Details for: HMGN1

Gene ID: 3150

Symbol: HMGN1

Ensembl ID: ENSG00000205581

Description: high mobility group nucleosome binding domain 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 643.4784
    Cell Significance Index: -100.0900
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 343.1195
    Cell Significance Index: -87.0300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 292.9499
    Cell Significance Index: -120.6800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 265.8661
    Cell Significance Index: -108.0100
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 262.8342
    Cell Significance Index: -124.0900
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 238.9454
    Cell Significance Index: -122.9100
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 185.1802
    Cell Significance Index: -124.2600
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 114.9524
    Cell Significance Index: -109.7500
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 93.8476
    Cell Significance Index: -115.7100
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 31.0589
    Cell Significance Index: -122.5600
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 24.5714
    Cell Significance Index: -75.4700
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 23.0807
    Cell Significance Index: -61.8300
  • Cell Name: epidermal Langerhans cell (CL0002457)
    Fold Change: 17.1343
    Cell Significance Index: -37.5000
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 10.9893
    Cell Significance Index: 67.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 8.3959
    Cell Significance Index: 291.7600
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 8.2112
    Cell Significance Index: 65.5600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 7.8178
    Cell Significance Index: 163.6400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 7.3257
    Cell Significance Index: 79.6400
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 6.7563
    Cell Significance Index: 796.7800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 5.4171
    Cell Significance Index: 69.3800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 4.9820
    Cell Significance Index: 131.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 4.6277
    Cell Significance Index: 344.9000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 4.5163
    Cell Significance Index: 122.9300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.3104
    Cell Significance Index: 202.5900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 4.2951
    Cell Significance Index: 2345.6500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 4.2395
    Cell Significance Index: 521.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 3.7116
    Cell Significance Index: 509.7000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 3.6393
    Cell Significance Index: 84.0800
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 3.5404
    Cell Significance Index: 223.1400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.4357
    Cell Significance Index: 221.6600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 3.3637
    Cell Significance Index: 606.3700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 3.0799
    Cell Significance Index: 143.6000
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.8586
    Cell Significance Index: 202.1700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.8234
    Cell Significance Index: 1248.2900
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: 2.6305
    Cell Significance Index: 138.1100
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.6191
    Cell Significance Index: 76.9200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 2.5100
    Cell Significance Index: 324.2800
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 2.0850
    Cell Significance Index: 19.2000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 2.0227
    Cell Significance Index: 54.0100
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 1.9647
    Cell Significance Index: 22.3200
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 1.8861
    Cell Significance Index: 115.9300
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 1.7981
    Cell Significance Index: 230.5100
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 1.7695
    Cell Significance Index: 92.1700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 1.3071
    Cell Significance Index: 67.9000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 1.2906
    Cell Significance Index: 256.1200
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.1774
    Cell Significance Index: 116.4700
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.8200
    Cell Significance Index: 740.3600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.7880
    Cell Significance Index: 158.0800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.7118
    Cell Significance Index: 121.5400
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.6999
    Cell Significance Index: 201.3800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: 0.6487
    Cell Significance Index: 36.4000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6424
    Cell Significance Index: 122.2600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.5995
    Cell Significance Index: 215.0300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.5641
    Cell Significance Index: 25.5700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.2124
    Cell Significance Index: 3.5600
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.2007
    Cell Significance Index: 151.9400
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.1272
    Cell Significance Index: 4.4700
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.1050
    Cell Significance Index: 76.9700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0066
    Cell Significance Index: 0.1900
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0030
    Cell Significance Index: 5.5900
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.0285
    Cell Significance Index: -0.3400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0348
    Cell Significance Index: -25.7500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0360
    Cell Significance Index: -48.9000
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0422
    Cell Significance Index: -77.9000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.0469
    Cell Significance Index: -1.3100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0476
    Cell Significance Index: -73.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0694
    Cell Significance Index: -11.3000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0778
    Cell Significance Index: -7.9500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0787
    Cell Significance Index: -49.1700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1086
    Cell Significance Index: -69.0000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.1380
    Cell Significance Index: -77.8500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1490
    Cell Significance Index: -67.6400
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1987
    Cell Significance Index: -41.8600
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.3360
    Cell Significance Index: -2.5900
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4181
    Cell Significance Index: -10.6800
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.5358
    Cell Significance Index: -61.3900
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.5768
    Cell Significance Index: -44.2600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6088
    Cell Significance Index: -88.5000
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.6359
    Cell Significance Index: -72.5900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.6552
    Cell Significance Index: -76.3600
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.6566
    Cell Significance Index: -21.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.7859
    Cell Significance Index: -62.2400
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.8852
    Cell Significance Index: -21.2300
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.9895
    Cell Significance Index: -13.5000
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -1.0859
    Cell Significance Index: -18.6100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -1.1475
    Cell Significance Index: -119.4900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3737
    Cell Significance Index: -92.3700
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.5039
    Cell Significance Index: -22.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -1.6275
    Cell Significance Index: -35.2600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.6783
    Cell Significance Index: -10.1400
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -1.7236
    Cell Significance Index: -46.1100
  • Cell Name: centroblast (CL0009112)
    Fold Change: -1.7895
    Cell Significance Index: -4.1800
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: -1.8693
    Cell Significance Index: -23.1900
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.9112
    Cell Significance Index: -84.5400
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: -1.9351
    Cell Significance Index: -20.5600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.9579
    Cell Significance Index: -57.6700
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -1.9785
    Cell Significance Index: -118.7800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -2.0101
    Cell Significance Index: -123.2400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -2.1278
    Cell Significance Index: -36.6800
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -2.1415
    Cell Significance Index: -61.7000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HMGN1 is a 37-kDa protein that belongs to the high mobility group (HMG) family of proteins. It is characterized by its ability to bind to nucleosomes, the fundamental units of chromatin, and modulate their structure and function. HMGN1 is highly conserved across species, with a high degree of sequence identity among different organisms. Its expression is widespread, with significant levels detected in various cell types, including immune cells, cancerous cells, and stem cells. **Pathways and Functions:** HMGN1 is involved in multiple chromatin-related pathways, including: 1. **Chromatin Organization:** HMGN1 regulates chromatin structure by interacting with histone proteins and other chromatin-associated proteins, influencing the compactness and accessibility of chromatin. 2. **DNA Repair:** HMGN1 is involved in the repair of DNA double-strand breaks, particularly in the context of transcription-coupled nucleotide excision repair (TC-NER). 3. **Transcriptional Regulation:** HMGN1 modulates transcriptional processes, including the regulation of gene expression and the maintenance of genome stability. 4. **Immune Response:** HMGN1 plays a critical role in the regulation of immune cell function, including the activation and differentiation of T cells and B cells. **Clinical Significance:** HMGN1 has been implicated in various diseases, including: 1. **Cancer:** HMGN1 overexpression has been observed in several types of cancer, including breast, lung, and colon cancer. Its expression is often associated with poor prognosis and aggressive tumor behavior. 2. **Autoimmune Diseases:** HMGN1 has been linked to autoimmune disorders, such as rheumatoid arthritis and lupus, where its dysregulation contributes to the development of disease. 3. **Neurological Disorders:** HMGN1 has been implicated in neurological diseases, including Alzheimer's disease and multiple sclerosis, where its dysregulation contributes to disease progression. 4. **Immunodeficiency:** HMGN1 has been identified as a key regulator of immune cell function, and its dysregulation has been linked to immunodeficiency disorders. In conclusion, HMGN1 is a complex protein that plays a critical role in regulating chromatin dynamics, DNA repair, and transcriptional processes. Its dysregulation has been implicated in various diseases, highlighting the importance of further research into the molecular mechanisms underlying HMGN1's functions. As an expert immunologist, I emphasize the need for continued investigation into the role of HMGN1 in immune regulation and its potential as a therapeutic target for the treatment of immune-related disorders.

Genular Protein ID: 2344040677

Symbol: HMGN1_HUMAN

Name: Non-histone chromosomal protein HMG-14

UniProtKB Accession Codes:

P05114 Q3KQR8

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 18 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 STRING 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 3782107

Title: Chromosomal protein HMG-14. Complete human cDNA sequence and evidence for a multigene family.

PubMed ID: 3782107

DOI: 10.1016/s0021-9258(18)66680-3

PubMed ID: 2563381

Title: Chromosomal protein HMG-14. Identification, characterization, and chromosome localization of a functional gene from the large human multigene family.

PubMed ID: 2563381

DOI: 10.1016/s0021-9258(18)94084-6

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10739259

Title: Phosphorylation and subcellular redistribution of high mobility group proteins 14 and 17, analyzed by mass spectrometry.

PubMed ID: 10739259

DOI: 10.1110/ps.9.1.170

PubMed ID: 18993075

Title: Evidence for insertional RNA editing in humans.

PubMed ID: 18993075

DOI: 10.1016/j.cub.2008.09.059

PubMed ID: 17924679

Title: Improved titanium dioxide enrichment of phosphopeptides from HeLa cells and high confident phosphopeptide identification by cross-validation of MS/MS and MS/MS/MS spectra.

PubMed ID: 17924679

DOI: 10.1021/pr070152u

PubMed ID: 19367720

Title: Phosphorylation analysis of primary human T lymphocytes using sequential IMAC and titanium oxide enrichment.

PubMed ID: 19367720

DOI: 10.1021/pr800500r

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 18318008

Title: Large-scale phosphoproteome analysis of human liver tissue by enrichment and fractionation of phosphopeptides with strong anion exchange chromatography.

PubMed ID: 18318008

DOI: 10.1002/pmic.200700884

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 28190768

Title: Serine ADP-ribosylation depends on HPF1.

PubMed ID: 28190768

DOI: 10.1016/j.molcel.2017.01.003

PubMed ID: 33468658

Title: A short ORF-encoded transcriptional regulator.

PubMed ID: 33468658

DOI: 10.1073/pnas.2021943118

Sequence Information:

  • Length: 100
  • Mass: 10659
  • Checksum: 8F4CB5374D51FBF3
  • Sequence:
    • MPKRKVSSAE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG 
KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

Genular Protein ID: 18271911

Symbol: Q6NSG7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q6NSG7

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 5 GO 4 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 1 SAM 1 SMART 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 100
  • Mass: 10689
  • Checksum: 92E7C5230845AAB6
  • Sequence:
    • MPKRKVSSTE GAAKEEPKRR SARLSAKPPA KVEAKPKKAA AKDKSSDKKV QTKGKRGAKG 
KQAEVANQET KEDLPAENGE TKTEESPASD EAGEKEAKSD

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.