Details for: FABP6

Gene ID: 2172

Symbol: FABP6

Ensembl ID: ENSG00000170231

Description: fatty acid binding protein 6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 2.75
    Marker Score: 4235
  • Cell Name: enterocyte of epithelium proper of ileum (CL1000342)
    Fold Change: 2.68
    Marker Score: 775
  • Cell Name: ciliated columnar cell of tracheobronchial tree (CL0002145)
    Fold Change: 2.15
    Marker Score: 18718
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 1.74
    Marker Score: 656.5
  • Cell Name: ciliated cell (CL0000064)
    Fold Change: 1.44
    Marker Score: 4937
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 866
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 1.33
    Marker Score: 927
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 1.32
    Marker Score: 601
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.21
    Marker Score: 2505
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 1.2
    Marker Score: 2275
  • Cell Name: multi-ciliated epithelial cell (CL0005012)
    Fold Change: 1.12
    Marker Score: 2121
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.05
    Marker Score: 16494
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 1.05
    Marker Score: 1010
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251797
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 1.04
    Marker Score: 4969
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 505
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.97
    Marker Score: 1982
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.91
    Marker Score: 5171
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 323
  • Cell Name: lung ciliated cell (CL1000271)
    Fold Change: 0.88
    Marker Score: 419
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.82
    Marker Score: 259
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.79
    Marker Score: 605.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.76
    Marker Score: 306
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 394
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.76
    Marker Score: 361
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 683
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.7
    Marker Score: 2916
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.67
    Marker Score: 615
  • Cell Name: type L enteroendocrine cell (CL0002279)
    Fold Change: 0.66
    Marker Score: 180
  • Cell Name: M cell of gut (CL0000682)
    Fold Change: 0.62
    Marker Score: 161.5
  • Cell Name: intraepithelial lymphocyte (CL0002496)
    Fold Change: 0.62
    Marker Score: 684
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.54
    Marker Score: 345
  • Cell Name: squamous epithelial cell (CL0000076)
    Fold Change: 0.53
    Marker Score: 359
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 315
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.52
    Marker Score: 762
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.52
    Marker Score: 517.5
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.51
    Marker Score: 225
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.5
    Marker Score: 5143
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: 0.48
    Marker Score: 211
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.48
    Marker Score: 219
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.43
    Marker Score: 713
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.41
    Marker Score: 133
  • Cell Name: alpha-beta T cell (CL0000789)
    Fold Change: 0.41
    Marker Score: 311
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.41
    Marker Score: 138
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4
    Marker Score: 293
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.37
    Marker Score: 116
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.37
    Marker Score: 3453
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.33
    Marker Score: 479
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.33
    Marker Score: 507
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.33
    Marker Score: 85
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.33
    Marker Score: 771
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.32
    Marker Score: 11001
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.29
    Marker Score: 2521
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.29
    Marker Score: 1172
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.29
    Marker Score: 104
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: 0.29
    Marker Score: 82
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.28
    Marker Score: 188
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.28
    Marker Score: 254
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.25
    Marker Score: 280
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.25
    Marker Score: 151
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.24
    Marker Score: 100.5
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.24
    Marker Score: 82
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.23
    Marker Score: 129
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.23
    Marker Score: 551
  • Cell Name: enteroendocrine cell (CL0000164)
    Fold Change: 0.23
    Marker Score: 120
  • Cell Name: microglial cell (CL0000129)
    Fold Change: 0.23
    Marker Score: 421.5
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.22
    Marker Score: 222
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 63
  • Cell Name: epithelial cell of alveolus of lung (CL0010003)
    Fold Change: 0.21
    Marker Score: 95.5
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.21
    Marker Score: 66
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.2
    Marker Score: 266
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 0.2
    Marker Score: 64
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.2
    Marker Score: 82
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.19
    Marker Score: 187
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.19
    Marker Score: 225
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.19
    Marker Score: 128
  • Cell Name: club cell (CL0000158)
    Fold Change: 0.19
    Marker Score: 220
  • Cell Name: melanocyte (CL0000148)
    Fold Change: 0.19
    Marker Score: 75
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.18
    Marker Score: 105
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.18
    Marker Score: 91
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.18
    Marker Score: 61
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.18
    Marker Score: 1694
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.18
    Marker Score: 309
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.18
    Marker Score: 177
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.17
    Marker Score: 50
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.17
    Marker Score: 64
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.17
    Marker Score: 1141
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.17
    Marker Score: 165

Hover over a box to see details here...

Hover over a box to see details here...

Hover over a box to see details here...

Other Information

**Key characteristics:** * FABP6 is a member of the FABP family of proteins, which are involved in the metabolism of fatty acids. * It is a transmembrane protein that is expressed in the cytoplasm and nucleus. * FABP6 is a key regulator of bile acid metabolism, and its expression is often upregulated in conditions such as obesity and liver disease. * It is also involved in the regulation of cell population proliferation and migration. **Pathways and functions:** * FABP6 is involved in the metabolism of both dietary and endogenous bile acids. * It is a key regulator of the enterohepatic circulation, which is the pathway by which bile is recirculated between the liver and the intestines. * FABP6 also plays a role in the regulation of cholesterol and lipid metabolism. * It is involved in the regulation of inflammation and fibrosis. **Clinical significance:** * FABP6 is a potential therapeutic target for the treatment of obesity, liver disease, and other metabolic disorders. * Studies have shown that FABP6 inhibitors can reduce bile acid production and improve liver function. * FABP6 is also a potential target for the treatment of cancer. **Conclusion:** FABP6 is a complex and important protein that plays a critical role in the metabolism of bile acids and salts. Its expression is often upregulated in conditions such as obesity and liver disease, and its inhibition can lead to improvements in liver function.

Genular Protein ID: 925232205

Symbol: FABP6_HUMAN

Name: Gastrotropin

UniProtKB Accession Codes:

P51161 Q07DR7 Q8TBI3 Q9UGI7

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BMRB 1 Bgee 1 BindingDB 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 3 EMBL 7 EPD 1 Ensembl 2 EvolutionaryTrace 1 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 9 PDBsum 6 PIR 1 PRINTS 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 3 RefSeq 3 SIGNOR 1 SMR 1 STRING 1 SUPFAM 1 SwissLipids 1 TreeFam 1 UCSC 1 UniProtKB 4 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7619861

Title: Cloning and chromosomal localization of the human ileal lipid-binding protein.

PubMed ID: 7619861

DOI: 10.1016/0005-2760(95)00098-w

PubMed ID: 7588781

Title: Molecular cloning, expression, and characterization of a human intestinal 15-kDa protein.

PubMed ID: 7588781

DOI: 10.1111/j.1432-1033.1995.406_2.x

PubMed ID: 17909007

Title: A novel variant of ileal bile acid binding protein is up-regulated through nuclear factor-kappaB activation in colorectal adenocarcinoma.

PubMed ID: 17909007

DOI: 10.1158/0008-5472.can-06-3690

PubMed ID: 15372022

Title: The DNA sequence and comparative analysis of human chromosome 5.

PubMed ID: 15372022

DOI: 10.1038/nature02919

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 11461829

Title: Ligand specificity and conformational stability of human fatty acid-binding proteins.

PubMed ID: 11461829

DOI: 10.1016/s1357-2725(01)00070-x

PubMed ID: 12486725

Title: Insights into the bile acid transportation system: the human ileal lipid-binding protein-cholyltaurine complex and its comparison with homologous structures.

PubMed ID: 12486725

DOI: 10.1002/prot.10289

PubMed ID: 26613247

Title: Structural determinants of ligand binding in the ternary complex of human ileal bile acid binding protein with glycocholate and glycochenodeoxycholate obtained from solution NMR.

PubMed ID: 26613247

DOI: 10.1111/febs.13610

PubMed ID: 19744871

Title: Evidence for the Thr79Met polymorphism of the ileal fatty acid binding protein (FABP6) to be associated with type 2 diabetes in obese individuals.

PubMed ID: 19744871

DOI: 10.1016/j.ymgme.2009.08.001

Sequence Information:

  • Length: 128
  • Mass: 14371
  • Checksum: 173CBC5DBEDADDE1
  • Sequence:
    • MAFTGKFEME SEKNYDEFMK LLGISSDVIE KARNFKIVTE VQQDGQDFTW SQHYSGGHTM 
TNKFTVGKES NIQTMGGKTF KATVQMEGGK LVVNFPNYHQ TSEIVGDKLV EVSTIGGVTY 
ERVSKRLA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.