Details for: TFAP4

Gene ID: 7023

Symbol: TFAP4

Ensembl ID: ENSG00000090447

Description: transcription factor AP-4

Associated with

  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    (GO:0006978)
  • E-box binding
    (GO:0070888)
  • Histone deacetylase binding
    (GO:0042826)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation by host of viral transcription
    (GO:0043922)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0045736)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna binding
    (GO:0043392)
  • Negative regulation of gene expression
    (GO:0010629)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation by host of viral transcription
    (GO:0043923)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of mitotic cell cycle phase transition
    (GO:1901990)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription repressor complex
    (GO:0017053)

Cells (max top 100)

(Marker Score score is uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: 1.61
    Marker Score: 1292
  • Cell Name: kidney proximal convoluted tubule epithelial cell (CL1000838)
    Fold Change: 1.39
    Marker Score: 2874
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: 1.11
    Marker Score: 17446.5
  • Cell Name: cerebral cortex GABAergic interneuron (CL0010011)
    Fold Change: 1
    Marker Score: 71772.5
  • Cell Name: forebrain radial glial cell (CL0013000)
    Fold Change: 1
    Marker Score: 47997
  • Cell Name: absorptive cell (CL0000212)
    Fold Change: 0.98
    Marker Score: 30404
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 0.95
    Marker Score: 488
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 0.95
    Marker Score: 2406
  • Cell Name: BEST4+ intestinal epithelial cell, human (CL4030026)
    Fold Change: 0.94
    Marker Score: 443
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: 0.91
    Marker Score: 2721
  • Cell Name: transit amplifying cell (CL0009010)
    Fold Change: 0.88
    Marker Score: 5014
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.87
    Marker Score: 5264
  • Cell Name: Unknown (CL0002371)
    Fold Change: 0.86
    Marker Score: 917
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.86
    Marker Score: 310
  • Cell Name: mesodermal cell (CL0000222)
    Fold Change: 0.84
    Marker Score: 11078
  • Cell Name: kidney proximal straight tubule epithelial cell (CL1000839)
    Fold Change: 0.82
    Marker Score: 1928
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: 0.8
    Marker Score: 542
  • Cell Name: lymphoid lineage restricted progenitor cell (CL0000838)
    Fold Change: 0.79
    Marker Score: 476
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.78
    Marker Score: 1267
  • Cell Name: immature innate lymphoid cell (CL0001082)
    Fold Change: 0.77
    Marker Score: 1562
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.76
    Marker Score: 1297
  • Cell Name: extravillous trophoblast (CL0008036)
    Fold Change: 0.76
    Marker Score: 674
  • Cell Name: early T lineage precursor (CL0002425)
    Fold Change: 0.75
    Marker Score: 570
  • Cell Name: gut endothelial cell (CL0000131)
    Fold Change: 0.74
    Marker Score: 266
  • Cell Name: Cajal-Retzius cell (CL0000695)
    Fold Change: 0.73
    Marker Score: 378
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.73
    Marker Score: 291
  • Cell Name: smooth muscle myoblast (CL0000514)
    Fold Change: 0.72
    Marker Score: 344
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: 0.69
    Marker Score: 1436
  • Cell Name: ovarian surface epithelial cell (CL2000064)
    Fold Change: 0.68
    Marker Score: 1856
  • Cell Name: brush cell (CL0002204)
    Fold Change: 0.68
    Marker Score: 622
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.68
    Marker Score: 4413.5
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.68
    Marker Score: 2842
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: 0.67
    Marker Score: 171
  • Cell Name: germ cell (CL0000586)
    Fold Change: 0.66
    Marker Score: 1152
  • Cell Name: neural crest cell (CL0011012)
    Fold Change: 0.63
    Marker Score: 678
  • Cell Name: kidney capillary endothelial cell (CL1000892)
    Fold Change: 0.62
    Marker Score: 193.5
  • Cell Name: fraction A pre-pro B cell (CL0002045)
    Fold Change: 0.62
    Marker Score: 620
  • Cell Name: tracheal goblet cell (CL1000329)
    Fold Change: 0.61
    Marker Score: 1732
  • Cell Name: mononuclear cell (CL0000842)
    Fold Change: 0.6
    Marker Score: 194
  • Cell Name: respiratory epithelial cell (CL0002368)
    Fold Change: 0.6
    Marker Score: 329.5
  • Cell Name: large pre-B-II cell (CL0000957)
    Fold Change: 0.57
    Marker Score: 1552
  • Cell Name: migratory enteric neural crest cell (CL0002607)
    Fold Change: 0.56
    Marker Score: 527
  • Cell Name: osteoclast (CL0000092)
    Fold Change: 0.56
    Marker Score: 277
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: 0.55
    Marker Score: 290
  • Cell Name: intestinal enteroendocrine cell (CL1001516)
    Fold Change: 0.54
    Marker Score: 434
  • Cell Name: Leydig cell (CL0000178)
    Fold Change: 0.54
    Marker Score: 584
  • Cell Name: erythroid progenitor cell, mammalian (CL0001066)
    Fold Change: 0.54
    Marker Score: 172.5
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.53
    Marker Score: 32565
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: 0.53
    Marker Score: 4956
  • Cell Name: primitive red blood cell (CL0002355)
    Fold Change: 0.53
    Marker Score: 395
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: 0.52
    Marker Score: 810
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 0.52
    Marker Score: 335
  • Cell Name: neuroblast (sensu Vertebrata) (CL0000031)
    Fold Change: 0.52
    Marker Score: 328
  • Cell Name: neural cell (CL0002319)
    Fold Change: 0.51
    Marker Score: 244
  • Cell Name: pro-B cell (CL0000826)
    Fold Change: 0.5
    Marker Score: 482
  • Cell Name: precursor B cell (CL0000817)
    Fold Change: 0.5
    Marker Score: 330
  • Cell Name: hematopoietic precursor cell (CL0008001)
    Fold Change: 0.5
    Marker Score: 174
  • Cell Name: common myeloid progenitor (CL0000049)
    Fold Change: 0.49
    Marker Score: 130
  • Cell Name: Bergmann glial cell (CL0000644)
    Fold Change: 0.49
    Marker Score: 198
  • Cell Name: primordial germ cell (CL0000670)
    Fold Change: 0.48
    Marker Score: 607
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: 0.48
    Marker Score: 4589.5
  • Cell Name: follicular B cell (CL0000843)
    Fold Change: 0.48
    Marker Score: 521.5
  • Cell Name: stem cell (CL0000034)
    Fold Change: 0.47
    Marker Score: 1108
  • Cell Name: kidney cell (CL1000497)
    Fold Change: 0.46
    Marker Score: 309
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: 0.46
    Marker Score: 577
  • Cell Name: neuronal receptor cell (CL0000006)
    Fold Change: 0.46
    Marker Score: 203
  • Cell Name: intestinal crypt stem cell of large intestine (CL0009016)
    Fold Change: 0.45
    Marker Score: 135
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: 0.44
    Marker Score: 16373
  • Cell Name: enteric smooth muscle cell (CL0002504)
    Fold Change: 0.44
    Marker Score: 1044.5
  • Cell Name: CD34-positive, CD38-negative hematopoietic stem cell (CL0001024)
    Fold Change: 0.43
    Marker Score: 312
  • Cell Name: megakaryocyte-erythroid progenitor cell (CL0000050)
    Fold Change: 0.43
    Marker Score: 180
  • Cell Name: intestinal crypt stem cell (CL0002250)
    Fold Change: 0.43
    Marker Score: 160
  • Cell Name: vip GABAergic cortical interneuron (CL4023016)
    Fold Change: 0.42
    Marker Score: 16123
  • Cell Name: transit amplifying cell of small intestine (CL0009012)
    Fold Change: 0.42
    Marker Score: 176
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.42
    Marker Score: 4182
  • Cell Name: B-1 B cell (CL0000819)
    Fold Change: 0.41
    Marker Score: 722.5
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: 0.41
    Marker Score: 1711
  • Cell Name: connective tissue cell (CL0002320)
    Fold Change: 0.41
    Marker Score: 107
  • Cell Name: mature alpha-beta T cell (CL0000791)
    Fold Change: 0.41
    Marker Score: 21633
  • Cell Name: mucous neck cell (CL0000651)
    Fold Change: 0.41
    Marker Score: 928
  • Cell Name: enteric neuron (CL0007011)
    Fold Change: 0.4
    Marker Score: 215
  • Cell Name: kidney collecting duct principal cell (CL1001431)
    Fold Change: 0.4
    Marker Score: 1013
  • Cell Name: caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.39
    Marker Score: 1521
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: 0.39
    Marker Score: 7810
  • Cell Name: plasmablast (CL0000980)
    Fold Change: 0.39
    Marker Score: 522
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.39
    Marker Score: 643
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: 0.39
    Marker Score: 4044
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: 0.39
    Marker Score: 5832
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: 0.39
    Marker Score: 2987
  • Cell Name: Unknown (CL0000548)
    Fold Change: 0.39
    Marker Score: 283
  • Cell Name: nephron tubule epithelial cell (CL1000494)
    Fold Change: 0.39
    Marker Score: 91
  • Cell Name: megakaryocyte (CL0000556)
    Fold Change: 0.39
    Marker Score: 220
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: 0.39
    Marker Score: 3315
  • Cell Name: mesenchymal stem cell (CL0000134)
    Fold Change: 0.39
    Marker Score: 594
  • Cell Name: enterocyte of colon (CL1000347)
    Fold Change: 0.38
    Marker Score: 589
  • Cell Name: late pro-B cell (CL0002048)
    Fold Change: 0.38
    Marker Score: 447
  • Cell Name: CD8-alpha-alpha-positive, alpha-beta intraepithelial T cell (CL0000915)
    Fold Change: 0.38
    Marker Score: 536
  • Cell Name: granulocyte monocyte progenitor cell (CL0000557)
    Fold Change: 0.38
    Marker Score: 238
  • Cell Name: preosteoblast (CL0007010)
    Fold Change: 0.37
    Marker Score: 106
  • Cell Name: double-positive, alpha-beta thymocyte (CL0000809)
    Fold Change: 0.37
    Marker Score: 732

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Other Information

**Key Characteristics** TFAP4 exhibits several key characteristics that distinguish it from other transcription factors: 1. **Dual functionality**: TFAP4 acts as both an activator and repressor of transcription, depending on the specific context and the presence of co-regulatory proteins. 2. **Specific DNA binding**: TFAP4 binds to specific DNA sequences, including E-boxes, which are critical for regulating gene expression in response to various cellular stimuli. 3. **Interactions with other transcription factors**: TFAP4 interacts with other transcription factors, such as p53 and AP-1, to regulate gene expression and cellular processes. 4. **Regulation of cell cycle and proliferation**: TFAP4 is involved in regulating the cell cycle and proliferation, particularly in response to DNA damage and viral infections. 5. **Involvement in neural development**: TFAP4 plays a critical role in neural development, particularly in the regulation of GABAergic interneuron differentiation and radial glial cell function. **Pathways and Functions** TFAP4 is involved in several key pathways, including: 1. **Cellular response to dexamethasone stimulus**: TFAP4 regulates gene expression in response to glucocorticoid signaling, which is critical for immune responses and inflammation. 2. **DNA damage response**: TFAP4 is involved in regulating gene expression in response to DNA damage, which is critical for maintaining genome stability. 3. **Apoptosis**: TFAP4 regulates apoptosis, particularly in response to viral infections and cellular stress. 4. **Mitochondrial function**: TFAP4 is involved in regulating mitochondrial function, particularly in response to cellular stress and energy demand. 5. **Transcriptional regulation**: TFAP4 regulates transcriptional activity, particularly in response to specific DNA sequences, such as E-boxes. **Clinical Significance** TFAP4's involvement in various cellular processes, including proliferation, apoptosis, and differentiation, has significant clinical implications: 1. **Cancer**: TFAP4's role in regulating cell cycle and proliferation makes it a potential target for cancer therapy. 2. **Neurological disorders**: TFAP4's involvement in neural development and function makes it a potential target for neurological disorders, such as autism and Alzheimer's disease. 3. **Immune responses**: TFAP4's role in regulating immune responses makes it a potential target for treating autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Viral infections**: TFAP4's involvement in regulating apoptosis and cellular stress makes it a potential target for treating viral infections, such as HIV and hepatitis. 5. **Gene therapy**: TFAP4's role in regulating gene expression makes it a potential target for gene therapy, particularly in treating genetic disorders, such as muscular dystrophy and cystic fibrosis. In conclusion, TFAP4 is a multifunctional transcription factor that plays critical roles in regulating gene expression, cellular processes, and development. Its involvement in various disease states, including cancer, neurological disorders, immune responses, and viral infections, underscores its significance as a potential therapeutic target.

Genular Protein ID: 1933088439

Symbol: TFAP4_HUMAN

Name: Transcription factor AP-4

UniProtKB Accession Codes:

Q01664 O60409

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 EPD 1 Ensembl 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 Genevisible 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 2 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 MaxQB 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PROSITE-ProRule 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SAM 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7933101

Title: Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.

PubMed ID: 7933101

DOI: 10.1128/jvi.68.11.7188-7199.1994

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2123466

Title: Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

PubMed ID: 2123466

DOI: 10.1101/gad.4.10.1741

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 338
  • Mass: 38726
  • Checksum: 540C008658596B83
  • Sequence:
    • MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR EIANSNERRR 
MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE QEKTRLLQQN TQLKRFIQEL 
SGSSPKRRRA EDKDEGIGSP DIWEDEKAED LRREMIELRQ QLDKERSVRM MLEEQVRSLE 
AHMYPEKLKV IAQQVQLQQQ QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP 
PPPPSHHINV VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP 
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. For the full schema, download it here.