Details for: HOXC6

Gene ID: 3223

Symbol: HOXC6

Ensembl ID: ENSG00000197757

Description: homeobox C6

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 23.1825
    Cell Significance Index: -10.9500
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 2.2625
    Cell Significance Index: 78.6200
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.7696
    Cell Significance Index: 37.0400
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.7286
    Cell Significance Index: 55.3700
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.6857
    Cell Significance Index: 130.5000
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.6170
    Cell Significance Index: 31.1800
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.4609
    Cell Significance Index: 3.6800
  • Cell Name: sensory neuron (CL0000101)
    Fold Change: 0.4381
    Cell Significance Index: 2.4900
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4242
    Cell Significance Index: 41.9600
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.3796
    Cell Significance Index: 11.1800
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.3690
    Cell Significance Index: 333.1700
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.2205
    Cell Significance Index: 35.8600
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1537
    Cell Significance Index: 16.7200
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.1355
    Cell Significance Index: 0.8300
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.1207
    Cell Significance Index: 3.0200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.0585
    Cell Significance Index: 4.0400
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0531
    Cell Significance Index: 1.5300
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0437
    Cell Significance Index: 1.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.0270
    Cell Significance Index: 3.1500
  • Cell Name: epithelial cell of esophagus (CL0002252)
    Fold Change: 0.0151
    Cell Significance Index: 0.1000
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.0148
    Cell Significance Index: 0.1900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: 0.0133
    Cell Significance Index: 9.7500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0107
    Cell Significance Index: 0.6500
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0082
    Cell Significance Index: 0.2200
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0063
    Cell Significance Index: 0.0700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.0030
    Cell Significance Index: 0.0500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0007
    Cell Significance Index: -0.1000
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0027
    Cell Significance Index: -2.0200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0113
    Cell Significance Index: -0.5100
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0142
    Cell Significance Index: -2.9900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.0145
    Cell Significance Index: -0.3100
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.0145
    Cell Significance Index: -0.1400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0147
    Cell Significance Index: -2.5100
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: -0.0151
    Cell Significance Index: -0.1900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0227
    Cell Significance Index: -12.4000
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0233
    Cell Significance Index: -13.1600
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.0340
    Cell Significance Index: -0.3700
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.0463
    Cell Significance Index: -2.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0468
    Cell Significance Index: -13.4800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0482
    Cell Significance Index: -8.6900
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0489
    Cell Significance Index: -2.1200
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0512
    Cell Significance Index: -0.4300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0518
    Cell Significance Index: -10.3900
  • Cell Name: chondroblast (CL0000058)
    Fold Change: -0.0528
    Cell Significance Index: -0.3100
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0611
    Cell Significance Index: -6.2400
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0630
    Cell Significance Index: -1.2300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.0719
    Cell Significance Index: -2.0600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0719
    Cell Significance Index: -1.0300
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.0749
    Cell Significance Index: -5.9400
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0777
    Cell Significance Index: -10.0400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.0848
    Cell Significance Index: -1.7600
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0874
    Cell Significance Index: -10.0100
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.0894
    Cell Significance Index: -0.7600
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0940
    Cell Significance Index: -0.9300
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0974
    Cell Significance Index: -7.2600
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0985
    Cell Significance Index: -6.0400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1264
    Cell Significance Index: -5.9400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.1328
    Cell Significance Index: -6.1900
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: -0.1379
    Cell Significance Index: -1.4400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.1643
    Cell Significance Index: -8.5400
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.1656
    Cell Significance Index: -10.6900
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: -0.1687
    Cell Significance Index: -1.2900
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.1864
    Cell Significance Index: -3.9700
  • Cell Name: kidney interstitial fibroblast (CL1000692)
    Fold Change: -0.1894
    Cell Significance Index: -2.2000
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: -0.1964
    Cell Significance Index: -1.7700
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.2027
    Cell Significance Index: -4.9100
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: -0.2117
    Cell Significance Index: -3.0900
  • Cell Name: Schwann cell precursor (CL0002375)
    Fold Change: -0.2405
    Cell Significance Index: -1.9100
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2407
    Cell Significance Index: -6.3300
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2593
    Cell Significance Index: -14.5500
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: -0.2648
    Cell Significance Index: -1.6700
  • Cell Name: PP cell (CL0000696)
    Fold Change: -0.2998
    Cell Significance Index: -3.0500
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3119
    Cell Significance Index: -4.7000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3158
    Cell Significance Index: -8.6000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.3204
    Cell Significance Index: -13.1300
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3307
    Cell Significance Index: -11.5900
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.3392
    Cell Significance Index: -3.8400
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.3471
    Cell Significance Index: -11.0600
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.3621
    Cell Significance Index: -6.1900
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: -0.3690
    Cell Significance Index: -2.3100
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.3716
    Cell Significance Index: -9.2800
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.3739
    Cell Significance Index: -12.2400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.3746
    Cell Significance Index: -13.7500
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.3780
    Cell Significance Index: -9.6300
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.3795
    Cell Significance Index: -11.1500
  • Cell Name: prostate gland microvascular endothelial cell (CL2000059)
    Fold Change: -0.3871
    Cell Significance Index: -2.7800
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.3882
    Cell Significance Index: -10.3900
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.3909
    Cell Significance Index: -1.8700
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.4067
    Cell Significance Index: -8.1100
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.4088
    Cell Significance Index: -10.9200
  • Cell Name: hepatic stellate cell (CL0000632)
    Fold Change: -0.4246
    Cell Significance Index: -4.3800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.4278
    Cell Significance Index: -6.0900
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: -0.4292
    Cell Significance Index: -5.4300
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4330
    Cell Significance Index: -4.9200
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: -0.4363
    Cell Significance Index: -4.4300
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.4389
    Cell Significance Index: -10.1400
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.4502
    Cell Significance Index: -11.5000
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.4553
    Cell Significance Index: -11.1100
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.4631
    Cell Significance Index: -6.3500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.4845
    Cell Significance Index: -11.6200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homeobox gene family member:** HOXC6 belongs to the homeobox gene family, which encodes transcription factors that regulate embryonic development and tissue patterning. 2. **Widespread expression:** HOXC6 is expressed in various cell types, including mesangial cells, hematopoietic stem cells, kidney proximal straight tubule epithelial cells, and connective tissue cells. 3. **RNA polymerase II-specific:** HOXC6 regulates transcription by interacting with RNA polymerase II, a key enzyme responsible for RNA synthesis. 4. **Chromatin and DNA-binding activities:** HOXC6 exhibits chromatin and DNA-binding activities, allowing it to regulate gene expression and transcription. **Pathways and Functions:** 1. **Anterior/posterior pattern specification:** HOXC6 plays a crucial role in establishing the anterior-posterior axis during embryonic development, which is essential for proper body patterning and organ formation. 2. **Embryonic skeletal system development:** HOXC6 is involved in regulating the development of the skeletal system, including the formation of bones and cartilage. 3. **Regulation of transcription by RNA polymerase II:** HOXC6 interacts with RNA polymerase II to regulate gene expression and transcription, which is essential for cell growth, differentiation, and survival. 4. **Immunological functions:** HOXC6 has been implicated in the regulation of immune cell development and function, including the development of hematopoietic stem cells and the differentiation of granulocytes and monocytes. **Clinical Significance:** 1. **Developmental abnormalities:** Dysregulation of HOXC6 can lead to developmental abnormalities, including skeletal dysplasias and cardiovascular defects. 2. **Immunological disorders:** Alterations in HOXC6 expression have been linked to immunological disorders, such as autoimmune diseases and leukemia. 3. **Cancer:** HOXC6 has been implicated in the development and progression of certain cancers, including leukemia and lymphoma. 4. **Stem cell therapy:** HOXC6 has been identified as a potential target for stem cell therapy, as it plays a crucial role in regulating the development and function of hematopoietic stem cells. In conclusion, HOXC6 is a critical gene involved in various developmental and immunological processes. Its dysregulation can have significant consequences on embryonic development, skeletal system formation, and immune function. Further research is needed to fully elucidate the role of HOXC6 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 1380465596

Symbol: HXC6_HUMAN

Name: Homeobox protein Hox-C6

UniProtKB Accession Codes:

P09630 B2RBV2 Q6DK09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2885844

Title: Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

PubMed ID: 2885844

DOI: 10.1073/pnas.84.14.4914

PubMed ID: 2898768

Title: At least three human homeoboxes on chromosome 12 belong to the same transcription unit.

PubMed ID: 2898768

DOI: 10.1093/nar/16.12.5379

PubMed ID: 8870653

Title: Cloning and expression of a new HOXC6 transcript encoding a repressing protein.

PubMed ID: 8870653

DOI: 10.1042/bj3190091

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 235
  • Mass: 26915
  • Checksum: BD695C7347CB71C0
  • Sequence:
    • MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN 
VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI 
QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL 
TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.