Details for: HOXA4

Gene ID: 3201

Symbol: HOXA4

Ensembl ID: ENSG00000197576

Description: homeobox A4

Associated with

  • Activation of anterior hox genes in hindbrain development during early embryogenesis
    (R-HSA-5617472)
  • Activation of hox genes during differentiation
    (R-HSA-5619507)
  • Developmental biology
    (R-HSA-1266738)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 38.6383
    Cell Significance Index: -6.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 22.9456
    Cell Significance Index: -5.8200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 13.1444
    Cell Significance Index: -5.3400
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 12.1579
    Cell Significance Index: -5.7400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 4.9110
    Cell Significance Index: -6.0600
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.6115
    Cell Significance Index: 9.9700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 1.5332
    Cell Significance Index: -6.0500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.7980
    Cell Significance Index: 78.9400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.6553
    Cell Significance Index: 591.7100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.4689
    Cell Significance Index: 12.5700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.4210
    Cell Significance Index: 68.4800
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.3991
    Cell Significance Index: 43.4100
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.2657
    Cell Significance Index: 15.9500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.2313
    Cell Significance Index: 15.9900
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.2204
    Cell Significance Index: 1.1600
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.1988
    Cell Significance Index: 2.7900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.1925
    Cell Significance Index: 6.6900
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.1752
    Cell Significance Index: 2.5100
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.1716
    Cell Significance Index: 11.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.1631
    Cell Significance Index: 2.7300
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1495
    Cell Significance Index: 17.4200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.1436
    Cell Significance Index: 7.4600
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.0960
    Cell Significance Index: 1.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0927
    Cell Significance Index: 16.7100
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.0892
    Cell Significance Index: 16.9700
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0750
    Cell Significance Index: 3.4000
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0747
    Cell Significance Index: 0.4700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: 0.0676
    Cell Significance Index: 8.3100
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.0664
    Cell Significance Index: 0.5300
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.0294
    Cell Significance Index: 0.8000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0273
    Cell Significance Index: 12.0600
  • Cell Name: peg cell (CL4033014)
    Fold Change: 0.0255
    Cell Significance Index: 0.5900
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0239
    Cell Significance Index: 0.6900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.0185
    Cell Significance Index: 2.5400
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.0152
    Cell Significance Index: 0.3300
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: 0.0134
    Cell Significance Index: 0.7000
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0114
    Cell Significance Index: 0.4000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: 0.0110
    Cell Significance Index: 1.4200
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0064
    Cell Significance Index: 0.3300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0026
    Cell Significance Index: 0.0700
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0017
    Cell Significance Index: -0.9400
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0019
    Cell Significance Index: -1.3700
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0028
    Cell Significance Index: -0.0300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.0067
    Cell Significance Index: -0.3200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0078
    Cell Significance Index: -5.9100
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: -0.0083
    Cell Significance Index: -0.0900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0087
    Cell Significance Index: -6.4600
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.0094
    Cell Significance Index: -0.2000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0107
    Cell Significance Index: -6.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0200
    Cell Significance Index: -0.1700
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0213
    Cell Significance Index: -6.1400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0232
    Cell Significance Index: -2.3700
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.0258
    Cell Significance Index: -0.5400
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0294
    Cell Significance Index: -2.0800
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0333
    Cell Significance Index: -0.2800
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0353
    Cell Significance Index: -6.0300
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: -0.0362
    Cell Significance Index: -0.2400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0416
    Cell Significance Index: -1.9400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.0467
    Cell Significance Index: -1.5000
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0489
    Cell Significance Index: -1.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0523
    Cell Significance Index: -5.9900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.0536
    Cell Significance Index: -0.5600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0542
    Cell Significance Index: -6.3900
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0581
    Cell Significance Index: -0.5800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0643
    Cell Significance Index: -3.9400
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0686
    Cell Significance Index: -5.4300
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0695
    Cell Significance Index: -0.6700
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0834
    Cell Significance Index: -6.4000
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.0855
    Cell Significance Index: -0.8900
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: -0.0881
    Cell Significance Index: -0.6900
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0882
    Cell Significance Index: -6.5700
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1161
    Cell Significance Index: -1.7500
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1226
    Cell Significance Index: -4.5000
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.1307
    Cell Significance Index: -3.8500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.1406
    Cell Significance Index: -3.7600
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: -0.1407
    Cell Significance Index: -0.8000
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1438
    Cell Significance Index: -3.7800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1636
    Cell Significance Index: -6.7000
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.1801
    Cell Significance Index: -1.7700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1825
    Cell Significance Index: -3.6400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.1922
    Cell Significance Index: -4.9100
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: -0.1962
    Cell Significance Index: -1.6600
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.1963
    Cell Significance Index: -2.5400
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.1964
    Cell Significance Index: -5.6300
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.2015
    Cell Significance Index: -3.5600
  • Cell Name: IgG plasma cell (CL0000985)
    Fold Change: -0.2176
    Cell Significance Index: -1.9900
  • Cell Name: epithelial cell of pancreas (CL0000083)
    Fold Change: -0.2179
    Cell Significance Index: -3.5900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2190
    Cell Significance Index: -5.5800
  • Cell Name: corneal epithelial cell (CL0000575)
    Fold Change: -0.2241
    Cell Significance Index: -3.1900
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2283
    Cell Significance Index: -2.1700
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.2310
    Cell Significance Index: -2.3500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2337
    Cell Significance Index: -6.2400
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2358
    Cell Significance Index: -5.8900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: -0.2436
    Cell Significance Index: -3.1200
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.2454
    Cell Significance Index: -3.4900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.2509
    Cell Significance Index: -2.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2541
    Cell Significance Index: -6.2000
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.2541
    Cell Significance Index: -4.9600
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2547
    Cell Significance Index: -6.1700
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2547
    Cell Significance Index: -1.5600

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HOXA4 is a transcription factor that belongs to the Hox gene family, which is characterized by the presence of a homeodomain and a paired domain. The homeodomain is responsible for DNA binding, while the paired domain mediates dimerization with other Hox proteins. HOXA4 is primarily expressed in the hindbrain during early embryogenesis, where it plays a crucial role in the specification of anterior-posterior patterning. Additionally, HOXA4 is involved in the regulation of gene expression during differentiation, morphogenesis, and chromatin remodeling. **Pathways and Functions:** HOXA4 is involved in various signaling pathways that regulate gene expression, including: 1. **Anterior-posterior patterning:** HOXA4 is essential for the specification of anterior-posterior patterning in the hindbrain, where it regulates the expression of other Hox genes and neural crest cells. 2. **Differentiation:** HOXA4 is involved in the regulation of gene expression during differentiation, particularly in the development of neural cells and epithelial cells. 3. **Morphogenesis:** HOXA4 plays a role in the morphogenesis of the embryonic skeletal system, where it regulates the expression of genes involved in bone formation and patterning. 4. **Chromatin remodeling:** HOXA4 is involved in chromatin remodeling, where it regulates the expression of genes by modifying chromatin structure. **Clinical Significance:** Dysregulation of HOXA4 has been implicated in various diseases, including: 1. **Neurodevelopmental disorders:** Mutations in HOXA4 have been associated with neurodevelopmental disorders, such as autism spectrum disorder and schizophrenia. 2. **Cancer:** HOXA4 is overexpressed in certain types of cancer, including leukemia and lymphoma, where it promotes cell proliferation and survival. 3. **Immune system disorders:** HOXA4 is involved in the regulation of immune cell development and function, where dysregulation can lead to immune system disorders, such as autoimmune diseases. In conclusion, HOXA4 is a complex gene that plays a multifaceted role in developmental processes and disease pathogenesis. Further studies are needed to fully elucidate the mechanisms by which HOXA4 regulates gene expression and to explore its therapeutic potential in various diseases.

Genular Protein ID: 4158274289

Symbol: HXA4_HUMAN

Name: Homeobox protein Hox-A4

UniProtKB Accession Codes:

Q00056 A4D180 O43366

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 7 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1675427

Title: Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.

PubMed ID: 1675427

DOI: 10.1128/mcb.11.7.3573-3583.1991

PubMed ID: 1981366

Title: Expression of HOX homeogenes in human neuroblastoma cell culture lines.

PubMed ID: 1981366

DOI: 10.1111/j.1432-0436.1990.tb00458.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 2571574

Title: Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.

PubMed ID: 2571574

DOI: 10.1016/0888-7543(89)90054-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 320
  • Mass: 34499
  • Checksum: D9B9C98901B06FE4
  • Sequence:
    • MTMSSFLINS NYIEPKFPPF EEYAQHSGSG GADGGPGGGP GYQQPPAPPT QHLPLQQPQL 
PHAGGGREPT ASYYAPRTAR EPAYPAAALY PAHGAADTAY PYGYRGGASP GRPPQPEQPP 
AQAKGPAHGL HASHVLQPQL PPPLQPRAVP PAAPRRCEAA PATPGVPAGG SAPACPLLLA 
DKSPLGLKGK EPVVYPWMKK IHVSAVNPSY NGGEPKRSRT AYTRQQVLEL EKEFHFNRYL 
TRRRRIEIAH TLCLSERQVK IWFQNRRMKW KKDHKLPNTK MRSSNSASAS AGPPGKAQTQ 
SPHLHPHPHP STSTPVPSSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.