Details for: HMGN1

Gene ID: 3150

Symbol: HMGN1

Ensembl ID: ENSG00000205581

Description: high mobility group nucleosome binding domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.71
    Cell Significance Index: 5
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 1.49
    Cell Significance Index: 2
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 1.38
    Cell Significance Index: 2
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 1.35
    Cell Significance Index: 1
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 1.29
    Cell Significance Index: 1
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 1.23
    Cell Significance Index: 1
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 1.17
    Cell Significance Index: 1
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.16
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Cell Significance Index: 1
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.15
    Cell Significance Index: 1
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 1.14
    Cell Significance Index: 1
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 1.13
    Cell Significance Index: 1
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.12
    Cell Significance Index: 1
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 1.1
    Cell Significance Index: 1
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 1.09
    Cell Significance Index: 1
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.08
    Cell Significance Index: 1
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 1.07
    Cell Significance Index: 1
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.06
    Cell Significance Index: 1
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.03
    Cell Significance Index: 1
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.02
    Cell Significance Index: 1
  • Cell Name: centroblast (CL0009112)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 1.01
    Cell Significance Index: 1
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: tuft cell of small intestine (CL0009080)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: glioblast (CL0000030)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 1
    Cell Significance Index: 1
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal cell (CL0000362)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: neuroblast (sensu Nematoda and Protostomia) (CL0000338)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: epithelial cell of sweat gland (CL1000448)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: sebaceous gland cell (CL2000021)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: perivascular cell (CL4033054)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: colon endothelial cell (CL1001572)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: OFF-bipolar cell (CL0000750)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: cell (CL0000000)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: ON-bipolar cell (CL0000749)
    Fold Change: 0.99
    Cell Significance Index: 1
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: granular cell of epidermis (CL0002189)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: Merkel cell (CL0000242)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: retinal cone cell (CL0000573)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.98
    Cell Significance Index: 1
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: 0.98
    Cell Significance Index: 1

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HMGN1 is a 37-kDa protein that belongs to the high mobility group (HMG) family of proteins. It is characterized by its ability to bind to nucleosomes, the fundamental units of chromatin, and modulate their structure and function. HMGN1 is highly conserved across species, with a high degree of sequence identity among different organisms. Its expression is widespread, with significant levels detected in various cell types, including immune cells, cancerous cells, and stem cells. **Pathways and Functions:** HMGN1 is involved in multiple chromatin-related pathways, including: 1. **Chromatin Organization:** HMGN1 regulates chromatin structure by interacting with histone proteins and other chromatin-associated proteins, influencing the compactness and accessibility of chromatin. 2. **DNA Repair:** HMGN1 is involved in the repair of DNA double-strand breaks, particularly in the context of transcription-coupled nucleotide excision repair (TC-NER). 3. **Transcriptional Regulation:** HMGN1 modulates transcriptional processes, including the regulation of gene expression and the maintenance of genome stability. 4. **Immune Response:** HMGN1 plays a critical role in the regulation of immune cell function, including the activation and differentiation of T cells and B cells. **Clinical Significance:** HMGN1 has been implicated in various diseases, including: 1. **Cancer:** HMGN1 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. Its expression is often associated with poor prognosis and aggressive tumor behavior. 2. **Autoimmune Diseases:** HMGN1 has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, where its dysregulation contributes to the development of disease. 3. **Neurological Disorders:** HMGN1 has been implicated in neurological diseases, including Alzheimer's disease and multiple sclerosis, where its dysregulation contributes to disease progression. 4. **Immunodeficiency:** HMGN1 has been identified as a key regulator of immune cell function, and its dysregulation has been linked to immunodeficiency disorders. In conclusion, HMGN1 is a complex protein that plays a critical role in regulating chromatin dynamics, DNA repair, and transcriptional processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying HMGN1's functions. As an expert immunologist, I emphasize the need for continued investigation into the role of HMGN1 in immune regulation and its potential as a therapeutic target for the treatment of immune-related disorders.

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.