Details for: CLEC3B

Gene ID: 7123

Symbol: CLEC3B

Ensembl ID: ENSG00000163815

Description: C-type lectin domain family 3 member B

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endothelial cell of pericentral hepatic sinusoid (CL0019022)
    Fold Change: 2.6005
    Cell Significance Index: 20.5300
  • Cell Name: endothelial cell of periportal hepatic sinusoid (CL0019021)
    Fold Change: 1.4660
    Cell Significance Index: 5.1000
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.9297
    Cell Significance Index: 14.7500
  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 0.8316
    Cell Significance Index: 4.9100
  • Cell Name: alveolar capillary type 1 endothelial cell (CL4028002)
    Fold Change: 0.7529
    Cell Significance Index: 5.4600
  • Cell Name: glomerular capillary endothelial cell (CL1001005)
    Fold Change: 0.6574
    Cell Significance Index: 2.4500
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.2892
    Cell Significance Index: 4.6400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: 0.2817
    Cell Significance Index: 3.2000
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.2801
    Cell Significance Index: 8.0300
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.2675
    Cell Significance Index: 1.6600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 0.1747
    Cell Significance Index: 3.4100
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.1251
    Cell Significance Index: 17.1800
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: 0.0949
    Cell Significance Index: 5.8300
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.0207
    Cell Significance Index: 1.0500
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: 0.0184
    Cell Significance Index: 0.3200
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0041
    Cell Significance Index: -3.0700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0060
    Cell Significance Index: -11.3400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0132
    Cell Significance Index: -1.6900
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0145
    Cell Significance Index: -3.0600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0149
    Cell Significance Index: -0.2300
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0153
    Cell Significance Index: -11.2300
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0154
    Cell Significance Index: -11.6800
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0174
    Cell Significance Index: -11.0800
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0177
    Cell Significance Index: -9.9800
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0181
    Cell Significance Index: -3.6400
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0237
    Cell Significance Index: -12.9400
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0271
    Cell Significance Index: -12.2800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0306
    Cell Significance Index: -10.9800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0398
    Cell Significance Index: -11.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0400
    Cell Significance Index: -1.6400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0428
    Cell Significance Index: -7.7200
  • Cell Name: endothelial cell of sinusoid (CL0002262)
    Fold Change: -0.0491
    Cell Significance Index: -0.3600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0562
    Cell Significance Index: -11.1600
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0575
    Cell Significance Index: -5.8700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0621
    Cell Significance Index: -0.8900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0668
    Cell Significance Index: -8.2100
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0777
    Cell Significance Index: -13.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0845
    Cell Significance Index: -0.7100
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0874
    Cell Significance Index: -11.2900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0946
    Cell Significance Index: -11.0300
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1124
    Cell Significance Index: -2.8900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.1141
    Cell Significance Index: -13.0700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1150
    Cell Significance Index: -5.0000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1238
    Cell Significance Index: -3.4600
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1342
    Cell Significance Index: -6.3100
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1419
    Cell Significance Index: -11.2400
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.1433
    Cell Significance Index: -3.0000
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1488
    Cell Significance Index: -11.0900
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.1587
    Cell Significance Index: -18.7200
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1724
    Cell Significance Index: -11.5900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.1774
    Cell Significance Index: -11.1800
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.1781
    Cell Significance Index: -13.6700
  • Cell Name: endothelial cell of hepatic sinusoid (CL1000398)
    Fold Change: -0.2293
    Cell Significance Index: -2.1800
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.2301
    Cell Significance Index: -2.6100
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.2326
    Cell Significance Index: -2.5500
  • Cell Name: ependymal cell (CL0000065)
    Fold Change: -0.2402
    Cell Significance Index: -2.8300
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.2533
    Cell Significance Index: -11.4800
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.2552
    Cell Significance Index: -8.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2690
    Cell Significance Index: -12.5400
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.2723
    Cell Significance Index: -2.9600
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2739
    Cell Significance Index: -7.3400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2794
    Cell Significance Index: -8.9000
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2824
    Cell Significance Index: -1.7300
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.2894
    Cell Significance Index: -6.9400
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2944
    Cell Significance Index: -9.6400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.3078
    Cell Significance Index: -15.9900
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.3167
    Cell Significance Index: -3.1000
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.3175
    Cell Significance Index: -6.4600
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: -0.3191
    Cell Significance Index: -4.5900
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.3315
    Cell Significance Index: -11.5200
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.3660
    Cell Significance Index: -3.7400
  • Cell Name: endothelial cell of vascular tree (CL0002139)
    Fold Change: -0.3754
    Cell Significance Index: -5.1600
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.3815
    Cell Significance Index: -2.6200
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.3827
    Cell Significance Index: -3.0400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.3860
    Cell Significance Index: -11.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.3878
    Cell Significance Index: -9.6700
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.3893
    Cell Significance Index: -9.7100
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.3896
    Cell Significance Index: -6.5200
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.3980
    Cell Significance Index: -5.1500
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4007
    Cell Significance Index: -10.7000
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.4009
    Cell Significance Index: -3.0900
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.4056
    Cell Significance Index: -10.8500
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.4090
    Cell Significance Index: -11.6700
  • Cell Name: endothelial cell (CL0000115)
    Fold Change: -0.4108
    Cell Significance Index: -5.0500
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.4111
    Cell Significance Index: -2.7900
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.4239
    Cell Significance Index: -12.4500
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4248
    Cell Significance Index: -9.0800
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.4317
    Cell Significance Index: -2.3400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.4331
    Cell Significance Index: -15.9000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.4336
    Cell Significance Index: -4.1800
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4341
    Cell Significance Index: -11.0900
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: -0.4412
    Cell Significance Index: -4.6500
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.4457
    Cell Significance Index: -2.7800
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.4470
    Cell Significance Index: -9.3300
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4547
    Cell Significance Index: -9.6500
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.4628
    Cell Significance Index: -10.0000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.4653
    Cell Significance Index: -9.2000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.4697
    Cell Significance Index: -12.7900
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.4797
    Cell Significance Index: -9.6300
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4834
    Cell Significance Index: -9.6400

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Lectin Domain**: CLEC3B contains a C-type lectin domain, which is a carbohydrate-binding domain that recognizes and binds to specific sugar molecules. 2. **Multiple Binding Partners**: Tetranectin, the protein encoded by CLEC3B, can bind to a variety of ligands, including carbohydrates, proteins, and calcium ions. 3. **Cellular Expression**: CLEC3B is expressed in various cell types, including endothelial cells, fibroblasts, and immune cells, suggesting its involvement in multiple cellular processes. 4. **Signaling and Regulation**: The binding of tetranectin to its ligands can trigger signaling pathways that regulate cellular responses, including hemostasis and inflammation. **Pathways and Functions:** 1. **Hemostasis**: CLEC3B plays a crucial role in regulating platelet activation, aggregation, and degranulation, which are essential for maintaining hemostasis. 2. **Cellular Response to Organic Substances**: Tetranectin can bind to carbohydrates, proteins, and other organic substances, triggering signaling pathways that regulate cellular responses, including inflammation and tissue repair. 3. **Tissue Development**: CLEC3B is involved in the development and maintenance of various tissues, including the lung, kidney, and cardiovascular system. 4. **Cellular Response to Transforming Growth Factor Beta (TGF-β)**: Tetranectin can bind to TGF-β, regulating its activity and influencing cellular responses, including differentiation and apoptosis. 5. **Calcium Ion Binding**: CLEC3B can bind to calcium ions, regulating its activity and influencing cellular responses, including cell signaling and membrane trafficking. **Clinical Significance:** 1. **Hemostatic Disorders**: Abnormalities in CLEC3B or tetranectin have been implicated in hemostatic disorders, including thrombocytopenia and bleeding tendencies. 2. **Cancer**: CLEC3B has been identified as a potential biomarker for cancer, as it is overexpressed in various types of cancer, including lung, breast, and colon cancer. 3. **Inflammatory Diseases**: Tetranectin has been implicated in inflammatory diseases, including atherosclerosis and rheumatoid arthritis, where it regulates inflammatory responses and tissue damage. 4. **Tissue Repair**: CLEC3B plays a crucial role in tissue repair and regeneration, as it regulates the activity of fibroblasts and other cell types involved in tissue development and maintenance. In conclusion, CLEC3B is a multifaceted gene involved in various cellular processes, including hemostasis, cellular response, and tissue development. Its clinical significance is evident in its involvement in hemostatic disorders, cancer, inflammatory diseases, and tissue repair. Further research is needed to fully elucidate the functions of CLEC3B and its role in human disease.

Genular Protein ID: 194358188

Symbol: TETN_HUMAN

Name: Tetranectin

UniProtKB Accession Codes:

P05452 Q6FGX6

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DisProt 1 DrugBank 3 EMBL 9 Ensembl 1 EvolutionaryTrace 1 ExpressionAtlas 1 GO 14 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 3 MINT 1 MalaCards 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 4 PDBsum 4 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 1 RefSeq 1 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 UniLectin 1 VEuPathDB 1 eggNOG 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 1354271

Title: Tetranectin, a plasminogen kringle 4-binding protein. Cloning and gene expression pattern in human colon cancer.

PubMed ID: 1354271

PubMed ID: 1511740

Title: The gene structure of tetranectin, a plasminogen binding protein.

PubMed ID: 1511740

DOI: 10.1016/0014-5793(92)80729-z

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 3427041

Title: Primary structure of tetranectin, a plasminogen kringle 4 binding plasma protein: homology with asialoglycoprotein receptors and cartilage proteoglycan core protein.

PubMed ID: 3427041

DOI: 10.1021/bi00395a027

PubMed ID: 10614823

Title: Mass spectrometric characterisation of post-translational modification and genetic variation in human tetranectin.

PubMed ID: 10614823

DOI: 10.1515/bc.1999.166

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

PubMed ID: 9256258

Title: Crystal structure of tetranectin, a trimeric plasminogen-binding protein with an alpha-helical coiled coil.

PubMed ID: 9256258

DOI: 10.1016/s0014-5793(97)00664-9

PubMed ID: 9757090

Title: Structure of the C-type lectin carbohydrate recognition domain of human tetranectin.

PubMed ID: 9757090

DOI: 10.1107/s0907444997016806

PubMed ID: 35331648

Title: CLEC3B is a novel causative gene for macular-retinal dystrophy.

PubMed ID: 35331648

DOI: 10.1016/j.gim.2022.02.012

Sequence Information:

  • Length: 202
  • Mass: 22537
  • Checksum: 370C174033F21B78
  • Sequence:
    • MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN TKMFEELKSR LDTLAQEVAL 
LKEQQALQTV CLKGTKVHMK CFLAFTQTKT FHEASEDCIS RGGTLGTPQT GSENDALYEY 
LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA RIAYKNWETE ITAQPDGGKT ENCAVLSGAA 
NGKWFDKRCR DQLPYICQFG IV

Genular Protein ID: 2561455488

Symbol: E9PHK0_HUMAN

Name: N/A

UniProtKB Accession Codes:

E9PHK0

Database IDs:

ARBA 2 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CDD 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 1 Ensembl 2 ExpressionAtlas 1 GO 1 Gene3D 1 GeneTree 1 HGNC 1 HOGENOM 1 InterPro 5 MassIVE 1 NCBI Taxonomy 1 OMA 1 OrthoDB 1 PANTHER 2 PRINTS 1 PROSITE 3 PeptideAtlas 2 Pfam 1 Proteomes 2 ProteomicsDB 2 RefSeq 1 SMART 1 SMR 1 SUPFAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 24275569

Title: An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome.

PubMed ID: 24275569

DOI: 10.1016/j.jprot.2013.11.014

Sequence Information:

  • Length: 160
  • Mass: 17794
  • Checksum: 08C7048182C0A887
  • Sequence:
    • MFEELKSRLD TLAQEVALLK EQQALQTVCL KGTKVHMKCF LAFTQTKTFH EASEDCISRG 
GTLGTPQTGS ENDALYEYLR QSVGNEAEIW LGLNDMAAEG TWVDMTGARI AYKNWETEIT 
AQPDGGKTEN CAVLSGAANG KWFDKRCRDQ LPYICQFGIV

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.