Details for: SFRP4

Gene ID: 6424

Symbol: SFRP4

Ensembl ID: ENSG00000106483

Description: secreted frizzled related protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 55.0379
    Cell Significance Index: -13.9600
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 26.4118
    Cell Significance Index: -10.7300
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 24.3369
    Cell Significance Index: -11.4900
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.8400
    Cell Significance Index: 46.0600
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 3.5352
    Cell Significance Index: -13.9500
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 3.2370
    Cell Significance Index: 92.7900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.1458
    Cell Significance Index: 294.6800
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.0454
    Cell Significance Index: 31.6500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: 1.7249
    Cell Significance Index: 25.4600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4787
    Cell Significance Index: 28.8600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: 1.0721
    Cell Significance Index: 25.9700
  • Cell Name: peg cell (CL4033014)
    Fold Change: 1.0561
    Cell Significance Index: 24.4000
  • Cell Name: adipocyte of breast (CL0002617)
    Fold Change: 0.7346
    Cell Significance Index: 9.2500
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.4521
    Cell Significance Index: 27.7900
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4351
    Cell Significance Index: 26.6800
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.3461
    Cell Significance Index: 2.3500
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.2661
    Cell Significance Index: 5.5200
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: 0.2327
    Cell Significance Index: 5.5800
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.2046
    Cell Significance Index: 2.6200
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.2041
    Cell Significance Index: 2.0600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1194
    Cell Significance Index: 42.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.1172
    Cell Significance Index: 5.9200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.0824
    Cell Significance Index: 6.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.0765
    Cell Significance Index: 69.1000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0765
    Cell Significance Index: 15.1800
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: 0.0606
    Cell Significance Index: 8.8100
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: 0.0552
    Cell Significance Index: 75.0000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0354
    Cell Significance Index: 6.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: 0.0286
    Cell Significance Index: 44.0900
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: 0.0270
    Cell Significance Index: 49.7300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0157
    Cell Significance Index: 29.6400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0125
    Cell Significance Index: 1.6000
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.0032
    Cell Significance Index: 2.0200
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0035
    Cell Significance Index: -0.0900
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: -0.0037
    Cell Significance Index: -2.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0046
    Cell Significance Index: -1.3100
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0061
    Cell Significance Index: -1.0000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0076
    Cell Significance Index: -1.3700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0076
    Cell Significance Index: -0.1300
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: -0.0094
    Cell Significance Index: -0.9300
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0156
    Cell Significance Index: -11.7800
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0176
    Cell Significance Index: -13.0600
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0205
    Cell Significance Index: -0.7200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0210
    Cell Significance Index: -13.1300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0231
    Cell Significance Index: -13.0200
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0234
    Cell Significance Index: -12.7800
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0258
    Cell Significance Index: -0.4100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0355
    Cell Significance Index: -7.1200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0454
    Cell Significance Index: -3.0500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0483
    Cell Significance Index: -1.0100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0497
    Cell Significance Index: -5.0800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0640
    Cell Significance Index: -7.8700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0640
    Cell Significance Index: -13.4800
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0677
    Cell Significance Index: -8.7400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0682
    Cell Significance Index: -11.6400
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0841
    Cell Significance Index: -1.2100
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0874
    Cell Significance Index: -3.9600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0957
    Cell Significance Index: -11.1500
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.0962
    Cell Significance Index: -1.2000
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: -0.0993
    Cell Significance Index: -10.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1096
    Cell Significance Index: -8.1700
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1144
    Cell Significance Index: -11.9100
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1177
    Cell Significance Index: -13.4900
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.1244
    Cell Significance Index: -3.1100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1288
    Cell Significance Index: -10.2000
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1409
    Cell Significance Index: -6.6200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.1461
    Cell Significance Index: -3.2000
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.1564
    Cell Significance Index: -10.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.1586
    Cell Significance Index: -4.5700
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1638
    Cell Significance Index: -9.1900
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.1735
    Cell Significance Index: -1.5800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1756
    Cell Significance Index: -11.3300
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.1796
    Cell Significance Index: -3.0300
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1803
    Cell Significance Index: -4.7400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1889
    Cell Significance Index: -9.8400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1913
    Cell Significance Index: -8.9200
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1947
    Cell Significance Index: -5.4400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.1966
    Cell Significance Index: -1.9000
  • Cell Name: ON midget ganglion cell (CL4033046)
    Fold Change: -0.1993
    Cell Significance Index: -2.5200
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.2073
    Cell Significance Index: -9.1700
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.2173
    Cell Significance Index: -11.4100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.2234
    Cell Significance Index: -8.4600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2520
    Cell Significance Index: -2.7400
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.2645
    Cell Significance Index: -8.3700
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2772
    Cell Significance Index: -7.9100
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.2973
    Cell Significance Index: -10.3300
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: -0.3034
    Cell Significance Index: -3.9200
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.3109
    Cell Significance Index: -6.6500
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3134
    Cell Significance Index: -16.2800
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3138
    Cell Significance Index: -11.5200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3171
    Cell Significance Index: -9.3400
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.3220
    Cell Significance Index: -4.5800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3263
    Cell Significance Index: -11.4300
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.3503
    Cell Significance Index: -7.5900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3543
    Cell Significance Index: -11.6000
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3702
    Cell Significance Index: -11.7900
  • Cell Name: CD8-positive, alpha-beta thymocyte (CL0000811)
    Fold Change: -0.3706
    Cell Significance Index: -3.4300
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.3866
    Cell Significance Index: -10.3600
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.3882
    Cell Significance Index: -3.8200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** SFRP4 is a secreted protein that belongs to the Frizzled-related protein family. It is primarily expressed in various cell types, including retinal bipolar neurons, stromal cells of the ovary, uterine smooth muscle cells, colon goblet cells, and fibroblasts from different organs. SFRP4 is characterized by its ability to bind to Wnt proteins, thereby modulating their activity. The protein's structure consists of a secreted domain, a Wnt-binding domain, and a transmembrane domain. **Pathways and Functions:** SFRP4 plays a significant role in regulating the canonical Wnt signaling pathway, which is essential for various cellular processes, including cell proliferation, differentiation, and survival. As a negative regulator, SFRP4 binds to Wnt proteins, inhibiting their interaction with Frizzled receptors and G-protein coupled receptors. This binding event prevents the activation of downstream signaling molecules, such as β-catenin, which are essential for the canonical Wnt pathway. In addition to its role in regulating the canonical Wnt pathway, SFRP4 is also involved in modulating the non-canonical Wnt signaling pathway. The non-canonical pathway is essential for cell migration, polarity, and the regulation of the epithelial-to-mesenchymal transition (EMT). SFRP4 has been shown to have a positive regulatory effect on the apoptotic process, cellular differentiation, and gene expression. Its involvement in these processes suggests that SFRP4 plays a crucial role in maintaining tissue homeostasis and regulating cellular behavior. **Clinical Significance:** Dysregulation of the Wnt signaling pathway has been implicated in various diseases, including cancer, osteoporosis, and metabolic disorders. SFRP4's role in regulating the canonical Wnt pathway makes it an attractive target for therapeutic interventions aimed at modulating Wnt signaling activity. In cancer, SFRP4 has been shown to act as a tumor suppressor, inhibiting the proliferation and survival of cancer cells. Its expression is often downregulated in cancer tissues, suggesting that SFRP4 may be a useful biomarker for diagnosing and monitoring cancer. In addition to its role in cancer, SFRP4 has been implicated in the regulation of bone metabolism. Its involvement in the Wnt signaling pathway makes it a potential target for the treatment of osteoporosis, a disease characterized by bone loss and increased risk of fractures. In conclusion, SFRP4 is a multifunctional protein that plays a crucial role in regulating various cellular processes, including cell differentiation, proliferation, and survival. Its involvement in the Wnt signaling pathway makes it an attractive target for therapeutic interventions aimed at modulating Wnt signaling activity. Further research is needed to fully understand the mechanisms by which SFRP4 regulates Wnt signaling and its clinical significance in various diseases.

Genular Protein ID: 3462235499

Symbol: SFRP4_HUMAN

Name: Secreted frizzled-related protein 4

UniProtKB Accession Codes:

Q6FHJ7 B4DYC1 O14877 Q05BG7 Q1ZYW2 Q4G124 Q6FHM0 Q6PD64

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 2 EMBL 9 Ensembl 1 ExpressionAtlas 1 GO 24 Gene3D 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 Orphanet 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 RefSeq 1 SMART 2 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10211996

Title: Differential expression of frpHE: a novel human stromal protein of the secreted frizzled gene family, during the endometrial cycle and malignancy.

PubMed ID: 10211996

PubMed ID: 12952927

Title: Secreted frizzled-related protein 4 is a potent tumor-derived phosphaturic agent.

PubMed ID: 12952927

DOI: 10.1172/jci18563

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 10728394

Title: Expression of secreted frizzled related proteins 3 and 4 in human ventricular myocardium correlates with apoptosis related gene expression.

PubMed ID: 10728394

DOI: 10.1016/s0008-6363(99)00376-4

PubMed ID: 19480240

Title: Expression of secreted frizzled-related protein 4 (SFRP4) in primary serous ovarian tumours.

PubMed ID: 19480240

PubMed ID: 27355534

Title: Cortical-Bone Fragility--Insights from sFRP4 Deficiency in Pyle's Disease.

PubMed ID: 27355534

DOI: 10.1056/nejmoa1509342

Sequence Information:

  • Length: 346
  • Mass: 39827
  • Checksum: 75D04089E446CE80
  • Sequence:
    • MFLSILVALC LWLHLALGVR GAPCEAVRIP MCRHMPWNIT RMPNHLHHST QENAILAIEQ 
YEELVDVNCS AVLRFFLCAM YAPICTLEFL HDPIKPCKSV CQRARDDCEP LMKMYNHSWP 
ESLACDELPV YDRGVCISPE AIVTDLPEDV KWIDITPDMM VQERPLDVDC KRLSPDRCKC 
KKVKPTLATY LSKNYSYVIH AKIKAVQRSG CNEVTTVVDV KEIFKSSSPI PRTQVPLITN 
SSCQCPHILP HQDVLIMCYE WRSRMMLLEN CLVEKWRDQL SKRSIQWEER LQEQRRTVQD 
KKKTAGRTSR SNPPKPKGKP PAPKPASPKK NIKTRSAQKR TNPKRV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.