Details for: ADAMDEC1

Gene ID: 27299

Symbol: ADAMDEC1

Ensembl ID: ENSG00000134028

Description: ADAM like decysin 1

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 12.4968
    Cell Significance Index: -5.9000
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 7.0385
    Cell Significance Index: -6.7200
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 2.4199
    Cell Significance Index: 37.4400
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: 0.4849
    Cell Significance Index: 359.2200
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: 0.3410
    Cell Significance Index: 192.3100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.2187
    Cell Significance Index: 5.8500
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.2145
    Cell Significance Index: 2.2200
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.2103
    Cell Significance Index: 1.4800
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: 0.1835
    Cell Significance Index: 38.6500
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0631
    Cell Significance Index: 39.3800
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.0192
    Cell Significance Index: 0.1200
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: -0.0027
    Cell Significance Index: -5.0200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0028
    Cell Significance Index: -0.3200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0034
    Cell Significance Index: -0.5800
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0051
    Cell Significance Index: -9.4700
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0062
    Cell Significance Index: -9.5400
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0070
    Cell Significance Index: -9.5400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0088
    Cell Significance Index: -0.4400
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0090
    Cell Significance Index: -0.3700
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0099
    Cell Significance Index: -6.3100
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0106
    Cell Significance Index: -3.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0146
    Cell Significance Index: -6.6400
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.0160
    Cell Significance Index: -0.4000
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.0203
    Cell Significance Index: -4.0700
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.0259
    Cell Significance Index: -2.9600
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0280
    Cell Significance Index: -5.0400
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0333
    Cell Significance Index: -6.6000
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0342
    Cell Significance Index: -4.3800
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: -0.0374
    Cell Significance Index: -1.6300
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0381
    Cell Significance Index: -3.8900
  • Cell Name: myeloid leukocyte (CL0000766)
    Fold Change: -0.0420
    Cell Significance Index: -0.3400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0428
    Cell Significance Index: -6.2200
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0492
    Cell Significance Index: -6.0600
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.0666
    Cell Significance Index: -7.8500
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.0669
    Cell Significance Index: -9.1900
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.0670
    Cell Significance Index: -7.8100
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: -0.0689
    Cell Significance Index: -1.0000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.0693
    Cell Significance Index: -1.1600
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0824
    Cell Significance Index: -6.3200
  • Cell Name: myofibroblast cell (CL0000186)
    Fold Change: -0.0868
    Cell Significance Index: -0.9100
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.0961
    Cell Significance Index: -4.9900
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.1027
    Cell Significance Index: -6.9100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.1034
    Cell Significance Index: -7.7100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1083
    Cell Significance Index: -3.0300
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1104
    Cell Significance Index: -6.7700
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1160
    Cell Significance Index: -2.9800
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.1178
    Cell Significance Index: -6.6100
  • Cell Name: osteoclast (CL0000092)
    Fold Change: -0.1273
    Cell Significance Index: -1.3000
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.1284
    Cell Significance Index: -6.6900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.1305
    Cell Significance Index: -8.0200
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.1330
    Cell Significance Index: -4.6600
  • Cell Name: stromal cell (CL0000499)
    Fold Change: -0.1370
    Cell Significance Index: -1.4000
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.1388
    Cell Significance Index: -6.1400
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: -0.1517
    Cell Significance Index: -2.0800
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.1600
    Cell Significance Index: -6.0600
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.1671
    Cell Significance Index: -5.3200
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.1683
    Cell Significance Index: -7.6300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1688
    Cell Significance Index: -7.9400
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.1741
    Cell Significance Index: -6.3900
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.1747
    Cell Significance Index: -5.7200
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.1787
    Cell Significance Index: -6.2800
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: -0.1886
    Cell Significance Index: -1.3000
  • Cell Name: neural progenitor cell (CL0011020)
    Fold Change: -0.2011
    Cell Significance Index: -1.9900
  • Cell Name: mesothelial cell of epicardium (CL0011019)
    Fold Change: -0.2104
    Cell Significance Index: -1.8200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.2169
    Cell Significance Index: -6.2500
  • Cell Name: monocyte-derived dendritic cell (CL0011031)
    Fold Change: -0.2189
    Cell Significance Index: -3.7600
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.2201
    Cell Significance Index: -2.5000
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: -0.2225
    Cell Significance Index: -2.6300
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: -0.2232
    Cell Significance Index: -3.6200
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2283
    Cell Significance Index: -5.7000
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.2361
    Cell Significance Index: -11.0100
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: -0.2407
    Cell Significance Index: -6.4500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.2411
    Cell Significance Index: -6.3400
  • Cell Name: hippocampal pyramidal neuron (CL1001571)
    Fold Change: -0.2413
    Cell Significance Index: -6.8900
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.2536
    Cell Significance Index: -6.4600
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: -0.2571
    Cell Significance Index: -3.1800
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.2595
    Cell Significance Index: -7.4400
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: -0.2612
    Cell Significance Index: -3.3800
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.2689
    Cell Significance Index: -7.1800
  • Cell Name: enterocyte (CL0000584)
    Fold Change: -0.2692
    Cell Significance Index: -1.6700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2702
    Cell Significance Index: -3.8700
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.2752
    Cell Significance Index: -5.8400
  • Cell Name: type I muscle cell (CL0002211)
    Fold Change: -0.2754
    Cell Significance Index: -6.7200
  • Cell Name: hematopoietic cell (CL0000988)
    Fold Change: -0.2755
    Cell Significance Index: -4.0300
  • Cell Name: leukocyte (CL0000738)
    Fold Change: -0.2761
    Cell Significance Index: -4.6900
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.2798
    Cell Significance Index: -5.8400
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: -0.2799
    Cell Significance Index: -3.7200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.2838
    Cell Significance Index: -7.7300
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: -0.2875
    Cell Significance Index: -7.1800
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.2901
    Cell Significance Index: -8.5200
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.2981
    Cell Significance Index: -6.4400
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.3009
    Cell Significance Index: -5.9500
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.3028
    Cell Significance Index: -5.9600
  • Cell Name: lens fiber cell (CL0011004)
    Fold Change: -0.3031
    Cell Significance Index: -9.5900
  • Cell Name: caudal ganglionic eminence derived cortical interneuron (CL4023064)
    Fold Change: -0.3164
    Cell Significance Index: -6.3100
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.3193
    Cell Significance Index: -6.4100
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.3203
    Cell Significance Index: -7.4000
  • Cell Name: medium spiny neuron (CL1001474)
    Fold Change: -0.3253
    Cell Significance Index: -4.3900
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.3278
    Cell Significance Index: -7.9400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.3279
    Cell Significance Index: -6.8000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** ADAMDEC1 exhibits several key characteristics that distinguish it from other ADAM family members. These include: 1. **Metalloendopeptidase activity**: ADAMDEC1 possesses a metalloendopeptidase domain, which is responsible for the cleavage of protein substrates. 2. **Zinc ion binding**: The protein contains a zinc-binding motif, which is essential for its enzymatic activity. 3. **Negative regulation of cell adhesion**: ADAMDEC1 has been shown to inhibit cell adhesion, suggesting its role in regulating cellular interactions. 4. **Involvement in immune response**: ADAMDEC1 is significantly expressed in immune cells and has been implicated in immune response regulation. **Pathways and Functions** ADAMDEC1's involvement in various signaling pathways underlines its multifunctional role in cellular processes. The gene's functions can be broadly categorized into: 1. **Immune response**: ADAMDEC1 regulates immune cell adhesion and migration, modulating the immune response. 2. **Cell adhesion**: The protein inhibits cell adhesion, which is essential for maintaining tissue homeostasis and preventing excessive inflammation. 3. **Proteolysis**: ADAMDEC1's metalloendopeptidase activity contributes to the degradation of protein substrates, influencing cellular signaling and homeostasis. 4. **Tissue development**: ADAMDEC1's expression in endothelial cells and neurons suggests its involvement in tissue development and maintenance. **Clinical Significance** ADAMDEC1's dysregulation has been implicated in various diseases, including: 1. **Autoimmune disorders**: ADAMDEC1's role in immune response regulation makes it a potential target for autoimmune disease treatment. 2. **Cancer**: The protein's involvement in cell adhesion and proteolysis may contribute to cancer progression and metastasis. 3. **Neurological disorders**: ADAMDEC1's expression in neurons suggests its potential involvement in neurological disorders, such as Alzheimer's disease and Parkinson's disease. In conclusion, ADAMDEC1 is a multifunctional protein with significant implications for various biological processes, including immune response, cell adhesion, and proteolysis. Further research is necessary to fully elucidate the gene's functions and its clinical significance in human disease.

Genular Protein ID: 1907456503

Symbol: ADEC1_HUMAN

Name: ADAM DEC1

UniProtKB Accession Codes:

O15204 B7ZAK5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CTD 1 ChEBI 4 ChiTaRS 1 DNASU 1 DisGeNET 1 EC 1 EMBL 7 Ensembl 2 ExpressionAtlas 1 GO 7 Gene3D 2 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 6 KEGG 1 MANE-Select 1 MEROPS 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PROSITE 3 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 RefSeq 3 SMART 1 SMR 1 STRING 1 SUPFAM 2 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 9271581

Title: Polymerase chain reaction selects a novel disintegrin proteinase from CD40-activated germinal center dendritic cells.

PubMed ID: 9271581

DOI: 10.1084/jem.186.5.655

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16421571

Title: DNA sequence and analysis of human chromosome 8.

PubMed ID: 16421571

DOI: 10.1038/nature04406

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14632642

Title: Inverse regulation of the ADAM-family members, decysin and MADDAM/ADAM19 during monocyte differentiation.

PubMed ID: 14632642

DOI: 10.1111/j.1365-2567.2003.01754.x

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19139490

Title: A strategy for precise and large scale identification of core fucosylated glycoproteins.

PubMed ID: 19139490

DOI: 10.1074/mcp.m800504-mcp200

Sequence Information:

  • Length: 470
  • Mass: 52775
  • Checksum: 35A454DD8A6A7E53
  • Sequence:
    • MLRGISQLPA VATMSWVLLP VLWLIVQTQA IAIKQTPELT LHEIVCPKKL HILHKREIKN 
NQTEKHGKEE RYEPEVQYQM ILNGEEIILS LQKTKHLLGP DYTETLYSPR GEEITTKPEN 
MEHCYYKGNI LNEKNSVASI STCDGLRGYF THHHQRYQIK PLKSTDEKEH AVFTSNQEEQ 
DPANHTCGVK STDGKQGPIR ISRSLKSPEK EDFLRAQKYI DLYLVLDNAF YKNYNENLTL 
IRSFVFDVMN LLNVIYNTID VQVALVGMEI WSDGDKIKVV PSASTTFDNF LRWHSSNLGK 
KIHDHAQLLS GISFNNRRVG LAASNSLCSP SSVAVIEAKK KNNVALVGVM SHELGHVLGM 
PDVPFNTKCP SGSCVMNQYL SSKFPKDFST SCRAHFERYL LSQKPKCLLQ APIPTNIMTT 
PVCGNHLLEV GEDCDCGSPK ECTNLCCEAL TCKLKPGTDC GGDAPNHTTE

Genular Protein ID: 973891758

Symbol: B7Z6V5_HUMAN

Name: N/A

UniProtKB Accession Codes:

B7Z6V5

Database IDs:

ARBA 2 AlphaFoldDB 1 BioGRID-ORCS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 2 GO 4 Gene3D 2 InterPro 6 KEGG 1 MEROPS 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PROSITE 4 PROSITE-ProRule 1 PeptideAtlas 1 Pfam 2 PharmGKB 1 RefSeq 3 SAM 1 SMART 1 SUPFAM 2

Sequence Information:

  • Length: 391
  • Mass: 43530
  • Checksum: 68CF78DCB66A71D8
  • Sequence:
    • MILNGEEIIL SLQKTKHLLG PDYTETLYSP RGEEITTKPE NMEHCYYKGN ILNEKNSVAS 
ISTCDGLRGY FTHHHQRYQI KPLKSTDEKE HAVFTSNQEE QDPANHTCGV KSTDGKQGPI 
RISRSLKSPE KEDFLRAQKY IDLYLVLDNA FYKNYNENLT LIRSFVFDVM NLLNVIYNTI 
DVQVALVGME IWSDGDKIKV VPSASTTFDN FLRWHSSNLG KKIHDHAQLL SGISFNNRRV 
GLAASNSLCS PSSVAVIEAK KKNNVALVGV MSHELGHVLG MPDVPFNTKC PSGSCVMNQY 
LSSKFPKDFS TSCRAHFERY LLSQKPKCLL QAPIPTNIMT TPVCGNHLLE VGEDCDCGSP 
KECTSLCCEA LTCKLKPGTD CGGDAPNHTT E

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.