Details for: HOXA4

Gene ID: 3201

Symbol: HOXA4

Ensembl ID: ENSG00000197576

Description: homeobox A4

Associated with

  • Activation of anterior hox genes in hindbrain development during early embryogenesis
    (R-HSA-5617472)
  • Activation of hox genes during differentiation
    (R-HSA-5619507)
  • Developmental biology
    (R-HSA-1266738)
  • Anatomical structure morphogenesis
    (GO:0009653)
  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic skeletal system morphogenesis
    (GO:0048704)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.39
    Marker Score: 1115
  • Cell Name: peripheral nervous system neuron (CL2000032)
    Fold Change: 1.26
    Marker Score: 1412
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 1.23
    Marker Score: 811
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4810.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.14
    Marker Score: 7600
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.98
    Marker Score: 506
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: primary sensory neuron (sensu Teleostei) (CL0000531)
    Fold Change: 0.98
    Marker Score: 329
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.97
    Marker Score: 459
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5314
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.92
    Marker Score: 370
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2741
  • Cell Name: motor neuron (CL0000100)
    Fold Change: 0.91
    Marker Score: 543
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.85
    Marker Score: 1481
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.84
    Marker Score: 530
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.82
    Marker Score: 1930
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: inhibitory motor neuron (CL0008015)
    Fold Change: 0.77
    Marker Score: 362
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 393
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.75
    Marker Score: 680
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.73
    Marker Score: 558.5
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.71
    Marker Score: 9335
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.7
    Marker Score: 660
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.64
    Marker Score: 682
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.62
    Marker Score: 425
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.6
    Marker Score: 857
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.56
    Marker Score: 174
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.55
    Marker Score: 192
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.54
    Marker Score: 1277
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.53
    Marker Score: 502
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.47
    Marker Score: 895.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 274
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.44
    Marker Score: 918
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.44
    Marker Score: 138
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.42
    Marker Score: 408
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.37
    Marker Score: 755
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.36
    Marker Score: 109
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.35
    Marker Score: 167
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.33
    Marker Score: 564
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 0.33
    Marker Score: 469
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.31
    Marker Score: 128
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.31
    Marker Score: 89.5
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.3
    Marker Score: 200
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.3
    Marker Score: 168
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.28
    Marker Score: 80
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.27
    Marker Score: 63
  • Cell Name: thymocyte (CL0000893)
    Fold Change: 0.27
    Marker Score: 281
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.27
    Marker Score: 86
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.27
    Marker Score: 140
  • Cell Name: renal principal cell (CL0005009)
    Fold Change: 0.26
    Marker Score: 203
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.26
    Marker Score: 167
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.26
    Marker Score: 263
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.26
    Marker Score: 168
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.25
    Marker Score: 135
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.25
    Marker Score: 104
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.25
    Marker Score: 260
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 0.24
    Marker Score: 208
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.24
    Marker Score: 63
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.24
    Marker Score: 214
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.24
    Marker Score: 160
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.23
    Marker Score: 74
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.23
    Marker Score: 55
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.23
    Marker Score: 2292
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.23
    Marker Score: 347
  • Cell Name: smooth muscle cell of large intestine (CL1000279)
    Fold Change: 0.22
    Marker Score: 84
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.22
    Marker Score: 132
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.22
    Marker Score: 62
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 74
  • Cell Name: oocyte (CL0000023)
    Fold Change: 0.22
    Marker Score: 54
  • Cell Name: ciliated epithelial cell (CL0000067)
    Fold Change: 0.22
    Marker Score: 99.5
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.22
    Marker Score: 57
  • Cell Name: podocyte (CL0000653)
    Fold Change: 0.22
    Marker Score: 80
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.21
    Marker Score: 73
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.21
    Marker Score: 54
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 0.21
    Marker Score: 227
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.21
    Marker Score: 139
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.21
    Marker Score: 549
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.21
    Marker Score: 560
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.21
    Marker Score: 531
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.2
    Marker Score: 247
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.2
    Marker Score: 195
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.2
    Marker Score: 52
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.19
    Marker Score: 91
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.18
    Marker Score: 164
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.18
    Marker Score: 645
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.18
    Marker Score: 83
  • Cell Name: luminal epithelial cell of mammary gland (CL0002326)
    Fold Change: 0.18
    Marker Score: 313
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.17
    Marker Score: 200
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.17
    Marker Score: 234
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.17
    Marker Score: 99
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.17
    Marker Score: 243

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Other Information

**Key characteristics:** * HOXA4 is a highly conserved gene, with a similar sequence in mammals, birds, and fish. * It is expressed in various tissues in the embryo, including the neural tube, heart, and endoderm. * HOXA4 is known to regulate the expression of other genes involved in A/P patterning, such as Hox genes. * It is a key regulator of neural tube specification, as mutations in HOXA4 can lead to neural tube defects. **Pathways and functions:** * HOXA4 is involved in various pathways involved in embryonic development, including: * Activation of anterior hox genes in hindbrain development. * Activation of hox genes during differentiation. * Specification of the anterior/posterior (A/P) axis. * Chromatin remodeling and nuclear body formation. * Regulation of neural tube specification. * It is also involved in the development of the heart, endoderm, and other tissues. **Clinical significance:** * Mutations in HOXA4 have been linked to a variety of human diseases, including: * Neural tube defects. * Heart defects. * Anomalies of the central nervous system. * Developmental disorders. **Conclusion:** HOXA4 is a critical gene for the development of the mammalian embryo. Its mutations can have significant consequences for human health, highlighting its importance in maintaining proper neural tube specification and preventing various developmental disorders.

Genular Protein ID: 4158274289

Symbol: HXA4_HUMAN

Name: Homeobox protein Hox-A4

UniProtKB Accession Codes:

Q00056 A4D180 O43366

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 5 EPD 1 Ensembl 2 ExpressionAtlas 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 2 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 Reactome 1 RefSeq 1 SAM 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 1675427

Title: Alteration of homeobox gene expression by N-ras transformation of PA-1 human teratocarcinoma cells.

PubMed ID: 1675427

DOI: 10.1128/mcb.11.7.3573-3583.1991

PubMed ID: 1981366

Title: Expression of HOX homeogenes in human neuroblastoma cell culture lines.

PubMed ID: 1981366

DOI: 10.1111/j.1432-0436.1990.tb00458.x

PubMed ID: 12853948

Title: The DNA sequence of human chromosome 7.

PubMed ID: 12853948

DOI: 10.1038/nature01782

PubMed ID: 12690205

Title: Human chromosome 7: DNA sequence and biology.

PubMed ID: 12690205

DOI: 10.1126/science.1083423

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

PubMed ID: 2571574

Title: Isolation, chromosomal localization, and nucleotide sequence of the human HOX 1.4 homeobox.

PubMed ID: 2571574

DOI: 10.1016/0888-7543(89)90054-2

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 320
  • Mass: 34499
  • Checksum: D9B9C98901B06FE4
  • Sequence:
    • MTMSSFLINS NYIEPKFPPF EEYAQHSGSG GADGGPGGGP GYQQPPAPPT QHLPLQQPQL 
PHAGGGREPT ASYYAPRTAR EPAYPAAALY PAHGAADTAY PYGYRGGASP GRPPQPEQPP 
AQAKGPAHGL HASHVLQPQL PPPLQPRAVP PAAPRRCEAA PATPGVPAGG SAPACPLLLA 
DKSPLGLKGK EPVVYPWMKK IHVSAVNPSY NGGEPKRSRT AYTRQQVLEL EKEFHFNRYL 
TRRRRIEIAH TLCLSERQVK IWFQNRRMKW KKDHKLPNTK MRSSNSASAS AGPPGKAQTQ 
SPHLHPHPHP STSTPVPSSI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.