Details for: TFAP4

Gene ID: 7023

Symbol: TFAP4

Ensembl ID: ENSG00000090447

Description: transcription factor AP-4

Associated with

  • Cellular response to dexamethasone stimulus
    (GO:0071549)
  • Chromatin
    (GO:0000785)
  • Dna-binding transcription activator activity, rna polymerase ii-specific
    (GO:0001228)
  • Dna-binding transcription factor activity, rna polymerase ii-specific
    (GO:0000981)
  • Dna binding
    (GO:0003677)
  • Dna damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
    (GO:0006978)
  • E-box binding
    (GO:0070888)
  • Histone deacetylase binding
    (GO:0042826)
  • Mitochondrion
    (GO:0005739)
  • Negative regulation by host of viral transcription
    (GO:0043922)
  • Negative regulation of cell population proliferation
    (GO:0008285)
  • Negative regulation of cyclin-dependent protein serine/threonine kinase activity
    (GO:0045736)
  • Negative regulation of dna-templated transcription
    (GO:0045892)
  • Negative regulation of dna binding
    (GO:0043392)
  • Negative regulation of gene expression
    (GO:0010629)
  • Nucleoplasm
    (GO:0005654)
  • Nucleus
    (GO:0005634)
  • Positive regulation by host of viral transcription
    (GO:0043923)
  • Positive regulation of apoptotic process
    (GO:0043065)
  • Positive regulation of dna-templated transcription
    (GO:0045893)
  • Positive regulation of transcription by rna polymerase ii
    (GO:0045944)
  • Protein-containing complex assembly
    (GO:0065003)
  • Protein binding
    (GO:0005515)
  • Protein homodimerization activity
    (GO:0042803)
  • Regulation of mitotic cell cycle phase transition
    (GO:1901990)
  • Regulation of transcription by rna polymerase ii
    (GO:0006357)
  • Rna polymerase ii cis-regulatory region sequence-specific dna binding
    (GO:0000978)
  • Sequence-specific dna binding
    (GO:0043565)
  • Sequence-specific double-stranded dna binding
    (GO:1990837)
  • Transcription cis-regulatory region binding
    (GO:0000976)
  • Transcription repressor complex
    (GO:0017053)

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: polychromatophilic erythroblast (CL0000550)
    Fold Change: 63.2935
    Cell Significance Index: -9.8500
  • Cell Name: hematopoietic oligopotent progenitor cell (CL0002032)
    Fold Change: 31.9937
    Cell Significance Index: -8.1200
  • Cell Name: mucosal type mast cell (CL0000485)
    Fold Change: 24.0488
    Cell Significance Index: -9.7700
  • Cell Name: ileal goblet cell (CL1000326)
    Fold Change: 16.7953
    Cell Significance Index: -11.2700
  • Cell Name: ciliated cell of the bronchus (CL0002332)
    Fold Change: 10.2645
    Cell Significance Index: -9.8000
  • Cell Name: orthochromatic erythroblast (CL0000552)
    Fold Change: 8.6418
    Cell Significance Index: -10.6600
  • Cell Name: CD8-alpha-beta-positive, alpha-beta intraepithelial T cell (CL0000796)
    Fold Change: 4.0577
    Cell Significance Index: -10.8700
  • Cell Name: stromal cell of bone marrow (CL0010001)
    Fold Change: 2.7623
    Cell Significance Index: -10.9000
  • Cell Name: CD8-positive, alpha-beta regulatory T cell (CL0000795)
    Fold Change: 2.0674
    Cell Significance Index: -6.3500
  • Cell Name: gut absorptive cell (CL0000677)
    Fold Change: 1.2228
    Cell Significance Index: 73.4100
  • Cell Name: tuft cell of colon (CL0009041)
    Fold Change: 1.1442
    Cell Significance Index: 1033.1300
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: 1.1020
    Cell Significance Index: 11.9800
  • Cell Name: decidual cell (CL2000002)
    Fold Change: 1.1011
    Cell Significance Index: 17.6700
  • Cell Name: intestinal crypt stem cell of colon (CL0009043)
    Fold Change: 1.0802
    Cell Significance Index: 117.5000
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: 0.9417
    Cell Significance Index: 15.7600
  • Cell Name: epithelial cell of small intestine (CL0002254)
    Fold Change: 0.8267
    Cell Significance Index: 134.4600
  • Cell Name: interstitial cell of ovary (CL0002094)
    Fold Change: 0.6052
    Cell Significance Index: 7.7500
  • Cell Name: microfold cell of epithelium of small intestine (CL1000353)
    Fold Change: 0.5619
    Cell Significance Index: 38.8600
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: 0.4572
    Cell Significance Index: 9.5700
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: 0.3314
    Cell Significance Index: 9.0200
  • Cell Name: enterocyte of epithelium of small intestine (CL1000334)
    Fold Change: 0.2935
    Cell Significance Index: 8.4600
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: 0.2839
    Cell Significance Index: 56.3500
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 0.2416
    Cell Significance Index: 48.4700
  • Cell Name: conjunctival epithelial cell (CL1000432)
    Fold Change: 0.2411
    Cell Significance Index: 3.2900
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: 0.2364
    Cell Significance Index: 32.4600
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: 0.2361
    Cell Significance Index: 10.7000
  • Cell Name: enteroendocrine cell of colon (CL0009042)
    Fold Change: 0.2340
    Cell Significance Index: 44.5300
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: 0.2207
    Cell Significance Index: 7.6700
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: 0.1954
    Cell Significance Index: 5.4600
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: 0.1798
    Cell Significance Index: 20.9500
  • Cell Name: paneth cell of epithelium of small intestine (CL1000343)
    Fold Change: 0.1639
    Cell Significance Index: 3.5500
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1488
    Cell Significance Index: 53.3700
  • Cell Name: colon goblet cell (CL0009039)
    Fold Change: 0.1481
    Cell Significance Index: 14.6500
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: 0.1405
    Cell Significance Index: 62.1100
  • Cell Name: pro-T cell (CL0000827)
    Fold Change: 0.1233
    Cell Significance Index: 3.1500
  • Cell Name: granulosa cell (CL0000501)
    Fold Change: 0.1202
    Cell Significance Index: 3.1600
  • Cell Name: sebum secreting cell (CL0000317)
    Fold Change: 0.1093
    Cell Significance Index: 7.7300
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: 0.1021
    Cell Significance Index: 12.0400
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: 0.0931
    Cell Significance Index: 4.3400
  • Cell Name: enteroendocrine cell of small intestine (CL0009006)
    Fold Change: 0.0880
    Cell Significance Index: 2.2000
  • Cell Name: intestinal crypt stem cell of small intestine (CL0009017)
    Fold Change: 0.0864
    Cell Significance Index: 1.8400
  • Cell Name: intestinal epithelial cell (CL0002563)
    Fold Change: 0.0845
    Cell Significance Index: 0.8800
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: 0.0773
    Cell Significance Index: 42.2200
  • Cell Name: GABAergic interneuron (CL0011005)
    Fold Change: 0.0665
    Cell Significance Index: 45.9600
  • Cell Name: radial glial cell (CL0000681)
    Fold Change: 0.0649
    Cell Significance Index: 0.3900
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: 0.0536
    Cell Significance Index: 3.4600
  • Cell Name: eye photoreceptor cell (CL0000287)
    Fold Change: 0.0511
    Cell Significance Index: 3.2200
  • Cell Name: bladder urothelial cell (CL1001428)
    Fold Change: 0.0395
    Cell Significance Index: 2.0500
  • Cell Name: small intestine goblet cell (CL1000495)
    Fold Change: 0.0381
    Cell Significance Index: 1.3400
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: 0.0335
    Cell Significance Index: 6.0400
  • Cell Name: odontoblast (CL0000060)
    Fold Change: 0.0324
    Cell Significance Index: 4.1500
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: 0.0027
    Cell Significance Index: 0.1300
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0012
    Cell Significance Index: 2.3200
  • Cell Name: cortical cell of adrenal gland (CL0002097)
    Fold Change: 0.0007
    Cell Significance Index: 0.0200
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0011
    Cell Significance Index: -2.0100
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0014
    Cell Significance Index: -2.2200
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0025
    Cell Significance Index: -3.4400
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.0045
    Cell Significance Index: -0.7800
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.0054
    Cell Significance Index: -0.6700
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0070
    Cell Significance Index: -5.3100
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0102
    Cell Significance Index: -6.4900
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0128
    Cell Significance Index: -9.3600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0136
    Cell Significance Index: -6.1500
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0141
    Cell Significance Index: -10.4100
  • Cell Name: neutrophil progenitor cell (CL0000834)
    Fold Change: -0.0144
    Cell Significance Index: -0.3900
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0186
    Cell Significance Index: -10.4900
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.0219
    Cell Significance Index: -2.2400
  • Cell Name: pancreatic PP cell (CL0002275)
    Fold Change: -0.0220
    Cell Significance Index: -13.7600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.0262
    Cell Significance Index: -1.4700
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.0278
    Cell Significance Index: -3.5900
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0300
    Cell Significance Index: -8.6500
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.0406
    Cell Significance Index: -2.1300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.0424
    Cell Significance Index: -6.1700
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: -0.0455
    Cell Significance Index: -0.7800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.0473
    Cell Significance Index: -2.0900
  • Cell Name: forebrain neuroblast (CL1000042)
    Fold Change: -0.0499
    Cell Significance Index: -3.0700
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.0591
    Cell Significance Index: -12.4400
  • Cell Name: kidney cell (CL1000497)
    Fold Change: -0.0601
    Cell Significance Index: -0.4800
  • Cell Name: lung endothelial cell (CL1001567)
    Fold Change: -0.0609
    Cell Significance Index: -3.1700
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.0626
    Cell Significance Index: -2.3700
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.0676
    Cell Significance Index: -7.7400
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.0730
    Cell Significance Index: -5.6000
  • Cell Name: hippocampal granule cell (CL0001033)
    Fold Change: -0.0895
    Cell Significance Index: -6.0200
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.0934
    Cell Significance Index: -6.9600
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.0950
    Cell Significance Index: -1.3600
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.0965
    Cell Significance Index: -10.0500
  • Cell Name: transit amplifying cell of colon (CL0009011)
    Fold Change: -0.1023
    Cell Significance Index: -3.2800
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.1074
    Cell Significance Index: -2.7600
  • Cell Name: CD4-positive, alpha-beta memory T cell, CD45RO-positive (CL0001204)
    Fold Change: -0.1284
    Cell Significance Index: -3.7700
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.1341
    Cell Significance Index: -10.6200
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.1504
    Cell Significance Index: -4.0200
  • Cell Name: BEST4+ enteroycte (CL4030026)
    Fold Change: -0.1725
    Cell Significance Index: -2.6000
  • Cell Name: intestinal tuft cell (CL0019032)
    Fold Change: -0.1817
    Cell Significance Index: -11.1400
  • Cell Name: proerythroblast (CL0000547)
    Fold Change: -0.1821
    Cell Significance Index: -2.6100
  • Cell Name: pulmonary interstitial fibroblast (CL0002241)
    Fold Change: -0.1835
    Cell Significance Index: -1.1400
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.1947
    Cell Significance Index: -9.8400
  • Cell Name: kidney epithelial cell (CL0002518)
    Fold Change: -0.2119
    Cell Significance Index: -6.2400
  • Cell Name: CD14-positive, CD16-negative classical monocyte (CL0002057)
    Fold Change: -0.2170
    Cell Significance Index: -4.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.2190
    Cell Significance Index: -6.9800
  • Cell Name: peg cell (CL4033014)
    Fold Change: -0.2251
    Cell Significance Index: -5.2000

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** TFAP4 exhibits several key characteristics that distinguish it from other transcription factors: 1. **Dual functionality**: TFAP4 acts as both an activator and repressor of transcription, depending on the specific context and the presence of co-regulatory proteins. 2. **Specific DNA binding**: TFAP4 binds to specific DNA sequences, including E-boxes, which are critical for regulating gene expression in response to various cellular stimuli. 3. **Interactions with other transcription factors**: TFAP4 interacts with other transcription factors, such as p53 and AP-1, to regulate gene expression and cellular processes. 4. **Regulation of cell cycle and proliferation**: TFAP4 is involved in regulating the cell cycle and proliferation, particularly in response to DNA damage and viral infections. 5. **Involvement in neural development**: TFAP4 plays a critical role in neural development, particularly in the regulation of GABAergic interneuron differentiation and radial glial cell function. **Pathways and Functions** TFAP4 is involved in several key pathways, including: 1. **Cellular response to dexamethasone stimulus**: TFAP4 regulates gene expression in response to glucocorticoid signaling, which is critical for immune responses and inflammation. 2. **DNA damage response**: TFAP4 is involved in regulating gene expression in response to DNA damage, which is critical for maintaining genome stability. 3. **Apoptosis**: TFAP4 regulates apoptosis, particularly in response to viral infections and cellular stress. 4. **Mitochondrial function**: TFAP4 is involved in regulating mitochondrial function, particularly in response to cellular stress and energy demand. 5. **Transcriptional regulation**: TFAP4 regulates transcriptional activity, particularly in response to specific DNA sequences, such as E-boxes. **Clinical Significance** TFAP4's involvement in various cellular processes, including proliferation, apoptosis, and differentiation, has significant clinical implications: 1. **Cancer**: TFAP4's role in regulating cell cycle and proliferation makes it a potential target for cancer therapy. 2. **Neurological disorders**: TFAP4's involvement in neural development and function makes it a potential target for neurological disorders, such as autism and Alzheimer's disease. 3. **Immune responses**: TFAP4's role in regulating immune responses makes it a potential target for treating autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. 4. **Viral infections**: TFAP4's involvement in regulating apoptosis and cellular stress makes it a potential target for treating viral infections, such as HIV and hepatitis. 5. **Gene therapy**: TFAP4's role in regulating gene expression makes it a potential target for gene therapy, particularly in treating genetic disorders, such as muscular dystrophy and cystic fibrosis. In conclusion, TFAP4 is a multifunctional transcription factor that plays critical roles in regulating gene expression, cellular processes, and development. Its involvement in various disease states, including cancer, neurological disorders, immune responses, and viral infections, underscores its significance as a potential therapeutic target.

Genular Protein ID: 1933088439

Symbol: TFAP4_HUMAN

Name: Transcription factor AP-4

UniProtKB Accession Codes:

Q01664 O60409

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 1 CDD 1 CTD 1 DIP 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 4 Ensembl 1 ExpressionAtlas 1 GO 29 Gene3D 1 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 GlyGen 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 3 KEGG 1 MANE-Select 1 MIM 1 MINT 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PIR 1 PRO 1 PROSITE 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 Pfam 1 PharmGKB 1 Pharos 1 PhosphoSitePlus 1 PhylomeDB 1 Proteomes 1 ProteomicsDB 1 Pumba 1 RNAct 1 RefSeq 1 SIGNOR 1 SMART 1 SMR 1 STRING 1 SUPFAM 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 jPOST 1 neXtProt 1

Citations:

PubMed ID: 7933101

Title: Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function.

PubMed ID: 7933101

DOI: 10.1128/jvi.68.11.7188-7199.1994

PubMed ID: 15616553

Title: The sequence and analysis of duplication-rich human chromosome 16.

PubMed ID: 15616553

DOI: 10.1038/nature03187

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 2123466

Title: Transcription factor AP-4 contains multiple dimerization domains that regulate dimer specificity.

PubMed ID: 2123466

DOI: 10.1101/gad.4.10.1741

PubMed ID: 17081983

Title: Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.

PubMed ID: 17081983

DOI: 10.1016/j.cell.2006.09.026

PubMed ID: 18669648

Title: A quantitative atlas of mitotic phosphorylation.

PubMed ID: 18669648

DOI: 10.1073/pnas.0805139105

PubMed ID: 19369195

Title: Large-scale proteomics analysis of the human kinome.

PubMed ID: 19369195

DOI: 10.1074/mcp.m800588-mcp200

PubMed ID: 20068231

Title: Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis.

PubMed ID: 20068231

DOI: 10.1126/scisignal.2000475

PubMed ID: 21406692

Title: System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation.

PubMed ID: 21406692

DOI: 10.1126/scisignal.2001570

PubMed ID: 23186163

Title: Toward a comprehensive characterization of a human cancer cell phosphoproteome.

PubMed ID: 23186163

DOI: 10.1021/pr300630k

PubMed ID: 28112733

Title: Site-specific mapping of the human SUMO proteome reveals co-modification with phosphorylation.

PubMed ID: 28112733

DOI: 10.1038/nsmb.3366

Sequence Information:

  • Length: 338
  • Mass: 38726
  • Checksum: 540C008658596B83
  • Sequence:
    • MEYFMVPTQK VPSLQHFRKT EKEVIGGLCS LANIPLTPET QRDQERRIRR EIANSNERRR 
MQSINAGFQS LKTLIPHTDG EKLSKAAILQ QTAEYIFSLE QEKTRLLQQN TQLKRFIQEL 
SGSSPKRRRA EDKDEGIGSP DIWEDEKAED LRREMIELRQ QLDKERSVRM MLEEQVRSLE 
AHMYPEKLKV IAQQVQLQQQ QEQVRLLHQE KLEREQQQLR TQLLPPPAPT HHPTVIVPAP 
PPPPSHHINV VTMGPSSVIN SVSTSRQNLD TIVQAIQHIE GTQEKQELEE EQRRAVIVKP 
VRSCPEAPTS DTASDSEASD SDAMDQSREE PSGDGELP

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.