Details for: HTR1F

Gene ID: 3355

Symbol: HTR1F

Ensembl ID: ENSG00000179097

Description: 5-hydroxytryptamine receptor 1F

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 29.1877
    Cell Significance Index: -4.5400
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 3.6984
    Cell Significance Index: -4.5600
  • Cell Name: urothelial cell (CL0000731)
    Fold Change: 0.8317
    Cell Significance Index: 5.8000
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.5904
    Cell Significance Index: 37.2100
  • Cell Name: macroglial cell (CL0000126)
    Fold Change: 0.3239
    Cell Significance Index: 3.7500
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.2941
    Cell Significance Index: 2.5000
  • Cell Name: cytotoxic T cell (CL0000910)
    Fold Change: 0.2916
    Cell Significance Index: 4.2500
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.2520
    Cell Significance Index: 16.2600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2383
    Cell Significance Index: 8.2800
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.2299
    Cell Significance Index: 66.1500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: 0.2298
    Cell Significance Index: 3.2300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2197
    Cell Significance Index: 44.0700
  • Cell Name: myometrial cell (CL0002366)
    Fold Change: 0.2014
    Cell Significance Index: 2.3200
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1752
    Cell Significance Index: 4.4800
  • Cell Name: photoreceptor cell (CL0000210)
    Fold Change: 0.1630
    Cell Significance Index: 2.2900
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.0795
    Cell Significance Index: 1.6500
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: 0.0709
    Cell Significance Index: 1.1400
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0488
    Cell Significance Index: 2.5400
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.0395
    Cell Significance Index: 0.8300
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0373
    Cell Significance Index: 0.8000
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 0.0297
    Cell Significance Index: 0.9500
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.0217
    Cell Significance Index: 0.5800
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.0160
    Cell Significance Index: 5.7400
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: -0.0009
    Cell Significance Index: -0.0100
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0022
    Cell Significance Index: -1.6200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0031
    Cell Significance Index: -5.7300
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0038
    Cell Significance Index: -5.8000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.0051
    Cell Significance Index: -0.2400
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0055
    Cell Significance Index: -3.1200
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0063
    Cell Significance Index: -0.2000
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0065
    Cell Significance Index: -4.9500
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0070
    Cell Significance Index: -4.4700
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.0073
    Cell Significance Index: -0.0800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0078
    Cell Significance Index: -4.2600
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0080
    Cell Significance Index: -5.0100
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0121
    Cell Significance Index: -5.5000
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0122
    Cell Significance Index: -2.2000
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: -0.0161
    Cell Significance Index: -2.6300
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0212
    Cell Significance Index: -4.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0237
    Cell Significance Index: -4.7100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.0241
    Cell Significance Index: -0.7900
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0273
    Cell Significance Index: -3.3600
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0274
    Cell Significance Index: -4.6800
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0300
    Cell Significance Index: -3.8400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0309
    Cell Significance Index: -4.2500
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.0328
    Cell Significance Index: -1.1500
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0331
    Cell Significance Index: -4.8200
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.0341
    Cell Significance Index: -0.6900
  • Cell Name: Mueller cell (CL0000636)
    Fold Change: -0.0377
    Cell Significance Index: -0.2900
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0394
    Cell Significance Index: -5.0900
  • Cell Name: erythroid progenitor cell (CL0000038)
    Fold Change: -0.0405
    Cell Significance Index: -0.5300
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.0419
    Cell Significance Index: -1.2400
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0452
    Cell Significance Index: -4.6200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0452
    Cell Significance Index: -5.1800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: -0.0468
    Cell Significance Index: -2.8100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0551
    Cell Significance Index: -4.1100
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.0560
    Cell Significance Index: -1.4400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0563
    Cell Significance Index: -2.8500
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: -0.0576
    Cell Significance Index: -0.7300
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0615
    Cell Significance Index: -2.5200
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0618
    Cell Significance Index: -4.7400
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0713
    Cell Significance Index: -4.8000
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0716
    Cell Significance Index: -4.4000
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.0760
    Cell Significance Index: -0.7200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.0810
    Cell Significance Index: -1.2200
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.0819
    Cell Significance Index: -0.8100
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.0822
    Cell Significance Index: -1.9900
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.0838
    Cell Significance Index: -1.6500
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0838
    Cell Significance Index: -4.7000
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0847
    Cell Significance Index: -3.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0863
    Cell Significance Index: -4.5300
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.0879
    Cell Significance Index: -1.2600
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0929
    Cell Significance Index: -0.7800
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.0931
    Cell Significance Index: -1.8400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1012
    Cell Significance Index: -4.7600
  • Cell Name: L4 intratelencephalic projecting glutamatergic neuron (CL4030063)
    Fold Change: -0.1013
    Cell Significance Index: -1.1100
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1083
    Cell Significance Index: -4.7900
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.1122
    Cell Significance Index: -2.8000
  • Cell Name: common lymphoid progenitor (CL0000051)
    Fold Change: -0.1123
    Cell Significance Index: -1.1400
  • Cell Name: vascular leptomeningeal cell (CL4023051)
    Fold Change: -0.1170
    Cell Significance Index: -1.7500
  • Cell Name: cortical interneuron (CL0008031)
    Fold Change: -0.1245
    Cell Significance Index: -2.9900
  • Cell Name: GABAergic neuron (CL0000617)
    Fold Change: -0.1252
    Cell Significance Index: -1.5800
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.1253
    Cell Significance Index: -2.6600
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.1266
    Cell Significance Index: -2.7400
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1320
    Cell Significance Index: -5.0000
  • Cell Name: paneth cell of colon (CL0009009)
    Fold Change: -0.1385
    Cell Significance Index: -2.0800
  • Cell Name: thymocyte (CL0000893)
    Fold Change: -0.1417
    Cell Significance Index: -1.7900
  • Cell Name: neural cell (CL0002319)
    Fold Change: -0.1449
    Cell Significance Index: -1.6900
  • Cell Name: hippocampal interneuron (CL1001569)
    Fold Change: -0.1488
    Cell Significance Index: -1.9300
  • Cell Name: respiratory goblet cell (CL0002370)
    Fold Change: -0.1493
    Cell Significance Index: -1.5400
  • Cell Name: endocrine cell (CL0000163)
    Fold Change: -0.1506
    Cell Significance Index: -1.8200
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.1509
    Cell Significance Index: -3.0100
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: -0.1509
    Cell Significance Index: -3.0700
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.1582
    Cell Significance Index: -4.1600
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.1632
    Cell Significance Index: -2.3700
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.1648
    Cell Significance Index: -4.1100
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.1658
    Cell Significance Index: -4.7300
  • Cell Name: retinal rod cell (CL0000604)
    Fold Change: -0.1695
    Cell Significance Index: -2.0200
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.1695
    Cell Significance Index: -3.0000
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.1704
    Cell Significance Index: -7.4100

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** HTR1F is a G protein-coupled receptor (GPCR) that belongs to the class A/1 rhodopsin-like receptors. It is a serotonin receptor, specifically a 5-HT1F receptor, which is activated by the neurotransmitter 5-hydroxytryptamine (5-HT). The HTR1F gene is highly expressed in various cell types, including thymocytes, colon goblet cells, enterocytes, and neural progenitor cells. Its expression is also observed in the cerebral cortex, forebrain, and spinal cord, highlighting its involvement in central nervous system functions. **Pathways and Functions:** The HTR1F gene is implicated in several signaling pathways, including: 1. **Adenylate cyclase-inhibiting GPCR signaling pathway**: HTR1F activation leads to the inhibition of adenylate cyclase, resulting in a decrease in cAMP levels and a subsequent decrease in intracellular signaling. 2. **Amine ligand-binding receptors**: HTR1F is a ligand-binding receptor for 5-HT, which binds to the receptor and triggers a conformational change, activating the receptor. 3. **G alpha (i) signaling events**: The activation of HTR1F leads to the activation of Gαi proteins, which inhibit adenylate cyclase and reduce cAMP levels. 4. **GPCR downstream signaling**: HTR1F is involved in various downstream signaling pathways, including the regulation of ion channels, potassium channels, and calcium channels. The functions of HTR1F are multifaceted, including: 1. **Regulation of mood and anxiety**: HTR1F is implicated in the regulation of mood and anxiety, particularly in response to 5-HT. 2. **Modulation of pain perception**: HTR1F is involved in the regulation of pain perception, particularly in response to 5-HT. 3. **Inflammation and immune response**: HTR1F is expressed on immune cells, including T cells and dendritic cells, and is involved in the regulation of inflammation and immune response. **Clinical Significance:** The HTR1F gene has been implicated in various neurological and psychiatric disorders, including: 1. **Major depressive disorder**: HTR1F has been shown to be associated with major depressive disorder, particularly in response to 5-HT. 2. **Anxiety disorders**: HTR1F has been implicated in the regulation of anxiety, particularly in response to 5-HT. 3. **Pain disorders**: HTR1F has been shown to be involved in the regulation of pain perception, particularly in response to 5-HT. 4. **Neurodegenerative disorders**: HTR1F has been implicated in the regulation of neurodegenerative disorders, including Alzheimer's disease and Parkinson's disease. In conclusion, the HTR1F gene is a complex and multifaceted gene that plays a crucial role in various physiological and pathological processes. Further research is needed to fully understand the mechanisms underlying HTR1F function and its implications for human health and disease. **Recommendations:** 1. **Further research**: Additional studies are needed to fully understand the mechanisms underlying HTR1F function and its implications for human health and disease. 2. **Therapeutic targeting**: HTR1F may be a potential target for therapeutic interventions in neurological and psychiatric disorders, particularly in response to 5-HT. 3. **Immunological applications**: HTR1F may have implications for immunological applications, including the regulation of inflammation and immune response. **Limitations:** The current review highlights the complexities of the HTR1F gene and its involvement in various physiological and pathological processes. However, further research is needed to fully understand the mechanisms underlying HTR1F function and its implications for human health and disease.

Genular Protein ID: 794442020

Symbol: 5HT1F_HUMAN

Name: N/A

UniProtKB Accession Codes:

P30939

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BindingDB 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 ChEBI 2 ChEMBL 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 DrugBank 21 DrugCentral 1 EMBL 5 Ensembl 1 GO 10 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 GuidetoPHARMACOLOGY 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 1 PDBsum 1 PIR 1 PRINTS 3 PRO 1 PROSITE 2 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 RNAct 1 Reactome 2 RefSeq 6 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 8384716

Title: Molecular cloning and functional expression of 5-HT1E-like rat and human 5-hydroxytryptamine receptor genes.

PubMed ID: 8384716

DOI: 10.1073/pnas.90.6.2184

PubMed ID: 8380639

Title: Cloning of another human serotonin receptor (5-HT1F): a fifth 5-HT1 receptor subtype coupled to the inhibition of adenylate cyclase.

PubMed ID: 8380639

DOI: 10.1073/pnas.90.2.408

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 16641997

Title: The DNA sequence, annotation and analysis of human chromosome 3.

PubMed ID: 16641997

DOI: 10.1038/nature04728

PubMed ID: 18476671

Title: Serotonin receptors.

PubMed ID: 18476671

DOI: 10.1021/cr078224o

PubMed ID: 21422162

Title: Toward selective drug development for the human 5-hydroxytryptamine 1E receptor: a comparison of 5-hydroxytryptamine 1E and 1F receptor structure-affinity relationships.

PubMed ID: 21422162

DOI: 10.1124/jpet.111.179606

PubMed ID: 35610220

Title: Structural insights into the ligand binding and Gi coupling of serotonin receptor 5-HT5A.

PubMed ID: 35610220

DOI: 10.1038/s41421-022-00412-3

PubMed ID: 20945968

Title: Serotonin receptors - from molecular biology to clinical applications.

PubMed ID: 20945968

DOI: 10.33549/physiolres.931903

PubMed ID: 34239069

Title: Structural basis for recognition of anti-migraine drug lasmiditan by the serotonin receptor 5-HT1F-G protein complex.

PubMed ID: 34239069

DOI: 10.1038/s41422-021-00527-4

Sequence Information:

  • Length: 366
  • Mass: 41709
  • Checksum: 16EA80344793B54F
  • Sequence:
    • MDFLNSSDQN LTSEELLNRM PSKILVSLTL SGLALMTTTI NSLVIAAIIV TRKLHHPANY 
LICSLAVTDF LVAVLVMPFS IVYIVRESWI MGQVVCDIWL SVDITCCTCS ILHLSAIALD 
RYRAITDAVE YARKRTPKHA GIMITIVWII SVFISMPPLF WRHQGTSRDD ECIIKHDHIV 
STIYSTFGAF YIPLALILIL YYKIYRAAKT LYHKRQASRI AKEEVNGQVL LESGEKSTKS 
VSTSYVLEKS LSDPSTDFDK IHSTVRSLRS EFKHEKSWRR QKISGTRERK AATTLGLILG 
AFVICWLPFF VKELVVNVCD KCKISEEMSN FLAWLGYLNS LINPLIYTIF NEDFKKAFQK 
LVRCRC

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.