Details for: HTR1F

Gene ID: 3355

Symbol: HTR1F

Ensembl ID: ENSG00000179097

Description: 5-hydroxytryptamine receptor 1F

Associated with

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: thymocyte (CL0000893)
    Fold Change: 2.05
    Marker Score: 2143
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 1.62
    Marker Score: 1177
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 1.51
    Marker Score: 1503
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 1.27
    Marker Score: 861
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 1.18
    Marker Score: 491
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 1.15
    Marker Score: 4825
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 1.1
    Marker Score: 507
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: 1.05
    Marker Score: 4064
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71838
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48062
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1
    Marker Score: 513
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.99
    Marker Score: 466
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30409
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.94
    Marker Score: 377
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5354
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.91
    Marker Score: 329
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.9
    Marker Score: 878.5
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5293
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1265
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 711
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.77
    Marker Score: 400
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.74
    Marker Score: 562
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.73
    Marker Score: 466
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.71
    Marker Score: 2948
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.68
    Marker Score: 452
  • Cell Name: type A enteroendocrine cell (CL0002067)
    Fold Change: 0.59
    Marker Score: 236
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.57
    Marker Score: 35285
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.57
    Marker Score: 882
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.56
    Marker Score: 444
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: 0.55
    Marker Score: 175
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.49
    Marker Score: 4674
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 129
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.47
    Marker Score: 250
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: 0.45
    Marker Score: 310
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: 0.39
    Marker Score: 449
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.37
    Marker Score: 278
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.37
    Marker Score: 373
  • Cell Name: hematopoietic multipotent progenitor cell (CL0000837)
    Fold Change: 0.33
    Marker Score: 163
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.33
    Marker Score: 240
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.3
    Marker Score: 2568
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.29
    Marker Score: 94
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.29
    Marker Score: 277
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.29
    Marker Score: 2984
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.28
    Marker Score: 2140
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: 0.27
    Marker Score: 381
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.26
    Marker Score: 255
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.26
    Marker Score: 2627
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.25
    Marker Score: 108.5
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.24
    Marker Score: 499
  • Cell Name: interneuron (CL0000099)
    Fold Change: 0.24
    Marker Score: 109
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.23
    Marker Score: 167
  • Cell Name: supporting cell (CL0000630)
    Fold Change: 0.23
    Marker Score: 435
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.23
    Marker Score: 80
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.23
    Marker Score: 65
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.22
    Marker Score: 75
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.22
    Marker Score: 213.5
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.21
    Marker Score: 144
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.21
    Marker Score: 116.5
  • Cell Name: tracheobronchial smooth muscle cell (CL0019019)
    Fold Change: 0.2
    Marker Score: 60
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.2
    Marker Score: 113
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.2
    Marker Score: 118
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.19
    Marker Score: 775
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 0.19
    Marker Score: 1244
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.19
    Marker Score: 78
  • Cell Name: double negative thymocyte (CL0002489)
    Fold Change: 0.19
    Marker Score: 256.5
  • Cell Name: glial cell (CL0000125)
    Fold Change: 0.18
    Marker Score: 201
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: 0.18
    Marker Score: 87
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.17
    Marker Score: 43
  • Cell Name: PP cell (CL0000696)
    Fold Change: 0.17
    Marker Score: 39
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: 0.17
    Marker Score: 89
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.17
    Marker Score: 51
  • Cell Name: neuron (CL0000540)
    Fold Change: 0.17
    Marker Score: 691
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.17
    Marker Score: 177
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.17
    Marker Score: 6290
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.14
    Marker Score: 403
  • Cell Name: early lymphoid progenitor (CL0000936)
    Fold Change: 0.12
    Marker Score: 59
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.12
    Marker Score: 70
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.12
    Marker Score: 53
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.11
    Marker Score: 263
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: 0.11
    Marker Score: 119
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: 0.11
    Marker Score: 320
  • Cell Name: immature B cell (CL0000816)
    Fold Change: 0.11
    Marker Score: 70
  • Cell Name: cord blood hematopoietic stem cell (CL2000095)
    Fold Change: 0.1
    Marker Score: 75
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.09
    Marker Score: 185
  • Cell Name: megakaryocyte progenitor cell (CL0000553)
    Fold Change: 0.09
    Marker Score: 26
  • Cell Name: basal cell (CL0000646)
    Fold Change: 0.09
    Marker Score: 120
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.09
    Marker Score: 53
  • Cell Name: secretory cell (CL0000151)
    Fold Change: 0.08
    Marker Score: 151
  • Cell Name: contractile cell (CL0000183)
    Fold Change: 0.08
    Marker Score: 44
  • Cell Name: mature B cell (CL0000785)
    Fold Change: 0.08
    Marker Score: 59
  • Cell Name: erythroblast (CL0000765)
    Fold Change: 0.08
    Marker Score: 49
  • Cell Name: common dendritic progenitor (CL0001029)
    Fold Change: 0.08
    Marker Score: 26
  • Cell Name: P/D1 enteroendocrine cell (CL0002268)
    Fold Change: 0.08
    Marker Score: 28
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.07
    Marker Score: 252
  • Cell Name: blood vessel smooth muscle cell (CL0019018)
    Fold Change: 0.06
    Marker Score: 17
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.06
    Marker Score: 161
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.06
    Marker Score: 14

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Other Information

**Key characteristics:** - 5HT1F is a G protein-coupled receptor belonging to the class a/1 (rhodopsin-like receptors). - It is a transmembrane protein with seven transmembrane domains and a conserved extracellular domain. - It is expressed in both the plasma membrane and intracellular compartments. **Pathways and functions:** - 5HT1F is involved in multiple signaling pathways, including the adenylate cyclase-inhibiting g protein-coupled receptor (AC-GPCR) pathway, the adenylate cyclase-inhibiting serotonin receptor (AC-SSR) pathway, the amine ligand-binding receptors pathway, and the G protein-coupled receptor (GPCR) signaling pathway. - It regulates the production and release of neurotransmitters, including serotonin, through these pathways. - In the AC-GPCR pathway, 5HT1F acts as a negative regulator, inhibiting the activity of adenylate cyclase. - In the AC-SSR pathway, it inhibits the activity of adenylate cyclase by interacting with a different receptor, the serotonin receptor. - In the amine ligand-binding receptors pathway, 5HT1F is a receptor for certain neurotransmitters, such as serotonin. - In the GPCR pathway, 5HT1F is a ligand-gated ion channel that opens upon binding of its specific ligand, serotonin. **Clinical significance:** - Mutations in the HTR1F gene have been linked to several neurological and psychiatric disorders, including autism, schizophrenia, and depression. - 5HT1F is a potential therapeutic target for these disorders, as it can modulate the activity of neurotransmitters involved in their pathogenesis. **Additional notes:** - 5HT1F is a highly conserved protein, with similar sequences found in mammals and birds. - It is a key regulator of serotonin signaling in the central nervous system. - Dysregulation of 5HT1F signaling has been implicated in the pathogenesis of various neurological and psychiatric disorders.

Genular Protein ID: 794442020

Symbol: 5HT1F_HUMAN

Name: 5-hydroxytryptamine receptor 1F

UniProtKB Accession Codes:

P30939

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 3 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EMBL 5 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 UniProtKB 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8384716

Title: Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.

PubMed ID: 8384716

DOI: 10.1073/pnas.90.6.2184

PubMed ID: 8380639

Title: Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

PubMed ID: 8380639

DOI: 10.1073/pnas.90.2.408

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 21422162

Title: Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships.

PubMed ID: 21422162

DOI: 10.1124/jpet.111.179606

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

Sequence Information:

  • Length: 366
  • Mass: 41709
  • Checksum: 16EA80344793B54F
  • Sequence:
    • MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY 
LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL SVDITCCTCS ILHLSAIALD 
RYRAITDAVE YARKRTPKHA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHDHIV 
STIYSTFGAF YIPLALILIL YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS 
VSTSYVLEKS LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG 
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK 
LVRCRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.