Details for: FMOD

Gene ID: 2331

Symbol: FMOD

Ensembl ID: ENSG00000122176

Description: fibromodulin

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: endocardial cell (CL0002350)
    Fold Change: 2.65
    Marker Score: 1500
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 2.11
    Marker Score: 4785
  • Cell Name: peptic cell (CL0000155)
    Fold Change: 1.94
    Marker Score: 811
  • Cell Name: transitional stage B cell (CL0000818)
    Fold Change: 1.76
    Marker Score: 623
  • Cell Name: bronchus fibroblast of lung (CL2000093)
    Fold Change: 1.72
    Marker Score: 2358
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 1.62
    Marker Score: 3286
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: 1.42
    Marker Score: 3719
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 1.37
    Marker Score: 8884
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.36
    Marker Score: 863
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 1.31
    Marker Score: 2017
  • Cell Name: respiratory basal cell (CL0002633)
    Fold Change: 1.29
    Marker Score: 1847.5
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.28
    Marker Score: 294.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.14
    Marker Score: 4797
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 1.13
    Marker Score: 38316
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.12
    Marker Score: 17524
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 1.1
    Marker Score: 658
  • Cell Name: pancreatic stellate cell (CL0002410)
    Fold Change: 1.06
    Marker Score: 668
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 1.04
    Marker Score: 251791
  • Cell Name: cortical thymic epithelial cell (CL0002364)
    Fold Change: 1.02
    Marker Score: 3786
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71808
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48033
  • Cell Name: stromal cell of lamina propria of small intestine (CL0009022)
    Fold Change: 0.98
    Marker Score: 221
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.97
    Marker Score: 502
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.97
    Marker Score: 12731
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.96
    Marker Score: 455
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2410
  • Cell Name: intestine goblet cell (CL0019031)
    Fold Change: 0.94
    Marker Score: 904
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.93
    Marker Score: 5311
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2738
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.9
    Marker Score: 322
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.89
    Marker Score: 1072
  • Cell Name: adventitial cell (CL0002503)
    Fold Change: 0.89
    Marker Score: 219
  • Cell Name: glandular cell of esophagus (CL0002657)
    Fold Change: 0.88
    Marker Score: 279
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5278
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.86
    Marker Score: 426
  • Cell Name: fibroblast of connective tissue of prostate (CL1000299)
    Fold Change: 0.84
    Marker Score: 209
  • Cell Name: prostate stromal cell (CL0002622)
    Fold Change: 0.83
    Marker Score: 209
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: 0.83
    Marker Score: 346
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.8
    Marker Score: 679
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.79
    Marker Score: 376
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1269
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.78
    Marker Score: 593
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 0.77
    Marker Score: 3329
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.77
    Marker Score: 309
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 391
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.75
    Marker Score: 494
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.73
    Marker Score: 708
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.72
    Marker Score: 660
  • Cell Name: fibroblast of cardiac tissue (CL0002548)
    Fold Change: 0.71
    Marker Score: 4253
  • Cell Name: tendon cell (CL0000388)
    Fold Change: 0.69
    Marker Score: 170
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.69
    Marker Score: 176
  • Cell Name: fibroblast of breast (CL4006000)
    Fold Change: 0.68
    Marker Score: 388
  • Cell Name: luminal cell of prostate epithelium (CL0002340)
    Fold Change: 0.68
    Marker Score: 394
  • Cell Name: thyroid follicular cell (CL0002258)
    Fold Change: 0.66
    Marker Score: 514
  • Cell Name: muscle cell (CL0000187)
    Fold Change: 0.64
    Marker Score: 181
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: 0.63
    Marker Score: 779.5
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.63
    Marker Score: 166
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: 0.61
    Marker Score: 196
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.6
    Marker Score: 135
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.6
    Marker Score: 692
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.6
    Marker Score: 264
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.57
    Marker Score: 378
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.56
    Marker Score: 6354
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.55
    Marker Score: 146
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.55
    Marker Score: 229
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.55
    Marker Score: 160
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.5
    Marker Score: 822
  • Cell Name: chondrocyte (CL0000138)
    Fold Change: 0.5
    Marker Score: 225
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.49
    Marker Score: 195
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.48
    Marker Score: 143
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.48
    Marker Score: 505
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.47
    Marker Score: 556
  • Cell Name: interstitial cell of Cajal (CL0002088)
    Fold Change: 0.46
    Marker Score: 159
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.44
    Marker Score: 259
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: 0.43
    Marker Score: 111
  • Cell Name: uterine smooth muscle cell (CL0002601)
    Fold Change: 0.43
    Marker Score: 554
  • Cell Name: bronchial smooth muscle cell (CL0002598)
    Fold Change: 0.42
    Marker Score: 118
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.42
    Marker Score: 782
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.42
    Marker Score: 179
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.41
    Marker Score: 342
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: 0.41
    Marker Score: 423
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.4
    Marker Score: 126
  • Cell Name: myoepithelial cell of mammary gland (CL0002324)
    Fold Change: 0.4
    Marker Score: 1951.5
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.4
    Marker Score: 288
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: 0.38
    Marker Score: 96
  • Cell Name: theca cell (CL0000503)
    Fold Change: 0.37
    Marker Score: 266
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.37
    Marker Score: 169
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.36
    Marker Score: 866
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.36
    Marker Score: 366
  • Cell Name: paneth cell (CL0000510)
    Fold Change: 0.35
    Marker Score: 246
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.34
    Marker Score: 220
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.34
    Marker Score: 211
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.33
    Marker Score: 138.5
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.32
    Marker Score: 83
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.32
    Marker Score: 213.5
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.32
    Marker Score: 742
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.31
    Marker Score: 594
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.3
    Marker Score: 132

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Other Information

**Key characteristics:** * FMOD is a large protein with a molecular weight of approximately 120 kDa. * It is a secreted protein that is expressed in a variety of cell types. * FMOD is a major component of the ECM, where it helps to maintain the structural integrity and integrity of tissues. * It is involved in the assembly and maintenance of collagen fibrils, which are essential for the strength and elasticity of tissues. * FMOD is also involved in the regulation of cell migration and proliferation. **Pathways and functions:** * FMOD is involved in the assembly and maintenance of collagen fibrils. * It is also involved in the regulation of cell migration and proliferation. * It is a key component of the ECM, where it helps to maintain the structural integrity and integrity of tissues. **Clinical significance:** Mutations in the FMOD gene have been linked to a number of diseases. These diseases are characterized by abnormal ECM structure and function. For example, mutations in the FMOD gene have been linked to: * Marfan syndrome, a genetic disorder that causes the formation of fragile blood vessels and tissues. * Ehlers-Danlos syndrome, a genetic disorder that causes the formation of fragile skin and blood vessels. * Heterotic aphasia, a genetic disorder that causes difficulty speaking and swallowing. FMOD is a promising target for the treatment of a variety of diseases that are characterized by abnormal ECM structure and function.

Genular Protein ID: 2563950772

Symbol: FMOD_HUMAN

Name: Fibromodulin

UniProtKB Accession Codes:

Q06828 Q15331 Q8IV47

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 6 Ensembl 1 ExpressionAtlas 1 GO 8 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 4 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 RNAct 1 Reactome 6 RefSeq 1 SMART 3 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 8357838

Title: Structure and deduced amino acid sequence of the human fibromodulin gene.

PubMed ID: 8357838

DOI: 10.1016/0167-4781(93)90117-v

PubMed ID: 8093006

Title: Interaction of the small interstitial proteoglycans biglycan, decorin and fibromodulin with transforming growth factor beta.

PubMed ID: 8093006

DOI: 10.1042/bj3020527

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16710414

Title: The DNA sequence and biological annotation of human chromosome 1.

PubMed ID: 16710414

DOI: 10.1038/nature04727

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14551184

Title: Identification of tyrosine sulfation in extracellular leucine-rich repeat proteins using mass spectrometry.

PubMed ID: 14551184

DOI: 10.1074/jbc.m308689200

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

Sequence Information:

  • Length: 376
  • Mass: 43179
  • Checksum: DC19D5E6724AB004
  • Sequence:
    • MQWTSLLLLA GLFSLSQAQY EDDPHWWFHY LRSQQSTYYD PYDPYPYETY EPYPYGVDEG 
PAYTYGSPSP PDPRDCPQEC DCPPNFPTAM YCDNRNLKYL PFVPSRMKYV YFQNNQITSI 
QEGVFDNATG LLWIALHGNQ ITSDKVGRKV FSKLRHLERL YLDHNNLTRM PGPLPRSLRE 
LHLDHNQISR VPNNALEGLE NLTALYLQHN EIQEVGSSMR GLRSLILLDL SYNHLRKVPD 
GLPSALEQLY MEHNNVYTVP DSYFRGAPKL LYVRLSHNSL TNNGLASNTF NSSSLLELDL 
SYNQLQKIPP VNTNLENLYL QGNRINEFSI SSFCTVVDVV NFSKLQVLRL DGNEIKRSAM 
PADAPLCLRL ASLIEI

Genular Protein ID: 3252752637

Symbol: B3KS64_HUMAN

Name: N/A

UniProtKB Accession Codes:

B3KS64

Database IDs:

ARBA 6 AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Gene3D 1 GenomeRNAi 1 InterPro 3 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 1 PeptideAtlas 1 Pfam 3 RefSeq 1 SAM 1 SMART 2 SUPFAM 1

Citations:

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

Sequence Information:

  • Length: 287
  • Mass: 32117
  • Checksum: 099CF6BF6CC35128
  • Sequence:
    • MKMTLIGGST TSAASSPPTT IPMTLTRMRP TSLTPMGWMK GQPTPTALHP LQIPATAPRK 
VFSKLRHLER LYLDHNNLTR MPGPLPRSLR ELHLDHNQIS RVPNNALEGL ENLTALYLQH 
NEIQEVGSSM RGLRSLILLD LSYNHLRKVP DGLPSALEQL YMEHNNVYTV PDSYFRGAPK 
LLYVRLSHNS LTNNGLASNT FNSSSLLELD LSYNQLQKIP PVNTNLENLY LQGNRINEFS 
ISSFCTVVDV VNFSKLQVLR LDGNEIKRSA MPADAPLCLR LASLIEI

Genular Protein ID: 2260105598

Symbol: Q12833_HUMAN

Name: N/A

UniProtKB Accession Codes:

Q12833

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 DNASU 1 EMBL 2 Genevisible 1 GenomeRNAi 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 PeptideAtlas 1 PharmGKB 1 RefSeq 1

Sequence Information:

  • Length: 58
  • Mass: 6470
  • Checksum: 822B24A3ACDD4D80
  • Sequence:
    • YLQGNRINEF SISSFCTVVD VVNFSKLQVL RLDGNEIKRS AMPADAPLCL RLASLIEI

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.