Details for: TAGLN2

Gene ID: 8407

Symbol: TAGLN2

Ensembl ID: ENSG00000158710

Description: transgelin 2

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 544.3433
    Cell Significance Index: -84.6700
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 257.1721
    Cell Significance Index: -65.2300
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 233.2335
    Cell Significance Index: -96.0800
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 218.7039
    Cell Significance Index: -88.8500
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 197.3322
    Cell Significance Index: -93.1700
  • Cell Name: peripheral blood mononuclear cell (CL2000001)
    Fold Change: 188.9634
    Cell Significance Index: -97.2000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 139.2428
    Cell Significance Index: -93.4400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 96.2249
    Cell Significance Index: -91.8700
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 72.8331
    Cell Significance Index: -89.8000
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 23.8542
    Cell Significance Index: -94.1300
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 19.8115
    Cell Significance Index: -60.8500
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 16.3689
    Cell Significance Index: -43.8500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 9.4325
    Cell Significance Index: 166.6900
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: 8.3314
    Cell Significance Index: 59.8400
  • Cell Name: oral mucosa squamous cell (CL1001576)
    Fold Change: 7.2664
    Cell Significance Index: 62.4400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 6.7038
    Cell Significance Index: 349.1900
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: 6.4479
    Cell Significance Index: 119.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.3475
    Cell Significance Index: 153.2900
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 5.1996
    Cell Significance Index: 59.0700
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: 4.9270
    Cell Significance Index: 144.7000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 4.5072
    Cell Significance Index: 27.8900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 4.1909
    Cell Significance Index: 196.9700
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 3.5846
    Cell Significance Index: 267.1600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 3.3352
    Cell Significance Index: 430.8900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 3.2466
    Cell Significance Index: 209.4600
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 3.1599
    Cell Significance Index: 86.0100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 3.0134
    Cell Significance Index: 1645.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 2.5866
    Cell Significance Index: 466.2900
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 2.5609
    Cell Significance Index: 153.7400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 2.5437
    Cell Significance Index: 413.7200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 2.5257
    Cell Significance Index: 1116.6800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 2.3885
    Cell Significance Index: 2156.6300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 2.2679
    Cell Significance Index: 267.4600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 2.1196
    Cell Significance Index: 149.9100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 2.1031
    Cell Significance Index: 258.6000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.7883
    Cell Significance Index: 245.5900
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 1.6821
    Cell Significance Index: 15.4900
  • Cell Name: luminal hormone-sensing cell of mammary gland (CL4033058)
    Fold Change: 1.6038
    Cell Significance Index: 9.8700
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.2837
    Cell Significance Index: 88.7800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.9539
    Cell Significance Index: 122.2800
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.7659
    Cell Significance Index: 17.7000
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.6012
    Cell Significance Index: 31.2300
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.5551
    Cell Significance Index: 25.8800
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.4252
    Cell Significance Index: 80.9200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: 0.3965
    Cell Significance Index: 300.0900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: 0.2945
    Cell Significance Index: 50.2900
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.2261
    Cell Significance Index: 1.5000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 0.0341
    Cell Significance Index: 0.9100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.0059
    Cell Significance Index: 0.6000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0197
    Cell Significance Index: -3.9100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0358
    Cell Significance Index: -26.5000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0401
    Cell Significance Index: -75.4400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0432
    Cell Significance Index: -1.9600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0504
    Cell Significance Index: -93.0400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0606
    Cell Significance Index: -1.0200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0621
    Cell Significance Index: -95.5500
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0687
    Cell Significance Index: -93.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0935
    Cell Significance Index: -52.7200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.1016
    Cell Significance Index: -74.5000
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.1120
    Cell Significance Index: -69.9300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.1127
    Cell Significance Index: -11.1500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.1364
    Cell Significance Index: -86.6000
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.1460
    Cell Significance Index: -52.3800
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.2094
    Cell Significance Index: -95.0400
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2250
    Cell Significance Index: -25.7800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.2453
    Cell Significance Index: -70.5800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.2951
    Cell Significance Index: -62.1600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.3010
    Cell Significance Index: -7.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3263
    Cell Significance Index: -10.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.4544
    Cell Significance Index: -91.1500
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.4802
    Cell Significance Index: -54.8100
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.4859
    Cell Significance Index: -6.6300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.5362
    Cell Significance Index: -62.4900
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.6148
    Cell Significance Index: -89.3700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.6412
    Cell Significance Index: -17.9200
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: -0.6792
    Cell Significance Index: -4.2200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.6818
    Cell Significance Index: -27.9400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.7259
    Cell Significance Index: -36.6800
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.8105
    Cell Significance Index: -17.5600
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.8946
    Cell Significance Index: -23.9300
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.8967
    Cell Significance Index: -93.3700
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.9161
    Cell Significance Index: -19.5100
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -1.0576
    Cell Significance Index: -81.1600
  • Cell Name: Sertoli cell (CL0000216)
    Fold Change: -1.1029
    Cell Significance Index: -15.4700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -1.1434
    Cell Significance Index: -90.5600
  • Cell Name: endothelial cell of placenta (CL0009092)
    Fold Change: -1.1660
    Cell Significance Index: -7.0500
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -1.1943
    Cell Significance Index: -73.2200
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -1.1985
    Cell Significance Index: -75.5400
  • Cell Name: CD4-positive, alpha-beta thymocyte (CL0000810)
    Fold Change: -1.2153
    Cell Significance Index: -20.9500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -1.2597
    Cell Significance Index: -77.4300
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -1.3597
    Cell Significance Index: -91.4300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.4308
    Cell Significance Index: -80.2900
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -1.5755
    Cell Significance Index: -16.3100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -1.6593
    Cell Significance Index: -57.6600
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -1.7205
    Cell Significance Index: -25.7800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -1.7792
    Cell Significance Index: -14.9500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -1.7955
    Cell Significance Index: -19.5200
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.8690
    Cell Significance Index: -98.1300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -1.9201
    Cell Significance Index: -40.1900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -2.0467
    Cell Significance Index: -60.2900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Actin-binding protein:** TAGLN2 is a member of the transgelin family, which is known to bind to actin filaments, regulating their dynamics and organization. 2. **Cellular localization:** TAGLN2 is primarily localized to the cytosol and actin filaments, suggesting its role in modulating actin-based cellular processes. 3. **Differential expression:** TAGLN2 is expressed in various cell types, including early promyelocytes, hematopoietic stem cells, and immune cells, highlighting its importance in cellular differentiation and development. 4. **Regulation of platelet function:** TAGLN2 is involved in regulating platelet activation, aggregation, and degranulation, suggesting its role in hemostasis and thrombosis. **Pathways and Functions:** 1. **Actin cytoskeleton organization:** TAGLN2 regulates actin filament organization and dynamics, which is essential for maintaining cellular shape, motility, and intracellular transport. 2. **Cell signaling:** TAGLN2 interacts with various signaling molecules, including cadherins, to regulate cell-cell adhesion and signaling. 3. **Hemostasis:** TAGLN2 is involved in regulating platelet activation, aggregation, and degranulation, which is critical for maintaining hemostasis and preventing thrombosis. 4. **Immune cell function:** TAGLN2 is expressed in immune cells, including T cells and B cells, and is involved in regulating their activation and function. 5. **Endothelial cell function:** TAGLN2 is expressed in endothelial cells and is involved in regulating their function, including vascular permeability and angiogenesis. **Clinical Significance:** 1. **Hemostatic disorders:** Alterations in TAGLN2 expression or function may contribute to hemostatic disorders, such as thrombocytopenia or bleeding tendencies. 2. **Cancer:** TAGLN2 is overexpressed in various cancers, including breast cancer, suggesting its role in cancer progression and metastasis. 3. **Immune-mediated disorders:** TAGLN2 is involved in regulating immune cell function, and alterations in its expression or function may contribute to immune-mediated disorders, such as autoimmune diseases. 4. **Neurological disorders:** TAGLN2 is expressed in the brain and is involved in regulating neuronal function, suggesting its potential role in neurological disorders, such as Alzheimer's disease. In conclusion, TAGLN2 is a critical regulator of actin dynamics and cellular differentiation, and its dysregulation may contribute to various diseases, including hemostatic disorders, cancer, immune-mediated disorders, and neurological disorders. Further research is necessary to fully elucidate the role of TAGLN2 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 1908091789

Symbol: TAGL2_HUMAN

Name: Transgelin-2

UniProtKB Accession Codes:

P37802 E9KL39 Q5JRQ6 Q5JRQ7 Q6FGI1 Q9BUH5 Q9H4P0

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 1 EMBL 10 Ensembl 3 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MetOSite 1 NCBI Taxonomy 1 OGP 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PRIDE 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 REPRODUCTION-2DPAGE 1 RNAct 1 Reactome 1 RefSeq 3 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 SwissPalm 1 TopDownProteomics 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7788527

Title: Prediction of the coding sequences of unidentified human genes. III. The coding sequences of 40 new genes (KIAA0081-KIAA0120) deduced by analysis of cDNA clones from human cell line KG-1.

PubMed ID: 7788527

DOI: 10.1093/dnares/2.1.37

PubMed ID: 20736409

Title: Systematic mapping and functional analysis of a family of human epididymal secretory sperm-located proteins.

PubMed ID: 20736409

DOI: 10.1074/mcp.m110.001719

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12665801

Title: Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides.

PubMed ID: 12665801

DOI: 10.1038/nbt810

PubMed ID: 18088087

Title: Phosphoproteome of resting human platelets.

PubMed ID: 18088087

DOI: 10.1021/pr0704130

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19413330

Title: Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach.

PubMed ID: 19413330

DOI: 10.1021/ac9004309

PubMed ID: 19690332

Title: Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions.

PubMed ID: 19690332

DOI: 10.1126/scisignal.2000007

PubMed ID: 19608861

Title: Lysine acetylation targets protein complexes and co-regulates major cellular functions.

PubMed ID: 19608861

DOI: 10.1126/science.1175371

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21269460

Title: Initial characterization of the human central proteome.

PubMed ID: 21269460

DOI: 10.1186/1752-0509-5-17

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 24129315

Title: Immunoaffinity enrichment and mass spectrometry analysis of protein methylation.

PubMed ID: 24129315

DOI: 10.1074/mcp.o113.027870

PubMed ID: 25944712

Title: N-terminome analysis of the human mitochondrial proteome.

PubMed ID: 25944712

DOI: 10.1002/pmic.201400617

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 199
  • Mass: 22391
  • Checksum: 07DFC1652CE2383D
  • Sequence:
    • MANRGPAYGL SREVQQKIEK QYDADLEQIL IQWITTQCRK DVGRPQPGRE NFQNWLKDGT 
VLCELINALY PEGQAPVKKI QASTMAFKQM EQISQFLQAA ERYGINTTDI FQTVDLWEGK 
NMACVQRTLM NLGGLAVARD DGLFSGDPNW FPKKSKENPR NFSDNQLQEG KNVIGLQMGT 
NRGASQAGMT GYGMPRQIL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.