Details for: FMOD

Gene ID: 2331

Symbol: FMOD

Ensembl ID: ENSG00000122176

Description: fibromodulin

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 160.3038
    Cell Significance Index: -40.6600
  • Cell Name: embryonic stem cell (CL0002322)
    Fold Change: 78.9178
    Cell Significance Index: -32.5100
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 32.9047
    Cell Significance Index: -40.5700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 10.2660
    Cell Significance Index: -40.5100
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 3.0586
    Cell Significance Index: 49.0700
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 2.3714
    Cell Significance Index: 13.9200
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 1.6754
    Cell Significance Index: 115.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 1.4490
    Cell Significance Index: 30.3300
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.4279
    Cell Significance Index: 1289.3000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9555
    Cell Significance Index: 155.4000
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.6279
    Cell Significance Index: 37.7000
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 0.6207
    Cell Significance Index: 3.8400
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.5427
    Cell Significance Index: 6.9500
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 0.5219
    Cell Significance Index: 8.2800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.4332
    Cell Significance Index: 55.5300
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.3195
    Cell Significance Index: 9.1600
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2865
    Cell Significance Index: 39.3500
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.2031
    Cell Significance Index: 20.0900
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.1788
    Cell Significance Index: 34.0200
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 0.1107
    Cell Significance Index: 0.7500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.0472
    Cell Significance Index: 2.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0452
    Cell Significance Index: 0.7000
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.0439
    Cell Significance Index: 19.4300
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0211
    Cell Significance Index: 13.1600
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.0135
    Cell Significance Index: 0.1400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.0106
    Cell Significance Index: 2.1100
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.0038
    Cell Significance Index: 0.1100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: -0.0004
    Cell Significance Index: -0.0100
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.0023
    Cell Significance Index: -0.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0063
    Cell Significance Index: -0.3200
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.0138
    Cell Significance Index: -0.2700
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0151
    Cell Significance Index: -28.4500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0400
    Cell Significance Index: -25.4300
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0415
    Cell Significance Index: -30.7200
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0457
    Cell Significance Index: -34.6200
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0556
    Cell Significance Index: -0.9300
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0576
    Cell Significance Index: -31.4700
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0617
    Cell Significance Index: -113.8100
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: -0.0720
    Cell Significance Index: -5.0900
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0722
    Cell Significance Index: -111.1400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0842
    Cell Significance Index: -114.4500
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0859
    Cell Significance Index: -48.4200
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0917
    Cell Significance Index: -3.7600
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0931
    Cell Significance Index: -33.4100
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0944
    Cell Significance Index: -17.0100
  • Cell Name: helper T cell (CL0000912)
    Fold Change: -0.0985
    Cell Significance Index: -1.4000
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.1035
    Cell Significance Index: -46.9900
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.1063
    Cell Significance Index: -18.1600
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1256
    Cell Significance Index: -3.5100
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1274
    Cell Significance Index: -1.9200
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.1312
    Cell Significance Index: -37.7600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1361
    Cell Significance Index: -15.8600
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1386
    Cell Significance Index: -20.1500
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1517
    Cell Significance Index: -3.9000
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.1582
    Cell Significance Index: -1.7200
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.1929
    Cell Significance Index: -40.6200
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2019
    Cell Significance Index: -4.3000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.2023
    Cell Significance Index: -40.5800
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2129
    Cell Significance Index: -15.8700
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.2129
    Cell Significance Index: -5.4400
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2135
    Cell Significance Index: -2.4300
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: -0.2171
    Cell Significance Index: -1.3300
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.2362
    Cell Significance Index: -4.9000
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.2481
    Cell Significance Index: -32.0500
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.2487
    Cell Significance Index: -30.5800
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.2556
    Cell Significance Index: -29.1800
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.2893
    Cell Significance Index: -29.5500
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2969
    Cell Significance Index: -34.0100
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.3222
    Cell Significance Index: -10.3200
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.3531
    Cell Significance Index: -3.8700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.3625
    Cell Significance Index: -28.7100
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.4023
    Cell Significance Index: -41.8900
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: -0.4371
    Cell Significance Index: -9.4700
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.4420
    Cell Significance Index: -19.2200
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.4421
    Cell Significance Index: -23.0300
  • Cell Name: myoblast (CL0000056)
    Fold Change: -0.4569
    Cell Significance Index: -4.4900
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.4673
    Cell Significance Index: -29.4500
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.4821
    Cell Significance Index: -22.4800
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.5035
    Cell Significance Index: -32.4900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.5099
    Cell Significance Index: -31.3400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.5281
    Cell Significance Index: -35.5100
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.5441
    Cell Significance Index: -7.7400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5562
    Cell Significance Index: -26.1400
  • Cell Name: cone retinal bipolar cell (CL0000752)
    Fold Change: -0.5721
    Cell Significance Index: -4.4100
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.6134
    Cell Significance Index: -6.3500
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6933
    Cell Significance Index: -53.2100
  • Cell Name: peridermal cell (CL0000078)
    Fold Change: -0.7023
    Cell Significance Index: -4.3800
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.7288
    Cell Significance Index: -3.9500
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: -0.7505
    Cell Significance Index: -3.5900
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: -0.7915
    Cell Significance Index: -7.6300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.7949
    Cell Significance Index: -27.6200
  • Cell Name: reticulocyte (CL0000558)
    Fold Change: -0.8583
    Cell Significance Index: -4.5200
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.9663
    Cell Significance Index: -16.6000
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.9684
    Cell Significance Index: -26.3600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -1.0021
    Cell Significance Index: -56.2300
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -1.0072
    Cell Significance Index: -21.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -1.0491
    Cell Significance Index: -30.9000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -1.0639
    Cell Significance Index: -55.8600
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -1.0669
    Cell Significance Index: -47.1900
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -1.0740
    Cell Significance Index: -26.7800

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** 1. **Structural Function:** Fibromodulin is a small leucine-rich proteoglycan that binds to collagen fibrils, modulating their organization and stability. 2. **Cellular Interactions:** Fibromodulin interacts with various cell surface receptors, influencing cell adhesion, migration, and differentiation. 3. **Glycosylation:** Fibromodulin undergoes extensive glycosylation, which affects its interactions with collagen and other molecules. 4. **Expression:** Fibromodulin is expressed in a wide range of cell types, including endothelial cells, fibroblasts, and immune cells. **Pathways and Functions:** 1. **Collagen Fibril Organization:** Fibromodulin regulates the formation and organization of collagen fibrils, which is crucial for maintaining tissue structure and function. 2. **Cell Adhesion and Migration:** Fibromodulin interacts with cell surface receptors, influencing cell adhesion and migration, which are essential for tissue development and repair. 3. **Glycosylation Regulation:** Fibromodulin's glycosylation status affects its interactions with collagen and other molecules, influencing ECM organization and function. 4. **Transforming Growth Factor Beta (TGF-β) Signaling:** Fibromodulin interacts with the TGF-β receptor complex, modulating TGF-β-mediated signaling pathways. **Clinical Significance:** Dysregulation of fibromodulin has been implicated in various diseases, including: 1. **Cardiovascular Disorders:** Fibromodulin deficiency has been linked to cardiovascular diseases, such as atherosclerosis and cardiac fibrosis. 2. **Respiratory Disorders:** Fibromodulin dysfunction has been implicated in respiratory diseases, including chronic obstructive pulmonary disease (COPD) and pulmonary fibrosis. 3. **Musculoskeletal Disorders:** Fibromodulin dysregulation has been linked to musculoskeletal disorders, including osteoarthritis and muscular dystrophy. In conclusion, fibromodulin is a critical component of the extracellular matrix, playing a pivotal role in regulating collagen fibril organization, cell adhesion, and migration. Dysregulation of fibromodulin has significant implications for human health, contributing to various diseases. Further research is needed to fully understand the mechanisms underlying fibromodulin's function and to develop therapeutic strategies for diseases associated with its dysregulation.

Genular Protein ID: 2563950772

Symbol: FMOD_HUMAN

Name: Fibromodulin

UniProtKB Accession Codes:

Q06828 Q15331 Q8IV47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8357838

Title: Structure and deduced amino acid sequence of the human fibromodulin gene.

PubMed ID: 8357838

DOI: 10.1016/0167-4781(93)90117-v

PubMed ID: 8093006

Title: Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.

PubMed ID: 8093006

DOI: 10.1042/bj3020527

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14551184

Title: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.

PubMed ID: 14551184

DOI: 10.1074/jbc.m308689200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 376
  • Mass: 43179
  • Checksum: DC19D5E6724AB004
  • Sequence:
    • MQWTSLLLLA GLFSLSQAQY EDDPHWWFHY LRSQQSTYYD PYDPYPYETY EPYPYGVDEG 
PAYTYGSPSP PDPRDCPQEC DCPPNFPTAM YCDNRNLKYL PFVPSRMKYV YFQNNQITSI 
QEGVFDNATG LLWIALHGNQ ITSDKVGRKV FSKLRHLERL YLDHNNLTRM PGPLPRSLRE 
LHLDHNQISR VPNNALEGLE NLTALYLQHN EIQEVGSSMR GLRSLILLDL SYNHLRKVPD 
GLPSALEQLY MEHNNVYTVP DSYFRGAPKL LYVRLSHNSL TNNGLASNTF NSSSLLELDL 
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVV NFSKLQVLRL DGNEIKRSAM 
PADAPLCLRL ASLIEI

Genular Protein ID: 3252752637

Symbol: B3KS64_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KS64

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 1 Gene3D 1 InterPro 4 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 287
  • Mass: 32117
  • Checksum: 099CF6BF6CC35128
  • Sequence:
    • MKMTLIGGST TSAASSPPTT IPMTLTRMRP TSLTPMGWMK GQPTPTALHP LQIPATAPRK 
VFSKLRHLER LYLDHNNLTR MPGPLPRSLR ELHLDHNQIS RVPNNALEGL ENLTALYLQH 
NEIQEVGSSM RGLRSLILLD LSYNHLRKVP DGLPSALEQL YMEHNNVYTV PDSYFRGAPK 
LLYVRLSHNS LTNNGLASNT FNSSSLLELD LSYNQLQKIP PVNTNLENLY LQGNRINEFS 
ISSFCTVVDV VNFSKLQVLR LDGNEIKRSA MPADAPLCLR LASLIEI

Genular Protein ID: 2260105598

Symbol: Q12833_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12833

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 RefSeq 1

Sequence Information:

  • Length: 58
  • Mass: 6470
  • Checksum: 822B24A3ACDD4D80
  • Sequence:
    • YLQGNRINEF SISSFCTVVD VVNFSKLQVL RLDGNEIKRS AMPADAPLCL RLASLIEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.