Details for: HMGN1

Gene ID: 3150

Symbol: HMGN1

Ensembl ID: ENSG00000205581

Description: high mobility group nucleosome binding domain 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 4.09
    Marker Score: 53900
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 3.97
    Marker Score: 53390
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 3.82
    Marker Score: 10907
  • Cell Name: germinal center B cell (CL0000844)
    Fold Change: 3.82
    Marker Score: 2324
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 3.75
    Marker Score: 6843
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.6
    Marker Score: 8784
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.6
    Marker Score: 35613.5
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.54
    Marker Score: 9766
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 3.43
    Marker Score: 3583
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 3.43
    Marker Score: 2591.5
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.38
    Marker Score: 21980.5
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 3.27
    Marker Score: 2921
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.22
    Marker Score: 111611
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 3.16
    Marker Score: 9371
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 3.16
    Marker Score: 4469
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.15
    Marker Score: 12158.5
  • Cell Name: centroblast (CL0009112)
    Fold Change: 3.14
    Marker Score: 1547
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 3.1
    Marker Score: 3443
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 3.06
    Marker Score: 730
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 3.03
    Marker Score: 2388
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.01
    Marker Score: 2968
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.99
    Marker Score: 22263
  • Cell Name: naive thymus-derived CD8-positive, alpha-beta T cell (CL0000900)
    Fold Change: 2.98
    Marker Score: 5330
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 2.97
    Marker Score: 1866
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 2.97
    Marker Score: 3505
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 2.94
    Marker Score: 3553
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 2.94
    Marker Score: 7412
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.92
    Marker Score: 22822
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 2.92
    Marker Score: 154411
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 2.88
    Marker Score: 12003
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.87
    Marker Score: 3470
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.85
    Marker Score: 18563
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: 2.85
    Marker Score: 16885
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 2.84
    Marker Score: 7622
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 2.84
    Marker Score: 1273.5
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 2.84
    Marker Score: 1157
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.83
    Marker Score: 4935.5
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.83
    Marker Score: 974
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 2.81
    Marker Score: 4666.5
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 2.81
    Marker Score: 12042
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 2.8
    Marker Score: 1630
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.8
    Marker Score: 4584
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.79
    Marker Score: 11431
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.79
    Marker Score: 2110
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.79
    Marker Score: 5823
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 2.79
    Marker Score: 830
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 2.78
    Marker Score: 14618
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 2.78
    Marker Score: 8765
  • Cell Name: lung secretory cell (CL1000272)
    Fold Change: 2.77
    Marker Score: 2467
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 2.77
    Marker Score: 2609
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 2.76
    Marker Score: 2595.5
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 2.76
    Marker Score: 4385
  • Cell Name: basophil (CL0000767)
    Fold Change: 2.74
    Marker Score: 1304
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.74
    Marker Score: 27760
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.73
    Marker Score: 2143.5
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 2.73
    Marker Score: 692
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 2.73
    Marker Score: 4634
  • Cell Name: activated CD8-positive, alpha-beta T cell (CL0000906)
    Fold Change: 2.73
    Marker Score: 1977
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 2.72
    Marker Score: 595
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 2.7
    Marker Score: 9600
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.7
    Marker Score: 1790
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 2.69
    Marker Score: 7335
  • Cell Name: naive T cell (CL0000898)
    Fold Change: 2.68
    Marker Score: 1726.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.67
    Marker Score: 1611
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 2.67
    Marker Score: 26857
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.67
    Marker Score: 2506
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 2.66
    Marker Score: 2844
  • Cell Name: DN3 thymocyte (CL0000807)
    Fold Change: 2.66
    Marker Score: 1327
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 2.65
    Marker Score: 1084
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 2.65
    Marker Score: 687
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 2.65
    Marker Score: 651
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 2.64
    Marker Score: 848
  • Cell Name: bronchial epithelial cell (CL0002328)
    Fold Change: 2.64
    Marker Score: 699
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.64
    Marker Score: 2675
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 2.64
    Marker Score: 2544
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 2.63
    Marker Score: 1544
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 2.63
    Marker Score: 22638
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 2.62
    Marker Score: 2940
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.62
    Marker Score: 4031
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 2.61
    Marker Score: 687
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.61
    Marker Score: 1902
  • Cell Name: blood cell (CL0000081)
    Fold Change: 2.61
    Marker Score: 30298
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.6
    Marker Score: 5897.5
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.6
    Marker Score: 2430
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 2.6
    Marker Score: 1541
  • Cell Name: natural T-regulatory cell (CL0000903)
    Fold Change: 2.59
    Marker Score: 1332
  • Cell Name: T follicular helper cell (CL0002038)
    Fold Change: 2.59
    Marker Score: 2152
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 2.59
    Marker Score: 896
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 2.58
    Marker Score: 1328
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.58
    Marker Score: 912
  • Cell Name: naive thymus-derived CD4-positive, alpha-beta T cell (CL0000895)
    Fold Change: 2.57
    Marker Score: 4416
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 2.57
    Marker Score: 6055
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.57
    Marker Score: 28913
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.56
    Marker Score: 11061
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 2.56
    Marker Score: 5209
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 2.56
    Marker Score: 586
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 2.55
    Marker Score: 662
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 2.55
    Marker Score: 2563
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.53
    Marker Score: 16202.5
  • Cell Name: exhausted T cell (CL0011025)
    Fold Change: 2.53
    Marker Score: 1456

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Other Information

**Key characteristics:** * HMGN1 is a protein of the high mobility group (HMGN) family of proteins. * It is a nucleosome-associated protein that is found in both mammals and yeast. * It is a key component of the tc-ner pathway, which is involved in the repair of double-strand DNA breaks. * It is also involved in the formation of the pre-incision complex for DNA repair. * It is a highly conserved protein that is found in a wide range of organisms. **Pathways and functions:** * The tc-ner pathway is a complex network of DNA repair mechanisms that is involved in the repair of double-strand DNA breaks. * HMGN1 is a key component of the tc-ner pathway. * It is involved in the formation of the pre-incision complex for DNA repair. * It is also involved in the repair of DNA breaks by facilitating the removal of damaged DNA sequences and the subsequent reassembly of the broken DNA. * HMGN1 is also involved in the regulation of the expression of genes involved in DNA repair and cell cycle regulation. **Clinical significance:** HMGN1 is a promising target for cancer therapy. Mutations in HMGN1 have been linked to a number of human cancers, including breast cancer, lung cancer, and colorectal cancer. Inhibition of HMGN1 has been shown to be effective in inhibiting tumor growth in vitro and in vivo.

Genular Protein ID: 2344040677

Symbol: HMGN1_HUMAN

Name: Non-histone chromosomal protein HMG-14

UniProtKB Accession Codes:

P05114 Q3KQR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 9 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 4 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3782107

Title: Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family.

PubMed ID: 3782107

DOI: 10.1016/s0021-9258(18)66680-3

PubMed ID: 2563381

Title: Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family.

PubMed ID: 2563381

DOI: 10.1016/s0021-9258(18)94084-6

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10739259

Title: Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.

PubMed ID: 10739259

DOI: 10.1110/ps.9.1.170

PubMed ID: 18993075

Title: Evidence for insertional RNA editing in humans.

PubMed ID: 18993075

DOI: 10.1016/j.cub.2008.09.059

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 33468658

Title: A short ORF-encoded transcriptional regulator.

PubMed ID: 33468658

DOI: 10.1073/pnas.2021943118

Sequence Information:

  • Length: 100
  • Mass: 10659
  • Checksum: 8F4CB5374D51FBF3
  • Sequence:
    • MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG 
KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

Genular Protein ID: 18271911

Symbol: Q6NSG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSG7

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 5 GO 3 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 100
  • Mass: 10689
  • Checksum: 92E7C5230845AAB6
  • Sequence:
    • MPKRKVSSTE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG 
KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.