GRIA1 | ENSG00000155511 | NCBI 2890

Details for: GRIA1

Gene ID: 2890

Symbol: GRIA1

Ensembl ID: ENSG00000155511

Description: glutamate ionotropic receptor AMPA type subunit 1

Associated with

Activation of ampa receptors
(R-HSA-399710)
Activation of nmda receptors and postsynaptic events
(R-HSA-442755)
Asparagine n-linked glycosylation
(R-HSA-446203)
Cargo concentration in the er
(R-HSA-5694530)
Copii-mediated vesicle transport
(R-HSA-204005)
Er to golgi anterograde transport
(R-HSA-199977)
Glutamate binding, activation of ampa receptors and synaptic plasticity
(R-HSA-399721)
Long-term potentiation
(R-HSA-9620244)
Membrane trafficking
(R-HSA-199991)
Metabolism of proteins
(R-HSA-392499)
Neuronal system
(R-HSA-112316)
Neurotransmitter receptors and postsynaptic signal transmission
(R-HSA-112314)
Post-translational protein modification
(R-HSA-597592)
Post nmda receptor activation events
(R-HSA-438064)
Protein-protein interactions at synapses
(R-HSA-6794362)
Synaptic adhesion-like molecules
(R-HSA-8849932)
Trafficking of ampa receptors
(R-HSA-399719)
Trafficking of glur2-containing ampa receptors
(R-HSA-416993)
Transmission across chemical synapses
(R-HSA-112315)
Transport to the golgi and subsequent modification
(R-HSA-948021)
Unblocking of nmda receptors, glutamate binding and activation
(R-HSA-438066)
Vesicle-mediated transport
(R-HSA-5653656)
Adenylate cyclase binding
(GO:0008179)
Ampa glutamate receptor activity
(GO:0004971)
Amyloid-beta binding
(GO:0001540)
Behavioral response to pain
(GO:0048266)
Beta-2 adrenergic receptor binding
(GO:0031698)
Calcium-mediated signaling
(GO:0019722)
Cell-cell junction
(GO:0005911)
Cell surface
(GO:0009986)
Cellular response to amine stimulus
(GO:0071418)
Cellular response to ammonium ion
(GO:0071242)
Cellular response to brain-derived neurotrophic factor stimulus
(GO:1990416)
Cellular response to dsrna
(GO:0071359)
Cellular response to l-glutamate
(GO:1905232)
Cellular response to peptide hormone stimulus
(GO:0071375)
Cerebral cortex development
(GO:0021987)
Chemical synaptic transmission
(GO:0007268)
Conditioned place preference
(GO:1990708)
Cytosol
(GO:0005829)
Dendrite
(GO:0030425)
Endocytic vesicle membrane
(GO:0030666)
Endoplasmic reticulum membrane
(GO:0005789)
Er to golgi transport vesicle membrane
(GO:0012507)
External side of plasma membrane
(GO:0009897)
G-protein alpha-subunit binding
(GO:0001965)
G-protein beta-subunit binding
(GO:0031681)
Glutamate-gated calcium ion channel activity
(GO:0022849)
Glutamate receptor activity
(GO:0008066)
Glutamate receptor binding
(GO:0035254)
Identical protein binding
(GO:0042802)
Immunoglobulin binding
(GO:0019865)
Ionotropic glutamate receptor signaling pathway
(GO:0035235)
Ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential
(GO:0099507)
Long-term memory
(GO:0007616)
Long-term synaptic depression
(GO:0060292)
Long-term synaptic potentiation
(GO:0060291)
Modulation of chemical synaptic transmission
(GO:0050804)
Monoatomic ion transmembrane transport
(GO:0034220)
Myosin v binding
(GO:0031489)
Neuronal action potential
(GO:0019228)
Neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099583)
Pdz domain binding
(GO:0030165)
Peptide hormone receptor binding
(GO:0051428)
Plasma membrane
(GO:0005886)
Positive regulation of excitatory postsynaptic potential
(GO:2000463)
Positive regulation of gene expression
(GO:0010628)
Positive regulation of locomotion involved in locomotory behavior
(GO:0090326)
Positive regulation of membrane potential
(GO:0045838)
Postsynaptic density
(GO:0014069)
Protein binding
(GO:0005515)
Protein kinase a binding
(GO:0051018)
Protein kinase binding
(GO:0019901)
Receptor internalization
(GO:0031623)
Regulation of monoatomic ion transmembrane transport
(GO:0034765)
Regulation of postsynaptic cytosolic calcium ion concentration
(GO:0099566)
Regulation of postsynaptic membrane potential
(GO:0060078)
Regulation of presynaptic membrane potential
(GO:0099505)
Regulation of receptor recycling
(GO:0001919)
Response to arsenic-containing substance
(GO:0046685)
Response to cocaine
(GO:0042220)
Response to electrical stimulus
(GO:0051602)
Response to estradiol
(GO:0032355)
Response to ethanol
(GO:0045471)
Response to fungicide
(GO:0060992)
Response to lithium ion
(GO:0010226)
Response to morphine
(GO:0043278)
Response to nutrient levels
(GO:0031667)
Response to psychosocial stress
(GO:1990911)
Response to sucrose
(GO:0009744)
Response to xenobiotic stimulus
(GO:0009410)
Scaffold protein binding
(GO:0097110)
Signal transduction
(GO:0007165)
Small gtpase binding
(GO:0031267)
Spinal cord development
(GO:0021510)
Synapse assembly
(GO:0007416)
Synaptic transmission, glutamatergic
(GO:0035249)
Transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential
(GO:1904315)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

Cell Name: ciliated cell of the bronchus (CL0002332)
Fold Change: 62.2367
Cell Significance Index: -59.4200
Cell Name: cortical interneuron (CL0008031)
Fold Change: 10.6352
Cell Significance Index: 255.0600
Cell Name: hippocampal pyramidal neuron (CL1001571)
Fold Change: 9.2887
Cell Significance Index: 265.0700
Cell Name: forebrain neuroblast (CL1000042)
Fold Change: 8.9298
Cell Significance Index: 548.8700
Cell Name: hippocampal granule cell (CL0001033)
Fold Change: 7.1219
Cell Significance Index: 478.8800
Cell Name: hippocampal interneuron (CL1001569)
Fold Change: 5.3453
Cell Significance Index: 69.3200
Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
Fold Change: 5.2514
Cell Significance Index: 1883.5700
Cell Name: Purkinje cell (CL0000121)
Fold Change: 4.3555
Cell Significance Index: 95.3700
Cell Name: indirect pathway medium spiny neuron (CL4023029)
Fold Change: 4.2302
Cell Significance Index: 187.1100
Cell Name: direct pathway medium spiny neuron (CL4023026)
Fold Change: 4.1957
Cell Significance Index: 158.8800
Cell Name: pyramidal neuron (CL0000598)
Fold Change: 3.7797
Cell Significance Index: 28.9900
Cell Name: GABAergic interneuron (CL0011005)
Fold Change: 3.5191
Cell Significance Index: 2433.9600
Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
Fold Change: 2.6372
Cell Significance Index: 529.0200
Cell Name: retinal progenitor cell (CL0002672)
Fold Change: 2.5450
Cell Significance Index: 142.8100
Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
Fold Change: 2.1781
Cell Significance Index: 29.0600
Cell Name: chandelier cell (CL4023083)
Fold Change: 2.0868
Cell Significance Index: 16.8500
Cell Name: sst GABAergic cortical interneuron (CL4023017)
Fold Change: 0.4380
Cell Significance Index: 8.6600
Cell Name: neoplastic cell (CL0001063)
Fold Change: 0.1879
Cell Significance Index: 37.2800
Cell Name: cerebral cortex neuron (CL0010012)
Fold Change: 0.1598
Cell Significance Index: 1.5200
Cell Name: VIP GABAergic cortical interneuron (CL4023016)
Fold Change: 0.0169
Cell Significance Index: 0.3400
Cell Name: eukaryotic cell (CL0000255)
Fold Change: -0.0127
Cell Significance Index: -0.5500
Cell Name: glutamatergic neuron (CL0000679)
Fold Change: -0.0147
Cell Significance Index: -0.1600
Cell Name: anterior lens cell (CL0002223)
Fold Change: -0.0259
Cell Significance Index: -47.6900
Cell Name: pigmented epithelial cell (CL0000529)
Fold Change: -0.0274
Cell Significance Index: -51.5600
Cell Name: lens epithelial cell (CL0002224)
Fold Change: -0.0316
Cell Significance Index: -48.6200
Cell Name: secondary lens fiber (CL0002225)
Fold Change: -0.0350
Cell Significance Index: -47.6100
Cell Name: hair follicular keratinocyte (CL2000092)
Fold Change: -0.0356
Cell Significance Index: -15.7200
Cell Name: GABAergic neuron (CL0000617)
Fold Change: -0.0745
Cell Significance Index: -0.9400
Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
Fold Change: -0.0796
Cell Significance Index: -1.1400
Cell Name: pancreatic A cell (CL0000171)
Fold Change: -0.0870
Cell Significance Index: -64.4800
Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
Fold Change: -0.0872
Cell Significance Index: -1.8500
Cell Name: pulmonary alveolar epithelial cell (CL0000322)
Fold Change: -0.0961
Cell Significance Index: -72.7500
Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
Fold Change: -0.1029
Cell Significance Index: -65.3300
Cell Name: pancreatic PP cell (CL0002275)
Fold Change: -0.1083
Cell Significance Index: -67.6000
Cell Name: type B pancreatic cell (CL0000169)
Fold Change: -0.1183
Cell Significance Index: -66.7300
Cell Name: ciliary muscle cell (CL1000443)
Fold Change: -0.1281
Cell Significance Index: -58.1500
Cell Name: dopaminergic neuron (CL0000700)
Fold Change: -0.1759
Cell Significance Index: -50.6100
Cell Name: L6b glutamatergic cortical neuron (CL4023038)
Fold Change: -0.2140
Cell Significance Index: -7.0100
Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
Fold Change: -0.2556
Cell Significance Index: -8.1400
Cell Name: inhibitory interneuron (CL0000498)
Fold Change: -0.2759
Cell Significance Index: -3.3000
Cell Name: intermediate cell of urothelium (CL4030055)
Fold Change: -0.3171
Cell Significance Index: -57.1700
Cell Name: odontoblast (CL0000060)
Fold Change: -0.3447
Cell Significance Index: -44.1900
Cell Name: pancreatic D cell (CL0000173)
Fold Change: -0.3666
Cell Significance Index: -77.2300
Cell Name: neural cell (CL0002319)
Fold Change: -0.3862
Cell Significance Index: -4.5100
Cell Name: stromal cell of ovary (CL0002132)
Fold Change: -0.4033
Cell Significance Index: -55.3800
Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
Fold Change: -0.4219
Cell Significance Index: -11.7900
Cell Name: pancreatic acinar cell (CL0002064)
Fold Change: -0.4303
Cell Significance Index: -73.4700
Cell Name: pigmented ciliary epithelial cell (CL0002303)
Fold Change: -0.4418
Cell Significance Index: -64.2200
Cell Name: basal cell of urothelium (CL1000486)
Fold Change: -0.4679
Cell Significance Index: -57.5400
Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
Fold Change: -0.5739
Cell Significance Index: -12.4000
Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
Fold Change: -0.5855
Cell Significance Index: -60.9600
Cell Name: epithelial cell of stomach (CL0002178)
Fold Change: -0.6102
Cell Significance Index: -71.1200
Cell Name: neuron (CL0000540)
Fold Change: -0.6119
Cell Significance Index: -5.8000
Cell Name: pancreatic ductal cell (CL0002079)
Fold Change: -0.6779
Cell Significance Index: -77.6600
Cell Name: cardiac muscle myoblast (CL0000513)
Fold Change: -0.7370
Cell Significance Index: -56.5600
Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
Fold Change: -0.8375
Cell Significance Index: -17.4800
Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
Fold Change: -0.8761
Cell Significance Index: -5.7000
Cell Name: acinar cell of salivary gland (CL0002623)
Fold Change: -0.8830
Cell Significance Index: -41.1700
Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
Fold Change: -0.8906
Cell Significance Index: -31.2000
Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
Fold Change: -0.9212
Cell Significance Index: -22.9800
Cell Name: glycinergic neuron (CL1001509)
Fold Change: -0.9776
Cell Significance Index: -51.3300
Cell Name: intratelencephalic-projecting glutamatergic cortical neuron (CL4023008)
Fold Change: -1.0349
Cell Significance Index: -10.6400
Cell Name: eye photoreceptor cell (CL0000287)
Fold Change: -1.0613
Cell Significance Index: -66.8900
Cell Name: lung endothelial cell (CL1001567)
Fold Change: -1.1398
Cell Significance Index: -59.3700
Cell Name: skeletal muscle fiber (CL0008002)
Fold Change: -1.2169
Cell Significance Index: -31.2800
Cell Name: forebrain radial glial cell (CL0013000)
Fold Change: -1.2420
Cell Significance Index: -9.0300
Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
Fold Change: -1.3270
Cell Significance Index: -62.3700
Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
Fold Change: -1.3645
Cell Significance Index: -27.2100
Cell Name: retinal bipolar neuron (CL0000748)
Fold Change: -1.4222
Cell Significance Index: -17.2400
Cell Name: sncg GABAergic cortical interneuron (CL4023015)
Fold Change: -1.4262
Cell Significance Index: -28.0700
Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
Fold Change: -1.5427
Cell Significance Index: -15.5400
Cell Name: stratified epithelial cell (CL0000079)
Fold Change: -1.5702
Cell Significance Index: -57.6400
Cell Name: skeletal muscle fibroblast (CL0011027)
Fold Change: -1.5940
Cell Significance Index: -10.8000
Cell Name: myeloid dendritic cell (CL0000782)
Fold Change: -1.6002
Cell Significance Index: -12.5500
Cell Name: small intestine goblet cell (CL1000495)
Fold Change: -1.6552
Cell Significance Index: -58.1600
Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
Fold Change: -1.6579
Cell Significance Index: -22.1000
Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
Fold Change: -1.7726
Cell Significance Index: -42.9400
Cell Name: GABAergic amacrine cell (CL4030027)
Fold Change: -1.7729
Cell Significance Index: -21.9900
Cell Name: medial ganglionic eminence derived GABAergic cortical interneuron (CL4023069)
Fold Change: -1.8570
Cell Significance Index: -17.5400
Cell Name: L6 corticothalamic-projecting glutamatergic cortical neuron (CL4023042)
Fold Change: -1.9242
Cell Significance Index: -21.2300
Cell Name: fibroblast of dermis (CL0002551)
Fold Change: -1.9502
Cell Significance Index: -40.8200
Cell Name: astrocyte of the cerebral cortex (CL0002605)
Fold Change: -1.9514
Cell Significance Index: -33.7400
Cell Name: midget ganglion cell of retina (CL4023188)
Fold Change: -1.9536
Cell Significance Index: -20.3500
Cell Name: radial glial cell (CL0000681)
Fold Change: -1.9986
Cell Significance Index: -11.8600
Cell Name: enterocyte of epithelium of small intestine (CL1000334)
Fold Change: -2.0106
Cell Significance Index: -57.9300
Cell Name: keratinocyte (CL0000312)
Fold Change: -2.0163
Cell Significance Index: -50.3600
Cell Name: preadipocyte (CL0002334)
Fold Change: -2.0382
Cell Significance Index: -39.7800
Cell Name: lens fiber cell (CL0011004)
Fold Change: -2.0728
Cell Significance Index: -65.5600
Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
Fold Change: -2.0996
Cell Significance Index: -72.9600
Cell Name: flat midget bipolar cell (CL4033033)
Fold Change: -2.1497
Cell Significance Index: -26.7200
Cell Name: hippocampal astrocyte (CL0002604)
Fold Change: -2.1654
Cell Significance Index: -30.2800
Cell Name: enteroendocrine cell of small intestine (CL0009006)
Fold Change: -2.2434
Cell Significance Index: -56.0800
Cell Name: cerebral cortex endothelial cell (CL1001602)
Fold Change: -2.2474
Cell Significance Index: -45.7300
Cell Name: fibroblast of mammary gland (CL0002555)
Fold Change: -2.2752
Cell Significance Index: -65.2200
Cell Name: erythrocyte (CL0000232)
Fold Change: -2.4543
Cell Significance Index: -62.5300
Cell Name: kidney epithelial cell (CL0002518)
Fold Change: -2.5069
Cell Significance Index: -73.8400
Cell Name: placental villous trophoblast (CL2000060)
Fold Change: -2.5118
Cell Significance Index: -67.0700
Cell Name: granulosa cell (CL0000501)
Fold Change: -2.6032
Cell Significance Index: -68.4500
Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
Fold Change: -2.6358
Cell Significance Index: -65.7300
Cell Name: glioblast (CL0000030)
Fold Change: -2.6530
Cell Significance Index: -16.6600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

**Key Characteristics:** 1. **Subunit Structure:** The GRIA1 gene encodes for the alpha 1 subunit of the AMPA-type glutamate receptor, which is a ligand-gated ion channel composed of five transmembrane domains and four intracellular domains. 2. **Expression Pattern:** GRIA1 is highly expressed in the cerebral cortex, hippocampus, and other brain regions, with high levels of expression in excitatory neurons. 3. **Function:** The GRIA1 subunit regulates synaptic transmission, synaptic plasticity, and neuronal excitability by controlling the flow of glutamate ions into the postsynaptic neuron. **Pathways and Functions:** 1. **Excitatory Synapse Formation:** GRIA1 plays a crucial role in the formation and maintenance of excitatory synapses by regulating the binding of glutamate to the AMPA receptor. 2. **Synaptic Plasticity:** The GRIA1 subunit is involved in the regulation of synaptic plasticity, including long-term potentiation (LTP) and long-term depression (LTD). 3. **Neuronal Excitability:** GRIA1 regulates neuronal excitability by controlling the flow of glutamate ions into the postsynaptic neuron, thereby influencing the excitability of neurons. 4. **Neurotransmission:** The GRIA1 subunit is involved in the regulation of neurotransmission, including the transmission of excitatory signals across chemical synapses. **Clinical Significance:** 1. **Neurodegenerative Diseases:** Alterations in GRIA1 expression and function have been implicated in various neurodegenerative diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease. 2. **Neuropsychiatric Disorders:** GRIA1 has been implicated in the pathophysiology of neuropsychiatric disorders, including schizophrenia, bipolar disorder, and depression. 3. **Cognitive Function:** The GRIA1 subunit plays a crucial role in regulating cognitive function, including attention, memory, and learning. 4. **Therapeutic Targeting:** The GRIA1 gene has been identified as a potential therapeutic target for the treatment of various neurological and psychiatric disorders. In conclusion, the GRIA1 gene plays a crucial role in regulating synaptic transmission, synaptic plasticity, and neuronal excitability. Its dysregulation has been implicated in various neurodegenerative and neuropsychiatric disorders, highlighting the importance of further research into the molecular mechanisms underlying GRIA1 function and its potential therapeutic applications.

Disclaimer: This summary is generated by an AI language model and may contain inaccuracies or hallucinations. However, it is cross-referenced with curated gene expression data from major biological sources. Please verify the information before use.

AMPA-selective glutamate receptor 1
Q59GL5_HUMAN

Genular Protein ID: 3604620142

Symbol: GRIA1_HUMAN

Name: AMPA-selective glutamate receptor 1

UniProtKB Accession Codes:

P42261 B7Z2S0 B7Z2W8 B7Z3F6 B7Z9G9 D3DQI4 E7ESV8 Q2NKM6

Database IDs:

Citations:

PubMed ID: 1652753

Title: Molecular cloning and chromosomal localization of one of the human glutamate receptor genes.

PubMed ID: 1652753

DOI: 10.1073/pnas.88.17.7557

PubMed ID: 1320959

Title: The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5.

PubMed ID: 1320959

DOI: 10.3109/10425179209020805

PubMed ID: 1311100

Title: Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors.

PubMed ID: 1311100

DOI: 10.1073/pnas.89.4.1443

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 21172611

Title: Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins.

PubMed ID: 21172611

DOI: 10.1016/j.neuron.2010.11.026

PubMed ID: 20805473

Title: Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating.

PubMed ID: 20805473

DOI: 10.1073/pnas.1011706107

PubMed ID: 23739980

Title: A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors.

PubMed ID: 23739980

DOI: 10.1523/jneurosci.2626-12.2013

PubMed ID: 30135643

Title: Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement.

PubMed ID: 30135643

DOI: 10.3389/fnmol.2018.00275

PubMed ID: 23033978

Title: Diagnostic exome sequencing in persons with severe intellectual disability.

PubMed ID: 23033978

DOI: 10.1056/nejmoa1206524

PubMed ID: 28628100

Title: Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains.

PubMed ID: 28628100

DOI: 10.1038/nn.4589

PubMed ID: 35675825

Title: Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome.

PubMed ID: 35675825

DOI: 10.1016/j.ajhg.2022.05.009

Sequence Information:

Length: 906
Mass: 101506
Checksum: 03EA1E026D0A9A2F
Sequence:

MQHIFAFFCT GFLGAVVGAN FPNNIQIGGL FPNQQSQEHA AFRFALSQLT EPPKLLPQID 
IVNISDSFEM TYRFCSQFSK GVYAIFGFYE RRTVNMLTSF CGALHVCFIT PSFPVDTSNQ 
FVLQLRPELQ DALISIIDHY KWQKFVYIYD ADRGLSVLQK VLDTAAEKNW QVTAVNILTT 
TEEGYRMLFQ DLEKKKERLV VVDCESERLN AILGQIIKLE KNGIGYHYIL ANLGFMDIDL 
NKFKESGANV TGFQLVNYTD TIPAKIMQQW KNSDARDHTR VDWKRPKYTS ALTYDGVKVM 
AEAFQSLRRQ RIDISRRGNA GDCLANPAVP WGQGIDIQRA LQQVRFEGLT GNVQFNEKGR 
RTNYTLHVIE MKHDGIRKIG YWNEDDKFVP AATDAQAGGD NSSVQNRTYI VTTILEDPYV 
MLKKNANQFE GNDRYEGYCV ELAAEIAKHV GYSYRLEIVS DGKYGARDPD TKAWNGMVGE 
LVYGRADVAV APLTITLVRE EVIDFSKPFM SLGISIMIKK PQKSKPGVFS FLDPLAYEIW 
MCIVFAYIGV SVVLFLVSRF SPYEWHSEEF EEGRDQTTSD QSNEFGIFNS LWFSLGAFMQ 
QGCDISPRSL SGRIVGGVWW FFTLIIISSY TANLAAFLTV ERMVSPIESA EDLAKQTEIA 
YGTLEAGSTK EFFRRSKIAV FEKMWTYMKS AEPSVFVRTT EEGMIRVRKS KGKYAYLLES 
TMNEYIEQRK PCDTMKVGGN LDSKGYGIAT PKGSALRNPV NLAVLKLNEQ GLLDKLKNKW 
WYDKGECGSG GGDSKDKTSA LSLSNVAGVF YILIGGLGLA MLVALIEFCY KSRSESKRMK 
GFCLIPQQSI NEAIRTSTLP RNSGAGASSG GSGENGRVVS HDFPKSMQSI PCMSHSSGMP 
LGATGL

Genular Protein ID: 938772174

Symbol: Q59GL5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q59GL5

Database IDs:

Sequence Information:

Length: 833
Mass: 93291
Checksum: BDBA6AF7FEC49566
Sequence:

ICSQFSKGVY AIFGFYERRT VNMLTSFCGA LHVCFITPSF PVDTSNQFVL QLRPELQDAL 
ISIIDHYKWQ KFVYIYDADR GLSVLQKVLD TAAEKNWQVT AVNILTTTEE GYRMLFQDLE 
KKKERLVVVD CESERLNAIL GQIIKLEKNG IGYHYILANL GFMDIDLNKF KESGANVTGF 
QLVNYTDTIP AKIMQQWKNS DARDHTRVDW KRPKYTSALT YDGVKVMAEA FQSLRRQRID 
ISRRGNAGDC LANPAVPWGQ GIDIQRALQQ VRFEGLTGNV QFNEKGRRTN YTLHVIEMKH 
DGIRKIGYWN EDDKFVPAAT DAQAGGDNSS VQNRTYIVTT ILEDPYVMLK KNANQFEGND 
RYEGYCVELA AEIAKHVGYS YRLEIVSDGK YGARDPDTKA WNGMVGELVY GRADVAVAPL 
TITLVREEVI DFSKPFMSLG ISIMIKKPQK SKPGVFSFLD PLAYEIWMCI VFAYIGVSVV 
LFLVSRFSPY EWHSEEFEEG RDQTTSDQSN EFGIFNSLWF SLGAFMQQGC DISPRSLSGR 
IVGGVWWFFT LIIISSYTAN LAAFLTVERM VSPIESAEDL AKQTEIAYGT LEAGSTKEFF 
RRSKIAVFEK MWTYMKSAEP SVFVRTTEEG MIRVRKSKGK YAYLLESTMN EYIEQRKPCD 
TMKVGGNLDS KGYGIATPKG SALRGPVNLA VLKLSEQGVL DKLKSKWWYD KGECGSKDSG 
SKDKTSALSL SNVAGVFYIL IGGLGLAMLV ALIEFCYKSR SESKRMKGFC LIPQQSINEA 
IRTSTLPRNS GAGASSGGSG ENGRVVSHDF PKSMQSIPCM SHSSGMPLGA TGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.

Details for: GRIA1

Associated with

Cells (max top 100)

Other Information

Molecular cloning and chromosomal localization of one of the human glutamate receptor genes. PubMed ID: 1652753

The human glutamate receptor cDNA GluR1: cloning, sequencing, expression and localization to chromosome 5. PubMed ID: 1320959

Molecular cloning, chromosomal mapping, and functional expression of human brain glutamate receptors. PubMed ID: 1311100

Complete sequencing and characterization of 21,243 full-length human cDNAs. PubMed ID: 14702039

The DNA sequence and comparative analysis of human chromosome 5. PubMed ID: 15372022

The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). PubMed ID: 15489334

Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins. PubMed ID: 21172611

Functional comparison of the effects of TARPs and cornichons on AMPA receptor trafficking and gating. PubMed ID: 20805473

A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors. PubMed ID: 23739980

Mechanisms of CPT1C-Dependent AMPAR Trafficking Enhancement. PubMed ID: 30135643

Diagnostic exome sequencing in persons with severe intellectual disability. PubMed ID: 23033978

Hotspots of missense mutation identify neurodevelopmental disorder genes and functional domains. PubMed ID: 28628100

Identification and functional evaluation of GRIA1 missense and truncation variants in individuals with ID: An emerging neurodevelopmental syndrome. PubMed ID: 35675825