Details for: ISLR

Gene ID: 3671

Symbol: ISLR

Ensembl ID: ENSG00000129009

Description: immunoglobulin superfamily containing leucine rich repeat

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 4.05
    Marker Score: 5820
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 3.16
    Marker Score: 4349
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 3.09
    Marker Score: 20097
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 2.64
    Marker Score: 11388
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 2.6
    Marker Score: 29325
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 2.31
    Marker Score: 3558
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 2.08
    Marker Score: 478
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 2.03
    Marker Score: 5314
  • Cell Name: Unknown (CL0002371)
    Fold Change: 1.76
    Marker Score: 1868
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 1.69
    Marker Score: 22295
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.53
    Marker Score: 5913
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.5
    Marker Score: 788
  • Cell Name: mural cell (CL0008034)
    Fold Change: 1.47
    Marker Score: 169151.5
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 1.43
    Marker Score: 1544
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 1.39
    Marker Score: 344
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 1.35
    Marker Score: 667
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 1.34
    Marker Score: 302
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 1.13
    Marker Score: 294
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 1.08
    Marker Score: 2030
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.06
    Marker Score: 672
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71813
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48038
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.98
    Marker Score: 1604
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.97
    Marker Score: 276
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5302
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.92
    Marker Score: 891
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.91
    Marker Score: 315
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 0.89
    Marker Score: 3300
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.89
    Marker Score: 1156
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5280
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 621
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.81
    Marker Score: 1002
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.81
    Marker Score: 635
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1259
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 705
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.74
    Marker Score: 382
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 177
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.68
    Marker Score: 449
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.68
    Marker Score: 307
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.67
    Marker Score: 444
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.62
    Marker Score: 717
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.62
    Marker Score: 21142
  • Cell Name: erythroid lineage cell (CL0000764)
    Fold Change: 0.61
    Marker Score: 302.5
  • Cell Name: adipose microvascular endothelial cell (CL2000072)
    Fold Change: 0.58
    Marker Score: 172
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 236
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.56
    Marker Score: 235
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.56
    Marker Score: 395
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 147
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.55
    Marker Score: 365
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.55
    Marker Score: 123
  • Cell Name: basal cell of epithelium of trachea (CL1000348)
    Fold Change: 0.54
    Marker Score: 3992
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.53
    Marker Score: 230
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.53
    Marker Score: 131
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.53
    Marker Score: 138
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.5
    Marker Score: 430
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.49
    Marker Score: 326
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.48
    Marker Score: 2018
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.47
    Marker Score: 117
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.47
    Marker Score: 117
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: 0.47
    Marker Score: 896
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.46
    Marker Score: 4600
  • Cell Name: ventricular cardiac muscle cell (CL2000046)
    Fold Change: 0.45
    Marker Score: 188
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.45
    Marker Score: 538
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.44
    Marker Score: 312
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.43
    Marker Score: 120.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.42
    Marker Score: 122
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.4
    Marker Score: 102
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 0.37
    Marker Score: 350
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.36
    Marker Score: 191
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.35
    Marker Score: 337
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.35
    Marker Score: 111
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.34
    Marker Score: 97
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.33
    Marker Score: 119
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.32
    Marker Score: 81
  • Cell Name: glandular epithelial cell (CL0000150)
    Fold Change: 0.32
    Marker Score: 777
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.31
    Marker Score: 430.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.3
    Marker Score: 306.5
  • Cell Name: precursor cell (CL0011115)
    Fold Change: 0.3
    Marker Score: 73
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.3
    Marker Score: 508
  • Cell Name: cardiac mesenchymal cell (CL0000569)
    Fold Change: 0.29
    Marker Score: 71
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: 0.29
    Marker Score: 347
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.29
    Marker Score: 2718
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.28
    Marker Score: 189
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.28
    Marker Score: 120
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.27
    Marker Score: 155
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.27
    Marker Score: 153
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.27
    Marker Score: 282
  • Cell Name: neuroendocrine cell (CL0000165)
    Fold Change: 0.26
    Marker Score: 102
  • Cell Name: Schwann cell (CL0002573)
    Fold Change: 0.26
    Marker Score: 91
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.26
    Marker Score: 544
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.26
    Marker Score: 520
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.26
    Marker Score: 89
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.26
    Marker Score: 300
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.25
    Marker Score: 445

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Other Information

**Key characteristics** * ISLRs are type I transmembrane proteins with a conserved leucine-rich repeat (LRR) domain. * They are expressed in different cell types, including epithelial cells, endothelial cells, immune cells, and stromal cells. * ISLRs are known to interact with various extracellular matrix proteins, including collagen, fibronectin, and proteoglycans. * They are involved in cell adhesion, migration, and signaling pathways. * ISLRs are expressed in high levels in tissues such as the lungs, skin, and ovary. **Pathways and functions** * ISLRs are involved in cell adhesion by binding to extracellular matrix proteins and facilitating cell-cell interactions. * They are also involved in cell migration and invasion by binding to extracellular matrix proteins and guiding cell movement. * ISLRs are important for the regulation of immune cell function. * They are expressed in high levels in immune cells, where they play a role in regulating immune cell adhesion, migration, and signaling. * ISLRs are also expressed in epithelial cells, where they are involved in cell adhesion and tissue organization. **Clinical significance** Mutations in the ISLR gene have been linked to various human diseases, including asthma, rheumatoid arthritis, and cancer. These mutations can disrupt the normal function of ISLRs, leading to the development of these diseases. **Conclusion** The ISLR gene is an important gene that plays a critical role in cell adhesion, migration, and signaling pathways in various cell types. Mutations in the ISLR gene have been linked to various human diseases, highlighting its importance in human health.

Genular Protein ID: 935511460

Symbol: ISLR_HUMAN

Name: Immunoglobulin superfamily containing leucine-rich repeat protein

UniProtKB Accession Codes:

O14498

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 4 ExpressionAtlas 1 GO 4 Gene3D 2 GeneCards 1 GeneTree 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 8 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 2 SMART 3 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9325048

Title: Cloning of the cDNA for a new member of the immunoglobulin superfamily (ISLR) containing leucine-rich repeat (LRR).

PubMed ID: 9325048

DOI: 10.1006/geno.1997.4889

PubMed ID: 10512678

Title: Human and mouse ISLR (immunoglobulin superfamily containing leucine-rich repeat) genes: genomic structure and tissue expression.

PubMed ID: 10512678

DOI: 10.1006/geno.1999.5934

PubMed ID: 12975309

Title: The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.

PubMed ID: 12975309

DOI: 10.1101/gr.1293003

PubMed ID: 16959974

Title: The consensus coding sequences of human breast and colorectal cancers.

PubMed ID: 16959974

DOI: 10.1126/science.1133427

Sequence Information:

  • Length: 428
  • Mass: 45997
  • Checksum: 3163F89D59F6F3A4
  • Sequence:
    • MQELHLLWWA LLLGLAQACP EPCDCGEKYG FQIADCAYRD LESVPPGFPA NVTTLSLSAN 
RLPGLPEGAF REVPLLQSLW LAHNEIRTVA AGALASLSHL KSLDLSHNLI SDFAWSDLHN 
LSALQLLKMD SNELTFIPRD AFRSLRALRS LQLNHNRLHT LAEGTFTPLT ALSHLQINEN 
PFDCTCGIVW LKTWALTTAV SIPEQDNIAC TSPHVLKGTP LSRLPPLPCS APSVQLSYQP 
SQDGAELRPG FVLALHCDVD GQPAPQLHWH IQIPSGIVEI TSPNVGTDGR ALPGTPVASS 
QPRFQAFANG SLLIPDFGKL EEGTYSCLAT NELGSAESSV DVALATPGEG GEDTLGRRFH 
GKAVEGKGCY TVDNEVQPSG PEDNVVIIYL SRAGNPEAAV AEGVPGQLPP GLLLLGQSLL 
LFFFLTSF

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.