Details for: HAS1

Gene ID: 3036

Symbol: HAS1

Ensembl ID: ENSG00000105509

Description: hyaluronan synthase 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 12.5782
    Cell Significance Index: -5.1100
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.9526
    Cell Significance Index: 10.4200
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: 0.6325
    Cell Significance Index: 13.8500
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.5677
    Cell Significance Index: 8.7800
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.4598
    Cell Significance Index: 4.6400
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.2467
    Cell Significance Index: 1.2000
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0984
    Cell Significance Index: 68.0600
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.0878
    Cell Significance Index: 2.5200
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0662
    Cell Significance Index: 29.2500
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.0620
    Cell Significance Index: 1.2100
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0553
    Cell Significance Index: 11.1000
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.0287
    Cell Significance Index: 0.3300
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0216
    Cell Significance Index: 7.7400
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: 0.0020
    Cell Significance Index: 0.0300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0029
    Cell Significance Index: -5.4300
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0043
    Cell Significance Index: -7.8900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0051
    Cell Significance Index: -7.8900
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0065
    Cell Significance Index: -1.1800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0071
    Cell Significance Index: -5.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0076
    Cell Significance Index: -4.8200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0096
    Cell Significance Index: -2.7600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0098
    Cell Significance Index: -7.2700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0109
    Cell Significance Index: -5.9600
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0111
    Cell Significance Index: -6.2600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0129
    Cell Significance Index: -5.8600
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0154
    Cell Significance Index: -0.2200
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0169
    Cell Significance Index: -2.3200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0280
    Cell Significance Index: -5.5500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0323
    Cell Significance Index: -4.7000
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0350
    Cell Significance Index: -5.9800
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.0370
    Cell Significance Index: -0.3200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0385
    Cell Significance Index: -4.7400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0428
    Cell Significance Index: -5.5400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0455
    Cell Significance Index: -2.3900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0469
    Cell Significance Index: -1.1700
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0518
    Cell Significance Index: -5.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0520
    Cell Significance Index: -6.0600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0538
    Cell Significance Index: -6.1600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0570
    Cell Significance Index: -5.9300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0624
    Cell Significance Index: -1.6700
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0661
    Cell Significance Index: -3.3400
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0674
    Cell Significance Index: -0.6500
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0674
    Cell Significance Index: -1.4100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0725
    Cell Significance Index: -5.4000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0758
    Cell Significance Index: -5.8200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0805
    Cell Significance Index: -5.4100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0838
    Cell Significance Index: -3.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: -0.0889
    Cell Significance Index: -1.4100
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0905
    Cell Significance Index: -5.5700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: -0.0916
    Cell Significance Index: -1.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.0946
    Cell Significance Index: -6.1000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0954
    Cell Significance Index: -4.9700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0959
    Cell Significance Index: -3.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.1058
    Cell Significance Index: -3.6800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1067
    Cell Significance Index: -5.9900
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1075
    Cell Significance Index: -1.9000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1138
    Cell Significance Index: -4.6600
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.1149
    Cell Significance Index: -2.8700
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1155
    Cell Significance Index: -5.4300
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1188
    Cell Significance Index: -6.1700
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.1212
    Cell Significance Index: -1.6400
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1212
    Cell Significance Index: -3.3900
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1232
    Cell Significance Index: -3.1700
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.1246
    Cell Significance Index: -2.1400
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1294
    Cell Significance Index: -5.8700
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1409
    Cell Significance Index: -4.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1432
    Cell Significance Index: -4.6900
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1435
    Cell Significance Index: -6.6900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.1474
    Cell Significance Index: -3.5700
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1479
    Cell Significance Index: -4.7100
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1496
    Cell Significance Index: -4.4100
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.1498
    Cell Significance Index: -2.1500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1509
    Cell Significance Index: -1.6400
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1538
    Cell Significance Index: -4.0500
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.1555
    Cell Significance Index: -1.7600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1607
    Cell Significance Index: -5.9000
  • Cell Name: osteoblast (CL0000062)
    Fold Change: -0.1639
    Cell Significance Index: -1.5900
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1669
    Cell Significance Index: -1.6400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1687
    Cell Significance Index: -2.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1756
    Cell Significance Index: -4.6900
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.1818
    Cell Significance Index: -2.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.1836
    Cell Significance Index: -4.9200
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.1879
    Cell Significance Index: -2.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1912
    Cell Significance Index: -4.7700
  • Cell Name: collagen secreting cell (CL0000667)
    Fold Change: -0.1958
    Cell Significance Index: -1.0900
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2022
    Cell Significance Index: -5.7700
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2077
    Cell Significance Index: -1.6500
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: -0.2085
    Cell Significance Index: -0.6200
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.2104
    Cell Significance Index: -4.1600
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2132
    Cell Significance Index: -2.5200
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.2165
    Cell Significance Index: -3.7100
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.2173
    Cell Significance Index: -2.0600
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2191
    Cell Significance Index: -4.6500
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.2241
    Cell Significance Index: -2.2900
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.2380
    Cell Significance Index: -1.2900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2402
    Cell Significance Index: -6.9200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2416
    Cell Significance Index: -1.4800
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.2435
    Cell Significance Index: -2.2600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.2472
    Cell Significance Index: -3.4700
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.2486
    Cell Significance Index: -4.9900

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Expression Pattern:** HAS1 is widely expressed in various cell types, including mesothelial cells, goblet cells, granulocyte monocyte progenitor cells, and immune cells such as GABAergic interneurons and forebrain radial glial cells. 2. **Function:** HAS1 catalyzes the synthesis of hyaluronic acid from UDP-glucose, a process that is essential for maintaining the integrity and structure of the ECM. 3. **Regulation:** HAS1 is regulated by various signaling pathways, including the PI3K/Akt and MAPK/ERK pathways, which play crucial roles in cell proliferation, differentiation, and survival. 4. **Biological Functions:** HAS1 has been implicated in various biological processes, including cell adhesion, migration, inflammation, tissue repair, and immune cell development. **Pathways and Functions:** 1. **Cell Adhesion:** HAS1 regulates cell adhesion by modulating the expression of adhesion molecules and the formation of cell-cell and cell-matrix interactions. 2. **Cell Migration:** HAS1 influences cell migration by regulating the expression of chemokines and cytokines, which are essential for immune cell migration and homing. 3. **Inflammation:** HAS1 modulates inflammation by regulating the production of pro-inflammatory cytokines and chemokines, which are essential for the recruitment of immune cells to sites of inflammation. 4. **Tissue Repair:** HAS1 plays a crucial role in tissue repair by regulating the production of ECM components, which are essential for the maintenance of tissue structure and function. 5. **Immune Cell Development:** HAS1 regulates the development and function of immune cells, including B cells, T cells, and dendritic cells, which are essential for the immune response. **Clinical Significance:** 1. **Cancer:** HAS1 has been implicated in cancer progression, as it regulates the production of HA, which is involved in tumor cell migration and metastasis. 2. **Autoimmune Diseases:** HAS1 has been implicated in autoimmune diseases, such as rheumatoid arthritis and lupus, as it regulates the production of pro-inflammatory cytokines and chemokines. 3. **Inflammatory Disorders:** HAS1 has been implicated in inflammatory disorders, such as asthma and chronic obstructive pulmonary disease (COPD), as it regulates the production of pro-inflammatory cytokines and chemokines. 4. **Neurological Disorders:** HAS1 has been implicated in neurological disorders, such as Alzheimer's disease and Parkinson's disease, as it regulates the production of HA, which is involved in neuronal function and survival. In conclusion, HAS1 plays a critical role in various immunological processes, including cell adhesion, migration, inflammation, tissue repair, and immune cell development. Its dysregulation has been implicated in various diseases, including cancer, autoimmune diseases, inflammatory disorders, and neurological disorders. Further research is needed to fully elucidate the role of HAS1 in immunological processes and its potential as a therapeutic target for the treatment of various diseases.

Genular Protein ID: 2090336097

Symbol: HYAS1_HUMAN

Name: Hyaluronan synthase 1

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 8651928

Title: Molecular cloning of human hyaluronan synthase.

PubMed ID: 8651928

DOI: 10.1006/bbrc.1996.0827

PubMed ID: 8798544

Title: Functional cloning of the cDNA for a human hyaluronan synthase.

PubMed ID: 8798544

DOI: 10.1074/jbc.271.38.23395

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 578
  • Mass: 64832
  • Checksum: 2FE3A44B0D5380FF
  • Sequence:
  • MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR YGLLAFGLYG 
    AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT ISAYQEDPAY LRQCLASARA 
    LLYPRARLRV LMVVDGNRAE DLYMVDMFRE VFADEDPATY VWDGNYHQPW EPAAAGAVGA 
    GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT 
    RLDPMALLEL VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH 
    CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG YATKYTSRSR 
    CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW MTYEAVVSGL FPFFVAATVL 
    RLFYAGRPWA LLWVLLCVQG VALAKAAFAA WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL 
    VTMNQSGWGT SGRRKLAANY VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH 
    LAAGAGAYVG YWVAMLTLYW VGVRRLCRRR TGGYRVQV

Genular Protein ID: 248499347

Symbol: D2N2G5_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Sequence Information:

  • Length: 37
  • Mass: 4043
  • Checksum: 228D304887B46F61
  • Sequence:
  • MRQDAPKPTP AACRCSGLAR RVLTIAFALL ILGLMTW

Genular Protein ID: 3707557302

Symbol: G3V1S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 577
  • Mass: 64704
  • Checksum: 6340521A5A55040B
  • Sequence:
  • MRQDAPKPTP AACRCSGLAR RVLTIAFALL ILGLMTWAYA AGVPLASDRY GLLAFGLYGA 
    FLSAHLVAQS LFAYLEHRRV AAAARGPLDA ATARSVALTI SAYQEDPAYL RQCLASARAL 
    LYPRARLRVL MVVDGNRAED LYMVDMFREV FADEDPATYV WDGNYHQPWE PAAAGAVGAG 
    AYREVEAEDP GRLAVEALVR TRRCVCVAQR WGGKREVMYT AFKALGDSVD YVQVCDSDTR 
    LDPMALLELV RVLDEDPRVG AVGGDVRILN PLDSWVSFLS SLRYWVAFNV ERACQSYFHC 
    VSCISGPLGL YRNNLLQQFL EAWYNQKFLG THCTFGDDRH LTNRMLSMGY ATKYTSRSRC 
    YSETPSSFLR WLSQQTRWSK SYFREWLYNA LWWHRHHAWM TYEAVVSGLF PFFVAATVLR 
    LFYAGRPWAL LWVLLCVQGV ALAKAAFAAW LRGCLRMVLL SLYAPLYMCG LLPAKFLALV 
    TMNQSGWGTS GRRKLAANYV PLLPLALWAL LLLGGLVRSV AHEARADWSG PSRAAEAYHL 
    AAGAGAYVGY WVAMLTLYWV GVRRLCRRRT GGYRVQV

Genular Protein ID: 2660677662

Symbol: Q8IYH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 577
  • Mass: 64789
  • Checksum: 61C9AC33AEDBD183
  • Sequence:
  • MRQDAPKPTP AARRCSGLAR RVLTIAFALL ILGLMTWAYA AGVPLASDRY GLLAFGLYGA 
    FLSAHLVAQS LFAYLEHRRV AAAARGPLDA ATARSVALTI SAYQEDPAYL RQCLASARAL 
    LYPRARLRVL MVVDGNRAED LYMVDMFREV FADEDPATYV WDGNYHQPWE PAAAGAVGAG 
    AYREVEAEDP GRLAVEALVR TRRCVCVAQR WGGKREVMYT AFKALGDSMD YVQVCDSDTR 
    LDPMALLELV RVLDEDPRVG AVGGDVRILN PLDSWVSFLS SLRYWVAFNV ERACQSYFHC 
    VSCISGPLGL YRNNLLQQFL EAWYNQKFLG THCTFGDDRH LTNRMLSMGY ATKYTSRSRC 
    YSETPSSFLR WLSQQTRWSK SYFREWLYNA LWWHRHHAWM TYEAVVSGLF PFFVAATVLR 
    LFYAGRPWAL LWVLLCVQGV ALAKAAFAAW LRGCLRMVLL SLYAPLYMCG LLPAKFLALV 
    TMNQSGWGTS GRRKLAANYV PLLPLALWAL LLLGGLVRSV AHEARADWSG PSRAAEAYHL 
    AAGAGAYVGY WVAMLTLYWV GVRRLCRRRT GGYRVQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.