Details for: HOXC6

Gene ID: 3223

Symbol: HOXC6

Ensembl ID: ENSG00000197757

Description: homeobox C6

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.25
    Marker Score: 2720
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.77
    Marker Score: 931
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.48
    Marker Score: 3482
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.44
    Marker Score: 2446
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.33
    Marker Score: 2779
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.1
    Marker Score: 285
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 682.5
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7139
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.02
    Marker Score: 354
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.02
    Marker Score: 1193
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48040
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 667.5
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2740
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.91
    Marker Score: 2148
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.88
    Marker Score: 11608
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 324.5
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 618.5
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11688
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.73
    Marker Score: 1124.5
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1376
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.72
    Marker Score: 162
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.71
    Marker Score: 1097
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2754
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.6
    Marker Score: 266
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1206
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 334
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 365
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 375
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.55
    Marker Score: 222
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.53
    Marker Score: 379
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 315
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.51
    Marker Score: 342
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.49
    Marker Score: 159
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.46
    Marker Score: 109
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.46
    Marker Score: 219
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.46
    Marker Score: 209
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.45
    Marker Score: 432
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.45
    Marker Score: 459
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.44
    Marker Score: 112
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.44
    Marker Score: 2637
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 743
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.43
    Marker Score: 121
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.43
    Marker Score: 2772
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.41
    Marker Score: 511
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.41
    Marker Score: 128.5
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 229
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 387
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.39
    Marker Score: 417
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.39
    Marker Score: 1040.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.38
    Marker Score: 277
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.38
    Marker Score: 113
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 333
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.34
    Marker Score: 324
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.33
    Marker Score: 189
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 868
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.32
    Marker Score: 253
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.31
    Marker Score: 329
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.31
    Marker Score: 305
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.29
    Marker Score: 70
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.28
    Marker Score: 285
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.28
    Marker Score: 236.5
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.28
    Marker Score: 121
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.28
    Marker Score: 393
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.27
    Marker Score: 145
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.27
    Marker Score: 176
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.26
    Marker Score: 183
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.25
    Marker Score: 8536
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.24
    Marker Score: 860
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 103
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.21
    Marker Score: 2092

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Other Information

**Key characteristics:** - HOXC6 is a homeobox gene, which are a family of transcription factors that are responsible for establishing and maintaining tissue identity. - It is expressed in a wide variety of cell types, including mesangial cells, hematopoietic stem cells, kidney proximal straight tubule epithelial cells, and more. - It is a key regulator of the A/P axis, which is responsible for determining the identity of the body's front and back. - It is involved in the regulation of the development of the cardiovascular, respiratory, and renal systems. **Pathways and functions:** - HOXC6 is a key regulator of the A/P axis. - It is required for the specification of the anterior (A) side of the embryo. - It is also required for the specification of the posterior (P) side of the embryo. - HOXC6 is a key regulator of the development of the cardiovascular, respiratory, and renal systems. - It is expressed in the mesoderm, which is responsible for the formation of these systems. - HOXC6 binds to DNA sequences in the promoters of genes involved in the development of the cardiovascular, respiratory, and renal systems. - This binding helps to regulate the expression of these genes and to ensure that they are expressed in the right cells at the right times. **Clinical significance:** - Mutations in the HOXC6 gene have been linked to a number of human diseases, including heart defects, kidney defects, and lung defects. - HOXC6 is a promising target for the treatment of these diseases. - By understanding the role of HOXC6 in development, it may be possible to develop new treatments for these diseases.

Genular Protein ID: 1380465596

Symbol: HXC6_HUMAN

Name: Homeobox protein Hox-C6

UniProtKB Accession Codes:

P09630 B2RBV2 Q6DK09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2885844

Title: Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

PubMed ID: 2885844

DOI: 10.1073/pnas.84.14.4914

PubMed ID: 2898768

Title: At least three human homeoboxes on chromosome 12 belong to the same transcription unit.

PubMed ID: 2898768

DOI: 10.1093/nar/16.12.5379

PubMed ID: 8870653

Title: Cloning and expression of a new HOXC6 transcript encoding a repressing protein.

PubMed ID: 8870653

DOI: 10.1042/bj3190091

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 235
  • Mass: 26915
  • Checksum: BD695C7347CB71C0
  • Sequence:
    • MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN 
VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI 
QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL 
TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.