Details for: MFAP5

Gene ID: 8076

Symbol: MFAP5

Ensembl ID: ENSG00000197614

Description: microfibril associated protein 5

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: reticular cell (CL0000432)
    Fold Change: 3.98
    Marker Score: 1454
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 3.78
    Marker Score: 2488
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.61
    Marker Score: 1169
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.59
    Marker Score: 392
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 1.51
    Marker Score: 3711
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.48
    Marker Score: 169467
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.46
    Marker Score: 1458.5
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: 1.39
    Marker Score: 5446
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.26
    Marker Score: 855
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4814
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.09
    Marker Score: 502
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 1.08
    Marker Score: 523
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.07
    Marker Score: 2791
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.06
    Marker Score: 1635.5
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.06
    Marker Score: 36044
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.01
    Marker Score: 233
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 462
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.94
    Marker Score: 389
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5348
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.93
    Marker Score: 374
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.91
    Marker Score: 1224
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5288
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.86
    Marker Score: 255
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.83
    Marker Score: 632.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.73
    Marker Score: 653
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.72
    Marker Score: 311
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.72
    Marker Score: 462
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.71
    Marker Score: 682
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.69
    Marker Score: 1406
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 0.67
    Marker Score: 922
  • Cell Name: fat cell (CL0000136)
    Fold Change: 0.64
    Marker Score: 356
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.61
    Marker Score: 3695
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.61
    Marker Score: 793
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 445
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 173
  • Cell Name: cardiac neuron (CL0010022)
    Fold Change: 0.53
    Marker Score: 658
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.52
    Marker Score: 624
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.5
    Marker Score: 283
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.49
    Marker Score: 932
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 126
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 0.48
    Marker Score: 1872
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.43
    Marker Score: 894.5
  • Cell Name: syncytiotrophoblast cell (CL0000525)
    Fold Change: 0.43
    Marker Score: 354
  • Cell Name: Hofbauer cell (CL3000001)
    Fold Change: 0.43
    Marker Score: 237
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.42
    Marker Score: 182
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.37
    Marker Score: 225
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.36
    Marker Score: 5598
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.35
    Marker Score: 172
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.34
    Marker Score: 645
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.34
    Marker Score: 89
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.33
    Marker Score: 80
  • Cell Name: trophoblast giant cell (CL0002488)
    Fold Change: 0.32
    Marker Score: 104
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.3
    Marker Score: 144
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.3
    Marker Score: 147.5
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.29
    Marker Score: 98
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.28
    Marker Score: 323
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.26
    Marker Score: 134
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 88
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.24
    Marker Score: 102
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.23
    Marker Score: 72
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.23
    Marker Score: 143
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.22
    Marker Score: 64
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 73
  • Cell Name: cardiac muscle cell (CL0000746)
    Fold Change: 0.21
    Marker Score: 2842
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.21
    Marker Score: 289
  • Cell Name: lymphocyte (CL0000542)
    Fold Change: 0.19
    Marker Score: 97
  • Cell Name: epithelial cell of uterus (CL0002149)
    Fold Change: 0.17
    Marker Score: 40
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.17
    Marker Score: 194
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 42
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 80
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.16
    Marker Score: 200
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 0.16
    Marker Score: 100
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.16
    Marker Score: 304
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.16
    Marker Score: 71
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.15
    Marker Score: 665
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.15
    Marker Score: 472
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.15
    Marker Score: 101
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.15
    Marker Score: 115
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.15
    Marker Score: 103
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.15
    Marker Score: 984
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.14
    Marker Score: 141
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.14
    Marker Score: 124
  • Cell Name: innate lymphoid cell (CL0001065)
    Fold Change: 0.14
    Marker Score: 49
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.14
    Marker Score: 99
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.13
    Marker Score: 133
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.13
    Marker Score: 131
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.12
    Marker Score: 178

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Other Information

**Key Characteristics:** 1. **Expression Pattern:** MFAP5 is highly expressed in cells of the ECM, including reticular cells, skeletal muscle fibroblasts, and cells of the intestinal epithelium. 2. **Protein Structure:** MFAP5 is a microfibril-associated protein, interacting with microfibrils to regulate their assembly and organization. 3. **Pathways and Functions:** MFAP5 is involved in collagen-containing ECM, elastic fibre formation, and supramolecular fiber organization, highlighting its critical role in ECM structure and function. 4. **Cell Types:** MFAP5 is expressed in various cell types, including reticular cells, skeletal muscle fibroblasts, and cells of the intestinal epithelium. **Pathways and Functions:** 1. **Collagen-Containing ECM:** MFAP5 interacts with microfibrils to regulate the assembly and organization of collagen-containing ECM, ensuring proper tissue structure and function. 2. **Elastic Fibre Formation:** MFAP5 is involved in the formation of elastic fibres, which provide elasticity and resilience to tissues, such as skin and lungs. 3. **Supramolecular Fiber Organization:** MFAP5 regulates the organization of supramolecular fibers, which are essential for maintaining tissue architecture and function. 4. **Definitive Hemopoiesis:** MFAP5 is involved in the organization of the hematopoietic microenvironment, influencing the development and function of blood cells. **Clinical Significance:** Understanding the role of MFAP5 in ECM organization and regulation has significant implications for various diseases, including: 1. **Fibrotic Diseases:** MFAP5 dysregulation may contribute to fibrotic diseases, such as liver cirrhosis and pulmonary fibrosis, by disrupting ECM structure and function. 2. **Cancer:** MFAP5 expression is altered in various cancers, including colon cancer, suggesting its potential role in tumour progression and metastasis. 3. **Neurological Diseases:** MFAP5 dysregulation may contribute to neurological diseases, such as Alzheimer's disease, by disrupting ECM structure and function in the central nervous system. In conclusion, MFAP5 is a critical gene that regulates ECM organization and structure, influencing various cellular processes and tissue homeostasis. Further research is necessary to fully elucidate the role of MFAP5 in disease pathology and to explore its therapeutic potential.

Genular Protein ID: 3101236014

Symbol: MFAP5_HUMAN

Name: Microfibrillar-associated protein 5

UniProtKB Accession Codes:

Q13361 B0AZL6 D3DUV1 Q7Z490

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 18 Ensembl 3 ExpressionAtlas 1 GO 7 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 3 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 2 RefSeq 2 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 2 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8557636

Title: Further characterization of proteins associated with elastic fiber microfibrils including the molecular cloning of MAGP-2 (MP25).

PubMed ID: 8557636

DOI: 10.1074/jbc.271.2.1096

PubMed ID: 9792630

Title: The exon structure of the human MAGP-2 gene. Similarity with the MAGP-1 gene is confined to two exons encoding a cysteine-rich region.

PubMed ID: 9792630

DOI: 10.1074/jbc.273.45.29309

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 22171320

Title: Human urinary glycoproteomics; attachment site specific analysis of N- and O-linked glycosylations by CID and ECD.

PubMed ID: 22171320

DOI: 10.1074/mcp.m111.013649

PubMed ID: 25434006

Title: MFAP5 loss-of-function mutations underscore the involvement of matrix alteration in the pathogenesis of familial thoracic aortic aneurysms and dissections.

PubMed ID: 25434006

DOI: 10.1016/j.ajhg.2014.10.018

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 173
  • Mass: 19612
  • Checksum: 70CE35B303C710A0
  • Sequence:
    • MSLLGPKVLL FLAAFIITSD WIPLGVNSQR GDDVTQATPE TFTEDPNLVN DPATDETVLA 
VLADIAPSTD DLASLSEKNT TAECWDEKFT CTRLYSVHRP VKQCIHQLCF TSLRRMYIVN 
KEICSRLVCK EHEAMKDELC RQMAGLPPRR LRRSNYFRLP PCENVDLQRP NGL

Genular Protein ID: 427762920

Symbol: B3KW70_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KW70

Database IDs:

ARBA 3 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 4 Ensembl 2 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 InterPro 1 KEGG 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 Proteomes 2 ProteomicsDB 1 RefSeq 5 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 148
  • Mass: 17114
  • Checksum: 51F9DE2AD7D08020
  • Sequence:
    • MSLLGPKVLL FLAAFIITSD WIPLGVNSQR GDDVTQATPE TFTEDPNLVN DPATDETECW 
DEKFTCTRLY SVHRPVKQCI HQLCFTSLRR MYIVNKEICS RLVCKEHEAM KDELCRQMAG 
LPPRRLRRSN YFRLPPCENV DLQRPNGL

Genular Protein ID: 3713229470

Symbol: F5GYX4_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5GYX4

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 151
  • Mass: 17285
  • Checksum: 0E8E24EA2C03EE16
  • Sequence:
    • MSLLGPKVLL FLAAFIITSD DVTQATPETF TEDPNLVNDP ATDETVLAVL ADIAPSTDDL 
ECWDEKFTCT RLYSVHRPVK QCIHQLCFTS LRRMYIVNKE ICSRLVCKEH EAMKDELCRQ 
MAGLPPRRLR RSNYFRLPPC ENVDLQRPNG L

Genular Protein ID: 1061765441

Symbol: F5H413_HUMAN

Name: N/A

UniProtKB Accession Codes:

F5H413

Database IDs:

ARBA 3 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 2 Ensembl 2 ExpressionAtlas 1 GO 2 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 109
  • Mass: 12035
  • Checksum: B943CC3893242EA7
  • Sequence:
    • MSLLGPKVLL FLAAFIITSD WIPLGVNSQR GDDVTQATPE TFTEDPNLVN DPATDETVLA 
VLADIAPSTD DLDELCRQMA GLPPRRLRRS NYFRLPPCEN VDLQRPNGL

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.