Details for: MAP3K7CL

Gene ID: 56911

Gene Type:  Protein-coding  - A gene that serves as a template for producing a messenger RNA (mRNA) molecule, which is then translated into a functional protein.

Symbol: MAP3K7CL

Ensembl ID: ENSG00000156265

Description: MAP3K7 C-terminal like

Selected Context(s):  Overall

Cell Significance Landscape

Contexts:

Associated with

Significant Cells

Cell Significance Index (CSI) scores for the chosen context(s)

  • perivascular cell CL4033054
    CSI 10.38
    rCSI 14.19%
    PRS 99.32
  • megakaryocyte CL0000556
    CSI 6.56
    rCSI 28.45%
    PRS 97.42
  • myofibroblast cell CL0000186
    CSI 5.62
    rCSI 7.78%
    PRS 97.68
  • platelet CL0000233
    CSI 4.68
    rCSI 19.4%
    PRS 95.77
  • melanocyte CL0000148
    CSI 3.84
    rCSI 2.85%
    PRS 97.69
  • vascular associated smooth muscle cell CL0000359
    CSI 3.74
    rCSI 12.12%
    PRS 98.52
  • cerebral cortex endothelial cell CL1001602
    CSI 3.72
    rCSI 6.44%
    PRS 96.98
  • microcirculation associated smooth muscle cell CL0008035
    CSI 3.16
    rCSI 9.14%
    PRS 98.32
  • lung secretory cell CL1000272
    CSI 3.04
    rCSI 7.52%
    PRS 99.14
  • muscle cell CL0000187
    CSI 2.75
    rCSI 5.65%
    PRS 97.81
  • tracheobronchial smooth muscle cell CL0019019
    CSI 2.34
    rCSI 4.12%
    PRS 99.12
  • CD14-positive, CD16-positive monocyte CL0002397
    CSI 2.24
    rCSI 2.94%
    PRS 99.7
  • kidney connecting tubule epithelial cell CL1000768
    CSI 2.04
    rCSI 5.18%
    PRS 97.34
  • cardiac muscle cell CL0000746
    CSI 2.01
    rCSI 2.88%
    PRS 95.49
  • renal interstitial pericyte CL1001318
    CSI 1.92
    rCSI 5.29%
    PRS 98.4
  • intermediate monocyte CL0002393
    CSI 1.86
    rCSI 2.8%
    PRS 99.46
  • blood vessel smooth muscle cell CL0019018
    CSI 0.83
    rCSI 6.75%
    PRS 98.39
  • indirect pathway medium spiny neuron CL4023029
    CSI 0.38
    rCSI 9.24%
    PRS 93
  • direct pathway medium spiny neuron CL4023026
    CSI 0.38
    rCSI 9.07%
    PRS 93.36

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.
Network Configuration

Explore relationships of the current gene. Select an Interaction Source: 'ONTOLOGY' for shared pathways (GO/Reactome) or 'STRING' for protein-protein interactions. Further refine by selecting context genes and comparing Cell Significance Index (CSI) scores between baseline and target cell types and their specific contexts.

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Legend:
  • Query Gene
  • Node Color (Target Cell CSI, relative to current network):
    • Very High
    • High
    • Medium
    • Low
    • Very Low
    • CSI N/A
  • Node Size: Proportional to Target Cell CSI magnitude
  • STRING PPI Edge
  • Shared Pathway Edge (ONTOLOGY)

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Other Information

This section provides additional information about the gene, including a description generated by an AI language model and details about associated proteins.

## Summary [MAP3K7CL](/details-gene/56911), or MAP3K7 C-terminal like, is a protein-coding gene located on human chromosome 21q21.3. While its function is not extensively characterized, its name and initial cloning studies suggest a relationship to the TGF-beta activated kinase (TAK1, or MAP3K7) signaling pathway [Link](https://doi.org/10.1023/b:bigi.0000020468.96238.54). Functional annotations indicate it is a protein-binding molecule localized to both the [cytosol](/details-go/GO:0005829) and [nucleus](/details-go/GO:0005634), consistent with a role in intracellular signal transduction. **Overall**, expression data reveals its highest significance in cell types associated with the vasculature and tissue structure, including [perivascular cell](/details-cell/CL4033054)s, [myofibroblast cell](/details-cell/CL0000186)s, and smooth muscle cells. It is also notably expressed in the hematopoietic lineage, particularly in [megakaryocyte](/details-cell/CL0000556)s and [platelet](/details-cell/CL0000233)s, suggesting a multifaceted role in both structural biology and hematopoiesis. ## Cellular Roles and Expression Landscape The expression profile of [MAP3K7CL](/details-gene/56911) indicates a prominent role in mesenchymal and hematopoietic cell lineages. The gene shows the highest significance in cells that constitute the structural and vascular components of tissues. These include [perivascular cell](/details-cell/CL4033054) (CSI: 10.38), [myofibroblast cell](/details-cell/CL0000186) (CSI: 5.62), [vascular associated smooth muscle cell](/details-cell/CL0000359) (CSI: 3.74), and [cerebral cortex endothelial cell](/details-cell/CL1001602) (CSI: 3.72). This strong association suggests its involvement in processes such as vascular tone regulation, tissue remodeling, and the maintenance of the extracellular matrix. In addition to its role in stromal cells, [MAP3K7CL](/details-gene/56911) is also a significant marker in the hematopoietic system, specifically within the megakaryocyte-platelet lineage. It is highly significant in [megakaryocyte](/details-cell/CL0000556)s (CSI: 6.56) and their anucleate descendants, [platelet](/details-cell/CL0000233)s (CSI: 4.68). This expression pattern points towards a potential function in megakaryopoiesis (the development of megakaryocytes) or in the subsequent physiological functions of platelets, such as hemostasis and thrombosis. The gene also shows moderate significance in [CD14-positive, CD16-positive monocyte](/details-cell/CL0002397)s, broadening its potential relevance within the myeloid compartment. ## Pathways and Molecular Function The functional annotations for [MAP3K7CL](/details-gene/56911) are currently broad, yet they align with a role in cellular signaling. Gene Ontology terms classify it as having [protein binding](/details-go/GO:0005515) capabilities and being localized to both the [cytosol](/details-go/GO:0005829) and the [nucleus](/details-go/GO:0005634). This dual localization is common for proteins involved in signal transduction cascades that relay signals from the cell periphery to the nucleus to enact transcriptional changes. The gene was first identified as part of a comprehensive transcription map of human chromosome 21 [Link](https://doi.org/10.1006/geno.2001.6640) and was later characterized as a "TGF-beta activated kinase-like gene" [Link](https://doi.org/10.1023/b:bigi.0000020468.96238.54). This suggests it may function as a regulator, scaffold, or downstream component of the MAP3K7/TAK1 pathway, which is a critical node in inflammatory and developmental signaling initiated by TGF-beta, TNF-alpha, and interleukins. Its expression in myofibroblasts and smooth muscle cells, which are highly responsive to TGF-beta, further supports this putative functional link. ## Research Directions The specific biological roles of [MAP3K7CL](/details-gene/56911) remain to be fully elucidated. Its expression pattern and inferred link to the MAP3K7 pathway provide a strong basis for further investigation, particularly concerning its function in tissue fibrosis and hematopoiesis. **Testable Hypotheses:** 1. Given its high significance in [myofibroblast cell](/details-cell/CL0000186)s and its potential connection to TGF-beta signaling, [MAP3K7CL](/details-gene/56911) may function as a key regulator of myofibroblast activation and extracellular matrix deposition, thereby playing a role in the pathogenesis of fibrotic diseases. 2. The high expression of [MAP3K7CL](/details-gene/56911) in [megakaryocyte](/details-cell/CL0000556)s and [platelet](/details-cell/CL0000233)s suggests it is involved in thrombopoiesis or the regulation of platelet function, possibly by modulating intracellular signaling cascades that control platelet activation and aggregation in response to vascular injury. **Proposed Experiment:** To test the first hypothesis, the role of [MAP3K7CL](/details-gene/56911) in myofibroblast differentiation could be investigated. This would involve using primary human lung or cardiac fibroblasts, which can be induced to differentiate into myofibroblasts upon stimulation with TGF-beta1. Using siRNA or CRISPR-Cas9 to knock down or knock out [MAP3K7CL](/details-gene/56911) in these cells, researchers could then assess the impact on myofibroblast differentiation. Key readouts would include the expression of canonical myofibroblast markers such as alpha-smooth muscle actin (α-SMA) and collagen I, measured by qPCR and Western blot, alongside functional assays like cell contractility in a collagen gel matrix. **Therapeutic Potential:** If [MAP3K7CL](/details-gene/56911) is confirmed to be a pro-fibrotic signaling molecule, it could emerge as a novel therapeutic target for conditions such as idiopathic pulmonary fibrosis, cardiac fibrosis, or chronic kidney disease. As an intracellular protein, it would not be amenable to antibody-based therapies but could be targeted by small molecule inhibitors. The therapeutic strategy would focus on **inhibition** to attenuate the pathological activation of fibroblasts and myofibroblasts. However, its significant expression in platelets and monocytes necessitates a thorough evaluation of potential on-target, off-tissue side effects, such as impacts on hemostasis or immune function, which would be critical for its development as a drug target.

Genular Protein ID: 3015455099

Symbol: M3KCL_HUMAN

Name: MAP3K7 C-terminal-like protein

UniProtKB Accession Codes:

P57077 D3DSE0 Q8TCL9

Database IDs:

AGR 1 AlphaFoldDB 1 Antibodypedia 1 Bgee 1 BioGRID 1 BioGRID-ORCS 1 BioMuta 1 CCDS 2 CTD 1 ChiTaRS 1 DMDM 1 DNASU 1 DisGeNET 1 EMBL 11 Ensembl 14 ExpressionAtlas 1 GO 2 GeneCards 1 GeneTree 1 GeneWiki 1 GenomeRNAi 1 HGNC 1 HOGENOM 1 HPA 1 InParanoid 1 IntAct 1 InterPro 1 KEGG 1 MANE-Select 1 MIM 1 MassIVE 1 NCBI Taxonomy 1 OMA 1 OpenTargets 1 OrthoDB 1 PANTHER 2 PRO 1 PathwayCommons 1 PaxDb 1 PeptideAtlas 1 PharmGKB 1 Pharos 1 PhylomeDB 1 Proteomes 1 RNAct 1 RefSeq 8 SMR 1 STRING 1 SignaLink 1 TreeFam 1 UCSC 1 VEuPathDB 1 eggNOG 1 iPTMnet 1 neXtProt 1

Citations:

PubMed ID: 11707072

Title: From PREDs and open reading frames to cDNA isolation: revisiting the human chromosome 21 transcription map.

PubMed ID: 11707072

DOI: 10.1006/geno.2001.6640

PubMed ID: 15168726

Title: Cloning and characterization of a novel human TGF-beta activated kinase-like gene.

PubMed ID: 15168726

DOI: 10.1023/b:bigi.0000020468.96238.54

PubMed ID: 17974005

Title: The full-ORF clone resource of the German cDNA consortium.

PubMed ID: 17974005

DOI: 10.1186/1471-2164-8-399

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 14759258

Title: An unappreciated role for RNA surveillance.

PubMed ID: 14759258

DOI: 10.1186/gb-2004-5-2-r8

Sequence Information:

  • Length: 142
  • Mass: 16372
  • Checksum: 7F9BCBAF69F25444
  • Sequence:
    • MISTARVPAD KPVRIAFSLN DASDDTPPED SIPLVFPELD QQLQPLPPCH DSEESMEVFK 
QHCQIAEEYH EVKKEITLLE QRKKELIAKL DQAEKEKVDA AELVREFEAL TEENRTLRLA 
QSQCVEQLEK LRIQYQKRQG SS

Genular Protein ID: 2052068529

Symbol: B0EVZ7_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0EVZ7

Database IDs:

AlphaFoldDB 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 4 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 RefSeq 1 SAM 1

Sequence Information:

  • Length: 87
  • Mass: 10360
  • Checksum: D78CA1B5A5E41203
  • Sequence:
    • MEVFKQHCQI AEEYHEVKKE ITLLEQRKKE LIAKLDQAEK EKVDAAELVR EFEALTEENR 
TLRLAQSQCV EQLEKLRIQY QKRQGSS

Genular Protein ID: 3670274236

Symbol: B0EVZ6_HUMAN

Name: N/A

UniProtKB Accession Codes:

B0EVZ6

Database IDs:

BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 2 GeneTree 1 HGNC 1 KEGG 1 NCBI Taxonomy 1 OrthoDB 1 Proteomes 2 RefSeq 6

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 124
  • Mass: 13393
  • Checksum: 2568C1F33FDA7B78
  • Sequence:
    • MVQLIAPLEV MWNEAADLKP LALSRRLECS GGIMAHYSPD LLGPEMESRY FAQVGLEHLA 
SSSPPAFGFL KCLDYSISVL CSATSLAMLE DNPKVSKLAT GDWMLTLKPK SITVPVEIPS 
SPLG

Genular Protein ID: 7184907

Symbol: B4DFW0_HUMAN

Name: N/A

UniProtKB Accession Codes:

B4DFW0

Database IDs:

Antibodypedia 1 Bgee 1 BioGRID-ORCS 1 CTD 1 ChiTaRS 1 DNASU 1 DisGeNET 1 EMBL 8 Ensembl 3 GeneTree 1 HGNC 1 InterPro 1 NCBI Taxonomy 1 OrthoDB 1 PANTHER 2 PeptideAtlas 1 Proteomes 2 ProteomicsDB 1 RefSeq 2 SAM 2 UCSC 1 VEuPathDB 1

Citations:

PubMed ID: 10830953

Title: The DNA sequence of human chromosome 21.

PubMed ID: 10830953

DOI: 10.1038/35012518

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

Sequence Information:

  • Length: 136
  • Mass: 15703
  • Checksum: D8FA1AE9039EA866
  • Sequence:
    • MLVSSSSLTP FPPVRTADDT PPEDSIPLVF PELDQQLQPL PPCHDSEESM EVFKQHCQIA 
EEYHEVKKEI TLLEQRKKEL IAKLDQAEKE KVDAAELVRE FEALTEENRT LRLAQSQCVE 
QLEKLRIQYQ KRQGSS