Details for: CLEC3B

Gene ID: 7123

Symbol: CLEC3B

Ensembl ID: ENSG00000163815

Description: C-type lectin domain family 3 member B

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.98
    Marker Score: 1587
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 1.97
    Marker Score: 5013
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 1.78
    Marker Score: 651
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.68
    Marker Score: 3416
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 1.6
    Marker Score: 904
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: 1.58
    Marker Score: 383
  • Cell Name: pulmonary artery endothelial cell (CL1001568)
    Fold Change: 1.5
    Marker Score: 1295
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 1.48
    Marker Score: 2450
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 870
  • Cell Name: type EC enteroendocrine cell (CL0000577)
    Fold Change: 1.33
    Marker Score: 1255
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.19
    Marker Score: 18659
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7677
  • Cell Name: capillary endothelial cell (CL0002144)
    Fold Change: 1.06
    Marker Score: 1139
  • Cell Name: endothelial tip cell (CL0000704)
    Fold Change: 1.06
    Marker Score: 246
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251803
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71822
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48047
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: alveolar capillary type 2 endothelial cell (CL4028003)
    Fold Change: 0.96
    Marker Score: 1383
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5351
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5287
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.86
    Marker Score: 656
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.8
    Marker Score: 249
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1262
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 709
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.77
    Marker Score: 1316.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.77
    Marker Score: 249
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.77
    Marker Score: 511
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.77
    Marker Score: 464
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.77
    Marker Score: 1458
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 398
  • Cell Name: choroid plexus epithelial cell (CL0000706)
    Fold Change: 0.71
    Marker Score: 649.5
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: vein endothelial cell (CL0002543)
    Fold Change: 0.67
    Marker Score: 605
  • Cell Name: renal beta-intercalated cell (CL0002201)
    Fold Change: 0.61
    Marker Score: 192
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.58
    Marker Score: 461
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 237
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 148
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.54
    Marker Score: 260
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.54
    Marker Score: 133
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.51
    Marker Score: 118
  • Cell Name: mucus secreting cell (CL0000319)
    Fold Change: 0.51
    Marker Score: 130
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 476
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.48
    Marker Score: 112
  • Cell Name: glomerular endothelial cell (CL0002188)
    Fold Change: 0.46
    Marker Score: 118
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: 0.43
    Marker Score: 387
  • Cell Name: retinal blood vessel endothelial cell (CL0002585)
    Fold Change: 0.42
    Marker Score: 100
  • Cell Name: endothelial cell of uterus (CL0009095)
    Fold Change: 0.41
    Marker Score: 826
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: 0.41
    Marker Score: 89
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.4
    Marker Score: 433
  • Cell Name: pulmonary ionocyte (CL0017000)
    Fold Change: 0.39
    Marker Score: 238
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.39
    Marker Score: 13180
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.37
    Marker Score: 152
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.37
    Marker Score: 619
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 330
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.34
    Marker Score: 150
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.33
    Marker Score: 141
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.32
    Marker Score: 322
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 0.32
    Marker Score: 825
  • Cell Name: lung microvascular endothelial cell (CL2000016)
    Fold Change: 0.31
    Marker Score: 67
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.31
    Marker Score: 316.5
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.31
    Marker Score: 187
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.31
    Marker Score: 163
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.29
    Marker Score: 169
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.28
    Marker Score: 3182
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: 0.27
    Marker Score: 395
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.25
    Marker Score: 258
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.25
    Marker Score: 65
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.24
    Marker Score: 134
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.22
    Marker Score: 90
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.21
    Marker Score: 59
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.21
    Marker Score: 894
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.2
    Marker Score: 236
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.19
    Marker Score: 95
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: 0.19
    Marker Score: 66
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.18
    Marker Score: 47
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.17
    Marker Score: 400
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.17
    Marker Score: 49
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.16
    Marker Score: 93
  • Cell Name: Kupffer cell (CL0000091)
    Fold Change: 0.15
    Marker Score: 149
  • Cell Name: papillary tips cell (CL1000597)
    Fold Change: 0.14
    Marker Score: 29
  • Cell Name: mononuclear phagocyte (CL0000113)
    Fold Change: 0.14
    Marker Score: 144
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.14
    Marker Score: 172
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.14
    Marker Score: 65
  • Cell Name: effector memory CD4-positive, alpha-beta T cell (CL0000905)
    Fold Change: 0.14
    Marker Score: 101
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.14
    Marker Score: 72
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.13
    Marker Score: 337
  • Cell Name: central nervous system macrophage (CL0000878)
    Fold Change: 0.13
    Marker Score: 66
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.13
    Marker Score: 797
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.13
    Marker Score: 35
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 0.13
    Marker Score: 36
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: 0.12
    Marker Score: 82
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.12
    Marker Score: 230
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.12
    Marker Score: 87
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.12
    Marker Score: 31
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.12
    Marker Score: 30
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.12
    Marker Score: 42
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.11
    Marker Score: 30

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Other Information

**Key Characteristics:** 1. **Lectin Domain**: CLEC3B contains a C-type lectin domain, which is a carbohydrate-binding domain that recognizes and binds to specific sugar molecules. 2. **Multiple Binding Partners**: Tetranectin, the protein encoded by CLEC3B, can bind to a variety of ligands, including carbohydrates, proteins, and calcium ions. 3. **Cellular Expression**: CLEC3B is expressed in various cell types, including endothelial cells, fibroblasts, and immune cells, suggesting its involvement in multiple cellular processes. 4. **Signaling and Regulation**: The binding of tetranectin to its ligands can trigger signaling pathways that regulate cellular responses, including hemostasis and inflammation. **Pathways and Functions:** 1. **Hemostasis**: CLEC3B plays a crucial role in regulating platelet activation, aggregation, and degranulation, which are essential for maintaining hemostasis. 2. **Cellular Response to Organic Substances**: Tetranectin can bind to carbohydrates, proteins, and other organic substances, triggering signaling pathways that regulate cellular responses, including inflammation and tissue repair. 3. **Tissue Development**: CLEC3B is involved in the development and maintenance of various tissues, including the lung, kidney, and cardiovascular system. 4. **Cellular Response to Transforming Growth Factor Beta (TGF-β)**: Tetranectin can bind to TGF-β, regulating its activity and influencing cellular responses, including differentiation and apoptosis. 5. **Calcium Ion Binding**: CLEC3B can bind to calcium ions, regulating its activity and influencing cellular responses, including cell signaling and membrane trafficking. **Clinical Significance:** 1. **Hemostatic Disorders**: Abnormalities in CLEC3B or tetranectin have been implicated in hemostatic disorders, including thrombocytopenia and bleeding tendencies. 2. **Cancer**: CLEC3B has been identified as a potential biomarker for cancer, as it is overexpressed in various types of cancer, including lung, breast, and colon cancer. 3. **Inflammatory Diseases**: Tetranectin has been implicated in inflammatory diseases, including atherosclerosis and rheumatoid arthritis, where it regulates inflammatory responses and tissue damage. 4. **Tissue Repair**: CLEC3B plays a crucial role in tissue repair and regeneration, as it regulates the activity of fibroblasts and other cell types involved in tissue development and maintenance. In conclusion, CLEC3B is a multifaceted gene involved in various cellular processes, including hemostasis, cellular response, and tissue development. Its clinical significance is evident in its involvement in hemostatic disorders, cancer, inflammatory diseases, and tissue repair. Further research is needed to fully elucidate the functions of CLEC3B and its role in human disease.

Genular Protein ID: 194358188

Symbol: TETN_HUMAN

Name: Tetranectin

UniProtKB Accession Codes:

P05452 Q6FGX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 16 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 7 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1354271

Title: Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer.

PubMed ID: 1354271

PubMed ID: 1511740

Title: The gene structure of tetranectin, a plasminogen binding protein.

PubMed ID: 1511740

DOI: 10.1016/0014-5793(92)80729-z

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3427041

Title: Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein.

PubMed ID: 3427041

DOI: 10.1021/bi00395a027

PubMed ID: 10614823

Title: Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin.

PubMed ID: 10614823

DOI: 10.1515/bc.1999.166

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9256258

Title: Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.

PubMed ID: 9256258

DOI: 10.1016/s0014-5793(97)00664-9

PubMed ID: 9757090

Title: Structure of the C-type lectin carbohydrate recognition domain of human tetranectin.

PubMed ID: 9757090

DOI: 10.1107/s0907444997016806

PubMed ID: 35331648

Title: CLEC3B is a novel causative gene for macular-retinal dystrophy.

PubMed ID: 35331648

DOI: 10.1016/j.gim.2022.02.012

Sequence Information:

  • Length: 202
  • Mass: 22537
  • Checksum: 370C174033F21B78
  • Sequence:
    • MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN TKMFEELKSR LDTLAQEVAL 
LKEQQALQTV CLKGTKVHMK CFLAFTQTKT FHEASEDCIS RGGTLGTPQT GSENDALYEY 
LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA RIAYKNWETE ITAQPDGGKT ENCAVLSGAA 
NGKWFDKRCR DQLPYICQFG IV

Genular Protein ID: 2561455488

Symbol: E9PHK0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PHK0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 EMBL 1 EPD 2 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 InterPro 4 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 1 Pfam 1 Proteomes 2 ProteomicsDB 1 RefSeq 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 160
  • Mass: 17794
  • Checksum: 08C7048182C0A887
  • Sequence:
    • MFEELKSRLD TLAQEVALLK EQQALQTVCL KGTKVHMKCF LAFTQTKTFH EASEDCISRG 
GTLGTPQTGS ENDALYEYLR QSVGNEAEIW LGLNDMAAEG TWVDMTGARI AYKNWETEIT 
AQPDGGKTEN CAVLSGAANG KWFDKRCRDQ LPYICQFGIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.