNILGRY CGNTIPDSID TSSNTAVVRF VTDGSVTASG FRLRFESSME ECGGDLQGSI 
GTFTSPNYPN PNPHGRICEW RITAPEGRRI TLMFNNLRLA THPSCNNEHV IVFNGIRSNS 
PQLEKLCSSV NVSNEIKSSG NTMKVIFFTD GSRPYGGFTA SYTSSEDAVC GGSLPNTPEG 
NFTSPGYDGV RNYSRNLNCE WTLSNPNQGN SSISIHFEDF YLESHQDCQF DVLEFRVGDA 
DGPLMWRLCG PSKPTLPLVI PYSQVWIHFV TNERVEHIGF HAKYSFTDCG GIQIGDSGVI 
TSPNYPNAYD SLTHCSSLLE APQGHTITLT FSDFDIEPHT TCAWDSVTVR NGGSPESPII 
GQYCGNSNPR TIQSGSNQLV VTFNSDHSLQ GGGFYATWNT QTLGCGGIFH SDNGTIRSPH 
WPQNFPENSR CSWTAITHKS KHLEISFDNN FLIPSGDGQC QNSFVKVWAG TEEVDKALLA 
TGCGNVAPGP VITPSNTFTA VFQSQEAPAQ GFSASFVSRC GSNFTGPSGY IISPNYPKQY 
DNNMNCTYVI EANPLSVVLL TFVSFHLEAR SAVTGSCVND GVHIIRGYSV MSTPFATVCG 
DEMPAPLTIA GPVLLNFYSN EQITDFGFKF SYRIISCGGV FNFSSGIITS PAYSYADYPN 
DMHCLYTITV SDDKVIELKF SDFDVVPSTS CSHDYLAIYD GANTSDPLLG KFCGSKRPPN 
VKSSNNSMLL VFKTDSFQTA KGWKMSFRQT LGPQQGCGGY LTGSNNTFAS PDSDSNGMYD 
KNLNCVWIII APVNKVIHLT FNTFALEAAS TRQRCLYDYV KLYDGDSENA NLAGTFCGST 
VPAPFISSGN FLTVQFISDL TLEREGFNAT YTIMDMPCGG TYNATWTPQN ISSPNSSDPD 
VPFSICTWVI DSPPHQQVKI TVWALQLTSQ DCTQNYLQLQ DSPQGHGNSR FQFCGRNASA 
VPVFYSSMST AMVIFKSGVV NRNSRMSFTY QIADCNRDYH KAFGNLRSPG WPDNYDNDKD 
CTVTLTAPQN HTISLFFHSL GIENSVECRN DFLEVRNGSN SNSPLLGKYC GTLLPNPVFS 
QNNELYLRFK SDSVTSDRGY EIIWTSSPSG CGGTLYGDRG SFTSPGYPGT YPNNTYCEWV 
LVAPAGRLVT INFYFISIDD PGDCVQNYLT LYDGPNASSP SSGPYCGGDT SIAPFVASSN 
QVFIKFHADY ARRPSAFRLT WDS

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.