Details for: ISLR

Gene ID: 3671

Symbol: ISLR

Ensembl ID: ENSG00000129009

Description: immunoglobulin superfamily containing leucine rich repeat

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.5615
    Cell Significance Index: -19.1500
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 40.2208
    Cell Significance Index: -16.3400
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 17.1041
    Cell Significance Index: -16.3300
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 10.5543
    Cell Significance Index: 135.1700
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 5.9490
    Cell Significance Index: 36.8100
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 2.9004
    Cell Significance Index: 60.7100
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.8302
    Cell Significance Index: 44.9000
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.9535
    Cell Significance Index: 268.2700
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.3564
    Cell Significance Index: 9.1900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 1.3509
    Cell Significance Index: 7.9300
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.8389
    Cell Significance Index: 4.1900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.7880
    Cell Significance Index: 15.3800
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 0.5455
    Cell Significance Index: 5.9300
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: 0.3954
    Cell Significance Index: 45.1300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.3591
    Cell Significance Index: 2.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2536
    Cell Significance Index: 7.2700
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.2492
    Cell Significance Index: 1.5600
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0845
    Cell Significance Index: 1.4200
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0417
    Cell Significance Index: 26.0600
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.0416
    Cell Significance Index: 0.8900
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0319
    Cell Significance Index: 1.6100
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0200
    Cell Significance Index: 0.3100
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0194
    Cell Significance Index: 36.5200
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0144
    Cell Significance Index: 1.8400
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.0136
    Cell Significance Index: 2.7300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0003
    Cell Significance Index: -0.1900
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0007
    Cell Significance Index: -0.5500
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0010
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0068
    Cell Significance Index: -1.4400
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.0092
    Cell Significance Index: -0.0500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0125
    Cell Significance Index: -7.9500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0125
    Cell Significance Index: -23.0400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0142
    Cell Significance Index: -2.4300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0152
    Cell Significance Index: -23.4700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0254
    Cell Significance Index: -19.2500
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0372
    Cell Significance Index: -16.8700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0470
    Cell Significance Index: -16.8600
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0601
    Cell Significance Index: -17.2800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0724
    Cell Significance Index: -13.0400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0880
    Cell Significance Index: -11.3700
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0919
    Cell Significance Index: -18.2300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0928
    Cell Significance Index: -13.4900
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1100
    Cell Significance Index: -5.1700
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1309
    Cell Significance Index: -16.1000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.1371
    Cell Significance Index: -5.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1424
    Cell Significance Index: -16.3100
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1624
    Cell Significance Index: -19.1500
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1667
    Cell Significance Index: -4.6600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1700
    Cell Significance Index: -19.8100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1728
    Cell Significance Index: -17.6500
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: -0.1803
    Cell Significance Index: -1.8200
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.1843
    Cell Significance Index: -19.2000
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.2273
    Cell Significance Index: -1.0500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.2431
    Cell Significance Index: -6.2500
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2433
    Cell Significance Index: -18.1300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2446
    Cell Significance Index: -18.7700
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2499
    Cell Significance Index: -11.6500
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.2524
    Cell Significance Index: -2.4700
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.2691
    Cell Significance Index: -2.2600
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2696
    Cell Significance Index: -7.0900
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2807
    Cell Significance Index: -14.6200
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.2918
    Cell Significance Index: -12.6900
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3073
    Cell Significance Index: -9.0500
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3165
    Cell Significance Index: -19.9500
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.3276
    Cell Significance Index: -4.9000
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.3339
    Cell Significance Index: -3.9400
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3394
    Cell Significance Index: -11.7900
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.3675
    Cell Significance Index: -20.6200
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3838
    Cell Significance Index: -4.3600
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: -0.3897
    Cell Significance Index: -3.7700
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3956
    Cell Significance Index: -20.5500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4007
    Cell Significance Index: -21.0400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.4139
    Cell Significance Index: -1.9800
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.4285
    Cell Significance Index: -4.2400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.4405
    Cell Significance Index: -14.0300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.4453
    Cell Significance Index: -15.6000
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.4486
    Cell Significance Index: -5.6500
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.4872
    Cell Significance Index: -21.5500
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.4892
    Cell Significance Index: -16.0200
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.4950
    Cell Significance Index: -12.3500
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.5024
    Cell Significance Index: -1.1600
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5129
    Cell Significance Index: -18.8300
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.5264
    Cell Significance Index: -14.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.5387
    Cell Significance Index: -20.4000
  • Cell Name: fibroblast (CL0000057)
    Fold Change: -0.5422
    Cell Significance Index: -5.0900
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.5438
    Cell Significance Index: -3.4200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.5755
    Cell Significance Index: -5.8800
  • Cell Name: theca cell (CL0000503)
    Fold Change: -0.5923
    Cell Significance Index: -3.4800
  • Cell Name: L5/6 near-projecting glutamatergic neuron (CL4030067)
    Fold Change: -0.6493
    Cell Significance Index: -3.4000
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.6546
    Cell Significance Index: -17.5400
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: -0.6605
    Cell Significance Index: -6.1300
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.6845
    Cell Significance Index: -21.6500
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: -0.6986
    Cell Significance Index: -6.3400
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.6996
    Cell Significance Index: -17.4500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.7007
    Cell Significance Index: -18.7100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.7151
    Cell Significance Index: -4.4600
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.7230
    Cell Significance Index: -7.3500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.7375
    Cell Significance Index: -18.7900
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.7467
    Cell Significance Index: -18.6500
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.7676
    Cell Significance Index: -15.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** ISLR is a member of the immunoglobulin superfamily, characterized by the presence of leucine-rich repeats (LRRs) in its protein structure. These LRRs are known to mediate cell-cell interactions and protein-protein interactions, facilitating the exchange of signals between cells. The gene's expression profile, which spans multiple cell types, highlights its broad role in tissue development and maintenance. The absence of specific information on the gene's function or regulation poses an intriguing question about the mechanisms underlying its expression and activity. **Pathways and Functions:** ISLR is implicated in several critical pathways, including: 1. **Cell Adhesion:** ISLR mediates cell-cell interactions through its LRRs, influencing cell migration, differentiation, and tissue organization. 2. **Extracellular Exosome:** ISLR is involved in the regulation of extracellular exosome formation and function, which plays a crucial role in intercellular communication and tissue repair. 3. **Platelet Activation:** ISLR interacts with platelet receptors, modulating platelet activation, aggregation, and signaling, thereby influencing hemostasis and thrombosis. 4. **Signaling and Aggregation:** ISLR participates in signaling pathways that regulate cell growth, differentiation, and survival, as well as the aggregation of platelets and other cells. **Clinical Significance:** The clinical significance of ISLR remains to be fully elucidated, but its involvement in various cellular processes and pathways suggests potential implications in: 1. **Cancer:** Alterations in ISLR expression or function could contribute to tumor progression, metastasis, or resistance to therapy. 2. **Cardiovascular Disease:** ISLR's role in platelet activation and aggregation may influence the development of cardiovascular diseases, such as atherosclerosis or thrombosis. 3. **Immunological Disorders:** ISLR's involvement in cell adhesion and signaling pathways may contribute to the pathogenesis of autoimmune or inflammatory diseases. 4. **Regenerative Medicine:** Understanding the mechanisms underlying ISLR's expression and function could provide insights into tissue repair and regeneration, particularly in the context of cardiovascular or musculoskeletal diseases. In conclusion, the ISLR gene is a fascinating example of a protein involved in multiple cellular processes and pathways, with significant implications for our understanding of immunological and cardiovascular diseases. Further research is necessary to elucidate the gene's function, regulation, and clinical significance, ultimately paving the way for the development of novel therapeutic strategies.

Genular Protein ID: 935511460

Symbol: ISLR_HUMAN

Name: Immunoglobulin superfamily containing leucine-rich repeat protein

UniProtKB Accession Codes:

O14498

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 9 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9325048

Title: Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR).

PubMed ID: 9325048

DOI: 10.1006/geno.1997.4889

PubMed ID: 10512678

Title: Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression.

PubMed ID: 10512678

DOI: 10.1006/geno.1999.5934

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 428
  • Mass: 45997
  • Checksum: 3163F89D59F6F3A4
  • Sequence:
    • MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA NVTTLSLSAN 
RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN 
LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINEN 
PFDCTCGIVW LKTWALTTAV SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP 
SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS 
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG GEDTLGRRFH 
GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV AEGVPGQLPP GLLLLGQSLL 
LFFFLTSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.