Details for: HOXC10

Gene ID: 3226

Symbol: HOXC10

Ensembl ID: ENSG00000180818

Description: homeobox C10

Associated with

  • Anterior/posterior pattern specification
    (GO:0009952)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Embryonic limb morphogenesis
    (GO:0030326)
  • Negative regulation of cold-induced thermogenesis
    (GO:0120163)
  • Neuromuscular process
    (GO:0050905)
  • Nuclear body
    (GO:0016604)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation of cell population proliferation
    (GO:0008284)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein binding
    (GO:0005515)
  • Proximal/distal pattern formation
    (GO:0009954)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Rna polymerase ii transcription regulatory region sequence-specific dna binding
    (GO:0000977)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Skeletal system development
    (GO:0001501)
  • Spinal cord motor neuron cell fate specification
    (GO:0021520)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: oligodendrocyte precursor cell (CL0002453)
    Fold Change: 3.74
    Marker Score: 4628
  • Cell Name: blood vessel endothelial cell (CL0000071)
    Fold Change: 2.15
    Marker Score: 2166
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 2.04
    Marker Score: 4269
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 1.37
    Marker Score: 871
  • Cell Name: goblet cell (CL0000160)
    Fold Change: 1.15
    Marker Score: 7673
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 1.1
    Marker Score: 737
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71811
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 48036.5
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30407
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: 0.96
    Marker Score: 1015
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2413
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.94
    Marker Score: 5344
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.92
    Marker Score: 2742
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.9
    Marker Score: 2116
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.88
    Marker Score: 249
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5292
  • Cell Name: kidney loop of Henle thick ascending limb epithelial cell (CL1001106)
    Fold Change: 0.82
    Marker Score: 2208
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.81
    Marker Score: 619
  • Cell Name: kidney loop of Henle thin ascending limb epithelial cell (CL1001107)
    Fold Change: 0.78
    Marker Score: 795
  • Cell Name: osteoblast (CL0000062)
    Fold Change: 0.78
    Marker Score: 420
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.78
    Marker Score: 708
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.77
    Marker Score: 1258
  • Cell Name: mast cell (CL0000097)
    Fold Change: 0.76
    Marker Score: 443
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.76
    Marker Score: 395
  • Cell Name: kidney interstitial cell (CL1000500)
    Fold Change: 0.73
    Marker Score: 517
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.72
    Marker Score: 377.5
  • Cell Name: epithelial cell of proximal tubule (CL0002306)
    Fold Change: 0.7
    Marker Score: 2497
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.7
    Marker Score: 180
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.7
    Marker Score: 163
  • Cell Name: myeloid cell (CL0000763)
    Fold Change: 0.69
    Marker Score: 1099
  • Cell Name: neutrophil (CL0000775)
    Fold Change: 0.63
    Marker Score: 385
  • Cell Name: epithelial cell of glomerular capsule (CL1000450)
    Fold Change: 0.6
    Marker Score: 153
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.6
    Marker Score: 394
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.57
    Marker Score: 457
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.57
    Marker Score: 276
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.57
    Marker Score: 150
  • Cell Name: conventional dendritic cell (CL0000990)
    Fold Change: 0.56
    Marker Score: 386
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.56
    Marker Score: 232
  • Cell Name: keratinocyte (CL0000312)
    Fold Change: 0.53
    Marker Score: 446
  • Cell Name: B cell (CL0000236)
    Fold Change: 0.53
    Marker Score: 505
  • Cell Name: reticular cell (CL0000432)
    Fold Change: 0.49
    Marker Score: 179.5
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.49
    Marker Score: 474
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.49
    Marker Score: 127
  • Cell Name: renal interstitial pericyte (CL1001318)
    Fold Change: 0.49
    Marker Score: 465
  • Cell Name: plasma cell (CL0000786)
    Fold Change: 0.47
    Marker Score: 529
  • Cell Name: T cell (CL0000084)
    Fold Change: 0.47
    Marker Score: 806
  • Cell Name: cerebral cortex endothelial cell (CL1001602)
    Fold Change: 0.47
    Marker Score: 278.5
  • Cell Name: kidney collecting duct intercalated cell (CL1001432)
    Fold Change: 0.46
    Marker Score: 765
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.44
    Marker Score: 250
  • Cell Name: male germ cell (CL0000015)
    Fold Change: 0.43
    Marker Score: 123
  • Cell Name: Unknown (CL0000003)
    Fold Change: 0.41
    Marker Score: 1260
  • Cell Name: kidney loop of Henle epithelial cell (CL1000909)
    Fold Change: 0.4
    Marker Score: 249
  • Cell Name: inflammatory cell (CL0009002)
    Fold Change: 0.37
    Marker Score: 161
  • Cell Name: muscle precursor cell (CL0000680)
    Fold Change: 0.36
    Marker Score: 94
  • Cell Name: skeletal muscle satellite stem cell (CL0008011)
    Fold Change: 0.36
    Marker Score: 379.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.34
    Marker Score: 339
  • Cell Name: stem cell of epidermis (CL1000428)
    Fold Change: 0.33
    Marker Score: 112
  • Cell Name: parietal epithelial cell (CL1000452)
    Fold Change: 0.33
    Marker Score: 118
  • Cell Name: mesangial cell (CL0000650)
    Fold Change: 0.32
    Marker Score: 387.5
  • Cell Name: cell of skeletal muscle (CL0000188)
    Fold Change: 0.32
    Marker Score: 241
  • Cell Name: kidney connecting tubule epithelial cell (CL1000768)
    Fold Change: 0.31
    Marker Score: 441
  • Cell Name: malignant cell (CL0001064)
    Fold Change: 0.31
    Marker Score: 4119
  • Cell Name: vascular associated smooth muscle cell (CL0000359)
    Fold Change: 0.29
    Marker Score: 135
  • Cell Name: stromal cell (CL0000499)
    Fold Change: 0.29
    Marker Score: 344
  • Cell Name: kidney distal convoluted tubule epithelial cell (CL1000849)
    Fold Change: 0.28
    Marker Score: 295
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: 0.23
    Marker Score: 7942
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.22
    Marker Score: 389
  • Cell Name: fibroblast (CL0000057)
    Fold Change: 0.22
    Marker Score: 209
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.21
    Marker Score: 67
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.21
    Marker Score: 329
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.21
    Marker Score: 63
  • Cell Name: endothelial cell of artery (CL1000413)
    Fold Change: 0.21
    Marker Score: 86
  • Cell Name: plasmacytoid dendritic cell (CL0000784)
    Fold Change: 0.21
    Marker Score: 111
  • Cell Name: kidney loop of Henle thin descending limb epithelial cell (CL1001111)
    Fold Change: 0.21
    Marker Score: 222
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 0.2
    Marker Score: 411.5
  • Cell Name: renal intercalated cell (CL0005010)
    Fold Change: 0.2
    Marker Score: 106
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.19
    Marker Score: 392
  • Cell Name: cardiac endothelial cell (CL0010008)
    Fold Change: 0.19
    Marker Score: 351
  • Cell Name: endothelial cell of lymphatic vessel (CL0002138)
    Fold Change: 0.18
    Marker Score: 112
  • Cell Name: smooth muscle cell (CL0000192)
    Fold Change: 0.17
    Marker Score: 114
  • Cell Name: oogonial cell (CL0000024)
    Fold Change: 0.17
    Marker Score: 245.5
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.17
    Marker Score: 55
  • Cell Name: enterocyte (CL0000584)
    Fold Change: 0.17
    Marker Score: 806
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.16
    Marker Score: 415
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.16
    Marker Score: 72
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.16
    Marker Score: 76
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: 0.16
    Marker Score: 88
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 0.16
    Marker Score: 2480
  • Cell Name: foveolar cell of stomach (CL0002179)
    Fold Change: 0.16
    Marker Score: 999
  • Cell Name: epithelial cell (CL0000066)
    Fold Change: 0.16
    Marker Score: 248
  • Cell Name: epithelial cell of stratum germinativum of esophagus (CL1000447)
    Fold Change: 0.16
    Marker Score: 37.5
  • Cell Name: mesenchymal lymphangioblast (CL0005021)
    Fold Change: 0.15
    Marker Score: 34.5
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.15
    Marker Score: 262
  • Cell Name: late promyelocyte (CL0002151)
    Fold Change: 0.15
    Marker Score: 38.5
  • Cell Name: peritubular capillary endothelial cell (CL1001033)
    Fold Change: 0.15
    Marker Score: 35.5
  • Cell Name: mesothelial cell (CL0000077)
    Fold Change: 0.15
    Marker Score: 61
  • Cell Name: vasa recta ascending limb cell (CL1001131)
    Fold Change: 0.15
    Marker Score: 39.5
  • Cell Name: kidney collecting duct cell (CL1001225)
    Fold Change: 0.15
    Marker Score: 28.5
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: 0.14
    Marker Score: 541
  • Cell Name: pericyte (CL0000669)
    Fold Change: 0.14
    Marker Score: 81

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Other Information

**Key characteristics:** * HOXC10 is a highly conserved transcription factor with an essential role in vertebrates. * It is expressed in a wide range of cell types, including oligodendrocytes, blood vessel endothelial cells, epithelial cells of the nephron, and many others. * Mutations in HOXC10 have been linked to a variety of human diseases, including developmental disorders, cancer, and cardiovascular disease. **Pathways and functions:** * HOXC10 is a key regulator of the AP boundary specification pathway, which is responsible for determining the left/right identity of the body. * It is also involved in the regulation of neural tube specification, cardiac development, and embryonic limb morphogenesis. * In the developing embryo, HOXC10 is expressed in a wave-like pattern, with high expression in the anterior region and low expression in the posterior region. * This pattern is essential for the formation of the neural tube and the subsequent development of the central nervous system. * HOXC10 is also a key regulator of the development of the skeletal system, the spinal cord, and the heart. **Clinical significance:** * HOXC10 mutations have been linked to a variety of human diseases, including: * Congenital heart defects * Neural tube defects * Kidney diseases * Cancer * Developmental disorders * HOXC10 is a promising target for the treatment of these diseases. **Conclusion:** HOXC10 is a critical transcription factor that plays a fundamental role in human development and disease. Its mutations have a significant impact on the development of various tissues and organs, including the brain, heart, and skeletal system. Further understanding of HOXC10 function is essential for the development of new therapeutic strategies for human diseases.

Genular Protein ID: 2098070266

Symbol: HXC10_HUMAN

Name: Homeobox protein Hox-C10

UniProtKB Accession Codes:

Q9NYD6 O15219 O15220 Q9BVD5

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 19 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyCosmos 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 5 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRINTS 1 PRO 1 PROSITE 2 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 10835276

Title: Selection of homeotic proteins for binding to a human DNA replication origin.

PubMed ID: 10835276

DOI: 10.1006/jmbi.2000.3782

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 9357979

Title: Distinct patterns of all-trans retinoic acid dependent expression of HOXB and HOXC homeogenes in human embryonal and small-cell lung carcinoma cell lines.

PubMed ID: 9357979

DOI: 10.1016/s0014-5793(97)01118-6

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 25218447

Title: Uncovering global SUMOylation signaling networks in a site-specific manner.

PubMed ID: 25218447

DOI: 10.1038/nsmb.2890

PubMed ID: 25772364

Title: SUMO-2 orchestrates chromatin modifiers in response to DNA damage.

PubMed ID: 25772364

DOI: 10.1016/j.celrep.2015.02.033

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 342
  • Mass: 38073
  • Checksum: BD8127FD43C2A37B
  • Sequence:
    • MTCPRNVTPN SYAEPLAAPG GGERYSRSAG MYMQSGSDFN CGVMRGCGLA PSLSKRDEGS 
SPSLALNTYP SYLSQLDSWG DPKAAYRLEQ PVGRPLSSCS YPPSVKEENV CCMYSAEKRA 
KSGPEAALYS HPLPESCLGE HEVPVPSYYR ASPSYSALDK TPHCSGANDF EAPFEQRASL 
NPRAEHLESP QLGGKVSFPE TPKSDSQTPS PNEIKTEQSL AGPKGSPSES EKERAKAADS 
SPDTSDNEAK EEIKAENTTG NWLTAKSGRK KRCPYTKHQT LELEKEFLFN MYLTRERRLE 
ISKTINLTDR QVKIWFQNRR MKLKKMNREN RIRELTSNFN FT

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.