Details for: GALNT9

Gene ID: 50614

Symbol: GALNT9

Ensembl ID: ENSG00000182870

Description: polypeptide N-acetylgalactosaminyltransferase 9

Associated with

Cells (max top 100)

(Cell Significance Index and respective Thresholds are uniquely calculated using our advanced thresholding algorithms to reveal cell-specific gene markers)

  • Cell Name: helper T cell (CL0000912)
    Fold Change: 2.6152
    Cell Significance Index: 37.1600
  • Cell Name: L2/3-6 intratelencephalic projecting glutamatergic neuron (CL4023040)
    Fold Change: 1.5661
    Cell Significance Index: 314.1500
  • Cell Name: CD8-positive, alpha-beta memory T cell, CD45RO-positive (CL0001203)
    Fold Change: 0.9787
    Cell Significance Index: 10.1500
  • Cell Name: medullary thymic epithelial cell (CL0002365)
    Fold Change: 0.2496
    Cell Significance Index: 2.7300
  • Cell Name: cerebellar granule cell (CL0001031)
    Fold Change: 0.1966
    Cell Significance Index: 3.3700
  • Cell Name: obsolete caudal ganglionic eminence derived GABAergic cortical interneuron (CL4023070)
    Fold Change: 0.1132
    Cell Significance Index: 40.6000
  • Cell Name: pigmented epithelial cell (CL0000529)
    Fold Change: 0.0304
    Cell Significance Index: 57.2300
  • Cell Name: eukaryotic cell (CL0000255)
    Fold Change: 0.0002
    Cell Significance Index: 0.0100
  • Cell Name: corticothalamic-projecting glutamatergic cortical neuron (CL4023013)
    Fold Change: -0.0044
    Cell Significance Index: -0.1400
  • Cell Name: fallopian tube secretory epithelial cell (CL4030006)
    Fold Change: -0.0045
    Cell Significance Index: -0.0700
  • Cell Name: hair follicular keratinocyte (CL2000092)
    Fold Change: -0.0103
    Cell Significance Index: -4.5400
  • Cell Name: non-pigmented ciliary epithelial cell (CL0002304)
    Fold Change: -0.0176
    Cell Significance Index: -11.1900
  • Cell Name: odontoblast (CL0000060)
    Fold Change: -0.0196
    Cell Significance Index: -2.5200
  • Cell Name: kidney loop of Henle cortical thick ascending limb epithelial cell (CL1001109)
    Fold Change: -0.0236
    Cell Significance Index: -17.3200
  • Cell Name: lens epithelial cell (CL0002224)
    Fold Change: -0.0310
    Cell Significance Index: -47.7900
  • Cell Name: cell in vitro (CL0001034)
    Fold Change: -0.0312
    Cell Significance Index: -17.0600
  • Cell Name: anterior lens cell (CL0002223)
    Fold Change: -0.0318
    Cell Significance Index: -58.5800
  • Cell Name: pulmonary alveolar epithelial cell (CL0000322)
    Fold Change: -0.0368
    Cell Significance Index: -27.8800
  • Cell Name: neuron associated cell (CL0000095)
    Fold Change: -0.0448
    Cell Significance Index: -1.8300
  • Cell Name: secondary lens fiber (CL0002225)
    Fold Change: -0.0556
    Cell Significance Index: -75.6600
  • Cell Name: pancreatic A cell (CL0000171)
    Fold Change: -0.0681
    Cell Significance Index: -50.4600
  • Cell Name: ciliary muscle cell (CL1000443)
    Fold Change: -0.0738
    Cell Significance Index: -33.5100
  • Cell Name: type B pancreatic cell (CL0000169)
    Fold Change: -0.0893
    Cell Significance Index: -50.3600
  • Cell Name: fibro/adipogenic progenitor cell (CL0009099)
    Fold Change: -0.0925
    Cell Significance Index: -4.6800
  • Cell Name: intermediate cell of urothelium (CL4030055)
    Fold Change: -0.0951
    Cell Significance Index: -17.1500
  • Cell Name: dopaminergic neuron (CL0000700)
    Fold Change: -0.0987
    Cell Significance Index: -28.4000
  • Cell Name: basal epithelial cell of tracheobronchial tree (CL0002329)
    Fold Change: -0.1217
    Cell Significance Index: -3.4000
  • Cell Name: neoplastic cell (CL0001063)
    Fold Change: -0.1343
    Cell Significance Index: -26.6500
  • Cell Name: abnormal cell (CL0001061)
    Fold Change: -0.1429
    Cell Significance Index: -14.6000
  • Cell Name: basal cell of urothelium (CL1000486)
    Fold Change: -0.1491
    Cell Significance Index: -18.3400
  • Cell Name: epithelial cell of nephron (CL1000449)
    Fold Change: -0.1682
    Cell Significance Index: -1.4300
  • Cell Name: pigmented ciliary epithelial cell (CL0002303)
    Fold Change: -0.1710
    Cell Significance Index: -24.8600
  • Cell Name: lactocyte (CL0002325)
    Fold Change: -0.1872
    Cell Significance Index: -24.1800
  • Cell Name: stromal cell of ovary (CL0002132)
    Fold Change: -0.2102
    Cell Significance Index: -28.8700
  • Cell Name: epithelial cell of stomach (CL0002178)
    Fold Change: -0.2342
    Cell Significance Index: -27.2900
  • Cell Name: kidney loop of Henle descending limb epithelial cell (CL1001021)
    Fold Change: -0.2602
    Cell Significance Index: -20.6100
  • Cell Name: L6b glutamatergic cortical neuron (CL4023038)
    Fold Change: -0.2666
    Cell Significance Index: -8.7300
  • Cell Name: near-projecting glutamatergic cortical neuron (CL4023012)
    Fold Change: -0.2798
    Cell Significance Index: -6.9800
  • Cell Name: smooth muscle cell of sphincter of pupil (CL0002243)
    Fold Change: -0.2801
    Cell Significance Index: -29.1700
  • Cell Name: medial ganglionic eminence derived interneuron (CL4023063)
    Fold Change: -0.2947
    Cell Significance Index: -4.2200
  • Cell Name: basal cell of prostate epithelium (CL0002341)
    Fold Change: -0.3057
    Cell Significance Index: -8.3200
  • Cell Name: early pro-B cell (CL0002046)
    Fold Change: -0.3091
    Cell Significance Index: -19.9400
  • Cell Name: skeletal muscle fiber (CL0008002)
    Fold Change: -0.3095
    Cell Significance Index: -7.9600
  • Cell Name: L5 extratelencephalic projecting glutamatergic cortical neuron (CL4023041)
    Fold Change: -0.3228
    Cell Significance Index: -11.3100
  • Cell Name: progenitor cell of mammary luminal epithelium (CL0009116)
    Fold Change: -0.3274
    Cell Significance Index: -24.4000
  • Cell Name: glycinergic neuron (CL1001509)
    Fold Change: -0.3484
    Cell Significance Index: -18.2900
  • Cell Name: pancreatic ductal cell (CL0002079)
    Fold Change: -0.3540
    Cell Significance Index: -40.5600
  • Cell Name: pancreatic D cell (CL0000173)
    Fold Change: -0.3571
    Cell Significance Index: -75.2200
  • Cell Name: pvalb GABAergic cortical interneuron (CL4023018)
    Fold Change: -0.4005
    Cell Significance Index: -8.5000
  • Cell Name: endothelial cell of venule (CL1000414)
    Fold Change: -0.4111
    Cell Significance Index: -4.6700
  • Cell Name: mesonephric nephron tubule epithelial cell (CL1000022)
    Fold Change: -0.4127
    Cell Significance Index: -14.3400
  • Cell Name: mesenchymal cell (CL0008019)
    Fold Change: -0.4138
    Cell Significance Index: -6.9300
  • Cell Name: fibroblast of dermis (CL0002551)
    Fold Change: -0.4285
    Cell Significance Index: -8.9700
  • Cell Name: leptomeningeal cell (CL0000708)
    Fold Change: -0.4412
    Cell Significance Index: -9.4300
  • Cell Name: pancreatic acinar cell (CL0002064)
    Fold Change: -0.4413
    Cell Significance Index: -75.3500
  • Cell Name: stellate neuron (CL0000122)
    Fold Change: -0.4420
    Cell Significance Index: -5.0200
  • Cell Name: tonsil germinal center B cell (CL2000006)
    Fold Change: -0.4787
    Cell Significance Index: -56.4500
  • Cell Name: enterocyte of epithelium of large intestine (CL0002071)
    Fold Change: -0.4822
    Cell Significance Index: -21.8600
  • Cell Name: preadipocyte (CL0002334)
    Fold Change: -0.4883
    Cell Significance Index: -9.5300
  • Cell Name: luminal adaptive secretory precursor cell of mammary gland (CL4033057)
    Fold Change: -0.5060
    Cell Significance Index: -23.7800
  • Cell Name: VIP GABAergic cortical interneuron (CL4023016)
    Fold Change: -0.5071
    Cell Significance Index: -10.1800
  • Cell Name: L6 intratelencephalic projecting glutamatergic neuron of the primary motor cortex (CL4023050)
    Fold Change: -0.5098
    Cell Significance Index: -6.8000
  • Cell Name: sst GABAergic cortical interneuron (CL4023017)
    Fold Change: -0.5128
    Cell Significance Index: -10.1400
  • Cell Name: melanocyte of skin (CL1000458)
    Fold Change: -0.5180
    Cell Significance Index: -7.2600
  • Cell Name: retinal progenitor cell (CL0002672)
    Fold Change: -0.5318
    Cell Significance Index: -29.8400
  • Cell Name: skeletal muscle fibroblast (CL0011027)
    Fold Change: -0.5437
    Cell Significance Index: -3.6800
  • Cell Name: acinar cell of salivary gland (CL0002623)
    Fold Change: -0.5619
    Cell Significance Index: -26.2000
  • Cell Name: slow muscle cell (CL0000189)
    Fold Change: -0.5762
    Cell Significance Index: -8.6200
  • Cell Name: professional antigen presenting cell (CL0000145)
    Fold Change: -0.6004
    Cell Significance Index: -5.4300
  • Cell Name: lamp5 GABAergic cortical interneuron (CL4023011)
    Fold Change: -0.6012
    Cell Significance Index: -12.9900
  • Cell Name: fast muscle cell (CL0000190)
    Fold Change: -0.6322
    Cell Significance Index: -8.2800
  • Cell Name: stromal cell of endometrium (CL0002255)
    Fold Change: -0.6485
    Cell Significance Index: -9.2300
  • Cell Name: decidual cell (CL2000002)
    Fold Change: -0.6545
    Cell Significance Index: -10.5000
  • Cell Name: cardiac muscle myoblast (CL0000513)
    Fold Change: -0.6731
    Cell Significance Index: -51.6500
  • Cell Name: skeletal muscle myoblast (CL0000515)
    Fold Change: -0.6926
    Cell Significance Index: -7.5300
  • Cell Name: obsolete epithelial cell of alveolus of lung (CL0010003)
    Fold Change: -0.7094
    Cell Significance Index: -17.6900
  • Cell Name: basal cell of epidermis (CL0002187)
    Fold Change: -0.7262
    Cell Significance Index: -11.0300
  • Cell Name: CD14-low, CD16-positive monocyte (CL0002396)
    Fold Change: -0.7571
    Cell Significance Index: -18.3400
  • Cell Name: retinal ganglion cell (CL0000740)
    Fold Change: -0.7608
    Cell Significance Index: -6.2800
  • Cell Name: centrilobular region hepatocyte (CL0019029)
    Fold Change: -0.7634
    Cell Significance Index: -12.8600
  • Cell Name: Purkinje cell (CL0000121)
    Fold Change: -0.7917
    Cell Significance Index: -17.3400
  • Cell Name: neuron (CL0000540)
    Fold Change: -0.8134
    Cell Significance Index: -7.7100
  • Cell Name: fibroblast of mammary gland (CL0002555)
    Fold Change: -0.8215
    Cell Significance Index: -23.5500
  • Cell Name: pulmonary capillary endothelial cell (CL4028001)
    Fold Change: -0.8384
    Cell Significance Index: -11.4800
  • Cell Name: L2/3 intratelencephalic projecting glutamatergic neuron (CL4030059)
    Fold Change: -0.8387
    Cell Significance Index: -11.1800
  • Cell Name: indirect pathway medium spiny neuron (CL4023029)
    Fold Change: -0.8399
    Cell Significance Index: -37.1500
  • Cell Name: periportal region hepatocyte (CL0019026)
    Fold Change: -0.8554
    Cell Significance Index: -12.6300
  • Cell Name: sncg GABAergic cortical interneuron (CL4023015)
    Fold Change: -0.8805
    Cell Significance Index: -17.3300
  • Cell Name: chandelier pvalb GABAergic cortical interneuron (CL4023036)
    Fold Change: -0.9137
    Cell Significance Index: -19.0700
  • Cell Name: smooth muscle cell of prostate (CL1000487)
    Fold Change: -0.9210
    Cell Significance Index: -10.6600
  • Cell Name: retinal astrocyte (CL4033015)
    Fold Change: -0.9251
    Cell Significance Index: -9.0600
  • Cell Name: erythrocyte (CL0000232)
    Fold Change: -0.9341
    Cell Significance Index: -23.8000
  • Cell Name: placental villous trophoblast (CL2000060)
    Fold Change: -0.9370
    Cell Significance Index: -25.0200
  • Cell Name: hematopoietic stem cell (CL0000037)
    Fold Change: -0.9454
    Cell Significance Index: -16.1600
  • Cell Name: suprabasal keratinocyte (CL4033013)
    Fold Change: -0.9559
    Cell Significance Index: -15.3700
  • Cell Name: OFF midget ganglion cell (CL4033047)
    Fold Change: -0.9712
    Cell Significance Index: -12.1100
  • Cell Name: direct pathway medium spiny neuron (CL4023026)
    Fold Change: -0.9824
    Cell Significance Index: -37.2000
  • Cell Name: glutamatergic neuron (CL0000679)
    Fold Change: -0.9849
    Cell Significance Index: -10.7300
  • Cell Name: fibroblast of connective tissue of glandular part of prostate (CL1000305)
    Fold Change: -0.9850
    Cell Significance Index: -10.8800
  • Cell Name: myoepithelial cell (CL0000185)
    Fold Change: -0.9891
    Cell Significance Index: -11.2200

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this specific cell.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Cell ID: Standard Cell Ontology term used for mapping and comparing cells across experiments. Ensures consistency in analyzing cellular functions across tissues.
Fold Change: Represents the ratio of the current Cell Significance Index to the Cell Significance Index Threshold, indicating how much the gene expression has changed compared to a baseline.
Cell Significance Index: Reflects how strongly a gene is expressed in this cell type. Calculated using techniques like effect size estimation and bootstrapping for reliability.

Other Information

**Key Characteristics** 1. **Polypeptide N-acetylgalactosaminyltransferase activity**: GALNT9 is a member of the polypeptide N-acetylgalactosaminyltransferase family, which is responsible for catalyzing the transfer of N-acetylgalactosamine (GalNAc) to the O-glycosylation sites of target proteins. 2. **O-linked glycosylation**: GALNT9 is involved in the processing of O-linked glycosylation of mucins and other proteins, which is a critical process for maintaining cellular function and interactions. 3. **Significant expression in various cell types**: GALNT9 is expressed in a wide range of cell types, including conventional dendritic cells, glutamatergic neurons, kidney epithelial cells, goblet cells, and granulocyte-monocyte progenitor cells. 4. **Metal ion binding**: GALNT9 has been shown to bind to metal ions, which is essential for its enzymatic activity. **Pathways and Functions** 1. **O-linked glycosylation**: GALNT9 is involved in the assembly of complex carbohydrates on the surface of cells, which is essential for maintaining cellular function and interactions. 2. **Golgi apparatus**: GALNT9 is localized to the Golgi apparatus, where it plays a crucial role in the processing of O-linked glycosylation. 3. **Polypeptide n-acetylgalactosaminyltransferase activity**: GALNT9 catalyzes the transfer of N-acetylgalactosamine (GalNAc) to the O-glycosylation sites of target proteins. 4. **Metal ion binding**: GALNT9 binds to metal ions, which is essential for its enzymatic activity. **Clinical Significance** 1. **Dysregulation of O-linked glycosylation**: Dysregulation of O-linked glycosylation has been implicated in various diseases, including cancer, neurodegenerative disorders, and inflammatory diseases. 2. **Implications for cancer therapy**: GALNT9 has been identified as a potential target for cancer therapy, as its inhibition has been shown to inhibit tumor growth and metastasis. 3. **Neurological disorders**: GALNT9 has been implicated in the pathogenesis of neurological disorders, including Alzheimer's disease and Parkinson's disease, where dysregulation of O-linked glycosylation has been observed. 4. **Inflammatory diseases**: GALNT9 has been implicated in the pathogenesis of inflammatory diseases, including rheumatoid arthritis and lupus, where dysregulation of O-linked glycosylation has been observed. In conclusion, GALNT9 is a critical enzyme involved in the processing of O-linked glycosylation of mucins and other proteins. Its dysregulation has been implicated in various diseases, including cancer, neurological disorders, and inflammatory diseases. Further research is needed to fully understand the role of GALNT9 in human disease and to explore its potential as a therapeutic target.

Genular Protein ID: 2288006340

Symbol: GALT9_HUMAN

Name: Polypeptide N-acetylgalactosaminyltransferase 9

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 10978536

Title: Brain-specific expression of a novel human UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase (GalNAc-T9).

PubMed ID: 10978536

DOI: 10.1016/s0167-4781(00)00180-9

PubMed ID: 15489334

Title: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).

PubMed ID: 15489334

DOI: 10.1101/gr.2596504

PubMed ID: 12407114

Title: Cloning and characterization of a new human UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase, designated pp-GalNAc-T13, that is specifically expressed in neurons and synthesizes GalNAc alpha-serine/threonine antigen.

PubMed ID: 12407114

DOI: 10.1074/jbc.m203094200

Sequence Information:

  • Length: 603
  • Mass: 68359
  • Checksum: 4B5888733D8577CF
  • Sequence:
  • MAVARKIRTL LTVNILVFVG IVLFSVYCRL QGRSQELVRI VSGDRRVRSR HAKVGTLGDR 
    EAILQRLDHL EEVVYNQLNG LAKPIGLVEG PGGLGQGGLA ATLRDDGQEA EGKYEEYGYN 
    AQLSDRISLD RSIPDYRPRK CRQMSYAQDL PQVSVVFIFV NEALSVILRS VHSVVNHTPS 
    QLLKEVILVD DNSDNVELKF NLDQYVNKRY PGLVKIVRNS RREGLIRARL QGWKAATAPV 
    VGFFDAHVEF NTGWAEPALS RIREDRRRIV LPAIDNIKYS TFEVQQYANA AHGYNWGLRC 
    MYIIPPQDWL DRGDESAPIR TPAMIGCSFV VDREYFGDIG LLDPGMEVYG GENVELGMRV 
    WQCGGSMEVL PCSRVAHIER TRKPYNNDID YYAKRNALRA AEVWMDDFKS HVYMAWNIPM 
    SNPGVDFGDV SERLALRQRL KCRSFKWYLE NVYPEMRVYN NTLTYGEVRN SKASAYCLDQ 
    GAEDGDRAIL YPCHGMSSQL VRYSADGLLQ LGPLGSTAFL PDSKCLVDDG TGRMPTLKKC 
    EDVARPTQRL WDFTQSGPIV SRATGRCLEV EMSKDANFGL RLVVQRCSGQ KWMIRNWIKH 
    ARH

Genular Protein ID: 443969982

Symbol: J3KNN1_HUMAN

Name: N/A

UniProtKB Accession Codes:

Database IDs:

Citations:

PubMed ID: 11237011

Title: Initial sequencing and analysis of the human genome.

PubMed ID: 11237011

DOI: 10.1038/35057062

PubMed ID: 15496913

Title: Finishing the euchromatic sequence of the human genome.

PubMed ID: 15496913

DOI: 10.1038/nature03001

PubMed ID: 16541075

Title: The finished DNA sequence of human chromosome 12.

PubMed ID: 16541075

DOI: 10.1038/nature04569

Sequence Information:

  • Length: 603
  • Mass: 68389
  • Checksum: B8824EA9F92DC117
  • Sequence:
  • MAVARKIRTL LTVNILVFVG IVLFSVYCRL QGRSQELVRI VSGDRRVRSR HAKVGTLGDR 
    EAILQRLDHL EEVVYNQLNG LAKPIGLVEG PGGLGQGGLA ATLRDDGQEA EGKYEEYGYN 
    AQLSDRISLD RSIPDYRPRK CRQMSYAQDL PQVSVVFIFV NEALSVILRS VHSVVNHTPS 
    QLLKEVILVD DNSDNVELKF NLDQYVNKRY PGLVKIVRNS RREGLIRARL QGWKAATAPV 
    VGFFDAHVEF NTGWAEPALS RIREDRRRIV LPAIDNIKYS TFEVQQYANA AHGYNWGLWC 
    MYIIPPQDWL DRGDESAPIR TPAMIGCSFV VDREYFGDIG LLDPGMEVYG GENVELGMRV 
    WQCGGSMEVL PCSRVAHIER TRKPYNNDID YYAKRNALRA AEVWMDDFKS HVYMAWNIPM 
    SNPGVDFGDV SERLALRQRL KCRSFKWYLE NVYPEMRVYN NTLTYGEVRN SKASAYCLDQ 
    GAEDGDRAIL YPCHGMSSQL VRYSADGLLQ LGPLGSTAFL PDSKCLVDDG TGRMPTLKKC 
    EDVARPTQRL WDFTQSGPIV SRATGRCLEV EMSKDANFGL RLVVQRCSGQ KWMIRNWIKH 
    ARH

Database document:

This is a preview of the gene's schema. Only a few entries are kept for 'singleCellExpressions,' 'mRNAExpressions,' and other large data arrays for visualization purposes. You can zoom in with the mouse wheel for a closer view, and the text will adjust automatically if necessary. For the full schema, download it here.