Details for: MFAP4

Gene ID: 4239

Symbol: MFAP4

Ensembl ID: ENSG00000166482

Description: microfibril associated protein 4

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 141.5023
    Cell Significance Index: -22.0100
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 85.2378
    Cell Significance Index: -21.6200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 45.4884
    Cell Significance Index: -18.4800
  • Cell Name: smooth muscle fiber of ileum (CL1000278)
    Fold Change: 40.6250
    Cell Significance Index: -19.1800
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 22.4375
    Cell Significance Index: 138.8200
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 19.3769
    Cell Significance Index: -18.5000
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 10.5550
    Cell Significance Index: 60.5200
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 9.9942
    Cell Significance Index: 52.5900
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 8.9668
    Cell Significance Index: 114.8400
  • Cell Name: theca cell (CL0000503)
    Fold Change: 7.8732
    Cell Significance Index: 46.2600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 6.3000
    Cell Significance Index: 131.8700
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 5.8600
    Cell Significance Index: 167.9800
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: 4.5411
    Cell Significance Index: 145.4500
  • Cell Name: chondroblast (CL0000058)
    Fold Change: 4.0869
    Cell Significance Index: 23.9900
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 3.9471
    Cell Significance Index: 42.9100
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 2.3291
    Cell Significance Index: 58.2200
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 2.0494
    Cell Significance Index: 44.4000
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: 1.6722
    Cell Significance Index: 11.3300
  • Cell Name: keratocyte (CL0002363)
    Fold Change: 1.5815
    Cell Significance Index: 25.0900
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: 1.4367
    Cell Significance Index: 28.0400
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 1.0310
    Cell Significance Index: 141.5800
  • Cell Name: fibroblast of the aortic adventitia (CL0002547)
    Fold Change: 0.9899
    Cell Significance Index: 9.9900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.7861
    Cell Significance Index: 100.7700
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.7379
    Cell Significance Index: 12.3500
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.5610
    Cell Significance Index: 106.7600
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.4386
    Cell Significance Index: 15.2400
  • Cell Name: muscle fibroblast (CL1001609)
    Fold Change: 0.3167
    Cell Significance Index: 1.9400
  • Cell Name: embryonic fibroblast (CL2000042)
    Fold Change: 0.2968
    Cell Significance Index: 1.4200
  • Cell Name: fibroblast of connective tissue of nonglandular part of prostate (CL1000304)
    Fold Change: 0.2968
    Cell Significance Index: 3.2400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: 0.2205
    Cell Significance Index: 11.1400
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.1569
    Cell Significance Index: 141.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.1055
    Cell Significance Index: 11.4800
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.0972
    Cell Significance Index: 5.8400
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.0896
    Cell Significance Index: 14.5700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.0873
    Cell Significance Index: 8.6400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: 0.0464
    Cell Significance Index: 28.9600
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: 0.0103
    Cell Significance Index: 0.1600
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0093
    Cell Significance Index: 17.5000
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.0052
    Cell Significance Index: 0.0500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0088
    Cell Significance Index: -3.8900
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: -0.0100
    Cell Significance Index: -0.3500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0117
    Cell Significance Index: -8.6700
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0117
    Cell Significance Index: -15.8500
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0146
    Cell Significance Index: -27.0000
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0164
    Cell Significance Index: -25.2000
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: -0.0170
    Cell Significance Index: -0.4900
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0217
    Cell Significance Index: -13.7600
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: -0.0232
    Cell Significance Index: -1.6100
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0255
    Cell Significance Index: -19.3300
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0303
    Cell Significance Index: -17.0600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0364
    Cell Significance Index: -16.5300
  • Cell Name: microcirculation associated smooth muscle cell (CL0008035)
    Fold Change: -0.0369
    Cell Significance Index: -0.3100
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0439
    Cell Significance Index: -23.9700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0548
    Cell Significance Index: -11.5400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0565
    Cell Significance Index: -10.1900
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: -0.0606
    Cell Significance Index: -21.7300
  • Cell Name: skin fibroblast (CL0002620)
    Fold Change: -0.0650
    Cell Significance Index: -0.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0755
    Cell Significance Index: -21.7200
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0770
    Cell Significance Index: -13.1500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.0822
    Cell Significance Index: -3.7200
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.0934
    Cell Significance Index: -18.5400
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.1015
    Cell Significance Index: -11.8300
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: -0.1134
    Cell Significance Index: -22.7400
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1301
    Cell Significance Index: -18.9100
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1438
    Cell Significance Index: -4.0200
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1490
    Cell Significance Index: -19.2600
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1493
    Cell Significance Index: -18.3600
  • Cell Name: pancreatic endocrine cell (CL0008024)
    Fold Change: -0.1584
    Cell Significance Index: -18.0800
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1664
    Cell Significance Index: -10.2000
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1815
    Cell Significance Index: -18.5400
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.1883
    Cell Significance Index: -8.8500
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2096
    Cell Significance Index: -21.8200
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.2165
    Cell Significance Index: -24.8000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: -0.2179
    Cell Significance Index: -4.6400
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.2265
    Cell Significance Index: -11.8000
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.2455
    Cell Significance Index: -10.0600
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: -0.2526
    Cell Significance Index: -2.6200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.2551
    Cell Significance Index: -19.0200
  • Cell Name: supporting cell (CL0000630)
    Fold Change: -0.2652
    Cell Significance Index: -1.2300
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.2705
    Cell Significance Index: -20.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.2757
    Cell Significance Index: -15.4700
  • Cell Name: vascular lymphangioblast (CL0005022)
    Fold Change: -0.3039
    Cell Significance Index: -5.3700
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.3345
    Cell Significance Index: -3.8000
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.3351
    Cell Significance Index: -5.0500
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.3364
    Cell Significance Index: -22.6200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3365
    Cell Significance Index: -21.7100
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: -0.3543
    Cell Significance Index: -22.3300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.3703
    Cell Significance Index: -4.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.3868
    Cell Significance Index: -23.7800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3960
    Cell Significance Index: -10.1800
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: -0.4016
    Cell Significance Index: -10.5600
  • Cell Name: articular chondrocyte (CL1001607)
    Fold Change: -0.4151
    Cell Significance Index: -2.2500
  • Cell Name: myeloid lineage restricted progenitor cell (CL0000839)
    Fold Change: -0.4161
    Cell Significance Index: -5.8400
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.4661
    Cell Significance Index: -24.4700
  • Cell Name: fibroblast of lung (CL0002553)
    Fold Change: -0.4665
    Cell Significance Index: -5.5400
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: -0.4975
    Cell Significance Index: -10.3200
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.5191
    Cell Significance Index: -15.2900
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: -0.5209
    Cell Significance Index: -27.0600
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: -0.5333
    Cell Significance Index: -13.6300
  • Cell Name: stratified epithelial cell (CL0000079)
    Fold Change: -0.5563
    Cell Significance Index: -20.4200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics:** MFAP4 is a small, secreted glycoprotein that is highly expressed in various cell types, including fibroblasts, mesenchymal stem cells, and enteric smooth muscle cells. It is characterized by its ability to bind to microfibrils, which are highly elastic fibers composed of tropoelastin. The binding of MFAP4 to microfibrils is thought to be essential for the assembly and organization of elastic fibers in the ECM. **Pathways and Functions:** MFAP4 is involved in several key pathways, including: 1. **Elastic fiber assembly:** MFAP4 plays a crucial role in the assembly and organization of elastic fibers, which are essential for maintaining tissue elasticity and resilience. 2. **Cell adhesion:** MFAP4 can interact with various cell surface receptors, facilitating cell adhesion and migration. 3. **Regulation of collagen metabolic process:** MFAP4 has been shown to regulate the expression and activity of collagen-related genes, which is essential for maintaining the integrity of the ECM. 4. **Uv protection:** MFAP4 has been implicated in protecting against UV radiation-induced damage, possibly through its ability to regulate the expression of genes involved in DNA repair. **Functions:** The functions of MFAP4 are multifaceted and include: 1. **Elastic fiber formation:** MFAP4 is essential for the assembly and organization of elastic fibers, which are critical for maintaining tissue elasticity and resilience. 2. **ECM organization:** MFAP4 plays a key role in regulating the organization and structure of the ECM, which is essential for maintaining tissue homeostasis. 3. **Cell migration and adhesion:** MFAP4 can facilitate cell migration and adhesion, which is essential for tissue repair and remodeling. 4. **UV protection:** MFAP4 has been shown to protect against UV radiation-induced damage, which is essential for maintaining tissue integrity. **Clinical Significance:** MFAP4 has been implicated in various diseases and disorders, including: 1. **Elastic fiber disorders:** Mutations in the MFAP4 gene have been associated with elastic fiber disorders, such as cutis laxa and Williams syndrome. 2. **Cancer:** MFAP4 has been shown to be overexpressed in various types of cancer, including breast and lung cancer. 3. **Skin disorders:** MFAP4 has been implicated in various skin disorders, including psoriasis and atopic dermatitis. 4. **UV radiation damage:** MFAP4 has been shown to protect against UV radiation-induced damage, which is essential for maintaining tissue integrity. In conclusion, MFAP4 is a critical component of the extracellular matrix that plays a significant role in the organization and function of elastic fibers. Its dysregulation has been implicated in various diseases and disorders, highlighting the importance of further research into the role of MFAP4 in maintaining tissue homeostasis.

Genular Protein ID: 1116402326

Symbol: MFAP4_HUMAN

Name: Microfibril-associated glycoprotein 4

UniProtKB Accession Codes:

P55083 A8KAJ1 A8MVM2 B4E317 Q6P680

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CDD 1 CPTAC 1 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 7 EMDB 2 Ensembl 2 ExpressionAtlas 1 GO 11 Gene3D 1 GeneCards 1 GeneTree 1 GenomeRNAi 1 GlyConnect 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 4 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 NCBIfam 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PDB 2 PDBsum 2 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 2 RNAct 1 Reactome 1 RefSeq 2 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7633408

Title: The gene for a human microfibril-associated glycoprotein is commonly deleted in Smith-Magenis syndrome patients.

PubMed ID: 7633408

DOI: 10.1093/hmg/4.4.589

PubMed ID: 14702039

Title: Complete sequencing and characterization of 21,243 full-length human cDNAs.

PubMed ID: 14702039

DOI: 10.1038/ng1285

PubMed ID: 16625196

Title: DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage.

PubMed ID: 16625196

DOI: 10.1038/nature04689

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 15340161

Title: Signal peptide prediction based on analysis of experimentally verified cleavage sites.

PubMed ID: 15340161

DOI: 10.1110/ps.04682504

PubMed ID: 16335952

Title: Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry.

PubMed ID: 16335952

DOI: 10.1021/pr0502065

PubMed ID: 19159218

Title: Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry.

PubMed ID: 19159218

DOI: 10.1021/pr8008012

PubMed ID: 26601954

Title: Characterization of microfibrillar-associated protein 4 (MFAP4) as a tropoelastin- and fibrillin-binding protein involved in elastic fiber formation.

PubMed ID: 26601954

DOI: 10.1074/jbc.m115.681775

Sequence Information:

  • Length: 255
  • Mass: 28648
  • Checksum: B8F0B47AC694435E
  • Sequence:
    • MKALLALPLL LLLSTPPCAP QVSGIRGDAL ERFCLQQPLD CDDIYAQGYQ SDGVYLIYPS 
GPSVPVPVFC DMTTEGGKWT VFQKRFNGSV SFFRGWNDYK LGFGRADGEY WLGLQNMHLL 
TLKQKYELRV DLEDFENNTA YAKYADFSIS PNAVSAEEDG YTLFVAGFED GGAGDSLSYH 
SGQKFSTFDR DQDLFVQNCA ALSSGAFWFR SCHFANLNGF YLGGSHLSYA NGINWAQWKG 
FYYSLKRTEM KIRRA

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.