Details for: HOXC6

Gene ID: 3223

Symbol: HOXC6

Ensembl ID: ENSG00000197757

Description: homeobox C6

Associated with

Cells (max top 100)

(Marker Scores and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 2.25
    Marker Score: 2,720
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 1.77
    Marker Score: 931
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 1.48
    Marker Score: 3,482
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 1.44
    Marker Score: 2,446
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 1.33
    Marker Score: 2,779
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 1.1
    Marker Score: 285
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.08
    Marker Score: 683
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.07
    Marker Score: 7,139
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 1.02
    Marker Score: 354
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 1.02
    Marker Score: 1,193
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71,815
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48,040
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.99
    Marker Score: 668
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.99
    Marker Score: 508
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30,408
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.98
    Marker Score: 461
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2,412
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5,322
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2,740
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.91
    Marker Score: 2,148
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.91
    Marker Score: 377
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 326
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.88
    Marker Score: 11,608
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5,293
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.85
    Marker Score: 393
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.81
    Marker Score: 325
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1,266
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.77
    Marker Score: 700
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 397
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.75
    Marker Score: 11,688
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.73
    Marker Score: 1,125
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.73
    Marker Score: 1,376
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.72
    Marker Score: 162
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.71
    Marker Score: 1,097
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 179
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.66
    Marker Score: 2,754
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.65
    Marker Score: 205
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.6
    Marker Score: 266
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.59
    Marker Score: 1,206
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.58
    Marker Score: 334
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.57
    Marker Score: 239
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.57
    Marker Score: 365
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.57
    Marker Score: 375
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.56
    Marker Score: 149
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.55
    Marker Score: 222
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.53
    Marker Score: 379
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.52
    Marker Score: 315
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.51
    Marker Score: 342
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.49
    Marker Score: 159
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.46
    Marker Score: 109
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.46
    Marker Score: 277
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.46
    Marker Score: 219
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.46
    Marker Score: 209
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.45
    Marker Score: 432
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.45
    Marker Score: 459
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.44
    Marker Score: 112
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.44
    Marker Score: 2,637
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.43
    Marker Score: 743
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.43
    Marker Score: 121
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.43
    Marker Score: 2,772
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.41
    Marker Score: 511
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.41
    Marker Score: 129
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.4
    Marker Score: 229
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.4
    Marker Score: 387
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.39
    Marker Score: 417
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.39
    Marker Score: 1,041
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.38
    Marker Score: 277
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.38
    Marker Score: 113
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 372
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.34
    Marker Score: 333
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.34
    Marker Score: 324
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.33
    Marker Score: 189
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.32
    Marker Score: 868
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.32
    Marker Score: 253
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.31
    Marker Score: 89
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.31
    Marker Score: 329
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.31
    Marker Score: 305
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.29
    Marker Score: 70
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 0.28
    Marker Score: 285
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.28
    Marker Score: 237
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.28
    Marker Score: 121
  • Cell Name: chromaffin cell (CL0000166)
    Fold Change: 0.28
    Marker Score: 393
  • Cell Name: sympathetic neuron (CL0011103)
    Fold Change: 0.28
    Marker Score: 91
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.27
    Marker Score: 145
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.27
    Marker Score: 176
  • Cell Name: skeletal muscle satellite cell (CL0000594)
    Fold Change: 0.26
    Marker Score: 174
  • Cell Name: renal alpha-intercalated cell (CL0005011)
    Fold Change: 0.26
    Marker Score: 135
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.26
    Marker Score: 183
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.25
    Marker Score: 8,536
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.25
    Marker Score: 91
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.24
    Marker Score: 860
  • Cell Name: smooth muscle cell of small intestine (CL1000275)
    Fold Change: 0.23
    Marker Score: 61
  • Cell Name: lung goblet cell (CL1000143)
    Fold Change: 0.23
    Marker Score: 67
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 66
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.23
    Marker Score: 133
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.22
    Marker Score: 58
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.21
    Marker Score: 103
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.21
    Marker Score: 2,092

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Marker Score to the Marker Score Threshold, indicating how much the gene expression has changed compared to a baseline.
Marker Score: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Homeobox gene family member:** HOXC6 belongs to the homeobox gene family, which encodes transcription factors that regulate embryonic development and tissue patterning. 2. **Widespread expression:** HOXC6 is expressed in various cell types, including mesangial cells, hematopoietic stem cells, kidney proximal straight tubule epithelial cells, and connective tissue cells. 3. **RNA polymerase II-specific:** HOXC6 regulates transcription by interacting with RNA polymerase II, a key enzyme responsible for RNA synthesis. 4. **Chromatin and DNA-binding activities:** HOXC6 exhibits chromatin and DNA-binding activities, allowing it to regulate gene expression and transcription. **Pathways and Functions:** 1. **Anterior/posterior pattern specification:** HOXC6 plays a crucial role in establishing the anterior-posterior axis during embryonic development, which is essential for proper body patterning and organ formation. 2. **Embryonic skeletal system development:** HOXC6 is involved in regulating the development of the skeletal system, including the formation of bones and cartilage. 3. **Regulation of transcription by RNA polymerase II:** HOXC6 interacts with RNA polymerase II to regulate gene expression and transcription, which is essential for cell growth, differentiation, and survival. 4. **Immunological functions:** HOXC6 has been implicated in the regulation of immune cell development and function, including the development of hematopoietic stem cells and the differentiation of granulocytes and monocytes. **Clinical Significance:** 1. **Developmental abnormalities:** Dysregulation of HOXC6 can lead to developmental abnormalities, including skeletal dysplasias and cardiovascular defects. 2. **Immunological disorders:** Alterations in HOXC6 expression have been linked to immunological disorders, such as autoimmune diseases and leukemia. 3. **Cancer:** HOXC6 has been implicated in the development and progression of certain cancers, including leukemia and lymphoma. 4. **Stem cell therapy:** HOXC6 has been identified as a potential target for stem cell therapy, as it plays a crucial role in regulating the development and function of hematopoietic stem cells. In conclusion, HOXC6 is a critical gene involved in various developmental and immunological processes. Its dysregulation can have significant consequences on embryonic development, skeletal system formation, and immune function. Further research is needed to fully elucidate the role of HOXC6 in human health and disease, and to explore its potential as a therapeutic target.

Genular Protein ID: 1380465596

Symbol: HXC6_HUMAN

Name: Homeobox protein Hox-C6

UniProtKB Accession Codes:

P09630 B2RBV2 Q6DK09

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 2 ExpressionAtlas 1 GO 9 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 3 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 Pumba 1 RNAct 1 RefSeq 2 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 2885844

Title: Two human homeobox genes, c1 and c8: structure analysis and expression in embryonic development.

PubMed ID: 2885844

DOI: 10.1073/pnas.84.14.4914

PubMed ID: 2898768

Title: At least three human homeoboxes on chromosome 12 belong to the same transcription unit.

PubMed ID: 2898768

DOI: 10.1093/nar/16.12.5379

PubMed ID: 8870653

Title: Cloning and expression of a new HOXC6 transcript encoding a repressing protein.

PubMed ID: 8870653

DOI: 10.1042/bj3190091

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2576652

Title: Organization of human class I homeobox genes.

PubMed ID: 2576652

DOI: 10.1139/g89-133

Sequence Information:

  • Length: 235
  • Mass: 26915
  • Checksum: BD695C7347CB71C0
  • Sequence:
    • MNSYFTNPSL SCHLAGGQDV LPNVALNSTA YDPVRHFSTY GAAVAQNRIY STPFYSPQEN 
VVFSSSRGPY DYGSNSFYQE KDMLSNCRQN TLGHNTQTSI AQDFSSEQGR TAPQDQKASI 
QIYPWMQRMN SHSGVGYGAD RRRGRQIYSR YQTLELEKEF HFNRYLTRRR RIEIANALCL 
TERQIKIWFQ NRRMKWKKES NLTSTLSGGG GGATADSLGG KEEKREETEE EKQKE

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.