Details for: FABP6

Gene ID: 2172

Symbol: FABP6

Ensembl ID: ENSG00000170231

Description: fatty acid binding protein 6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 17.5802
    Cell Significance Index: -8.3000
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 12.7865
    Cell Significance Index: -8.5800
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.7193
    Cell Significance Index: 6.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 2.6034
    Cell Significance Index: 135.2400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.6302
    Cell Significance Index: 46.9700
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 1.0071
    Cell Significance Index: 10.4300
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6456
    Cell Significance Index: 122.8700
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.6281
    Cell Significance Index: 6.2200
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.5797
    Cell Significance Index: 34.8000
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.5356
    Cell Significance Index: 5.2400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.4782
    Cell Significance Index: 431.7600
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4409
    Cell Significance Index: 43.6100
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3962
    Cell Significance Index: 43.1000
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.2969
    Cell Significance Index: 6.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2908
    Cell Significance Index: 83.6600
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.2642
    Cell Significance Index: 144.2600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.2624
    Cell Significance Index: 9.2200
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2462
    Cell Significance Index: 40.0500
  • Cell Name: umbrella cell of urothelium (CL4030056)
    Fold Change: 0.2275
    Cell Significance Index: 2.1000
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 0.1579
    Cell Significance Index: 1.4500
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1033
    Cell Significance Index: 1.7700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.1004
    Cell Significance Index: 1.3700
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0724
    Cell Significance Index: 1.1200
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0573
    Cell Significance Index: 10.3300
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 0.0411
    Cell Significance Index: 0.4500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0268
    Cell Significance Index: 5.3800
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0153
    Cell Significance Index: 3.0300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0140
    Cell Significance Index: 1.6300
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0140
    Cell Significance Index: 6.2100
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 0.0075
    Cell Significance Index: 0.1100
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0055
    Cell Significance Index: 0.6800
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.0039
    Cell Significance Index: 0.1100
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0033
    Cell Significance Index: 1.2000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0006
    Cell Significance Index: -1.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0033
    Cell Significance Index: -6.1800
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0041
    Cell Significance Index: -0.1800
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0055
    Cell Significance Index: -7.5400
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0096
    Cell Significance Index: -7.2400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0110
    Cell Significance Index: -6.9700
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0122
    Cell Significance Index: -9.0600
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0129
    Cell Significance Index: -9.4800
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0134
    Cell Significance Index: -8.3500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0156
    Cell Significance Index: -8.8200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0176
    Cell Significance Index: -0.8000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0182
    Cell Significance Index: -8.2600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0324
    Cell Significance Index: -3.3100
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0338
    Cell Significance Index: -4.9200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0364
    Cell Significance Index: -6.2200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0415
    Cell Significance Index: -8.7500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0455
    Cell Significance Index: -6.2600
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: -0.0461
    Cell Significance Index: -0.6400
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.0463
    Cell Significance Index: -0.7800
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0471
    Cell Significance Index: -3.3300
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0514
    Cell Significance Index: -2.7000
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.0548
    Cell Significance Index: -0.7800
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0592
    Cell Significance Index: -1.4800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0607
    Cell Significance Index: -3.7200
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.0649
    Cell Significance Index: -0.9100
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0732
    Cell Significance Index: -4.9200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0734
    Cell Significance Index: -1.5900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0736
    Cell Significance Index: -9.5100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0760
    Cell Significance Index: -8.7100
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.0823
    Cell Significance Index: -0.5600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0826
    Cell Significance Index: -8.6000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0855
    Cell Significance Index: -1.8200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0866
    Cell Significance Index: -10.2200
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0880
    Cell Significance Index: -1.2600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0981
    Cell Significance Index: -4.3400
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: -0.1037
    Cell Significance Index: -0.7300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1087
    Cell Significance Index: -8.3400
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1128
    Cell Significance Index: -1.6900
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1130
    Cell Significance Index: -3.6200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1171
    Cell Significance Index: -3.0100
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1191
    Cell Significance Index: -2.9700
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1199
    Cell Significance Index: -7.3700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1206
    Cell Significance Index: -9.5500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1214
    Cell Significance Index: -7.6500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.1259
    Cell Significance Index: -1.8800
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1261
    Cell Significance Index: -1.9000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1273
    Cell Significance Index: -9.4900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.1342
    Cell Significance Index: -2.6200
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1360
    Cell Significance Index: -5.1500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1454
    Cell Significance Index: -8.1600
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.1470
    Cell Significance Index: -0.7700
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1500
    Cell Significance Index: -4.9100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1537
    Cell Significance Index: -9.9200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1633
    Cell Significance Index: -5.2000
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1634
    Cell Significance Index: -3.4200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1661
    Cell Significance Index: -8.6500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1693
    Cell Significance Index: -5.9300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1848
    Cell Significance Index: -4.6100
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1857
    Cell Significance Index: -8.6600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1872
    Cell Significance Index: -8.8000
  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: -0.1925
    Cell Significance Index: -1.5200
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1927
    Cell Significance Index: -5.5000
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1938
    Cell Significance Index: -4.8400
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.2107
    Cell Significance Index: -1.9100
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.2149
    Cell Significance Index: -7.8900
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: -0.2251
    Cell Significance Index: -1.5700

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** FABP6 is a small, cytoplasmic protein that binds to fatty acids, facilitating their transport and metabolism. Its structure and function are similar to those of other FABPs, but it exhibits distinct tissue-specific expression patterns. FABP6 is primarily expressed in enterocytes, which are responsible for the absorption of dietary lipids. Its expression is also observed in ciliated cells, intestinal crypt stem cells, and progenitor cells, suggesting a broader role in lipid metabolism and cellular differentiation. **Pathways and Functions:** FABP6 is involved in various lipid-related pathways, including: 1. **Bile acid and bile salt metabolism:** FABP6 is regulated by nuclear receptors, such as NR1H2 and NR1H3, which control bile acid homeostasis. The dysregulation of FABP6 can lead to alterations in bile acid metabolism, contributing to the development of liver diseases. 2. **Fatty acid binding and transport:** FABP6 facilitates the binding and transport of fatty acids, which are essential for energy production and lipid synthesis. 3. **Lipid metabolic process:** FABP6 is involved in the regulation of lipid metabolic pathways, including triglyceride catabolism and triglyceride metabolism. 4. **Negative regulation of cell population proliferation:** FABP6 may play a role in regulating cell growth and proliferation, particularly in the context of intestinal epithelial cells. **Clinical Significance:** Dysregulation of FABP6 has been implicated in various diseases, including: 1. **Liver diseases:** Altered bile acid metabolism, resulting from FABP6 dysregulation, has been linked to liver diseases, such as cholestasis and cirrhosis. 2. **Metabolic disorders:** FABP6 may contribute to the development of metabolic disorders, such as obesity and type 2 diabetes, by regulating lipid metabolism and energy balance. 3. **Cancer:** FABP6 has been identified as a potential biomarker for cancer, particularly in the context of intestinal and liver cancers. In conclusion, FABP6 plays a critical role in regulating bile acid homeostasis and lipid metabolism. Its dysregulation has been linked to various diseases, highlighting the importance of this protein in maintaining physiological balance. Further research is necessary to elucidate the mechanisms underlying FABP6 function and to explore its potential as a therapeutic target for disease prevention and treatment.

Genular Protein ID: 925232205

Symbol: FABP6_HUMAN

Name: Gastrotropin

UniProtKB Accession Codes:

P51161 Q07DR7 Q8TBI3 Q9UGI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 6 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7619861

Title: Cloning and chromosomal localization of the human ileal lipid-binding protein.

PubMed ID: 7619861

DOI: 10.1016/0005-2760(95)00098-w

PubMed ID: 7588781

Title: Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein.

PubMed ID: 7588781

DOI: 10.1111/j.1432-1033.1995.406_2.x

PubMed ID: 17909007

Title: A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma.

PubMed ID: 17909007

DOI: 10.1158/0008-5472.can-06-3690

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11461829

Title: Ligand specificity and conformational stability of human fatty acid-binding proteins.

PubMed ID: 11461829

DOI: 10.1016/s1357-2725(01)00070-x

PubMed ID: 12486725

Title: Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures.

PubMed ID: 12486725

DOI: 10.1002/prot.10289

PubMed ID: 26613247

Title: Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.

PubMed ID: 26613247

DOI: 10.1111/febs.13610

PubMed ID: 19744871

Title: Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.

PubMed ID: 19744871

DOI: 10.1016/j.ymgme.2009.08.001

Sequence Information:

  • Length: 128
  • Mass: 14371
  • Checksum: 173CBC5DBEDADDE1
  • Sequence:
    • MAFTGKFEME SEKNYDEFMK LLGISSDVIE KARNFKIVTE VQQDGQDFTW SQHYSGGHTM 
TNKFTVGKES NIQTMGGKTF KATVQMEGGK LVVNFPNYHQ TSEIVGDKLV EVSTIGGVTY 
ERVSKRLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.