Details for: TAGLN2

Gene ID: 8407

Symbol: TAGLN2

Ensembl ID: ENSG00000158710

Description: transgelin 2

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: early promyelocyte (CL0002154)
    Fold Change: 5.24
    Marker Score: 4192
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 4.74
    Marker Score: 3574
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 4.39
    Marker Score: 11152
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 4.15
    Marker Score: 26458
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 4.07
    Marker Score: 5897
  • Cell Name: mature gamma-delta T cell (CL0000800)
    Fold Change: 3.93
    Marker Score: 12405
  • Cell Name: CD38-negative naive B cell (CL0002102)
    Fold Change: 3.89
    Marker Score: 8158
  • Cell Name: blood cell (CL0000081)
    Fold Change: 3.81
    Marker Score: 44329
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.77
    Marker Score: 128330
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 3.74
    Marker Score: 209212
  • Cell Name: decidual natural killer cell, human (CL0002343)
    Fold Change: 3.67
    Marker Score: 10135
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 3.64
    Marker Score: 31950
  • Cell Name: T-helper 22 cell (CL0001042)
    Fold Change: 3.55
    Marker Score: 15206
  • Cell Name: IgG-negative class switched memory B cell (CL0002117)
    Fold Change: 3.51
    Marker Score: 3462
  • Cell Name: epithelial cell of lung (CL0000082)
    Fold Change: 3.49
    Marker Score: 18325
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 3.46
    Marker Score: 182944
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 3.46
    Marker Score: 2946
  • Cell Name: type I pneumocyte (CL0002062)
    Fold Change: 3.44
    Marker Score: 4145
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 3.41
    Marker Score: 2938
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 3.32
    Marker Score: 4010
  • Cell Name: double negative T regulatory cell (CL0011024)
    Fold Change: 3.28
    Marker Score: 3168
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 3.26
    Marker Score: 1463
  • Cell Name: CD4-positive, alpha-beta memory T cell (CL0000897)
    Fold Change: 3.21
    Marker Score: 1882
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 3.18
    Marker Score: 3391
  • Cell Name: myelocyte (CL0002193)
    Fold Change: 3.15
    Marker Score: 1361
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 3.14
    Marker Score: 788
  • Cell Name: effector memory CD8-positive, alpha-beta T cell, terminally differentiated (CL0001062)
    Fold Change: 3.11
    Marker Score: 4585
  • Cell Name: basophil (CL0000767)
    Fold Change: 3.11
    Marker Score: 1478
  • Cell Name: mature T cell (CL0002419)
    Fold Change: 3.07
    Marker Score: 30452
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 3.07
    Marker Score: 6136
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 3.07
    Marker Score: 4885
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 3.03
    Marker Score: 1262
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 3.02
    Marker Score: 3457.5
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 3.01
    Marker Score: 3243
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.99
    Marker Score: 7824
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 2.93
    Marker Score: 7158
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: 2.9
    Marker Score: 22646.5
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 2.89
    Marker Score: 4889
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 2.87
    Marker Score: 11054
  • Cell Name: CD14-positive, CD16-positive monocyte (CL0002397)
    Fold Change: 2.87
    Marker Score: 5583
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 2.86
    Marker Score: 99080.5
  • Cell Name: IgG memory B cell (CL0000979)
    Fold Change: 2.85
    Marker Score: 1716
  • Cell Name: class switched memory B cell (CL0000972)
    Fold Change: 2.85
    Marker Score: 2676
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 2.83
    Marker Score: 4925
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 2.81
    Marker Score: 4601
  • Cell Name: type G enteroendocrine cell (CL0000508)
    Fold Change: 2.8
    Marker Score: 964
  • Cell Name: epithelial cell of urethra (CL1000296)
    Fold Change: 2.78
    Marker Score: 2194
  • Cell Name: mucosal invariant T cell (CL0000940)
    Fold Change: 2.78
    Marker Score: 2472.5
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 2.77
    Marker Score: 3809.5
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.76
    Marker Score: 6266
  • Cell Name: alveolar macrophage (CL0000583)
    Fold Change: 2.76
    Marker Score: 70668
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 2.75
    Marker Score: 1989
  • Cell Name: NKp46-positive innate lymphoid cell, human (CL0001076)
    Fold Change: 2.73
    Marker Score: 7967
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 2.72
    Marker Score: 20276
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 2.72
    Marker Score: 3956
  • Cell Name: platelet (CL0000233)
    Fold Change: 2.72
    Marker Score: 1230
  • Cell Name: unswitched memory B cell (CL0000970)
    Fold Change: 2.71
    Marker Score: 1589
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 2.7
    Marker Score: 5289
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 2.69
    Marker Score: 17194
  • Cell Name: type II pneumocyte (CL0002063)
    Fold Change: 2.67
    Marker Score: 17436
  • Cell Name: effector CD4-positive, alpha-beta T cell (CL0001044)
    Fold Change: 2.65
    Marker Score: 2481
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 2.65
    Marker Score: 1293
  • Cell Name: effector CD8-positive, alpha-beta T cell (CL0001050)
    Fold Change: 2.64
    Marker Score: 2226
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 2.64
    Marker Score: 2370
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 2.64
    Marker Score: 1105
  • Cell Name: CD56-positive, CD161-positive immature natural killer cell, human (CL0002338)
    Fold Change: 2.63
    Marker Score: 867
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 2.6
    Marker Score: 919
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 2.59
    Marker Score: 7278
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 2.59
    Marker Score: 3579
  • Cell Name: Unknown (CL0000548)
    Fold Change: 2.59
    Marker Score: 1888
  • Cell Name: pneumocyte (CL0000322)
    Fold Change: 2.59
    Marker Score: 4164
  • Cell Name: activated CD4-positive, alpha-beta T cell (CL0000896)
    Fold Change: 2.59
    Marker Score: 1872
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 2.59
    Marker Score: 2589
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 2.57
    Marker Score: 10514
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 2.57
    Marker Score: 998
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 2.56
    Marker Score: 1459
  • Cell Name: type I NK T cell (CL0000921)
    Fold Change: 2.56
    Marker Score: 2006
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 2.54
    Marker Score: 858.5
  • Cell Name: colon epithelial cell (CL0011108)
    Fold Change: 2.53
    Marker Score: 7946
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 2.53
    Marker Score: 2382
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 2.52
    Marker Score: 1849
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 2.48
    Marker Score: 4388
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.47
    Marker Score: 21491
  • Cell Name: naive B cell (CL0000788)
    Fold Change: 2.47
    Marker Score: 2207.5
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 2.47
    Marker Score: 1634.5
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 2.45
    Marker Score: 2583
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 2.45
    Marker Score: 2865
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 2.44
    Marker Score: 1160
  • Cell Name: mammary gland epithelial cell (CL0002327)
    Fold Change: 2.44
    Marker Score: 867
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 2.43
    Marker Score: 6289
  • Cell Name: memory B cell (CL0000787)
    Fold Change: 2.43
    Marker Score: 1836
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 2.42
    Marker Score: 32548
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.42
    Marker Score: 10443
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 2.41
    Marker Score: 1652
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 2.41
    Marker Score: 2173
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 2.4
    Marker Score: 24328
  • Cell Name: IgA plasma cell (CL0000987)
    Fold Change: 2.4
    Marker Score: 2042
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 2.39
    Marker Score: 572
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 2.39
    Marker Score: 596
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 2.39
    Marker Score: 2426

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Other Information

**Key Characteristics:** 1. **Actin-binding protein:** TAGLN2 is a member of the transgelin family, which is known to bind to actin filaments, regulating their dynamics and organization. 2. **Cellular localization:** TAGLN2 is primarily localized to the cytosol and actin filaments, suggesting its role in modulating actin-based cellular processes. 3. **Differential expression:** TAGLN2 is expressed in various cell types, including early promyelocytes, hematopoietic stem cells, and immune cells, highlighting its importance in cellular differentiation and development. 4. **Regulation of platelet function:** TAGLN2 is involved in regulating platelet activation, aggregation, and degranulation, suggesting its role in hemostasis and thrombosis. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** TAGLN2 regulates actin filament organization and dynamics, which is essential for maintaining cellular shape, motility, and intracellular transport. 2. **Cell signaling:** TAGLN2 interacts with various signaling molecules, including cadherins, to regulate cell-cell adhesion and signaling. 3. **Hemostasis:** TAGLN2 is involved in regulating platelet activation, aggregation, and degranulation, which is critical for maintaining hemostasis and preventing thrombosis. 4. **Immune cell function:** TAGLN2 is expressed in immune cells, including T cells and B cells, and is involved in regulating their activation and function. 5. **Endothelial cell function:** TAGLN2 is expressed in endothelial cells and is involved in regulating their function, including vascular permeability and angiogenesis. **Clinical Significance:** 1. **Hemostatic disorders:** Alterations in TAGLN2 expression or function may contribute to hemostatic disorders, such as thrombocytopenia or bleeding tendencies. 2. **Cancer:** TAGLN2 is overexpressed in various cancers, including breast cancer, suggesting its role in cancer progression and metastasis. 3. **Immune-mediated disorders:** TAGLN2 is involved in regulating immune cell function, and alterations in its expression or function may contribute to immune-mediated disorders, such as autoimmune diseases. 4. **Neurological disorders:** TAGLN2 is expressed in the brain and is involved in regulating neuronal function, suggesting its potential role in neurological disorders, such as Alzheimer's disease. In conclusion, TAGLN2 is a critical regulator of actin dynamics and cellular differentiation, and its dysregulation may contribute to various diseases, including hemostatic disorders, cancer, immune-mediated disorders, and neurological disorders. Further research is necessary to fully elucidate the role of TAGLN2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1908091789

Symbol: TAGL2_HUMAN

Name: Transgelin-2

UniProtKB Accession Codes:

P37802 E9KL39 Q5JRQ6 Q5JRQ7 Q6FGI1 Q9BUH5 Q9H4P0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DOSAC-COBS-2DPAGE 1 DisGeNET 1 DrugBank 1 EMBL 10 EPD 1 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 199
  • Mass: 22391
  • Checksum: 07DFC1652CE2383D
  • Sequence:
    • MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE NFQNWLKDGT 
VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK 
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT 
NRGASQAGMT GYGMPRQIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.