Details for: HAS1

Gene ID: 3036

Symbol: HAS1

Ensembl ID: ENSG00000105509

Description: hyaluronan synthase 1

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 1.77
    Marker Score: 567
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.09
    Marker Score: 7252
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.09
    Marker Score: 688.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 1.02
    Marker Score: 411
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71826
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48051
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5345
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.84
    Marker Score: 1713
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.84
    Marker Score: 641.5
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 396
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 178
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.63
    Marker Score: 418.5
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 460
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.55
    Marker Score: 1448
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.51
    Marker Score: 186
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 475
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277.5
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.46
    Marker Score: 539
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.43
    Marker Score: 106
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.42
    Marker Score: 408
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.41
    Marker Score: 1127
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.37
    Marker Score: 704
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.37
    Marker Score: 124
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.31
    Marker Score: 382
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.31
    Marker Score: 91
  • Cell Name: CD1c-positive myeloid dendritic cell (CL0002399)
    Fold Change: 0.28
    Marker Score: 721
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.27
    Marker Score: 114
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.27
    Marker Score: 418
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.25
    Marker Score: 170
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.24
    Marker Score: 111
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.23
    Marker Score: 3675
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.22
    Marker Score: 890
  • Cell Name: group 3 innate lymphoid cell (CL0001071)
    Fold Change: 0.2
    Marker Score: 84
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.19
    Marker Score: 1597
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.18
    Marker Score: 6179
  • Cell Name: eurydendroid cell (CL0000253)
    Fold Change: 0.18
    Marker Score: 74
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.18
    Marker Score: 44
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.18
    Marker Score: 188
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.17
    Marker Score: 44
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.17
    Marker Score: 82
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.15
    Marker Score: 92
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.15
    Marker Score: 152
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.15
    Marker Score: 229
  • Cell Name: monocyte (CL0000576)
    Fold Change: 0.14
    Marker Score: 188
  • Cell Name: epicardial adipocyte (CL1000309)
    Fold Change: 0.14
    Marker Score: 67
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.13
    Marker Score: 1282
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.13
    Marker Score: 58
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.13
    Marker Score: 97
  • Cell Name: retinal pigment epithelial cell (CL0002586)
    Fold Change: 0.13
    Marker Score: 39
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 793
  • Cell Name: dendritic cell (CL0000451)
    Fold Change: 0.13
    Marker Score: 90
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.13
    Marker Score: 1227
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.13
    Marker Score: 75
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.13
    Marker Score: 155
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.12
    Marker Score: 75
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.12
    Marker Score: 377
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.12
    Marker Score: 448
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.12
    Marker Score: 1188
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.11
    Marker Score: 61
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.11
    Marker Score: 80
  • Cell Name: macrophage (CL0000235)
    Fold Change: 0.11
    Marker Score: 124
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.11
    Marker Score: 6854
  • Cell Name: lung macrophage (CL1001603)
    Fold Change: 0.11
    Marker Score: 121
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: 0.11
    Marker Score: 438
  • Cell Name: GABAergic amacrine cell (CL4030027)
    Fold Change: 0.1
    Marker Score: 209
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.1
    Marker Score: 25
  • Cell Name: glycinergic amacrine cell (CL4030028)
    Fold Change: 0.1
    Marker Score: 93
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.1
    Marker Score: 161
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.1
    Marker Score: 203
  • Cell Name: large intestine goblet cell (CL1000320)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: granulocyte (CL0000094)
    Fold Change: 0.09
    Marker Score: 42
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.09
    Marker Score: 46
  • Cell Name: ON retinal ganglion cell (CL4023032)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: colon macrophage (CL0009038)
    Fold Change: 0.09
    Marker Score: 25
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.09
    Marker Score: 29
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.09
    Marker Score: 1771
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.09
    Marker Score: 40
  • Cell Name: vasa recta descending limb cell (CL1001285)
    Fold Change: 0.09
    Marker Score: 24
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.09
    Marker Score: 146
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: 0.09
    Marker Score: 94
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.08
    Marker Score: 37
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.08
    Marker Score: 68
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.08
    Marker Score: 23
  • Cell Name: elicited macrophage (CL0000861)
    Fold Change: 0.08
    Marker Score: 492
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.08
    Marker Score: 39
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.08
    Marker Score: 90
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.08
    Marker Score: 18
  • Cell Name: adipocyte of epicardial fat of left ventricle (CL1000311)
    Fold Change: 0.08
    Marker Score: 21
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: 0.08
    Marker Score: 23

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Other Information

**Key characteristics:** * Has a molecular weight of approximately 120 kDa * Is a transmembrane protein * Is expressed in a variety of cell types * Is a key regulator of cell adhesion, migration, and differentiation * Is involved in the assembly of extracellular matrix proteins **Pathways and functions:** * HAS1 is involved in the assembly of the extracellular matrix protein hyaluronan. * Hyaluronan is a major component of the extracellular matrix, which provides structural support and protection for cells. * HAS1 is also involved in the regulation of cell migration and adhesion. * HAS1 is a key regulator of the formation of blood vessels and the growth of new blood vessels. **Clinical significance:** * Mutations in HAS1 have been linked to a number of human diseases, including cardiovascular disease, stroke, and cancer. * HAS1 inhibitors are being investigated as a treatment for these diseases. * HAS1 is a promising target for the treatment of cancer and other diseases that are characterized by abnormal cell migration and adhesion. **Additional notes:** * HAS1 is a highly conserved protein that is found in organisms from yeast to humans. * HAS1 is a member of the hyaluronan synthase family of proteins. * HAS1 is a key regulator of the balance between the formation of new blood vessels and the remodeling of the extracellular matrix.

Genular Protein ID: 2090336097

Symbol: HYAS1_HUMAN

Name: Hyaluronan synthase 1

UniProtKB Accession Codes:

Q92839 Q14470 Q9NS49

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 BRENDA 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CAZy 1 CCDS 1 CORUM 1 CTD 1 ChEBI 11 DMDM 1 DNASU 1 DisGeNET 1 EC 3 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 11 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 Rhea 6 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TCDB 1 TreeFam 1 UCSC 1 UniPathway 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8651928

Title: Molecular cloning of human hyaluronan synthase.

PubMed ID: 8651928

DOI: 10.1006/bbrc.1996.0827

PubMed ID: 8798544

Title: Functional cloning of the cDNA for a human hyaluronan synthase.

PubMed ID: 8798544

DOI: 10.1074/jbc.271.38.23395

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 578
  • Mass: 64832
  • Checksum: 2FE3A44B0D5380FF
  • Sequence:
    • MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR YGLLAFGLYG 
AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT ISAYQEDPAY LRQCLASARA 
LLYPRARLRV LMVVDGNRAE DLYMVDMFRE VFADEDPATY VWDGNYHQPW EPAAAGAVGA 
GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT 
RLDPMALLEL VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH 
CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG YATKYTSRSR 
CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW MTYEAVVSGL FPFFVAATVL 
RLFYAGRPWA LLWVLLCVQG VALAKAAFAA WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL 
VTMNQSGWGT SGRRKLAANY VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH 
LAAGAGAYVG YWVAMLTLYW VGVRRLCRRR TGGYRVQV

Genular Protein ID: 248499347

Symbol: D2N2G5_HUMAN

Name: N/A

UniProtKB Accession Codes:

D2N2G5

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 GO 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 RefSeq 2 SAM 1

Sequence Information:

  • Length: 37
  • Mass: 4043
  • Checksum: 228D304887B46F61
  • Sequence:
    • MRQDAPKPTP AACRCSGLAR RVLTIAFALL ILGLMTW

Genular Protein ID: 3707557302

Symbol: G3V1S7_HUMAN

Name: N/A

UniProtKB Accession Codes:

G3V1S7

Database IDs:

ARBA 4 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 3 EPD 1 Ensembl 2 GO 6 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 1 MANE-Select 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SAM 1 SUPFAM 1 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11181995

Title: The sequence of the human genome.

PubMed ID: 11181995

DOI: 10.1126/science.1058040

PubMed ID: 15057824

Title: The DNA sequence and biology of human chromosome 19.

PubMed ID: 15057824

DOI: 10.1038/nature02399

Sequence Information:

  • Length: 577
  • Mass: 64704
  • Checksum: 6340521A5A55040B
  • Sequence:
    • MRQDAPKPTP AACRCSGLAR RVLTIAFALL ILGLMTWAYA AGVPLASDRY GLLAFGLYGA 
FLSAHLVAQS LFAYLEHRRV AAAARGPLDA ATARSVALTI SAYQEDPAYL RQCLASARAL 
LYPRARLRVL MVVDGNRAED LYMVDMFREV FADEDPATYV WDGNYHQPWE PAAAGAVGAG 
AYREVEAEDP GRLAVEALVR TRRCVCVAQR WGGKREVMYT AFKALGDSVD YVQVCDSDTR 
LDPMALLELV RVLDEDPRVG AVGGDVRILN PLDSWVSFLS SLRYWVAFNV ERACQSYFHC 
VSCISGPLGL YRNNLLQQFL EAWYNQKFLG THCTFGDDRH LTNRMLSMGY ATKYTSRSRC 
YSETPSSFLR WLSQQTRWSK SYFREWLYNA LWWHRHHAWM TYEAVVSGLF PFFVAATVLR 
LFYAGRPWAL LWVLLCVQGV ALAKAAFAAW LRGCLRMVLL SLYAPLYMCG LLPAKFLALV 
TMNQSGWGTS GRRKLAANYV PLLPLALWAL LLLGGLVRSV AHEARADWSG PSRAAEAYHL 
AAGAGAYVGY WVAMLTLYWV GVRRLCRRRT GGYRVQV

Genular Protein ID: 2660677662

Symbol: Q8IYH3_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q8IYH3

Database IDs:

ARBA 4 AlphaFoldDB 1 BioGRID-ORCS 1 CAZy 1 CTD 1 DNASU 1 EMBL 2 GO 1 Genevisible 1 GenomeRNAi 1 InterPro 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Pfam 1 PharmGKB 1 RefSeq 2 SAM 1 SUPFAM 1

Citations:

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

Sequence Information:

  • Length: 577
  • Mass: 64789
  • Checksum: 61C9AC33AEDBD183
  • Sequence:
    • MRQDAPKPTP AARRCSGLAR RVLTIAFALL ILGLMTWAYA AGVPLASDRY GLLAFGLYGA 
FLSAHLVAQS LFAYLEHRRV AAAARGPLDA ATARSVALTI SAYQEDPAYL RQCLASARAL 
LYPRARLRVL MVVDGNRAED LYMVDMFREV FADEDPATYV WDGNYHQPWE PAAAGAVGAG 
AYREVEAEDP GRLAVEALVR TRRCVCVAQR WGGKREVMYT AFKALGDSMD YVQVCDSDTR 
LDPMALLELV RVLDEDPRVG AVGGDVRILN PLDSWVSFLS SLRYWVAFNV ERACQSYFHC 
VSCISGPLGL YRNNLLQQFL EAWYNQKFLG THCTFGDDRH LTNRMLSMGY ATKYTSRSRC 
YSETPSSFLR WLSQQTRWSK SYFREWLYNA LWWHRHHAWM TYEAVVSGLF PFFVAATVLR 
LFYAGRPWAL LWVLLCVQGV ALAKAAFAAW LRGCLRMVLL SLYAPLYMCG LLPAKFLALV 
TMNQSGWGTS GRRKLAANYV PLLPLALWAL LLLGGLVRSV AHEARADWSG PSRAAEAYHL 
AAGAGAYVGY WVAMLTLYWV GVRRLCRRRT GGYRVQV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.