GRIA1 | ENSG00000155511 | NCBI 2890

Details for: GRIA1

Gene ID: 2890

Symbol: GRIA1

Ensembl ID: ENSG00000155511

Description: glutamate ionotropic receptor AMPA type subunit 1

Associated with

Activation of ampa receptors
(R-HSA-399710)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Long-term potentiation
(R-HSA-9620244)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Protein-protein interactions at synapses
(R-HSA-6794362)
Synaptic adhesion-like molecules
(R-HSA-8849932)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Vesicle-mediated transport
(R-HSA-5653656)
Adenylate cyclase binding
(GO:0008179)
Ampa glutamate receptor activity
(GO:0004971)
Ampa glutamate receptor complex
(GO:0032281)
Amyloid-beta binding
(GO:0001540)
Axonal spine
(GO:0044308)
Beta-2 adrenergic receptor binding
(GO:0031698)
Cell-cell junction
(GO:0005911)
Cell surface
(GO:0009986)
Cellular response to amine stimulus
(GO:0071418)
Cellular response to amino acid stimulus
(GO:0071230)
Cellular response to ammonium ion
(GO:0071242)
Cellular response to brain-derived neurotrophic factor stimulus
(GO:1990416)
Cellular response to dsrna
(GO:0071359)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cerebral cortex development
(GO:0021987)
Chemical synaptic transmission
(GO:0007268)
Dendrite
(GO:0030425)
Dendritic shaft
(GO:0043198)
Dendritic spine
(GO:0043197)
Dendritic spine membrane
(GO:0032591)
Early endosome membrane
(GO:0031901)
Endocytic vesicle membrane
(GO:0030666)
Endoplasmic reticulum-golgi intermediate compartment membrane
(GO:0033116)
Endoplasmic reticulum membrane
(GO:0005789)
Er to golgi transport vesicle membrane
(GO:0012507)
Excitatory synapse
(GO:0060076)
G-protein alpha-subunit binding
(GO:0001965)
G-protein beta-subunit binding
(GO:0031681)
Glutamate receptor activity
(GO:0008066)
Glutamate receptor binding
(GO:0035254)
Identical protein binding
(GO:0042802)
Immunoglobulin binding
(GO:0019865)
Ionotropic glutamate receptor signaling pathway
(GO:0035235)
Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
(GO:0099507)
Long-term memory
(GO:0007616)
Long-term synaptic depression
(GO:0060292)
Modulation of chemical synaptic transmission
(GO:0050804)
Monoatomic ion transmembrane transport
(GO:0034220)
Myosin v binding
(GO:0031489)
Neuromuscular junction
(GO:0031594)
Neuronal action potential
(GO:0019228)
Neuronal cell body
(GO:0043025)
Neuronal cell body membrane
(GO:0032809)
Neuron spine
(GO:0044309)
Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099583)
Pdz domain binding
(GO:0030165)
Plasma membrane
(GO:0005886)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of membrane potential
(GO:0045838)
Positive regulation of synaptic transmission
(GO:0050806)
Postsynaptic density
(GO:0014069)
Presynaptic active zone membrane
(GO:0048787)
Protein binding
(GO:0005515)
Protein kinase a binding
(GO:0051018)
Protein kinase binding
(GO:0019901)
Receptor internalization
(GO:0031623)
Recycling endosome
(GO:0055037)
Recycling endosome membrane
(GO:0055038)
Regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099566)
Regulation of postsynaptic membrane potential
(GO:0060078)
Regulation of presynaptic membrane potential
(GO:0099505)
Regulation of receptor recycling
(GO:0001919)
Response to arsenic-containing substance
(GO:0046685)
Response to cocaine
(GO:0042220)
Response to electrical stimulus
(GO:0051602)
Response to estradiol
(GO:0032355)
Response to fungicide
(GO:0060992)
Response to lithium ion
(GO:0010226)
Response to xenobiotic stimulus
(GO:0009410)
Scaffold protein binding
(GO:0097110)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Spinal cord development
(GO:0021510)
Synapse assembly
(GO:0007416)
Synaptic transmission, glutamatergic
(GO:0035249)
Synaptic vesicle membrane
(GO:0030672)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: Purkinje cell (CL0000121)
Fold Change: 5.98
Marker Score: 201,964
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: 4.05
Marker Score: 18,759
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 3.1
Marker Score: 8,852
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 3.01
Marker Score: 5,056
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 2.91
Marker Score: 57,788
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: 2.84
Marker Score: 21,743
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: 2.83
Marker Score: 42,373
Cell Name: vip GABAergic cortical interneuron (CL4023016)
Fold Change: 2.63
Marker Score: 100,025
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: 2.62
Marker Score: 10,878
Cell Name: chromaffin cell (CL0000166)
Fold Change: 2.57
Marker Score: 3,619
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: 2.44
Marker Score: 90,168
Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 2.36
Marker Score: 9,115
Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
Fold Change: 2.31
Marker Score: 4,774
Cell Name: cardiac endothelial cell (CL0010008)
Fold Change: 2.29
Marker Score: 4,343
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: 2.15
Marker Score: 20,191
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.06
Marker Score: 126,753
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: 2.03
Marker Score: 20,919
Cell Name: alveolar type 2 fibroblast cell (CL4028006)
Fold Change: 2.02
Marker Score: 1,121
Cell Name: GABAergic neuron (CL0000617)
Fold Change: 1.93
Marker Score: 8,050
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: 1.92
Marker Score: 18,248
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: 1.88
Marker Score: 16,130
Cell Name: neuron (CL0000540)
Fold Change: 1.82
Marker Score: 7,400
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 1.72
Marker Score: 660
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: 1.65
Marker Score: 2,552
Cell Name: cardiac neuron (CL0010022)
Fold Change: 1.58
Marker Score: 1,968
Cell Name: immature innate lymphoid cell (CL0001082)
Fold Change: 1.53
Marker Score: 3,112
Cell Name: mural cell (CL0008034)
Fold Change: 1.46
Marker Score: 167,565
Cell Name: cerebellar granule cell precursor (CL0002362)
Fold Change: 1.42
Marker Score: 798
Cell Name: epithelial cell of alveolus of lung (CL0010003)
Fold Change: 1.33
Marker Score: 598
Cell Name: rod bipolar cell (CL0000751)
Fold Change: 1.32
Marker Score: 687
Cell Name: microglial cell (CL0000129)
Fold Change: 1.3
Marker Score: 2,366
Cell Name: pulmonary interstitial fibroblast (CL0002241)
Fold Change: 1.26
Marker Score: 1,008
Cell Name: retinal ganglion cell (CL0000740)
Fold Change: 1.17
Marker Score: 1,460
Cell Name: Bergmann glial cell (CL0000644)
Fold Change: 1.17
Marker Score: 475
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: 1.15
Marker Score: 18,033
Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
Fold Change: 1.03
Marker Score: 619
Cell Name: oligodendrocyte precursor cell (CL0002453)
Fold Change: 1
Marker Score: 1,236
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: 1
Marker Score: 71,795
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: 1
Marker Score: 48,019
Cell Name: absorptive cell (CL0000212)
Fold Change: 0.98
Marker Score: 30,406
Cell Name: sympathetic neuron (CL0011103)
Fold Change: 0.97
Marker Score: 321
Cell Name: intestinal crypt stem cell of colon (CL0009043)
Fold Change: 0.95
Marker Score: 2,426
Cell Name: transit amplifying cell (CL0009010)
Fold Change: 0.94
Marker Score: 5,355
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: 0.92
Marker Score: 19,583
Cell Name: abnormal cell (CL0001061)
Fold Change: 0.92
Marker Score: 2,743
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.87
Marker Score: 5,296
Cell Name: ganglion interneuron (CL0000397)
Fold Change: 0.87
Marker Score: 264
Cell Name: kidney capillary endothelial cell (CL1000892)
Fold Change: 0.87
Marker Score: 271
Cell Name: intestinal epithelial cell (CL0002563)
Fold Change: 0.78
Marker Score: 1,265
Cell Name: photoreceptor cell (CL0000210)
Fold Change: 0.78
Marker Score: 584
Cell Name: brush cell (CL0002204)
Fold Change: 0.77
Marker Score: 706
Cell Name: goblet cell (CL0000160)
Fold Change: 0.77
Marker Score: 5,105
Cell Name: Cajal-Retzius cell (CL0000695)
Fold Change: 0.76
Marker Score: 396
Cell Name: mature astrocyte (CL0002627)
Fold Change: 0.74
Marker Score: 486
Cell Name: Mueller cell (CL0000636)
Fold Change: 0.73
Marker Score: 1,016
Cell Name: CNS interneuron (CL0000402)
Fold Change: 0.73
Marker Score: 349
Cell Name: bipolar neuron (CL0000103)
Fold Change: 0.72
Marker Score: 242
Cell Name: smooth muscle myoblast (CL0000514)
Fold Change: 0.71
Marker Score: 340
Cell Name: mononuclear cell (CL0000842)
Fold Change: 0.71
Marker Score: 229
Cell Name: stellate neuron (CL0000122)
Fold Change: 0.71
Marker Score: 3,815
Cell Name: vascular leptomeningeal cell (CL4023051)
Fold Change: 0.7
Marker Score: 804
Cell Name: astrocyte (CL0000127)
Fold Change: 0.67
Marker Score: 579
Cell Name: neuronal receptor cell (CL0000006)
Fold Change: 0.66
Marker Score: 293
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: 0.63
Marker Score: 6,339
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: 0.61
Marker Score: 365
Cell Name: visceromotor neuron (CL0005025)
Fold Change: 0.59
Marker Score: 173
Cell Name: intestinal enteroendocrine cell (CL1001516)
Fold Change: 0.58
Marker Score: 461
Cell Name: connective tissue cell (CL0002320)
Fold Change: 0.55
Marker Score: 142
Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
Fold Change: 0.54
Marker Score: 1,273
Cell Name: brainstem motor neuron (CL2000047)
Fold Change: 0.52
Marker Score: 303
Cell Name: myofibroblast cell (CL0000186)
Fold Change: 0.45
Marker Score: 561
Cell Name: meningeal macrophage (CL0000879)
Fold Change: 0.45
Marker Score: 126
Cell Name: neuronal brush cell (CL0000555)
Fold Change: 0.42
Marker Score: 1,421
Cell Name: endothelial cell (CL0000115)
Fold Change: 0.39
Marker Score: 351
Cell Name: mature microglial cell (CL0002629)
Fold Change: 0.39
Marker Score: 140
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: 0.38
Marker Score: 780
Cell Name: interneuron (CL0000099)
Fold Change: 0.37
Marker Score: 167
Cell Name: leptomeningeal cell (CL0000708)
Fold Change: 0.36
Marker Score: 180
Cell Name: neural progenitor cell (CL0011020)
Fold Change: 0.32
Marker Score: 1,220
Cell Name: macroglial cell (CL0000126)
Fold Change: 0.31
Marker Score: 702
Cell Name: granule cell (CL0000120)
Fold Change: 0.29
Marker Score: 2,224
Cell Name: retina horizontal cell (CL0000745)
Fold Change: 0.29
Marker Score: 282
Cell Name: fibroblast (CL0000057)
Fold Change: 0.29
Marker Score: 279
Cell Name: glial cell (CL0000125)
Fold Change: 0.29
Marker Score: 316
Cell Name: B cell (CL0000236)
Fold Change: 0.29
Marker Score: 272
Cell Name: macrophage (CL0000235)
Fold Change: 0.28
Marker Score: 315
Cell Name: oligodendrocyte (CL0000128)
Fold Change: 0.28
Marker Score: 676
Cell Name: radial glial cell (CL0000681)
Fold Change: 0.28
Marker Score: 104
Cell Name: ependymal cell (CL0000065)
Fold Change: 0.27
Marker Score: 95
Cell Name: fibroblast of cardiac tissue (CL0002548)
Fold Change: 0.26
Marker Score: 1,583
Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
Fold Change: 0.26
Marker Score: 58
Cell Name: keratocyte (CL0002363)
Fold Change: 0.26
Marker Score: 59
Cell Name: retinal blood vessel endothelial cell (CL0002585)
Fold Change: 0.25
Marker Score: 59
Cell Name: cardiac mesenchymal cell (CL0000569)
Fold Change: 0.24
Marker Score: 60
Cell Name: late promyelocyte (CL0002151)
Fold Change: 0.24
Marker Score: 61
Cell Name: mast cell (CL0000097)
Fold Change: 0.24
Marker Score: 140
Cell Name: neuron associated cell (sensu Vertebrata) (CL0000123)
Fold Change: 0.24
Marker Score: 1,260
Cell Name: fibroblast of lung (CL0002553)
Fold Change: 0.23
Marker Score: 614
Cell Name: retinal pigment epithelial cell (CL0002586)
Fold Change: 0.23
Marker Score: 68
Cell Name: Schwann cell (CL0002573)
Fold Change: 0.23
Marker Score: 80

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

**Key Characteristics:** 1. **Subunit Structure:** The GRIA1 gene encodes for the alpha 1 subunit of the AMPA-type glutamate receptor, which is a ligand-gated ion channel composed of five transmembrane domains and four intracellular domains. 2. **Expression Pattern:** GRIA1 is highly expressed in the cerebral cortex, hippocampus, and other brain regions, with high levels of expression in excitatory neurons. 3. **Function:** The GRIA1 subunit regulates synaptic transmission, synaptic plasticity, and neuronal excitability by controlling the flow of glutamate ions into the postsynaptic neuron. **Pathways and Functions:** 1. **Excitatory Synapse Formation:** GRIA1 plays a crucial role in the formation and maintenance of excitatory synapses by regulating the binding of glutamate to the AMPA receptor. 2. **Synaptic Plasticity:** The GRIA1 subunit is involved in the regulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). 3. **Neuronal Excitability:** GRIA1 regulates neuronal excitability by controlling the flow of glutamate ions into the postsynaptic neuron, thereby influencing the excitability of neurons. 4. **Neurotransmission:** The GRIA1 subunit is involved in the regulation of neurotransmission, including the transmission of excitatory signals across chemical synapses. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Alterations in GRIA1 expression and function have been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Neuropsychiatric Disorders:** GRIA1 has been implicated in the pathophysiology of neuropsychiatric disorders, including schizophrenia, bipolar disorder, and depression. 3. **Cognitive Function:** The GRIA1 subunit plays a crucial role in regulating cognitive function, including attention, memory, and learning. 4. **Therapeutic Targeting:** The GRIA1 gene has been identified as a potential therapeutic target for the treatment of various neurological and psychiatric disorders. In conclusion, the GRIA1 gene plays a crucial role in regulating synaptic transmission, synaptic plasticity, and neuronal excitability. Its dysregulation has been implicated in various neurodegenerative and neuropsychiatric disorders, highlighting the importance of further research into the molecular mechanisms underlying GRIA1 function and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AMPA-selective glutamate receptor 1
Q59GL5_HUMAN

Genular Protein ID: 3604620142

Symbol: GRIA1_HUMAN

Name: AMPA-selective glutamate receptor 1

UniProtKB Accession Codes:

P42261 B7Z2S0 B7Z2W8 B7Z3F6 B7Z9G9 D3DQI4 E7ESV8 Q2NKM6

Database IDs:

Citations:

PubMed ID: 1652753

Title: Molecular cloning and chromosomal localization of one of the human glutamate receptor genes.

PubMed ID: 1652753

DOI: 10.1073/pnas.88.17.7557

PubMed ID: 1320959

Title: The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5.

PubMed ID: 1320959

DOI: 10.3109/10425179209020805

PubMed ID: 1311100

Title: Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.

PubMed ID: 1311100

DOI: 10.1073/pnas.89.4.1443

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 20805473

Title: Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.

PubMed ID: 20805473

DOI: 10.1073/pnas.1011706107

PubMed ID: 23739980

Title: A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.

PubMed ID: 23739980

DOI: 10.1523/jneurosci.2626-12.2013

PubMed ID: 30135643

Title: Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement.

PubMed ID: 30135643

DOI: 10.3389/fnmol.2018.00275

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 28628100

Title: Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.

PubMed ID: 28628100

DOI: 10.1038/nn.4589

PubMed ID: 35675825

Title: Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.

PubMed ID: 35675825

DOI: 10.1016/j.ajhg.2022.05.009

Sequence Information:

Length: 906
Mass: 101506
Checksum: 03EA1E026D0A9A2F
Sequence:

MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT 
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL 
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM 
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW 
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP 
LGATGL

Genular Protein ID: 938772174

Symbol: Q59GL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GL5

Database IDs:

Sequence Information:

Length: 833
Mass: 93291
Checksum: BDBA6AF7FEC49566
Sequence:

ICSQFSKGVY AIFGFYERRT VNMLTSFCGA LHVCFITPSF PVDTSNQFVL QLRPELQDAL 
ISIIDHYKWQ KFVYIYDADR GLSVLQKVLD TAAEKNWQVT AVNILTTTEE GYRMLFQDLE 
KKKERLVVVD CESERLNAIL GQIIKLEKNG IGYHYILANL GFMDIDLNKF KESGANVTGF 
QLVNYTDTIP AKIMQQWKNS DARDHTRVDW KRPKYTSALT YDGVKVMAEA FQSLRRQRID 
ISRRGNAGDC LANPAVPWGQ GIDIQRALQQ VRFEGLTGNV QFNEKGRRTN YTLHVIEMKH 
DGIRKIGYWN EDDKFVPAAT DAQAGGDNSS VQNRTYIVTT ILEDPYVMLK KNANQFEGND 
RYEGYCVELA AEIAKHVGYS YRLEIVSDGK YGARDPDTKA WNGMVGELVY GRADVAVAPL 
TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI VFAYIGVSVV 
LFLVSRFSPY EWHSEEFEEG RDQTTSDQSN EFGIFNSLWF SLGAFMQQGC DISPRSLSGR 
IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL AKQTEIAYGT LEAGSTKEFF 
RRSKIAVFEK MWTYMKSAEP SVFVRTTEEG MIRVRKSKGK YAYLLESTMN EYIEQRKPCD 
TMKVGGNLDS KGYGIATPKG SALRGPVNLA VLKLSEQGVL DKLKSKWWYD KGECGSKDSG 
SKDKTSALSL SNVAGVFYIL IGGLGLAMLV ALIEFCYKSR SESKRMKGFC LIPQQSINEA 
IRTSTLPRNS GAGASSGGSG ENGRVVSHDF PKSMQSIPCM SHSSGMPLGA TGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GRIA1

Associated with

Cells (max top 100)

Other Information

Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. PubMed ID: 1652753

The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. PubMed ID: 1320959

Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. PubMed ID: 1311100

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. PubMed ID: 21172611

Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. PubMed ID: 20805473

A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors. PubMed ID: 23739980

Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement. PubMed ID: 30135643

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978

Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. PubMed ID: 28628100

Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome. PubMed ID: 35675825